A target within the target: Probing cruzain's P1' site to define structural determinants for the Chagas' disease protease

Structure

Volumn 8, Issue 8, 2000, Pages 831-840

  Brinen, Linda S ^a   Hansell, Elizabeth ^a   Cheng, Jianming ^b   Roush, William R ^b   McKerrow, James H ^b   Fletterick, Robert J ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Chagas' disease; Cruzain; Cysteine protease; Drug design; P1' specificity

Indexed keywords

ANTIPROTOZOAL AGENT; CRUZIPAIN; CYSTEINE PROTEINASE; ENZYME INHIBITOR; PHENYL GROUP; SULFONE DERIVATIVE; VINYL DERIVATIVE;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; CRYSTAL STRUCTURE; DRUG DESIGN; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; TRYPANOSOMA CRUZI;

BACTERIA (MICROORGANISMS); EUKARYOTA; PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

EID: 0034662749     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00173-8     Document Type: Article

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