Synthesis of peptide aldehyde derivatives as selective inhibitors of human cathepsin L and their inhibitory effect on bone resorption

Journal of Medicinal Chemistry

Volumn 41, Issue 22, 1998, Pages 4301-4308

  Yasuma, Tsuneo ^a   Oi, Satoru ^a   Choh, Nobuo ^a   Nomura, Toshiyuki ^a   Furuyama, Naoki ^a   Nishimura, Atsushi ^a   Fujisawa, Yukio ^a   Sohda, Takashi ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DERIVATIVE; CALCIUM ION; CATHEPSIN INHIBITOR; CATHEPSIN L; HYDROXYPROLINE; N (1 NAPHTHALENYLSULFONYLISOLEUCYLTRYPTOPHANAL; N,O DIMETHYLHYDROXYLAMINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; COLLAGEN DEGRADATION; CONTROLLED STUDY; DRUG POTENCY; DRUG SELECTIVITY; ENZYME SYNTHESIS; FEMALE; INHIBITION KINETICS; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; OSTEOLYSIS; OVARIECTOMY;

ALDEHYDES; ANIMALS; BONE AND BONES; BONE RESORPTION; CALCIUM; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDES; ENDOPEPTIDASES; FEMALE; HUMANS; HYDROXYPROLINE; MICE; MICE, INBRED C3H; NAPHTHALENESULFONATES; ORGAN CULTURE TECHNIQUES; OVARIECTOMY; PEPTIDES; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; SKULL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0032561376     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9803065     Document Type: Article

References (26)

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