Identification of potent and selective mechanism-based inhibitors of the cysteine protease cruzain using solid-phase parallel synthesis

Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2002, Pages 676-684

  Huang, Lily ^a   Lee, Alice ^a   Ellman, Jonathan A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRUZIPAIN; CYSTEINE PROTEINASE INHIBITOR; NANOPARTICLE;

ACYLATION; ARTICLE; CHAGAS DISEASE; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; SOLID PHASE EXTRACTION; SOLUBILIZATION; SYNTHESIS; TRYPANOSOMA CRUZI;

ANIMALS; CATHEPSIN B; CATHEPSINS; CYSTEINE ENDOPEPTIDASES; ENZYME INHIBITORS; FLUOROMETRY; HUMANS; KETONES; KINETICS; MOLECULAR WEIGHT; PROTOZOAN PROTEINS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TRYPANOSOMA CRUZI;

EID: 0037203970     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010333m     Document Type: Article

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