WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp. I. Taxonomy, production, purification and structure elucidation

Journal of Antibiotics

Volumn 52, Issue 6, 1999, Pages 536-541

  Otsuka, Takanao ^a   Muramatsu, Yuko ^a   Higaki, Tomoji ^a   Nakanishi, Tomoko ^a   Takase, Shigehiro ^a   Hatanaka, Hiroshi ^a   Okamoto, Masanori ^a   Hino, Motohiro ^a   Hashimoto, Seiji ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [N [1 [N (4 AMINOBUTYL) N (3 AMINOPROPYL)CARBAMOYL] 2 (4 HYDROXYPHENYL)ETHYL]CARBAMOYL] 2 OXIRANECARBOXYLIC ACID; CATHEPSIN B; CATHEPSIN L; ENZYME INHIBITOR; SPERMIDINE; SUCCINIC ACID DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; COLLETOTRICHUM; CONTROLLED STUDY; DRUG POTENCY; DRUG PURIFICATION; DRUG SELECTIVITY; DRUG STRUCTURE; FERMENTATION; PRIORITY JOURNAL; SPECTROSCOPY; TAXONOMY;

COLLETOTRICHUM;

EID: 0032817682     PISSN: 00218820     EISSN: None     Source Type: Journal    
DOI: 10.7164/antibiotics.52.536     Document Type: Article

References (17)

1. AHMED, N. K.; L. A. MARTIN, L. M. WATTS, J. PALMER, L. THORNBURG, J. PRIOR & R. E. ESSER: Peptidyl fluoromethyl ketones as inhibitors of cathepsin B. Biochem. Pharmacol. 44: 1201-1207, 1992
2. DELAISSÉ, J.-M.; P. LEDENT & G. VAES: Collagenolytic cysteine proteinases of bone tissue. Biochem. J. 279: 167-174, 1991
3. MATSUNAGA, Y.; T. SAIBARA, H. KIDO & N. KATUNUMA: Participation of cathepsin B in processing of antigen presentation to MHC class II. FEBS 324: 325-330, 1993
4. NAKAMURA, Y.; M. TAKEDA, H. SUZUKI, H. HATTORI, K. TADA, S. HARIGUCHI, S. HASHIMOTO & T. NISHIMURA: Abnormal distribution of cathepsins in the brain of patients with Alzheimer's disease. Neurosci. Lett. 130: 195-198, 1991
5. INAOKA, T.; G. BILBE, O. ISHIBASHI, K. TEZUKA, M. KUMEGAWA & T. KOKUBO: Molecular cloning of human cDNA for cathepsin K. Biochem. Biophys. Res. Commun. 206: 89-96, 1995
6. OTSUKA, T.; Y. MURAMATSU, K. NIIKURA, M. OKAMOTO, M. HINO & S. HASHIMOTO: WF14861, A new cathepsins B and L inhibitor produced by Colletotrichum sp. II. Biological properties. J. Antibiotics 52: 542-547, 1999
7. NAKASE, T.: JCM Catalogue of Strains, 6th edition. Japan Collection of Microorganisms, the Institute of Physical and Chemical Research (RIKEN), Toppan, 1995
8. KORNERUP, A. & J. H. WANSCHER: Methuen Handbook of Colour, 3rd edition. Methuen, London, 1978
9. MIURA, K. & M. KUDO: Trans. Mycol. Soc. Japan 11: 116-118, 1970
10. VON ARX, J. A.: The Genera of Fungi - Sporulating in Pure Culture, 3rd ed., J. Cramer, Vaduz, 1974
11. BARRON, G. L.: The Genera of Hyphomycetes from Soil. Williams & Wilkins, Baltimore, 1968
12. DOMSCH, K. H.; W. GAMS & T.-H. ANDERSON: Compendium of Soil Fungi. Vol. 1. Academic Press, London, 1980
13. HANADA, K; M. TAMAI, M. YAMAGISHI, S. OHMURA, J. SAWADA & I. TANAKA: Isolation and characterization of E-64, a new thiol protease inhibitor. Agric. Biol. Chem. 42: 523-528, 1978
14. YAMADA, T.; J. HIRATAKE, M. AIKAWA, T. SUIZU, Y. SAITO, A. KAWATO, K. SUGINAMI & J. ODA: Cysteine protease inhibitors produced by the industrial koji mold, Aspergillus orysae O-1018. Biosci. Biotech. Biochem. 62: 907-914, 1998
15. WOO, J.-T.; H. ONO & T. TSUJI: Cathestatins, new cysteine protease inhibitors produced by Penicillium citrinum. Biocsi. Biotech. Biochem. 59: 350-352, 1995
16. YAGINUMA, S.; A. ASAHI, A. MORISHITA, M. HAYASHI, M. TSUJINO & M. TAKADA: Isolation and characterization of new thiol protease inhibitors estatins A and B. J. Antibiotics 42: 1362-1369, 1989
17. ISSHIKI K.; M. NISHIO, N. SAKURAI, T. UCHIDA, T. OKUDA & S. KOMATSUBARA: TMC-52A to D, Novel cysteine proteinase inhibitors, produced by Gliocladium sp. J. Antibiotics 51: 629-634, 1998