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Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 5, 2002, Pages 733-738

Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: Structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics

(14) Dragovich, Peter S a Prins, Thomas J a Zhou, Ru a Johnson, Theodore O a Brown, Edward L a Maldonado, Fausto C a Fuhrman, Shella A a Zalman, Leora S a Patick, Amy K a Matthews, David A a Hou, Xinjun a Meador, James W a Ferre, Rose Ann a Worland, Stephen T a,b

a PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United States)

b F HOFFMANN LA ROCHE LTD (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 PYRIDONE DERIVATIVE; ENZYME INHIBITOR; PROTEINASE; VIRUS ENZYME;

ANTIVIRAL ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; HUMAN RHINOVIRUS; NONHUMAN; SEROTYPE; STRUCTURE ACTIVITY RELATION;

ANTIVIRAL AGENTS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL LINE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HUMANS; MOLECULAR MIMICRY; PYRIDONES; RHINOVIRUS; SEROTYPING; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

HUMAN RHINOVIRUS 3; HUMAN RHINOVIRUS SP.; RHINOVIRUS;

EID: 0037060908 PISSN: 0960894X EISSN: None Source Type: Journal
DOI: 10.1016/S0960-894X(02)00008-2 Document Type: Article

Times cited : (73)

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