Inhibition of human cytomegalovirus UL80 protease by specific intramolecular disulfide bond formation

Biochemistry

Volumn 35, Issue 18, 1996, Pages 5838-5846

  Baum, Ellen Z ^a   Siegel, Marshall M ^a   Bebernitz, Geraldine A ^a   Hulmes, Jeffrey D ^a,b   Sridharan, Latha ^a   Sun, Lei ^a   Tabei, Keiko ^a   Johnston, Stuart H ^a,c   Wildey, Mary Jo ^a,d   Nygaard, John ^a,e   Jones, Thomas R ^a   Gluzman, Yakov ^a  

^a WYETH RESEARCH   (United States)

^b Adirondack Biomedical Research Institute Inc   (United States)

^c PRINCETON UNIVERSITY   (United States)

^d R W JOHNSON PHARMACEUTICAL RES I   (United States)

^e Microcide Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1' (DITHIO DIPHENYLENE)BIS(5 PHENYLBIGUANIDE); ALANINE; CL 13933; CYSTEINE; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DISULFIDE BOND; DRUG MECHANISM; HUMAN CYTOMEGALOVIRUS; MASS SPECTROMETRY; NONHUMAN; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEINASE INHIBITION; REDUCTION;

AMINO ACID SEQUENCE; BIGUANIDES; BINDING SITES; CYSTEINE; CYTOMEGALOVIRUS; DISULFIDES; ENDOPEPTIDASES; ESCHERICHIA COLI; HUMANS; MASS SPECTROMETRY; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; POINT MUTATION; PROTEASE INHIBITORS; VIRAL PROTEINS;

EID: 15844366372     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952996+     Document Type: Article

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