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Volumn 247, Issue 1, 2018, Pages 33-46

Neurodegeneration in ataxia-telangiectasia: Multiple roles of ATM kinase in cellular homeostasis

Author keywords

autophagy; insulin signaling; mitochondria; peroxisomes; Reactive oxygen species; synaptic vesicles

Indexed keywords

ATM PROTEIN; INSULIN; REACTIVE OXYGEN METABOLITE;

EID: 85038405741     PISSN: 10588388     EISSN: 10970177     Source Type: Journal    
DOI: 10.1002/dvdy.24522     Document Type: Review
Times cited : (57)

References (166)
  • 1
    • 0030175487 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase related kinases
    • Abraham RT. 1996. Phosphatidylinositol 3-kinase related kinases. Curr Opin Immunol 8:412–418.
    • (1996) Curr Opin Immunol , vol.8 , pp. 412-418
    • Abraham, R.T.1
  • 2
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT. 2001. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 15:2177–2196.
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 5
    • 34548430918 scopus 로고    scopus 로고
    • Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells
    • Ambrose M, Goldstine JV, Gatti RA. 2007. Intrinsic mitochondrial dysfunction in ATM-deficient lymphoblastoid cells. Hum Mol Genet 16:2154–2164.
    • (2007) Hum Mol Genet , vol.16 , pp. 2154-2164
    • Ambrose, M.1    Goldstine, J.V.2    Gatti, R.A.3
  • 6
    • 84878527709 scopus 로고    scopus 로고
    • Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions
    • Ambrose M, Gatti RA. 2013. Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions. Blood 121:4036–4045.
    • (2013) Blood , vol.121 , pp. 4036-4045
    • Ambrose, M.1    Gatti, R.A.2
  • 8
    • 85009772322 scopus 로고    scopus 로고
    • Peroxisome protein import: a complex journey
    • Baker A, Hogg TL, Warriner SL. 2016. Peroxisome protein import: a complex journey. Biochem Soc Trans 44:783–789.
    • (2016) Biochem Soc Trans , vol.44 , pp. 783-789
    • Baker, A.1    Hogg, T.L.2    Warriner, S.L.3
  • 9
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist CJ, Kastan MB. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499–506.
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 13
    • 84881028628 scopus 로고    scopus 로고
    • The interrelations between malfunctioning DNA damage response (DDR) and the functionality of the neuro-glio-vascular unit
    • Barzilai A. 2013. The interrelations between malfunctioning DNA damage response (DDR) and the functionality of the neuro-glio-vascular unit. DNA Repair 12: 543–557.
    • (2013) DNA Repair , vol.12 , pp. 543-557
    • Barzilai, A.1
  • 16
    • 84985021251 scopus 로고    scopus 로고
    • Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells
    • Bhatt N, Ghosh R, Roy S, Gao Y, Armanios M, Cheng L, Franco S. 2016. Robust reprogramming of Ataxia-Telangiectasia patient and carrier erythroid cells to induced pluripotent stem cells. Stem Cell Res 17:296–305.
    • (2016) Stem Cell Res , vol.17 , pp. 296-305
    • Bhatt, N.1    Ghosh, R.2    Roy, S.3    Gao, Y.4    Armanios, M.5    Cheng, L.6    Franco, S.7
  • 18
    • 44949238447 scopus 로고    scopus 로고
    • The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle
    • Biton S, Barzilai A, Shiloh Y. 2008. The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle. DNA Repair 7:1028–1038.
    • (2008) DNA Repair , vol.7 , pp. 1028-1038
    • Biton, S.1    Barzilai, A.2    Shiloh, Y.3
  • 19
    • 78651043982 scopus 로고
    • Ataxia-telangiectasia; a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection
    • Boder E, Sedgwick RP. 1958. Ataxia-telangiectasia; a familial syndrome of progressive cerebellar ataxia, oculocutaneous telangiectasia and frequent pulmonary infection. Pediatrics 21:526–554.
    • (1958) Pediatrics , vol.21 , pp. 526-554
    • Boder, E.1    Sedgwick, R.P.2
  • 20
    • 33845742491 scopus 로고    scopus 로고
    • Constitutive expression and cytoplasmic compartmentalization of ATM protein in differentiated human neuron-like SH-SY5Y cells
    • Boehrs JK, He J, Halaby MJ, Yang DQ. 2007. Constitutive expression and cytoplasmic compartmentalization of ATM protein in differentiated human neuron-like SH-SY5Y cells. J Neurochem 100:337–345.
    • (2007) J Neurochem , vol.100 , pp. 337-345
    • Boehrs, J.K.1    He, J.2    Halaby, M.J.3    Yang, D.Q.4
  • 22
    • 78649231611 scopus 로고    scopus 로고
    • mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α
    • Cam H, Easton JB, High A, Houghton PJ. 2010. mTORC1 signaling under hypoxic conditions is controlled by ATM-dependent phosphorylation of HIF-1α. Mol Cell 40:509–520.
    • (2010) Mol Cell , vol.40 , pp. 509-520
    • Cam, H.1    Easton, J.B.2    High, A.3    Houghton, P.J.4
  • 23
    • 84949033551 scopus 로고    scopus 로고
    • A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioural defect and a low incidence of lymphoma but no increased oxidative burden
    • Campbell A, Krupp B, Bushman J, Noble M, Pröschel C, Mayer-Pröschel M. 2015. A novel mouse model for ataxia-telangiectasia with a N-terminal mutation displays a behavioural defect and a low incidence of lymphoma but no increased oxidative burden. Hum Mol Genet 24:6331–6349.
    • (2015) Hum Mol Genet , vol.24 , pp. 6331-6349
    • Campbell, A.1    Krupp, B.2    Bushman, J.3    Noble, M.4    Pröschel, C.5    Mayer-Pröschel, M.6
  • 24
    • 84953835492 scopus 로고    scopus 로고
    • Mutation of ataxia–telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia
    • Campbell A, Bushman J, Munger J, Noble M, Pröschel C, Mayer-Pröschel M. 2016. Mutation of ataxia–telangiectasia mutated is associated with dysfunctional glutathione homeostasis in cerebellar astroglia. Glia 64:227–239.
    • (2016) Glia , vol.64 , pp. 227-239
    • Campbell, A.1    Bushman, J.2    Munger, J.3    Noble, M.4    Pröschel, C.5    Mayer-Pröschel, M.6
  • 25
    • 84880624619 scopus 로고    scopus 로고
    • ATM-deficient human neural stem cells as an in vitro model system to study neurodegeneration
    • Carlessi L, Poli EF, De Filippis L, Delia D. 2013. ATM-deficient human neural stem cells as an in vitro model system to study neurodegeneration. DNA Repair 12:605–611.
    • (2013) DNA Repair , vol.12 , pp. 605-611
    • Carlessi, L.1    Poli, E.F.2    De Filippis, L.3    Delia, D.4
  • 27
    • 77951096150 scopus 로고    scopus 로고
    • Mitochondrial dynamics—fusion, fission, movement, and mitophagy—in neurodegenerative diseases
    • Chen H, Chan DC. 2009. Mitochondrial dynamics—fusion, fission, movement, and mitophagy—in neurodegenerative diseases. Hum Mol Genet 18:R169–76.
    • (2009) Hum Mol Genet , vol.18 , pp. R169-R176
    • Chen, H.1    Chan, D.C.2
  • 29
    • 0347479231 scopus 로고    scopus 로고
    • Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice
    • Chen P, Peng C, Luff J, Spring K, Watters D, Bottle S, Furuya S, Lavin MF. 2003. Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice. J Neurosci 23:11453–1160.
    • (2003) J Neurosci , vol.23 , pp. 11160-11453
    • Chen, P.1    Peng, C.2    Luff, J.3    Spring, K.4    Watters, D.5    Bottle, S.6    Furuya, S.7    Lavin, M.F.8
  • 30
    • 0034011725 scopus 로고    scopus 로고
    • Atm-deficient mice Purkinje cells show age-dependent defects in calcium spike bursts and calcium currents
    • Chiesa N, Barlow C, Wynshaw-Boris A, Strata P, Tempia F. 2000. Atm-deficient mice Purkinje cells show age-dependent defects in calcium spike bursts and calcium currents. Neurosci 96:575–583.
    • (2000) Neurosci , vol.96 , pp. 575-583
    • Chiesa, N.1    Barlow, C.2    Wynshaw-Boris, A.3    Strata, P.4    Tempia, F.5
  • 31
    • 79551580561 scopus 로고    scopus 로고
    • ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    • Cosentino C, Grieco D, Costanzo V. 2011. ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J 30:546–555.
    • (2011) EMBO J , vol.30 , pp. 546-555
    • Cosentino, C.1    Grieco, D.2    Costanzo, V.3
  • 32
    • 84871927066 scopus 로고    scopus 로고
    • Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia
    • D'Souza A, Parish IA, Krause DS, Kaech SM, Shadel GS. 2013. Reducing mitochondrial ROS improves disease-related pathology in a mouse model of ataxia-telangiectasia. Mol Ther 21:42–48.
    • (2013) Mol Ther , vol.21 , pp. 42-48
    • D'Souza, A.1    Parish, I.A.2    Krause, D.S.3    Kaech, S.M.4    Shadel, G.S.5
  • 35
    • 84942854769 scopus 로고    scopus 로고
    • Regulation of the target of rapamycin and other phosphatidylinositol 3-kinase-related kinases by membrane targeting
    • De Cicco M, Rahim MS, Dames SA. 2015. Regulation of the target of rapamycin and other phosphatidylinositol 3-kinase-related kinases by membrane targeting. Membranes 5:553–575
    • (2015) Membranes , vol.5 , pp. 553-575
    • De Cicco, M.1    Rahim, M.S.2    Dames, S.A.3
  • 36
    • 84919380771 scopus 로고    scopus 로고
    • Type 3 diabetes is sporadic Alzheimer's disease: Mini-review
    • de la Monte SM 2014. Type 3 diabetes is sporadic Alzheimer's disease: Mini-review. Eur Neuropsychopharmacol 24:1954–1960.
    • (2014) Eur Neuropsychopharmacol , vol.24 , pp. 1954-1960
    • de la Monte, S.M.1
  • 37
    • 77953500851 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in neurodegenerative diseases and cancer
    • De Moura MB, dos Santos LS, Van Houten B. 2010. Mitochondrial dysfunction in neurodegenerative diseases and cancer. Environ Mol Mutagen 51:391–405.
    • (2010) Environ Mol Mutagen , vol.51 , pp. 391-405
    • De Moura, M.B.1    dos Santos, L.S.2    Van Houten, B.3
  • 40
    • 34848835736 scopus 로고    scopus 로고
    • Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis
    • Eaton JS, Lin ZP, Sartorelli AC, Bonawitz ND, Shadel GS. 2007. Ataxia-telangiectasia mutated kinase regulates ribonucleotide reductase and mitochondrial homeostasis. J Clin Invest 117:2723–2734.
    • (2007) J Clin Invest , vol.117 , pp. 2723-2734
    • Eaton, J.S.1    Lin, Z.P.2    Sartorelli, A.C.3    Bonawitz, N.D.4    Shadel, G.S.5
  • 47
    • 0022308737 scopus 로고
    • Cerebellar pathology in ataxia-telangiectasia: the significance of basket cells
    • Gatti RA, Vinters HV. 1985. Cerebellar pathology in ataxia-telangiectasia: the significance of basket cells. Kroc Found Ser 19:225–232.
    • (1985) Kroc Found Ser , vol.19 , pp. 225-232
    • Gatti, R.A.1    Vinters, H.V.2
  • 49
    • 33747371969 scopus 로고    scopus 로고
    • Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant
    • Gueven N, Luff J, Peng C, Hosokawa K, Bottle SE, Lavin MF. 2006. Dramatic extension of tumor latency and correction of neurobehavioral phenotype in Atm-mutant mice with a nitroxide antioxidant. Free Radic Biol Med 41:992–1000.
    • (2006) Free Radic Biol Med , vol.41 , pp. 992-1000
    • Gueven, N.1    Luff, J.2    Peng, C.3    Hosokawa, K.4    Bottle, S.E.5    Lavin, M.F.6
  • 50
    • 84959543438 scopus 로고    scopus 로고
    • ATM kinase: much more than a DNA damage responsive protein
    • Guleria A, Chandna S. 2016. ATM kinase: much more than a DNA damage responsive protein. DNA Repair 39:1–20.
    • (2016) DNA Repair , vol.39 , pp. 1-20
    • Guleria, A.1    Chandna, S.2
  • 52
    • 78650378982 scopus 로고    scopus 로고
    • ATM activation in the presence of oxidative stress
    • Guo Z, Deshpande R, Paull TT. 2010b. ATM activation in the presence of oxidative stress. Cell Cycle 9:4805–4811.
    • (2010) Cell Cycle , vol.9 , pp. 4805-4811
    • Guo, Z.1    Deshpande, R.2    Paull, T.T.3
  • 53
    • 45449097412 scopus 로고    scopus 로고
    • ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells
    • Halaby MJ, Hibma JC, He J, Yang DQ. 2008. ATM protein kinase mediates full activation of Akt and regulates glucose transporter 4 translocation by insulin in muscle cells. Cell Signal 20:1555–1563.
    • (2008) Cell Signal , vol.20 , pp. 1555-1563
    • Halaby, M.J.1    Hibma, J.C.2    He, J.3    Yang, D.Q.4
  • 54
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    • Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ. 1998. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 280:1089–1091.
    • (1998) Science , vol.280 , pp. 1089-1091
    • Herzog, K.H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    McKinnon, P.J.5
  • 57
    • 59749091850 scopus 로고    scopus 로고
    • A complex interplay between Akt, TSC2 and the two mTOR complexes
    • Huang J, Manning D. 2009. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem Soc Trans 37: 217–222.
    • (2009) Biochem Soc Trans , vol.37 , pp. 217-222
    • Huang, J.1    Manning, D.2
  • 58
    • 84949532719 scopus 로고    scopus 로고
    • Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency
    • Jiang D, Zhang Y, Hart RP, Chen J, Herrup K, Li J. 2015. Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. Brain 138:3520–3536.
    • (2015) Brain , vol.138 , pp. 3520-3536
    • Jiang, D.1    Zhang, Y.2    Hart, R.P.3    Chen, J.4    Herrup, K.5    Li, J.6
  • 60
    • 0035266308 scopus 로고    scopus 로고
    • Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
    • Kamsler A, Daily D, Hochman A, Stern N, Shiloh Y, Rotman G, Barzilai A. 2001. Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. Cancer Res 61:1849–1854.
    • (2001) Cancer Res , vol.61 , pp. 1849-1854
    • Kamsler, A.1    Daily, D.2    Hochman, A.3    Stern, N.4    Shiloh, Y.5    Rotman, G.6    Barzilai, A.7
  • 61
    • 84978864589 scopus 로고    scopus 로고
    • The role of oxidative stress in neurodegenerative diseases
    • Kim GH, Kim JE, Rhie SJ, Yoon S. 2015. The role of oxidative stress in neurodegenerative diseases. Exp Neurobiol 24:325–340.
    • (2015) Exp Neurobiol , vol.24 , pp. 325-340
    • Kim, G.H.1    Kim, J.E.2    Rhie, S.J.3    Yoon, S.4
  • 62
    • 67649794703 scopus 로고    scopus 로고
    • Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes
    • Kim J, Wong PK. 2009. Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes. J Biol Chem 284:14396–14404.
    • (2009) J Biol Chem , vol.284 , pp. 14396-14404
    • Kim, J.1    Wong, P.K.2
  • 63
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • Kim J, Kundu M, Viollet B, Guan KL. 2011. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 13:132–141.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 64
    • 78649262870 scopus 로고    scopus 로고
    • The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress
    • Kim TS, Kawaguchi M, Suzuki M, Jung CG, Asai K, Shibamoto Y, Lavin MF, Khanna KK, Miura Y. 2010. The ZFHX3 (ATBF1) transcription factor induces PDGFRB, which activates ATM in the cytoplasm to protect cerebellar neurons from oxidative stress. Dis Model Mech 3:752–762.
    • (2010) Dis Model Mech , vol.3 , pp. 752-762
    • Kim, T.S.1    Kawaguchi, M.2    Suzuki, M.3    Jung, C.G.4    Asai, K.5    Shibamoto, Y.6    Lavin, M.F.7    Khanna, K.K.8    Miura, Y.9
  • 66
    • 84962550498 scopus 로고    scopus 로고
    • Reactive Oxygen Species (ROS)-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large-scale phosphoproteomics screen
    • Kozlov SV, Waardenberg AJ, Engholm-Keller K, Arthur JW, Graham ME, Lavin M. 2016. Reactive Oxygen Species (ROS)-activated ATM-dependent phosphorylation of cytoplasmic substrates identified by large-scale phosphoproteomics screen. Mol Cell Proteomics 15:1032–1047.
    • (2016) Mol Cell Proteomics , vol.15 , pp. 1032-1047
    • Kozlov, S.V.1    Waardenberg, A.J.2    Engholm-Keller, K.3    Arthur, J.W.4    Graham, M.E.5    Lavin, M.6
  • 68
    • 84934281252 scopus 로고    scopus 로고
    • p53 in survival, death and metabolic health: a lifeguard with a licence to kill
    • Kruiswijk F, Labuschagne CF, Vousden KH. 2015. p53 in survival, death and metabolic health: a lifeguard with a licence to kill. Nat Rev Mol Cell Biol 16:393–405.
    • (2015) Nat Rev Mol Cell Biol , vol.16 , pp. 393-405
    • Kruiswijk, F.1    Labuschagne, C.F.2    Vousden, K.H.3
  • 69
    • 0030730292 scopus 로고    scopus 로고
    • Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia
    • Kuljis RO, Xu Y, Aguila MC, Baltimore D. 1997. Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia. Proc Natl Acad Sci U S A 94:12688–12693.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 12688-12693
    • Kuljis, R.O.1    Xu, Y.2    Aguila, M.C.3    Baltimore, D.4
  • 70
    • 33745028132 scopus 로고    scopus 로고
    • The role of mitochondria in inherited neurodegenerative diseases
    • Kwong JQ, Beal MF, Manfredi G. 2006. The role of mitochondria in inherited neurodegenerative diseases. J Neurochem 97:1659–1675.
    • (2006) J Neurochem , vol.97 , pp. 1659-1675
    • Kwong, J.Q.1    Beal, M.F.2    Manfredi, G.3
  • 72
    • 84880606646 scopus 로고    scopus 로고
    • The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration
    • Lavin MF. 2013. The appropriateness of the mouse model for ataxia-telangiectasia: neurological defects but no neurodegeneration. DNA Repair 12:612–619.
    • (2013) DNA Repair , vol.12 , pp. 612-619
    • Lavin, M.F.1
  • 73
    • 85012065316 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor
    • Lavin MF, Kozlov S, Gatei M, Kijas AW. 2015. ATM-dependent phosphorylation of all three members of the MRN complex: from sensor to adaptor. Biomolecules 5:2877–28902.
    • (2015) Biomolecules , vol.5 , pp. 2877-28902
    • Lavin, M.F.1    Kozlov, S.2    Gatei, M.3    Kijas, A.W.4
  • 75
    • 72449147303 scopus 로고    scopus 로고
    • Cytoplasmic ATM in neurons modulates synaptic function
    • Li J, Han YR, Plummer MR, Herrup K. 2009. Cytoplasmic ATM in neurons modulates synaptic function. Curr Biol 19:2091–2096.
    • (2009) Curr Biol , vol.19 , pp. 2091-2096
    • Li, J.1    Han, Y.R.2    Plummer, M.R.3    Herrup, K.4
  • 76
    • 84860692938 scopus 로고    scopus 로고
    • Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia
    • Li J, Chen J, Ricupero CL, Hart RP, Schwartz MS, Kusnecov A, Herrup K. 2012. Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia. Nat Med 18:783–790.
    • (2012) Nat Med , vol.18 , pp. 783-790
    • Li, J.1    Chen, J.2    Ricupero, C.L.3    Hart, R.P.4    Schwartz, M.S.5    Kusnecov, A.6    Herrup, K.7
  • 77
    • 84865183979 scopus 로고    scopus 로고
    • Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells
    • Li Y, Xiong H, Yang DQ. 2012. Functional switching of ATM: sensor of DNA damage in proliferating cells and mediator of Akt survival signal in post-mitotic human neuron-like cells. Chin J Cancer 31:364–372.
    • (2012) Chin J Cancer , vol.31 , pp. 364-372
    • Li, Y.1    Xiong, H.2    Yang, D.Q.3
  • 80
    • 27944476980 scopus 로고    scopus 로고
    • ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes
    • Liu N, Stoica G, Yan M, Scofield VL, Qiang W, Lynn WS, Wong PK. 2005. ATM deficiency induces oxidative stress and endoplasmic reticulum stress in astrocytes. Lab Invest 85:1471–1480.
    • (2005) Lab Invest , vol.85 , pp. 1471-1480
    • Liu, N.1    Stoica, G.2    Yan, M.3    Scofield, V.L.4    Qiang, W.5    Lynn, W.S.6    Wong, P.K.7
  • 81
    • 0037067688 scopus 로고    scopus 로고
    • Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells
    • López-Carballo G, Moreno L, Masiá S, Pérez P, Barettino D. 2002. Activation of the phosphatidylinositol 3-kinase/Akt signaling pathway by retinoic acid is required for neural differentiation of SH-SY5Y human neuroblastoma cells. J Biol Chem 277:25297–304.
    • (2002) J Biol Chem , vol.277 , pp. 25297-25304
    • López-Carballo, G.1    Moreno, L.2    Masiá, S.3    Pérez, P.4    Barettino, D.5
  • 82
    • 84960888035 scopus 로고    scopus 로고
    • Mitochondrial dysfunction in DDR-related cancer predisposition syndromes
    • Lyakhovich A, Graifer D, Stefanovie B, Krejci L. 2016. Mitochondrial dysfunction in DDR-related cancer predisposition syndromes. Biochim Biophys Acta 1865:184–189.
    • (2016) Biochim Biophys Acta , vol.1865 , pp. 184-189
    • Lyakhovich, A.1    Graifer, D.2    Stefanovie, B.3    Krejci, L.4
  • 83
    • 0035811559 scopus 로고    scopus 로고
    • Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase
    • Macaulay VM, Salisbury AJ, Bohula EA, Playford MP, Smorodinsky NI, Shiloh Y. 2001. Downregulation of the type 1 insulin-like growth factor receptor in mouse melanoma cells is associated with enhanced radiosensitivity and impaired activation of Atm kinase. Oncogene 20:4029.
    • (2001) Oncogene , vol.20 , pp. 4029
    • Macaulay, V.M.1    Salisbury, A.J.2    Bohula, E.A.3    Playford, M.P.4    Smorodinsky, N.I.5    Shiloh, Y.6
  • 84
    • 85007524587 scopus 로고    scopus 로고
    • Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome
    • Maciejczyk M, Mikoluc B, Pietrucha B, Heropolitanska-Pliszka E, Pac M, Motkowski R, Car H. 2017. Oxidative stress, mitochondrial abnormalities and antioxidant defense in Ataxia-telangiectasia, Bloom syndrome and Nijmegen breakage syndrome. Redox 11:375–383.
    • (2017) Redox , vol.11 , pp. 375-383
    • Maciejczyk, M.1    Mikoluc, B.2    Pietrucha, B.3    Heropolitanska-Pliszka, E.4    Pac, M.5    Motkowski, R.6    Car, H.7
  • 87
    • 84883605293 scopus 로고    scopus 로고
    • Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration
    • McInnes J. 2013. Insights on altered mitochondrial function and dynamics in the pathogenesis of neurodegeneration. Transl Neurodegener 2:12.
    • (2013) Transl Neurodegener , vol.2 , pp. 12
    • McInnes, J.1
  • 88
    • 84856866360 scopus 로고    scopus 로고
    • ATM and the molecular pathogenesis of ataxia telangiectasia
    • McKinnon PJ. 2012. ATM and the molecular pathogenesis of ataxia telangiectasia. Annu Rev Pathol 7:303–321.
    • (2012) Annu Rev Pathol , vol.7 , pp. 303-321
    • McKinnon, P.J.1
  • 89
    • 84886867688 scopus 로고    scopus 로고
    • Maintaining genome stability in the nervous system
    • McKinnon PJ. 2013. Maintaining genome stability in the nervous system. Nat Neurosci 16:1523–1529.
    • (2013) Nat Neurosci , vol.16 , pp. 1523-1529
    • McKinnon, P.J.1
  • 92
    • 0023160233 scopus 로고
    • Impaired glutathione biosynthesis in cultured human ataxia-telangiectasia cells
    • Meredith MJ, Dodson ML. 1987. Impaired glutathione biosynthesis in cultured human ataxia-telangiectasia cells. Cancer Res 47:4576–4581.
    • (1987) Cancer Res , vol.47 , pp. 4576-4581
    • Meredith, M.J.1    Dodson, M.L.2
  • 94
    • 84893725571 scopus 로고    scopus 로고
    • Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells
    • Morita A, Tanimoto K, Murakami T, Morinaga T, Hosoi Y. 2014. Mitochondria are required for ATM activation by extranuclear oxidative stress in cultured human hepatoblastoma cell line Hep G2 cells. Biochem Biophys Res Commun 443:1286–1290.
    • (2014) Biochem Biophys Res Commun , vol.443 , pp. 1286-1290
    • Morita, A.1    Tanimoto, K.2    Murakami, T.3    Morinaga, T.4    Hosoi, Y.5
  • 97
    • 84895098727 scopus 로고    scopus 로고
    • Peroxisomal metabolism and oxidative stress
    • Nordgren M, Fransen M. 2014. Peroxisomal metabolism and oxidative stress. Biochimie 98:56–62.
    • (2014) Biochimie , vol.98 , pp. 56-62
    • Nordgren, M.1    Fransen, M.2
  • 98
    • 0032555458 scopus 로고    scopus 로고
    • Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development
    • Oka A, Takashima S. 1998. Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development. Neurosci Lett 252:195–198.
    • (1998) Neurosci Lett , vol.252 , pp. 195-198
    • Oka, A.1    Takashima, S.2
  • 101
    • 84924384551 scopus 로고    scopus 로고
    • Mechanisms of ATM activation
    • Paull TT. 2015. Mechanisms of ATM activation. Annu Rev Biochem 84:711–738.
    • (2015) Annu Rev Biochem , vol.84 , pp. 711-738
    • Paull, T.T.1
  • 102
    • 0035852706 scopus 로고    scopus 로고
    • ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response
    • Peretz S, Jensen R, Baserga R, Glazer PM. 2001. ATM-dependent expression of the insulin-like growth factor-I receptor in a pathway regulating radiation response. Proc Natl Acad Sci U S A 98:1676–81.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 1676-1681
    • Peretz, S.1    Jensen, R.2    Baserga, R.3    Glazer, P.M.4
  • 104
    • 84858264276 scopus 로고    scopus 로고
    • ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
    • Petersen AJ, Rimkus SA, Wasserman DA. 2012. ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proc Natl Acad Sci U S A 109:E656–E664.
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E656-E664
    • Petersen, A.J.1    Rimkus, S.A.2    Wasserman, D.A.3
  • 108
    • 84973127054 scopus 로고    scopus 로고
    • ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts
    • Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y. 2016. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep 6:24700.
    • (2016) Sci Rep , vol.6 , pp. 24700
    • Qi, Y.1    Qiu, Q.2    Gu, X.3    Tian, Y.4    Zhang, Y.5
  • 109
    • 0035011079 scopus 로고    scopus 로고
    • Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia
    • Quick KL, Dugan LL. 2001. Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia. Ann Neurol 49:627–635.
    • (2001) Ann Neurol , vol.49 , pp. 627-635
    • Quick, K.L.1    Dugan, L.L.2
  • 113
    • 3442902484 scopus 로고    scopus 로고
    • Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice
    • Reliene R, Fischer E, Schiestl RH. 2004. Effect of N-acetyl cysteine on oxidative DNA damage and the frequency of DNA deletions in atm-deficient mice. Cancer Res 64:5148–5153.
    • (2004) Cancer Res , vol.64 , pp. 5148-5153
    • Reliene, R.1    Fischer, E.2    Schiestl, R.H.3
  • 114
    • 84861357242 scopus 로고    scopus 로고
    • Experimental antioxidant therapy in ataxia telangiectasia
    • Reliene R, Schiestl RH. 2008. Experimental antioxidant therapy in ataxia telangiectasia. Clin Med Oncol 2:431–436.
    • (2008) Clin Med Oncol , vol.2 , pp. 431-436
    • Reliene, R.1    Schiestl, R.H.2
  • 115
    • 84930945768 scopus 로고    scopus 로고
    • Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction
    • Resseguie EA, Staversky RJ, Brookes PS, O'Reilly MA. 2015. Hyperoxia activates ATM independent from mitochondrial ROS and dysfunction. Redox Biol 5:176–185.
    • (2015) Redox Biol , vol.5 , pp. 176-185
    • Resseguie, E.A.1    Staversky, R.J.2    Brookes, P.S.3    O'Reilly, M.A.4
  • 122
    • 33845292901 scopus 로고    scopus 로고
    • Peroxisomes and oxidative stress
    • Schrader M, Fahimi HD. 2006. Peroxisomes and oxidative stress. Biochim Biophys Acta 1763:1755–1766.
    • (2006) Biochim Biophys Acta , vol.1763 , pp. 1755-1766
    • Schrader, M.1    Fahimi, H.D.2
  • 124
    • 0001183734 scopus 로고
    • Hereditary neuropathies and spinocerebellar atrophies
    • Sedgwick RP, Boder E. 1991. Hereditary neuropathies and spinocerebellar atrophies. Handb Clin Neurol 16:347–423.
    • (1991) Handb Clin Neurol , vol.16 , pp. 347-423
    • Sedgwick, R.P.1    Boder, E.2
  • 129
    • 85010243158 scopus 로고    scopus 로고
    • Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling
    • ENEURO-0124-15.2016
    • Shen X, Chen J, Li J, Kofler J, Herrup K. 2016. Neurons in Vulnerable Regions of the Alzheimer's Disease Brain Display Reduced ATM Signaling. eNeuro 3:ENEURO-0124-15.2016
    • (2016) eNeuro , vol.3
    • Shen, X.1    Chen, J.2    Li, J.3    Kofler, J.4    Herrup, K.5
  • 130
    • 84971596911 scopus 로고    scopus 로고
    • Ataxia-telangiectasia (AT): An emerging dimension of premature ageing
    • Shiloh Y, Lederman HM. 2017. Ataxia-telangiectasia (AT): An emerging dimension of premature ageing. Ageing Res Rev 33:76–88.
    • (2017) Ageing Res Rev , vol.33 , pp. 76-88
    • Shiloh, Y.1    Lederman, H.M.2
  • 131
    • 84875423827 scopus 로고    scopus 로고
    • The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    • Shiloh Y, Ziv Y. 2013. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 14:197–210.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 197-210
    • Shiloh, Y.1    Ziv, Y.2
  • 132
    • 84895927173 scopus 로고    scopus 로고
    • Synaptic activity bidirectionally regulates a novel sequence-specific S-Q phosphoproteome in neurons
    • Siddoway B, Hou H, Yang H, Petralia R, Xia H. 2014. Synaptic activity bidirectionally regulates a novel sequence-specific S-Q phosphoproteome in neurons. J Neurochem 128:841–851.
    • (2014) J Neurochem , vol.128 , pp. 841-851
    • Siddoway, B.1    Hou, H.2    Yang, H.3    Petralia, R.4    Xia, H.5
  • 134
    • 0037016764 scopus 로고    scopus 로고
    • Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice
    • Stern N, Hochman A, Zemach N, Weizman N, Hammel I, Shiloh Y, Rotman G, Barzilai A. 2002. Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice. J Biol Chem 277:602–608.
    • (2002) J Biol Chem , vol.277 , pp. 602-608
    • Stern, N.1    Hochman, A.2    Zemach, N.3    Weizman, N.4    Hammel, I.5    Shiloh, Y.6    Rotman, G.7    Barzilai, A.8
  • 136
    • 0034700243 scopus 로고    scopus 로고
    • Mortality rates among carriers of ataxia-telangiectasia mutant alleles
    • Su Y, Swift M. 2000. Mortality rates among carriers of ataxia-telangiectasia mutant alleles. Ann Intern Med 133:770–778.
    • (2000) Ann Intern Med , vol.133 , pp. 770-778
    • Su, Y.1    Swift, M.2
  • 137
    • 84946482827 scopus 로고    scopus 로고
    • A mammalian pexophagy target
    • Subramani S. 2015. A mammalian pexophagy target. Nat Cell Biol 17:1371–1373
    • (2015) Nat Cell Biol , vol.17 , pp. 1371-1373
    • Subramani, S.1
  • 138
    • 84921853118 scopus 로고    scopus 로고
    • ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels
    • Sullivan KD, Palaniappan VV, Espinosa JM. 2015. ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels. Cell Cycle 14:56–63.
    • (2015) Cell Cycle , vol.14 , pp. 56-63
    • Sullivan, K.D.1    Palaniappan, V.V.2    Espinosa, J.M.3
  • 139
    • 0037182751 scopus 로고    scopus 로고
    • Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia
    • Taylor A, Shang F, Nowell T, Galanty Y, Shiloh Y. 2002. Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia. Oncogene 21:4363–4373.
    • (2002) Oncogene , vol.21 , pp. 4363-4373
    • Taylor, A.1    Shang, F.2    Nowell, T.3    Galanty, Y.4    Shiloh, Y.5
  • 140
    • 84922688515 scopus 로고    scopus 로고
    • Ataxia telangiectasia: more variation at clinical and cellular levels
    • Taylor AM, Lam Z, Last JI, Byrd PJ. 2015. Ataxia telangiectasia: more variation at clinical and cellular levels. Clin Genet 87:199–208.
    • (2015) Clin Genet , vol.87 , pp. 199-208
    • Taylor, A.M.1    Lam, Z.2    Last, J.I.3    Byrd, P.J.4
  • 142
    • 59649128916 scopus 로고    scopus 로고
    • Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death
    • Tian B, Yang Q, Mao Z. 2009. Phosphorylation of ATM by Cdk5 mediates DNA damage signalling and regulates neuronal death. Nat Cell Biol 11:211–218.
    • (2009) Nat Cell Biol , vol.11 , pp. 211-218
    • Tian, B.1    Yang, Q.2    Mao, Z.3
  • 144
    • 84878775802 scopus 로고    scopus 로고
    • Structure and function of Parkin, PINK1, and DJ-1, the three musketeers of neuroprotection
    • Trempe JF, Fon EA. 2013. Structure and function of Parkin, PINK1, and DJ-1, the three musketeers of neuroprotection. Front Neurol 4:38.
    • (2013) Front Neurol , vol.4 , pp. 38
    • Trempe, J.F.1    Fon, E.A.2
  • 146
    • 84960082750 scopus 로고    scopus 로고
    • The peroxisome as a cell signalling organelle
    • Tripathi DN, Walker CL. 2016. The peroxisome as a cell signalling organelle. Curr Opin Cell Biol 39:109–112.
    • (2016) Curr Opin Cell Biol , vol.39 , pp. 109-112
    • Tripathi, D.N.1    Walker, C.L.2
  • 149
    • 84904967279 scopus 로고    scopus 로고
    • New functions of mitochondria associated membranes in cellular signaling
    • van Vliet AR, Verfaillie T, Agostinis P. 2014. New functions of mitochondria associated membranes in cellular signaling. Biochim Biophys Acta 1843:2253–2262.
    • (2014) Biochim Biophys Acta , vol.1843 , pp. 2253-2262
    • van Vliet, A.R.1    Verfaillie, T.2    Agostinis, P.3
  • 152
    • 0022308073 scopus 로고
    • Sequence of cellular events in cerebellar ontogeny relevant to expression of neuronal abnormalities in ataxia-telangiectasia
    • Vinters HV, Gatti RA, Rakic P. 1984. Sequence of cellular events in cerebellar ontogeny relevant to expression of neuronal abnormalities in ataxia-telangiectasia. Kroc Found Ser 19:233–255.
    • (1984) Kroc Found Ser , vol.19 , pp. 233-255
    • Vinters, H.V.1    Gatti, R.A.2    Rakic, P.3
  • 153
    • 84901411227 scopus 로고    scopus 로고
    • Brain glucose metabolism in adults with ataxia-telangiectasia and their asymptomatic relatives
    • Volkow ND, Tomasi D, Wang GJ, Studentsova Y, Margus B, Crawford TO. 2014. Brain glucose metabolism in adults with ataxia-telangiectasia and their asymptomatic relatives. Brain 137:1753–1761.
    • (2014) Brain , vol.137 , pp. 1753-1761
    • Volkow, N.D.1    Tomasi, D.2    Wang, G.J.3    Studentsova, Y.4    Margus, B.5    Crawford, T.O.6
  • 158
    • 84903701668 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects
    • Werner H, LeRoith D. 2014. Insulin and insulin-like growth factor receptors in the brain: physiological and pathological aspects. Eur Neuropsychopharmacol 24:1947–1953.
    • (2014) Eur Neuropsychopharmacol , vol.24 , pp. 1947-1953
    • Werner, H.1    LeRoith, D.2
  • 160
    • 0029821651 scopus 로고    scopus 로고
    • Dual roles of ATM in the cellular response to radiation and in cell growth control
    • Xu Y, Baltimore D. 1996. Dual roles of ATM in the cellular response to radiation and in cell growth control. Genes Dev 10:2401–2410.
    • (1996) Genes Dev , vol.10 , pp. 2401-2410
    • Xu, Y.1    Baltimore, D.2
  • 161
    • 0033662156 scopus 로고    scopus 로고
    • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
    • Yang DQ, Kastan MB. 2000. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat Cell Biol 2:893–898.
    • (2000) Nat Cell Biol , vol.2 , pp. 893-898
    • Yang, D.Q.1    Kastan, M.B.2
  • 162
    • 14944346310 scopus 로고    scopus 로고
    • Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism
    • Yang Y, Herrup K. 2005. Loss of neuronal cell cycle control in ataxia-telangiectasia: a unified disease mechanism. J Neurosci 25:2522–2529.
    • (2005) J Neurosci , vol.25 , pp. 2522-2529
    • Yang, Y.1    Herrup, K.2
  • 163
    • 84919348850 scopus 로고    scopus 로고
    • The interaction of the atm genotype with inflammation and oxidative stress
    • Yang Y, Hui CW, Li J, Herrup K. 2014. The interaction of the atm genotype with inflammation and oxidative stress. PLoS One 9:e85863.
    • (2014) PLoS One , vol.9
    • Yang, Y.1    Hui, C.W.2    Li, J.3    Herrup, K.4


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