Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality

Journal of Biological Chemistry

Volumn 275, Issue 21, 2000, Pages 16007-16014

  Lee, Dennis ^a,b   Long, Scott A ^a   Adams, Jerry L ^a   Chan, George ^a   Vaidya, Kalindi S ^a   Francis, Terry A ^a   Kikly, Kristine ^a   Winkler, James D ^a   Sung, Chiu Mei ^a   Debouck, Christine ^a   Richardson, Susan ^a   Levy, Mark A ^a   DeWolf Jr , Walter E ^a   Keller, Paul M ^a   Tomaszek, Thaddeus ^a   Head, Martha S ^a   Ryan, M Dominic ^a   Haltiwanger, R Curtis ^a   Liang, Po Huang ^a   Janson, Cheryl A ^a   McDevitt, Patrick J ^a   Johanson, Kyung ^a   Concha, Nestor O ^a   Chan, Winnie ^a   Abdel Meguid, Sherin S ^a   Badger, Alison M ^a   Lark, Michael W ^a   Nadeau, Daniel P ^a   Suva, Larry J ^a   Gowen, Maxine ^a   Nuttall, Mark E ^a,c   more..

^a GLAXOSMITHKLINE   (United Kingdom)

^b Sunesis Pharmaceuticals Inc   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CASPASE 3; CASPASE 7; ISATIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARTILAGE CELL; CELL FUNCTION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HOMEOSTASIS; HUMAN; HUMAN CELL; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL;

AMINO ACID CHLOROMETHYL KETONES; ANIMALS; APOPTOSIS; BINDING SITES; CAMPTOTHECIN; CASPASE 3; CASPASE 7; CASPASES; CHONDROCYTES; COLLAGEN; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; ISATIN; MICE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEUTROPHILS; OSTEOARTHRITIS; PROMOTER REGIONS (GENETICS); RECOMBINANT PROTEINS; SULFONAMIDES;

EID: 0034717269     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.275.21.16007     Document Type: Article

References (50)

1. Kaufmann, S. H. (ed) (1997) Adv. Pharmacol. 41
2. Lockshin, R. A., Zakeri, Z., and Tilly, J. L. (eds) (1998) When Cells Die, John Wiley & Sons, New York
3. Humke, E. M., Ni, J., and Dixit, V. M. (1998) J. Biol. Chem. 273, 15702-15707
4. Kuida, K., Zheng, T. S., Na, S., Kuan, C.-Y., Yang, D., Karasuyama, H., Rakic, P., and Flavell, R. A. (1996) Nature 384, 368-372
5. Woo, M., Hakem, R., Soengas, M. S., Duncan, G. S., Shahinian, D. K., Hakem, A., McCurrach, M., Khoo, W., Kaufman, S. A., Senaldi, G., Howard, T., Lowe, S W., and Mak, T. W. (1998) Genes Dev. 12, 806-819
6. Kuida, D., Haydar, T. F., Kuan, C.-Y., Gu, Y., Taya, C., Karasuyama, H., Su, M. S.-S., Rakic, P., and Flavell, R. A. (1998) Cell 94, 325-337
7. Hakem, R., Hakem, A., Duncan, G. S., Henderson, J. T., Woo, M., Soengas, M. S., Elia, A., de la Pompa, J. L., Kagi, D., Khoo, W., Potter, J., Yoshida, R., Kaufman, S. A., Lowe, S. W., Penninger, J. M., and Mak, T. W. (1998) Cell 94, 339-352
8. Bergeron, L., Perez, G. I., Macdonald, G., Shi, L., Sun, Y., Jurisicova, A., Varmuza, S., Latham, K. E., Flaws, J. A., Salter, J. C. M., Hara, H., Moskowitz, M. A., Li, E., Greenberg, A., Tilly, J. L., and Yuan, J. (1998) Genes Dev. 12, 130 4-1314
9. Cryns, V. L., and Yuan, J. (1998) in When Cells Die (Lockshin, R. A., Zakeri, Z., and Tilly, J. L., eds) pp. 177-210, John Wiley & Sons, New York
10. Garcia-Calvo, M., Peterson, E. P., Leiting, B., Ruel, R., Nicholson, D. W., and Thornberry, N. A. (1998) J. Biol. Chem. 273, 32608-32613
11. Schotte, P., Declercq, W., Van Huffel, S., Vandenabeele, P., and Beyaert, R. (1999) FEBS Lett. 442, 117-121
12. Porter, A. G., and Janicke, R. U. (1999) Cell Death Differ. 8, 99-104
13. Nicholson, D. W., and Thornberry, N. A. (1997) Trends Biochem. Sci. 22, 299-306
14. Enari, M., Sakahira, H., Yokoyama, H., Okawa, K., Iwamatsu, A., and Nagata, S. (1998) Nature 391, 43-50
15. Blanco, F. J., Guitan, R., Vasquez-Martul, E., Toror, F. J., and Galdo, F. (1998) Arthritis Rheum. 41, 284-289
16. Hashimoto, S., Ochs, R. L., Komiya, S., and Lotz, M. (1998) Arthritis Rheum. 41, 1632-1638
17. Erlacher, L., Maier, R., Ullrich, R., Keiner, R., Aringer, M., Menschik, M., and Graninger, W. (1995) J. Rheumatol. 22, 926-931
18. Hatori, M., Klatte, K. J., Teixeira, C. C., and Shapiro, I. M. (1995) J. Bone Miner. Res. 10, 1960-1968
19. Hollander, A. P., Pidoux, I., Reiner, A., Rorabeck, C., Bourne, R., and Poole, A. R (1995) J. Clin. Invest. 96, 2859-2869
20. Mankin, H., Dorfman, H., Lippiello, L., and Zarins, A. (1971) J. Bone Joint Surg. 53, 523-537
21. Vignon, E., Arlot, M., Meunier, P., and Vignon, G. (1974) Clin. Orthop. 121, 269-278
22. Karaplis, A. C., and Vautour, L. (1997) Curr. Opin. Nephrol. Hypertens. 6, 308-313
23. Veis, D. J., Sorenson, C. M., Shutter, J. R., and Korsmeyer, S. J. (1993) Cell 75, 229-240
24. Yang, C., Li, S.-W., Helmein, H. J., Khillan, J. S., Bao, Y., and Prokop, D. J. (1997) Exp. Cell Res. 236, 370-373
25. Hashimoto, S., Takahashi, S., Amiel, D., Coutts, R. D., and Lotz, M. (1998) Arthritis Rheum. 41, 1266-1274
26. Martinez, F., and Naarmann, H. (1990) Synth. Met. 39, 195-203
27. Von Tacconi, G., Righetti, P. P., and Desimoni, G. (1973) J. Prakt. Chem. 315, 339-344
28. Brünger, T. A. (1992) X-PLOR Version 3.1: A System for X-ray Crystallography and NMR, Yale University Press, New Haven, CT
29. Brünger, T. A. (1992) Nature 355, 472-475
30. Jones, T. A., Zou, J.-Y., Cowan, S. W., and Kjelgaard, M. (1991) Acta Crystallogr. Sect. A 47, 110-119
31. Goldring, M. B., Birkhead, J. R., Suen, L.-F., Yamin, R., Mizuno, S., Glowacki, J., Arbiser, J. L., and Apperley, J. F. (1994) J. Clin. Invest. 94, 2307-2316
32. Goldring, M. B., Fukuo, K., Birkhead, J. R., Dudek, E., and Sandell, L. J. (1994) J. Cell. Biochem. 54, 85-99
33. Rotonda, J., Nicholson, D. W., Fazil, K. M., Gallant, M., Gareau, Y., Labelle, M., Peterson, E. P., Rasper, D. M., Ruel, R., Vaillancourt, J. P., Thornberry, N. A., and Becker, J. W. (1996) Nat. Struct. Biol. 3, 619-625
34. Webber, S. E., Tikhe, J., Worland, S. T., Fuhrman, S. A., Hendrickson, T. F., Matthews, D. A., Love, R. A., Patick, A. K., Meador, J. W., Ferre, R. A., Brown, E. L., DeLisle, D. M., Ford, C. E., and Binford, S. L. (1996) J. Med. Chem. 39, 5072-5082
35. Schechter, I., and Berger, A. (1967) Biochem. Biophys. Res. Commun. 27, 157-162
36. Parkinson, A. (1996) in Casarett and Doull's Toxicology (Klaassen, C. D., ed) pp. 120-121, McGraw-Hill, New York
37. Black, R. A., Kronheim, S. R., Merriam, J. E., March, C. J., and Hopp, T. P. (1989) J Biol. Chem. 264, 5323-5326
38. Sleath, P. R., Hendrickson, R. C., Kronheim, S. R., March, C. J., and Black, R. A. (1990) J. Biol. Chem. 265, 14526-14528
39. Howard, A. D., Kostura, M. J., Thornberry, N., Ding, G. J. F., Limjuco, G., Weidner, J., Salley, J. P., Hogquist, K. A., Chaplin, D. D., Mumford, R. A., Schmidt, J. A., and Tocci, M. J. (1991) J. Immunol. 147, 2964-2969
40. Votta, B J., Levy, M. A., Badger, A., Bradbeer, J., Dodds, R. A., James, I. E., Thompson, S., Bossard, M. J., Carr, T., Connor, J. R., Tomaszek, T. A., Szewczuk, L., Drake, F. H., Veber, D. F., and Gowen, M. (1997) J. Bone Miner. Res. 12, 1396-1406
41. Wang, K. K. (2000) Trends Neurosci. 23, 20-26
42. Hamerman, D. (1993) J. Am. Geriatr. Soc. 41, 760-770
43. Wang, C. Y., Mayo, M. W., and Baldwin, A. S., Jr. (1996) Science 274, 784-787
44. Vaishnaw, A. K., McNally, J. D., and Elkon, K. B. (1997) Arthritis Rheum. 40, 1917-1927
45. Nuttall, M. E., Gowen, M., and Lark, M. W. (1999) in Apoptosis and Inflammation (Winkler, J. D., ed) pp 163-179, Birkhauser, Basel
46. Davidson, F. F., and Steller, H. (1998) Nature 391, 587-591
47. Esnouf, R. M. (1997) J. Mol. Graph. 15, 132-134
48. Koradi, R., Billeter, M., and Wuttrich, K. (1996) J. Mol. Graph. 14, 51-55
49. Engh, R. A., and Huber, R. (1991) Acta Crystallogr. Sect. A 47, 392-400
50. Nuttall, M. E., Lee, D., Levy, M. A., DeWolf, W. E., Jr., Keller, P. M., Badger, A. M., Lark, M. W., Nadeau, D. P., Suva, L. J., and Gowen, M. (2000) J. Orthop. Res., in press