Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo

European Journal of Pharmacology

Volumn 300, Issue 1-2, 1996, Pages 131-135

  Woo, Je Tae ^a   Yamaguchi, Kohji ^a   Hayama, Takahiro ^a   Kobori, Takeo ^a   Sigeizumi, Sanae ^a   Sugimoto, Kikuo ^a   Kondo, Kiyosi ^a   Tsuji, Tomoko ^a   Ohba, Yasuo ^b   Tagami, Kahori ^b   Sumitani, Koji ^b  

^a SAGAMI CHEMICAL RESEARCH CENTER   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Bone resorption; Cathepsin L; Cysteine protease inhibitor; Dipeptidyl aldehyde

Indexed keywords

CALPAIN II; CATHEPSIN B; CATHEPSIN L INHIBITOR; CYSTEINE PROTEINASE INHIBITOR; ENZYME INHIBITOR; HYDROXYPROLINE; N (BENZYLOXYCARBONYL)PHENYLALANYLTYROSINAL; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PARATHYROID HORMONE; PEPTIDE ALDEHYDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; COLLAGEN DEGRADATION; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; DRUG SCREENING; ENZYME INHIBITION; ETIOLOGY; FEMALE; FEMUR; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NEWBORN; NONHUMAN; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL; RAT;

EID: 0029944602     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00858-6     Document Type: Article

References (22)

1. Baron, R., L. Neff, D. Louvard and P.J. Courtoy, 1985, Cell-mediated extracellular acidification and bone resorption. Evidence for a low pH in resorbing lacunae and localization of a 100 kd lysosomal membrane protein at the osteoclast ruffled border, J. Cell Biol. 101, 2210.
2. Barrett, A. and H. Kirschke, 1985, Cathepsin B, cathepsin H and cathepsin L, Methods Enzymol. 80, 535.
3. Burleigh, M.C., A.J. Barrett and G.S. Lazarus, 1974, A lysosomal enzyme that degrades native collagen, Biochem. J. 137, 387.
4. Delaisse, J.M., Y. Eeckhout and G. Vaes, 1980, Inhibition of bone resorption in culture by inhibitors of thiol proteases, Biochem. J. 192, 365.
5. Delaisse, J.M., Y. Eeckhout and G. Vaes, 1984, In vivo and in vitro evidence for the involvement of cysteine proteases in bone resorption, Biochem. Biophys. Res. Commun. 125, 441.
6. Delaisse, J.M., P. Ledent and G. Vaes, 1991, Collagenolytic cysteine proteases of bone tissue: Cathepsin B, (pro) cathepsin L and cathepsin L-like 70 kd proteases, Biochem. J. 279, 167.
7. Evans, P. and D.J. Etherington, 1978, Characterization of cathepsin B and collagenolytic cathepsin from human placenta, Eur. J. Biochem. 83, 87.
8. Gabor, H., J. Malocco and F. Naftolin, 1986, Monitoring of collagen and collagen fragments in chromatograhy of protein mixtures, Anal. Biochem. 105, 424.
9. Kakegawa, H, T. Nikawa, K. Tagami, H. Kamioka, K. Sumitani, T. Kawata, D.-K. Marinka, L. Brigita, T. Vito and N. Katunuma, 1993, Participation of cathepsin L on bone resorption, FEBS Lett. 321, 247.
10. Kirschke, H., A.A. Kembhavi, P. Bohley and A.J. Barrett, 1982, Action of rat liver cathepsin L on collagen and other substrates, Biochem. J. 201, 367.
11. Kopitar, M., A. Ritonja and T. Popovic, 1989, A new type of low-molecular mass cysteine protease inhibitor from pig leukocytes, Biol. Chem. Hoppe Seyler 370, 1145.
12. Maciewicz, R.A. and D.J. Etherington, 1985, Separation of cathepsin B, L, N and S from rabbit spleen, Biochem. Soc. Trans. 13, 1169.
13. Maciewicz, R.A. and D.J. Etherington, 1988, A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabit spleen, Biochem. J. 256, 433.
14. Maciewicz, R.A., D.J. Etherington and V. Turk, 1987, Collagenolytic cathepsins of rabbit spleen: a kinetic analysis of collagen degradation and inhibition by chicken cystatin, Coll. Relat. Res. 7, 295.
15. 3 stimulates rat osteoblastic cell to release a soluble factor that increases osteoclastic bone resorption, J. Clin. Invest. 80, 425.
16. Murata, M, S. Miyasaka, C. Yokoo, M. Tamai, K. Hatayama, T. Towatari, T. Nikawa and N. Katunuma, 1991, Novel epoxysuccinyl peptides: selective inhibitors of cathepsin B in vivo, FEBS Lett. 280, 307.
17. Sakamoto, M. and S. Sakamoto, 1984, Immunocytochemical localization of collagenase in isolated mouse bone cells, Biomed. Res. 5, 29.
18. Sasaki, T., T. Kikuchi, N. Yumoto, N. Yoshimura and T. Murachi, 1984, Comparative specificity and kinetic study on porcine cal pain I and calpain II with naturally occuring peptide and synthetic fluorogenic substrates, J. Biol. Chem. 259, 12489.
19. Tagami, K, H. Kakegawa, H. Kamioka, K. Sumitani, T. Kawata, L. Brigita, T. Vito and N. Katunuma, 1994, The mechanisms and regulation of procathepsin L secretion from osteoclasts in bone resorption, FEBS Lett. 342, 308.
20. Vaes, G., 1968, The action of parathyroid hormone on the excretion and synthesis of lysosomal enzymes and on the extracellular release of acid by cells, J. Cell Biol. 39, 676.
21. Vaes, G., 1980, Collagenase, lysosomes and osteoclastic bone resorption, in: Collagenase in Normal and Pathological Connective Tissues, eds. D.E. Woolley, J.M. Evanson, and W. Chichester, p. 185.
22. Woo, J.-T., S. Sigeizumi, K. Yamaguchi, K. Sugimoto, T. Kobori, T. Tsuji and K. Kondo, 1995, Peptidyl aldehyde derivatives as potent and selective inhibitiors of cathepsin L, Bioorg. Med. Chem. Lett. 5, 1501.