1,2-Benzothiazine 1,1-dioxide P2-P3 peptide mimetic aldehyde calpain I inhibitors

Journal of Medicinal Chemistry

Volumn 44, Issue 21, 2001, Pages 3488-3503

  Wells, G J ^a   Tao, M ^a   Josef, K A ^a   Bihovsky, R ^a  

^a CEPHALON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3,4 DIHYDRO 1,2 BENZOTHIAZINE 3 CARBOXYLATE 1,1 DIOXIDE DERIVATIVE; ALDEHYDE; AMINO ACID; BENZOTHIAZINE DERIVATIVE; CALPAIN; CALPAIN I; CALPASTATIN; FUNCTIONAL GROUP; LEUCINE; N (1 OXO 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBONYL)PHENYLALANINAL; N (1 OXO 2 METHYL 1,2,3,4 TETRAHYDROISOQUINOLINE 3 CARBONYL)PHENYLALANINAL; N (2 METHYL 4 METHOXY 2H 1,2 BENZOTHIAZINE 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; N (2H 1,2,4 BENZOTHIADIAZINE 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; N (2H 6,7 ETHYLENEDIOXY 1,2,4 BENZOTHIADIAZINE 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; N (3,4 DIHYDRO 6,7 DIMETHOXY 2,1 BENZOXATHIIN 3 CARBONYL)LEUCINAL 1,1 DIOXIDE; N (3,4 DIHYDRO 6,7 DIMETHOXY 2,1 BENZOXATHIIN 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; N (3,4 DIHYDRO 6,7 ETHYLENEDIOXY 2 ETHYL 2H 1,2 BENZOTHIAZINE 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; N (6,7 DICHLORO 2 METHYL 2H 1,2 BENZOTHIAZINE 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; N (6,7 ETHYLENEDIOXY 2 ETHYL 2H 1,2 BENZOTHIAZINE 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; N (6,7 ETHYLENEDIOXY 2 METHYL 2H 1,2 BENZOTHIAZINE 3 CARBONYL)PHENYLALANINAL 1,1 DIOXIDE; UNCLASSIFIED DRUG; VALINE;

ARTICLE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

ALDEHYDES; CALPAIN; CYCLIC S-OXIDES; ELECTROPHORESIS, POLYACRYLAMIDE GEL; HUMANS; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES; PHENYLALANINE; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES; TUMOR CELLS, CULTURED;

EID: 0035846184     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010178b     Document Type: Article

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