Arginine-based structures are specific inhibitors of cathepsin C. Application of peptide combinatorial libraries

European Journal of Biochemistry

Volumn 267, Issue 11, 2000, Pages 3330-3336

  Horn, Martin ^a   Pavlik, Manfred ^a   Dolečková, Lucie ^a   Baudys, Miroslav ^b   Mareš, Michael ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b UNIVERSITY OF UTAH   (United States)

Author keywords

Cathepsin C; Combinatorial libraries; Dipeptidyl peptidase I; Lysosomal cysteine proteinase; Peptide inhibitor

Indexed keywords

ARGININE; CYSTEINE PROTEINASE; DIPEPTIDYL PEPTIDASE; GUANIDINE DERIVATIVE; PEPTIDE LIBRARY; PROTEIN INHIBITOR; SYNTHETIC PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; COMPETITIVE INHIBITION; ENZYME INHIBITION; ENZYME SPECIFICITY; FLUORESCENCE; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS;

ANIMALS; ARGININE; BINDING SITES; CATTLE; COMBINATORIAL CHEMISTRY TECHNIQUES; CYSTEINE PROTEINASE INHIBITORS; DIPEPTIDYL PEPTIDASE I; DRUG DESIGN; PEPTIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034129207     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01364.x     Document Type: Article

References (26)

1. 1. McGuire, M.J., Lipsky, P.E. & Thiele, D.L. (1993) Generation of active myeloid and lymphoid granule serine proteases requires processing by the granule thiol protease dipeptidyl peptidase I. J. Biol. Chem. 268, 2458-2467.
2. 2. Murakami, M., Karnik, S.S. & Husain, A. (1995) Human prochymase activation. A novel role for heparin in zymogen processing. J. Biol. Chem. 270, 2218-2223.
3. 3. Nauland, U. & Rijken, D.C. (1994) Activation of thrombin-inactivated single-chain urokinase-type plasminogen activator by dipeptidyl peptidase I (cathepsin C). Eur. J. Biochem. 223, 497-501.
4. 4. Muno, D., Ishidoh, K., Ueno, T. & Kominami, E. (1993) Processing and transport of the precursor of cathepsin C during its transfer into lysosomes. Arch. Biochem. Biophys. 306, 103-110.
5. 5. Dolenc, I., Turk, B., Pungercic, G., Ritonja, A. & Turk, V. (1995) Oligomeric structure and substrate induced inhibition of human cathepsin C. J. Biol. Chem. 270, 21626-21631.
6. 6. Kuribayashi, M., Yamada, H., Ohmori, T., Yanai, M. & Imoto, T. (1993) Endopeptidase activity of cathepsin C, dipeptidyl aminopeptidase I, from bovine spleen. J. Biochem. (Tokyo) 113, 441-449.
7. 7. Green, G.D.J. & Shaw, E. (1981) Peptidyl diazomethyl ketones are specific inactivators of thiol proteinases. J. Biol. Chem. 256, 1923-1928.
8. 8. Rich, D.H. (1986) Inhibitors of cysteine proteinases. In Proteinase Inhibitors (Barrett, A.J. & Salvesen, G., eds), pp. 153-178. Elsevier. Amsterdam, New York.
9. 9. Palmer, J.T., Rasnick, D., Klaus, J.L. & Bromme, D. (1995) Vinyl sulfones as mechanism-based cysteine protease inhibitors. J. Med. Chemistry. 38, 3193-3196.
10. 10. Barrett, A.J., Kembhavi, A.A., Brown. M.A., Kirschke, H., Knight, C.G., Tamai, M. & Hanada, K. (1982) L-trans-Epoxysuccinylleucylamido (4-guanidino) butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L. Biochem. J. 201, 189-198.
11. 11. Eichler, J. & Houghten, R.A. (1993) Identification of substrate-analog trypsin inhibitors through the screening of synthetic peptide combinatorial libraries. Biochemistry 32, 11035-11041.
12. 12. Meldal, M., Svedsen, I.B., Juliano, L., Juliano, M.A., Nery, E.D. & Scharfstein, J. (1998) Inhibition of cruzipain visualized in a fluorescence quenched solid-phase inhibitor library assay. D-Amino acid inhibitors for cruzipain, cathepsin B and cathepsin L. J. Pept. Sci. 4, 83-91.
13. 13. Jiráček, J., Yiotakis, A., Vincent, B., Checler, F. & Dive, V. (1996) Development of highly potent and selective phosphinic peptide inhibitors of zinc endopeptidase 24-15 using combinatorial chemistry. J. Biol. Chem. 271, 19606-19611.
14. 14. Mycek, M.J. (1970) Cathepsin C (dipeptidyl transferase). Methods Enzymol. 19, 285-315.
15. 15. Baudyš, M., Meloun, B., Gan-Erdene, T., Fusek, M., Mareš, M., Kostka, V., Pohl, J. & Blake, C.C.F. ( 1991) S-S bridges of cathepsin B and H from bovine spleen: a basis for cathepsin B model building and possible functional implications for discrimination between exo-and endopeptidase activities among cathepsins B, H and L. Biomed. Biochim. Acta 50, 569-577.
16. 16. Meloun, B., Baudyš, M., Pohl, J., Pavlik, M. & Kostka, V. (1988) Amino acid sequence of bovine spleen cathepsin B. J. Biol. Chem. 263, 9087-9093.
17. 17. Pinilla, C., Appel, J., Blondelle, S., Dooley, C., Dorner, B., Eichler, J., Ostresh, J. & Houghten, R.A. (1995) A review of the utility of soluble peptide combinatorial libraries. Biopolymers 37, 221-240.
18. 18. McDonald, J.K., Zeitman, B.B., Reilly, T.J. & Ellis, S. (1969) New observations on the substrate specificity of cathepsin C (dipeptidyl-aminopeptidase I). Including the degradation of beta-corticotropin and other peptide hormones. J. Biol. Chem. 244, 2693-2709.
19. 19. McGuire, M.J., Lipsky, P.E. & Thiele, D.L. (1992) Purification and characterization of dipeptidyl peptidase I from human spleen. Arch. Biochem. Biophys. 295, 280-288.
20. 20. Stubbs, M.T. & Bode, W. (1993) A player of many parts: the spotlight falls on thrombin's structure. Thromb. Res. 69, 1-58.
21. 21. Dolenc, I., Turk, B., Kos, J. & Turk, V. (1996) Interaction of human cathepsin C with chicken cystatin. FEBS Lett. 392, 277-280.
22. 22. Lindahl, P., Alriksson, E., Jörnvall, H. & Björk, I. (1988) Interaction of the cysteine proteinase inhibitor chicken cystatin with papain. Biochemistry 27, 5074-5082.
23. 23. Kirschke, H., Barret, A.J. & Rawlings, N.D. (1995) Protein profile. In Lysosomal Cysteine Proteinases (Sheterline, P., ed.) pp. 34-48. Academic Press, London.
24. 24. Cigiæ, B. & Pain, R.H. (1999) Competitive inhibition of cathepsin C by guanidinium ions and reexamination of substrate inhibition. Biochem. Biophys. Res. Commun. 258, 6-10.
25. 25. Bode, W. & Huber, R. (1992) Natural protein proteinase inhibitors and their interaction wilh proteinases. Eur. J. Biochem. 204, 433-451.
26. 26. Bromme, D., Klaus, J.L., Okamoto, K., Rasnick, D. & Palmer, J.T. (1996) Peptidyl vinyl sulphones: a new class of potent and selective cysteine protease inhibitors: S2P2 specificity of human cathepsin O2 in comparison with cathepsins S and L. Biochem. J. 315, 85-8927.