Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design

Journal of Medicinal Chemistry

Volumn 44, Issue 26, 2001, Pages 4524-4534

  Greenspan, P D ^a   Clark, K L ^a   Tommasi, R A ^a   Cowen, S D ^a   McQuire, L W ^a   Farley, D L ^a   Van Duzer, J H ^a   Goldberg, R L ^a   Zhou, H ^a   Du, Z ^a   Fitt, J J ^a   Coppa, D E ^a   Fang, Z ^a   Macchia, W ^a   Zhu, L ^a   Capparelli, M P ^a   Goldstein, R ^a   Wigg, A M ^a   Doughty, J R ^a   Bohacek, R S ^a   Knap, A K ^a   more..

^a NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; CYSTEINE PROTEINASE INHIBITOR; N [2 [(3 CARBOXYPHENYL)METHOXY] 1 CYANOETHYL] 3 METHYL NALPHA (2,4 DIFLUOROBENZOYL) PHENYLALANINAMIDE; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANIMALS; BINDING SITES; CATHEPSIN B; CRYSTALLOGRAPHY, X-RAY; DIPEPTIDES; DRUG DESIGN; ENZYME INHIBITORS; MODELS, MOLECULAR; NITRILES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035924180     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010206q     Document Type: Article

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