Caspases: Recent advances in small molecule inhibitors

Expert Opinion on Therapeutic Patents

Volumn 11, Issue 10, 2001, Pages 1593-1603

  Ashwell, S ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

Apoptosis; Caspases; Cysteine proteases; IL 1 converting enzyme; Inflammation; Ischaemia; Neurodegeneration

Indexed keywords

ASPARTIC ACID; CASPASE; CASPASE 3; CASPASE 7; CASPASE INHIBITOR; CYSTEINE PROTEINASE; CYTOKINE; FO 6903 A; FO 6903 B; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; GLYCINE DERIVATIVE; HYDROXAMIC ACID DERIVATIVE; INDOLE DERIVATIVE; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; ISATIN DERIVATIVE; ISOXAZOLINE 5 CARBOXAMIDE DERIVATIVE; LIPOPOLYSACCHARIDE; OXADIAZOLE DERIVATIVE; OXATHIAZOLE DERIVATIVE; PRALNACASAN; PRALNASCAN; PROTEIN INHIBITOR; PYRIMIDINONE DERIVATIVE; SECOBATZELLINE A; SULFONAMIDE; TETRAZOLE DERIVATIVE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; CELL DEATH; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; DRUG STRUCTURE; HUMAN; HUMAN CELL; INFLAMMATORY DISEASE; ISCHEMIA; MALE; MATURATION; MODULATION; MOUSE; NONHUMAN; PATENT; PATHOLOGY; PHASE 2 CLINICAL TRIAL; PROTEIN FAMILY; RAT; REVIEW; RHEUMATOID ARTHRITIS;

EID: 0034764332     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.11.10.1593     Document Type: Review

References (56)

1. The C. Elegans cell death gene ced-3 encodes a protein similar to the mammalian interleukin-1β converting enzyme
2. Human ICE/CED-3 protease nomenclature
3. Activation of interleukin-1β by a co-induced protease
4. Identification of a monocyte specific pre-interleukin-1β convertase activity
5. Apoptosis: A basic biological phenomenon with wide ranging implications in tissue kinetics
6. Suicidal tendencies: Apoptotic cell death by caspase family proteases
7. Caspases: Key mediators of apoptosis
8. Caspases are activated in a branched protease cascade and control distinct downstream processes in Fas-induced apoptosis
9. Caspases: Enemies within
10. Caspases: Key players in programmed cell death
11. A combinatorial approach defines specificities of members of the caspase family and Granzyme B. Functional relationships established for key mediators of apoptosis
12. A combinatorial approach for determining protease specificities: Application to interleukin-1β converting enzyme (ICE)
13. Biochemical pathways of caspase activation during apoptosis
14. Mammalian caspases: Structure, activation, substrates and functions during apoptosis
15. Crystal structure of the cysteine protease interleukin-1β converting enzyme: A (p20/p10)2 homodimer
16. Structure and mechanism of interleukin-1β converting enzyme
17. The three dimensional structure of apopain/CPP32, a key mediator of apoptosis
18. Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone
19. Caspase-8 specificity probed at subsite S4: Crystal structure of the caspase-8-Z-DEVD-CHO complex
20. Caspase structure, proteolytic substrates and function during apoptotic cell death
21. Catalytic properties of the caspases
22. Inhibition of human caspases by peptide-based and macromolecular inhibition
23. To die or not to die: An overview of apoptosis and its role in disease
24. Neuronal apoptosis as a therapeutic target in neurodegenerative disease
25. The role of caspases in development, immunity and apoptotic signal transduction: Lessons from knockout mice
26. Emerging therapeutic targets in caspase-dependent disease
27. Recent advances on neuronal caspases in development and neurodegeneration
28. Apoptosis and the nervous system
29. Caspases as targets for anti-inflammatory and anti-apoptotic drug discovery
30. Neuroprotection by caspase inhibitors
31. Caspases as treatment targets in stroke and neurodegenerative diseases
32. Cell death: The significance of apoptosis
33. Apoptosis in the pathogenesis and treatment of disease
34. Alternative cleavage of Alzheimer-associated presenillins during apoptosis by a caspase 3 family protease
35. Increased production of amyloid precursor protein provides a substrate for caspase 3 in dying motorneurons
36. Phosphorylation of presenilin-2 regulates its cleavage by caspases and retards progression of apoptosis
37. Involvement of caspases in proteolytic cleavage of Alzheimers amyloid-beta precursor protein and amyloidogenic A β peptide formation
38. Caspase 3-like proteases and 6-hydroxydopamine induced neuronal cell death
39. Involvement of caspase-like proteinases in apoptosis of neuronal Pc12 cells and primary cultured microglia induced by 6-hydroxydopamine
40. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase
41. Caspase-8 is required for cell death induced by expanded polyglutamine repeats
42. Glutamine repeats and neurodegenerative diseases: Molecular aspects
43. Apoptosis and congestive heart failure
44. Apoptosis in heart failure: Release of cytochrome c from mitochondria and activation of caspase 3 in human cardiomyopathy
45. Release of caspase-9 from mitochondria during neuronal apoptosis and cerebral ischemia
46. Postmitochondrial regulation of apoptosis during heart failure
47. A caspase inhibitor fully protects rats against lethal normothermic liver ischemia by inhibition of liver apoptosis
48. A caspase inhibitor blocks ischemia-induced delayed neuronal cell death in the gerbil
49. Caspase 1 (ICE) and other caspases as drug discovery targets: Opportunities and progress
50. Recent advances in cytokine synthesis inhibitors
51. Fas-mediated stimulation induces IL-8 secretion by rheumatoid arthritis synovicytes independent of CPP32-mediated apoptosis
52. Expression of a murine homologue of the inhibitor of apoptosis protein is related to cell proliferation
53. Potent and selective non-peptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality
54. Potent and selective non-peptide inhibitors of caspases 3 and 7
55. Characterization of the caspase inhibitor IDN-1965 in a model of apoptosis-associated liver injury
56. Secobatzellines A and B, two new enzyme inhibitors from a deep water Caribbean sponge of the genus Batzella