Substrate/propeptide-derived endo-epoxysuccinyl peptides as highly potent and selective cathepsin B inhibitors

FEBS Letters

Volumn 421, Issue 1, 1998, Pages 80-82

  Schaschke, Norbert ^a   Assfalg Machleidt, Irmgard ^b   MacHleidt, Werner ^b   Moroder, Luis ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

Author keywords

Cathepsin B; Cathepsin L; Configuration; Cysteine proteinase; Epoxysuccinyl peptide; Inhibitor; Selective inhibition

Indexed keywords

CATHEPSIN B; CYSTEINE PROTEINASE INHIBITOR; DIPEPTIDE; ENDO EPOXYSUCCINYL PEPTIDE DERIVATIVE; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEIN PRECURSOR; TRIPEPTIDE; UNCLASSIFIED DRUG;

ARTICLE; DIASTEREOISOMER; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; PRIORITY JOURNAL;

EID: 0032472272     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)01538-X     Document Type: Article

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