Potent and selective nonpeptide inhibitors of caspases 3 and 7

Journal of Medicinal Chemistry

Volumn 44, Issue 12, 2001, Pages 2015-2026

  Lee, D ^a,b   Long, S A ^a   Murray, J H ^a   Adams, J L ^a   Nuttall, M E ^a   Nadeau, D P ^a   Kikly, K ^a   Winkler, J D ^a   Sung, C M ^a   Ryan, M D ^a   Levy, M A ^a   Keller, P M ^a   DeWolf Jr , W E ^a  

^a GLAXOSMITHKLINE   (United States)

^b Sunesis Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 BENZYL 5 [1 [2 (PHENOXYMETHYL)PYRROLIDINYL]SULFONYL]ISATIN; 5 AMINOSULFONYLISATIN; CASPASE 3; CASPASE 7; CASPASE INHIBITOR; UNCLASSIFIED DRUG;

ALKYLATION; ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CULTURE; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SEQUENCE ANALYSIS; X RAY ANALYSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 7; CASPASES; CELL LINE; CELL SURVIVAL; CHONDROCYTES; CYSTEINE PROTEINASE INHIBITORS; DRUG DESIGN; HUMANS; ISATIN; JURKAT CELLS; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NEUTROPHILS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035821595     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0100537     Document Type: Article

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