Discovery and parallel synthesis of a new class of cathepsin K inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 22, 2001, Pages 2951-2954

  Smith, Roger A ^a   Bhargava, Ajay ^a   Browe, Christopher ^a   Chen, Jinshan ^a   Dumas, Jacques ^a   Hatoum Mokdad, Holia ^a   Romero, Romulo ^a  

^a BAYER CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOMETHYL KETONE DERIVATIVE; CATHEPSIN K; DRUG DERIVATIVE; ENZYME INHIBITOR; NEW DRUG; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

CATHEPSINS; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; INHIBITORY CONCENTRATION 50; KETONES; KINETICS; MOLECULAR MIMICRY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035914606     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00600-X     Document Type: Article

References (23)