Cathepsin K, osteoclastic resorption, and osteoporosis therapy

Journal of Bone and Mineral Research

Volumn 16, Issue 10, 2001, Pages 1747-1749

  Zaidi, M ^a   Troen, B ^a   Moonga, B S ^a   Abe, E ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN K; CYSTEINE PROTEINASE INHIBITOR; SB 357114; UNCLASSIFIED DRUG;

DRUG EFFECT; DRUG INHIBITION; DRUG POTENCY; DRUG SELECTIVITY; EDITORIAL; FEMALE; NONHUMAN; OSTEOCLAST; OSTEOLYSIS; POSTMENOPAUSE OSTEOPOROSIS; PRIMATE;

EID: 0034803277     PISSN: 08840431     EISSN: None     Source Type: Journal    
DOI: 10.1359/jbmr.2001.16.10.1747     Document Type: Editorial

References (33)

1. Potent and selective inhibition of human cathepsin K leads to inhibition of bone resorption in vivo in a non-human primate
2. The collagenolytic activity of cathepsin K is unique among mammalian proteinases
3. Cellular biology and biochemical mechanism of bone resorption. A review of recent developments on the formation, activation, and mode of action of osteoclasts
4. Molecular mechanisms of bone resorption by the osteoclast
5. Pycnodysostosis, a lysosomal disease caused by cathepsin K deficiency
6. A nonsense mutation in the cathepsin K gene observed in a family with pycnodysostosis
7. Characterization of novel cathepsin K mutations in the pro and mature polypeptide regions causing pycnodysostosis
8. Mutations of CTSK result in pycnodysostosis via a reduction in cathepsin K protein
9. Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice
10. Cathepsin K knockout mice develop osteopetrosis due to a deficit in matrix degradation but not demineralization
11. The genetic transformation of bone biology
12. Cathepsin K, but not cathepsins B, L, or S, is abundantly expressed in human osteoclasts
13. Cathepsin K mRNA detection is restricted to osteoclasts during fetal mouse development
14. Transgenic mice lacking cathepsin L activity
15. Localization of rat cathepsin K in osteoclasts and resorption pits: Inhibition of bone resorption and cathepsin K-activity by peptidyl vinyl sulfones
16. Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resorption in vitro
17. Cynomolgus monkey (Macaca fascicularis) cathepsin K: Cloning, expression, purification, and activation
18. Cathepsin K antisense oligodeoxynucleotide inhibits osteoclastic bone resorption
19. Distinct roles of cathepsin K and cathepsin L in osteoclastic bone resorption
20. Mechanism of inhibition of cathepsin K by potent, selective 1,5-diacylcarbohydrazides: A new class of mechanism-based inhibitors of thiol proteases
21. Cyclic ketone inhibitors of the cysteine protease cathepsin K
22. Potent dipeptidylketone inhibitors of the cysteine protease cathepsin K
23. Peptide aldehyde inhibitors of cathepsin K inhibit bone resorption both in vitro and in vivo
24. New insights into regulation of cathepsin K gene expression by osteoprotegerin ligand
25. Molecular cloning of human cathepsin O, a novel endoproteinase and homologue of rabbit OC2
26. Regulation of elastolytic cysteine proteinase activity in normal and cathepsin K-deficient human macrophages
27. Expression of cathepsin K in lung epithelial cells
28. Human cathepsin O2, a novel cysteine protease highly expressed in osteoclastomas and ovary molecular cloning, sequencing and tissue distribution
29. Cathepsin K in thyroid epithelial cells: Sequence, localization and possible function in extracellular proteolysis of thyroglobulin
30. Cysteine proteinase cathepsin K mRNA is expressed in synovium of patients with rheumatoid arthritis and is detected at sites of synovial bone destruction
31. The osteoclast-associated protease cathepsin K is expressed in human breast carcinoma
32. A putative role for cathepsin K in degradation of AA and AL amyloidosis
33. Effect of parathyroid hormone (1-34) on fractures and bone mineral density in postmenopausal women with osteoporosis