Regulation of elastinolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages

Journal of Experimental Medicine

Volumn 192, Issue 6, 2000, Pages 789-799

  Punturieri, Antonello ^a,c   Filippov, Sergey ^a   Allen, Edward ^a   Caras, Ingrid ^b   Murray, Richard ^b   Reddy, Vivek ^a,d   Weiss, Stephen J ^a  

^a UNIVERSITY OF MICHIGAN COMPREHENSIVE CANCER CENTER   (United States)

^b Eos Biotechnology   (United States)

^c VA ANN ARBOR HEALTHCARE SYSTEM   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cathepsin K; Cysteine proteinases; Elastinolysis; Macrophages; Pycnodysostosis

Indexed keywords

CATHEPSIN B; CATHEPSIN D; CATHEPSIN K; CATHEPSIN L; CATHEPSIN S; CYSTEINE PROTEINASE; CYTOCHALASIN D; GLYCOPROTEIN GP 39; LATEX; NOCODAZOLE; OSTEOPONTIN; PACLITAXEL; ZYMOSAN;

ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; ELASTOLYSIS; ENZYME ACTIVITY; ENZYME REGULATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; TISSUE INJURY;

CATHEPSIN B; CATHEPSIN D; CATHEPSINS; CELL DIFFERENTIATION; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; KINETICS; MACROPHAGES; MONOCYTES; PROTON-TRANSLOCATING ATPASES; TIME FACTORS; TRANSCRIPTION, GENETIC;

EID: 0033802292     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.192.6.789     Document Type: Article

References (58)

1. Urokinase-generated plasmin activates matrix metalloproteinases during aneurysm formation
2. Correlation of the topographical arrangement and the functional pattern of tissue-infiltrating macrophages in giant cell arteritis
3. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
4. Expression of elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells
5. Cystatin C deficiency in human atherosclerosis and aortic aneurysms
6. Emerging roles for cysteine proteases in human biology
7. Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte-derived macrophages
8. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2
9. Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction
10. Expression of cathepsin K messenger RNA in giant cells and their precursors in human osteoarthritic synovial tissues
11. Human cathepsin O2, a matrix protein-degrading cysteine protease expressed in osteoclasts. Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme
12. Proteolytic activity of human osteoclast cathepsin K
13. Study of immunoelectron microscopic localization of cathepsin K in osteoclasts and other bone cells in the mouse femur
14. Localization of rat cathepsin K in osteoclasts and resorption pits: Inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones
15. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
16. Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein
17. Expression monitoring by hybridization to high-density oligonucleotide arrays
18. Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins
19. Sequestration of acetylated LDL and cholesterol crystals by human monocyte-derived macrophages
20. +exchange activity in phagosomal membranes of human neutrophils
21. Cell-mediated extracellular acidification and bone resorption: Evidence for a low pH in resorbing lacunae and localization of a 100-kD lysosomal membrane protein at the osteoclast ruffled border
22. +-ATPase, inhibits acidification and protein degradation in lysosomes of cultured cells
23. Inhibition of the acidification of endosomes and lysosomes by the antibiotic concanamycin B in macrophage J774
24. A fluorescence quenching technique using trypan blue to differentiate between attached and ingested glutaraldehyde-fixed red blood cells in phagocytosing murine macrophages
25. Strong induction of members of the chitinase family of proteins in atherosclerosis. Chitotriosidase and human cartilage gp-39 expressed in lesion macrophages
26. Effect of carbohydrate position on lysosomal transport of procathepsin L
27. Protein synthesis-dependent and protein synthesis-independent secretion of lysosomal hydrolases from rabbit and human macrophages
28. Lysosomal enzyme trafficking between phagosomes, endosomes, and lysosomes in J774 macrophages
29. In vitro fusion of phagosomes with different endocytic organelles from J774 macrophages
30. Biosynthesis and transport of lysosomal enzymes in human monocytes and macrophages. Effects of ammonium chloride, zymosan and tunicamycin
31. 2+-regulated exocytic vesicles in fibroblasts and epithelial cells
32. Pericellular pH affects distribution and secretion of cathepsin B in malignant cells
33. Actin filament disassembly is a sufficient final trigger for exocytosis in nonexcitable cells
34. A novel transcription factor regulates expression of the vacuolar H+-ATPase subunit through AP-2 sites during monocytic differentiation
35. +)-ATPase
36. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: A kinetic analysis
37. Effect of proteinase inhibitors on intracellular processing of cathepsin B, H and L in rat macrophages
38. The collagenolytic activity of cathepsin K is unique among mammalian proteinases
39. Human cathepsin K cleaves native type I and II collagens at the N-terminal end of the triple helix
40. Molecular cloning of a possible cysteine proteinase predominantly expressed in osteoclasts
41. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts
42. Expression of cathepsin K in lung epithelial cells
43. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
44. Structure and chromosomal assignment of the human cathepsin K gene
45. Genomic organization and chromosome localization of the human cathepsin K gene (CTSK)
46. Neither type of mannose 6-phosphate receptor is sufficient for targeting of lysosomal enzymes along intracellular routes
47. Differential sorting of lysosomal enzymes out of the regulated secretory pathway in pancreatic β-cells
48. Secretory lysosomes - A special mechanism of regulated secretion in hemopoietic cells
49. Secretion of lysosomal hydrolases by stimulated and nonstimulated macrophages
50. +-ATPases in regulating cytoplasmic pH and function in murine peritoneal macrophages
51. Microelectrode studies on the acid microenvironment beneath adherent macrophages and osteoclasts
52. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
53. Secretion and localization of cathepsin D in synovial tissues removed from rheumatoid and traumatized joints
54. Extracellular presence of the lysosomal proteinase cathepsin B in rheumatoid synovium and its activity at neutral pH
55. Macrophage cathepsin L, a factor in the erosion of subchondral bone in rheumatoid arthritis
56. Involvement of V-ATPase in the digestion of soft connective tissue collagen
57. Cathepsin B and glioma invasion
58. Secreted cathepsin L generates endostatin from collagen XVIII