Synthesis and biological properties of novel pyridinioalkanoyl thiolesters (PATE) as anti-HIV-1 agents that target the viral nucleocapsid protein zinc fingers

Journal of Medicinal Chemistry

Volumn 42, Issue 1, 1999, Pages 67-86

  Turpin, Jim A ^a,d   Song, Yongsheng ^b   Inman, John K ^a   Huang, Mingjun ^a,d   Wallqvist, Anders ^c   Maynard, Andrew ^c   Covell, David G ^c   Rice, William G ^a,e   Ettore, Appella ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

^d SOUTHERN RESEARCH INSTITUTE   (United States)

^e Achillion Pharmaceuticals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; BENZAMIDE DERIVATIVE; DIMER; DISULFIDE; PROTEIN INHIBITOR; SULFONE; THIOESTER; VIRUS PROTEIN; ZINC FINGER PROTEIN;

ANTIVIRAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; IMMUNOBLOTTING; MOLECULAR MODEL; VIRUS NUCLEOCAPSID; VIRUS REPLICATION;

ANIMALS; ANTI-HIV AGENTS; CAPSID; CAPSID PROTEINS; CELL LINE; GENE PRODUCTS, GAG; HIV-1; LIGANDS; MICE; MODELS, MOLECULAR; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; SULFONES; VIRAL PROTEINS; VIRUS REPLICATION; ZINC FINGERS;

EID: 0033552881     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9802517     Document Type: Article

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