Cysteine protease activity is up-regulated in inflamed ankle joints of rats with adjuvant-induced arthritis and decreases with in vivo administration of a vinyl sulfone cysteine protease inhibitor

Arthritis and Rheumatism

Volumn 44, Issue 3, 2001, Pages 703-711

  Biroc, Sandra L ^{a,b,c,d,e,f,g,h}   Gay, Steffen ^{a,b,c,d,e,f,g,h}   Hummel, Klaus ^{a,b,c,d,e,f,g,h}   Magill, Catherine ^{a,b,c,d,e,f,g,h}   Palmer, James T ^{a,b,c,d,e,f,g,h}   Spenc, Donna R ^{a,b,c,d,e,f,g,h}   Sa, Susan ^{a,b,c,d,e,f,g,h}   Klaus, Jeffrey L ^{a,b,c,d,e,f,g,h}   Michel, Beat A ^{a,b,c,d,e,f,g,h}   Rasnick, David ^{a,b,c,d,e,f,g,h}   Gay, Renate E ^{a,b,c,d,e,f,g,h}  

^a BAYER AG   (Germany)

^b UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^c UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

^d Axys Pharmaceuticals Inc   (United States)

^e Anosys Inc   (United States)

^f LabVelocity   (United States)

^g ABBOTT LABORATORIES   (United States)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (2 AMINOETHYL)BENZENESULFONYL FLUORIDE; BENZYLOXYCARBONYLARGINYLARGINYL AMC; BENZYLOXYCARBONYLARGINYLARGINYL MNA; CHROMOGENIC SUBSTRATE; CYSTEINE PROTEINASE; EDETIC ACID; FORMALDEHYDE; MULEUCYLHOMOPHENYL VINYLSULFONE; PEPSTATIN; UNCLASSIFIED DRUG; VINYL SULFONE CYSTEINE PROTEASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANKLE; ARTHRITIS; ARTICLE; AUTOPSY; BONE EROSION; CARTILAGE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOCHEMISTRY; DISEASE ASSOCIATION; ENZYME ACTIVITY; ENZYME IMMUNOASSAY; FEMALE; HISTOPATHOLOGY; INFLAMMATION; JOINT DESTRUCTION; NONHUMAN; PANNUS; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SYNOVIOCYTE;

ANIMALS; ANKLE JOINT; ARTHRITIS, EXPERIMENTAL; CATHEPSIN B; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; FEMALE; PILOT PROJECTS; RATS; RATS, INBRED LEW; SULFONES; UP-REGULATION;

EID: 0035079963     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/1529-0131(200103)44:3<703::AID-ANR120>3.0.CO;2-2     Document Type: Article

References (28)

1. Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L, and S, by human monocyte derived macrophages
2. Cysteine proteinases in arthritis and inflammation
3. Degradation of bone matrix proteins by osteoclast cathepsins
4. Human cathepsin O2 (Cat K) a novel cysteine protease highly expressed in osteoclastomas and ovary: Molecular cloning sequencing and tissue distribution
5. Human cathepsin O2 (Cat K), a matrix protein-degrading cysteine protease expressed in osteoclasts: Functional expression of human cathepsin O2 in Spodoptera frugiperda and characterization of the enzyme
6. Determination of cathepsin B and H in sera and synovial fluids of patients with different joint diseases
7. Human cathepsin B and cysteine proteinase inhibitors (CPIs) in inflammatory and metabolic joint disease
8. Cysteine proteinase activity in arthritic rat knee joints and the effects of a selective systemic inhibitor, Z-phe-ala-CH2F
9. Enzyme histochemical reactions in unfixed and undecalcified cryostat sections of mouse knee joints with special reference to arthritic lesions
10. Cathepsin B in synovial cells at the site of joint destruction in rheumatoid arthritis
11. Expression of the collagenolytic and ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/1 mice and patients with rheumatoid arthritis (RA)
12. The effect of fluoromethyl ketone inhibitors of cathepsin B on adjuvant induced arthritis
13. Cysteine proteinase inhibitors decrease articular cartilage and bone destruction in chronic inflammatory arthritis
14. Peptidyl fluoromethyl ketones as inhibitors of cathepsin B: Implication for the treatment of rheumatoid arthritis
15. The routine sectioning of undecalcified bone for cytochemical studies
16. Producing frozen sections of calcified bone
17. Vinyl sulfones as mechanism-based cysteine protease inhibitors
18. Metalloproteinases and their inhibitors in matrix remodeling
19. Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor
20. Comparative analysis of cathepsin L, cathepsin D, and collagenase messenger RNA expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis, by in situ hybridization
21. Cysteine proteinase activity in the development of arthritis in an adjuvant model of the rat
22. Cathepsin B and human tumor progression
23. Enzyme immunoassay for cathepsins B & L in synovial fluids from patients with arthritis
24. The cystatins: A diverse superfamily of cysteine peptidase inhibitors
25. Essential role for cathepsin S in MHC class II-associated invariant chain processing and peptide loading
26. Cathepsin S activity regulates antigen presentation and immunity
27. Increased vulnerability of postarthritic cartilage to a second arthritic insult: Accelerated MMP activity in a flare up of arthritis
28. 342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin 1 in matrix metalloproteinase activity