The structure of calpain

Journal of Biochemistry

Volumn 129, Issue 5, 2001, Pages 653-664

  Sorimachi, Hiroyuki ^a   Suzuki, Koichi ^b  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

C2 domain; Calcium; Calpain; Connectin titin; EF hand motif

Indexed keywords

AMINO ACID; CALPAIN; GENE PRODUCT; PROTEINASE;

AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; GENE ISOLATION; GENOME; HUMAN; NONHUMAN; PROTEIN DOMAIN; PROTEIN MOTIF; PROTEIN SECONDARY STRUCTURE; REVIEW; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANIMALS; CALPAIN; GENE LIBRARY; HUMANS; MOLECULAR SEQUENCE DATA; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034992155     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a002903     Document Type: Review

References (50)

1. A neutral calcium-activated proteinase from the soluble fraction of rat brain
2. Studies of a calcium-activated neutral protease from chicken skeletal muscle. I. Purification and characterization
3. Nomenclature of calcium dependent proteinase
4. Historical Background, current status, and future prospect fo research on calcium dependent protease: Determination of strucure of calpain and East-West problem; In search of physiological function of calpain
5. CLAN CA-C2
6. Structure and physiological function of calpains
7. The evolution of the calpain family as reflected in paralogous chromosome regions
8. Gene structure, chromosomal localization, and expression pattern of capn12, a new member of the calpain large subunit gene family
9. Structure and function of calpain and its homologues
10. Calpain: A protease in search of a function?
11. A novel aspect of calpain activation
12. Skeletal muscle-specific calpain, p94: Structure and physiological function
13. Disease taxonomy - Monogenic muscular dystrophy
14. Calpainopathy-a survey of mutations and polymorphisms
15. A putative role for calpain in demyelination associated with optic neuritis
16. Caspase and calpain substrates: Roles in synaptic plasticity and cell death
17. On the role of calpain and Rho proteins in regulating integrin-induced signaling
18. Calpain inhibitors as therapeutic agents in nerve and muscle degeneration
19. Calpains and muscular dystrophies
20. Calcium ion in skeletal muscle: Its crucial role for muscle function, plasticity, and disease
21. Calpain and caspase: Can you tell the difference?
22. Calcium and muscle disease: Pathophysiology of calpains and limb-girdle muscular dystrophy type 2A (LGMD2A)
23. Evolutionary origin of a calcium-dependent protease by fusion of genes for a thiol protease and a calcium-binding protein?
24. Identification of a third ubiquitous calpain species - Chicken muscle expresses four distinct calpains
25. 2+-binding domain
26. Double C2 protein. A review
27. Classification and evolution of EF-hand proteins
28. 2+-binding proteins with five EF-hand motifs
29. Crystal structure of human grancalcin, a member of the penta-EF-hand protein family
30. The crystal structure of calcium-free human m-calpain suggests an electrostatic switch mechanism for activation by calcium
31. 2+-dependent protease activity and a novel mode of enzyme activation
32. Crystal structure of calcium bound domain VI of calpain at 1.9 Å resolution and its role in enzyme assembly, regulation, and inhibitor binding
33. 2+-induced conformational changes
34. Diversity of conformational states and changes within the EF-hand protein superfamily
35. Introduction: Clan CA containing papain and its relatives
36. Alignment/phylogeny of the papain superfamily of cysteine proteases
37. Cloning, expression, and sequencing of a protease gene (tpr) from Porphyromonas gingivalis W83 in Escherichia coli
38. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
39. Functional cleavage of the common cytokine receptor γ chain (c) by calpain
40. The presenilin 2 loop domain interacts with the μ-calpain C-terminal region
41. Loss of calpain 3 proteolytic activity leads to muscular dystrophy and to apoptosis-associated IκBα/Nuclear Factor κB pathway perturbation in mince
42. Influence of specific regions in Lp82 calpain on protein stability, activity, and localization within lens
43. Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily
44. Molecular cloning of PalBH, a mammalian homologue of the Aspergillus atypical calpain PalB
45. 2+-binding domain
46. Antisense RNA-mediated deficiency of the calpain protease, nCL-4, in NIH3T3 cells is associated with neoplastic transformation and tumorigenesis
47. CAPN11: A calpain with high mRNA levels in testis and located on chromosome 6
48. Solh, the mouse homologue of the Drosophila melanogaster small optic lobes gene: Organization, chromosomal mapping, and localization of gene product to the olfactory bulb
49. Autolysis of calpain large subunit inducing irreversible dissociation of stoichiometric heterodimer of calpain
50. Effects of epinephrine infusion on expression of calpastatin in porcine cardiac and skeletal muscle