NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Cell Metabolism

Volumn 24, Issue 4, 2016, Pages 566-581

  Fang, Evandro Fei ^a   Kassahun, Henok ^b   Croteau, Deborah L ^a   Scheibye Knudsen, Morten ^a,e   Marosi, Krisztina ^a   Lu, Huiming ^a   Shamanna, Raghavendra A ^a   Kalyanasundaram, Sumana ^b,c   Bollineni, Ravi Chand ^d   Wilson, Mark A ^a   Iser, Wendy B ^a   Wollman, Bradley N ^a   Morevati, Marya ^a,e   Li, Jun ^f   Kerr, Jesse S ^a   Lu, Qiping ^a   Waltz, Tyler B ^a   Tian, Jane ^a   Sinclair, David A ^f,g   Mattson, Mark P ^a,h   Nilsen, Hilde ^b   Bohr, Vilhelm A ^a,e   more..

^a NATIONAL INSTITUTE ON AGING   (United States)

^b AKERSHUS UNIVERSITY HOSPITAL   (Norway)

^c OSLO UNIVERSITY HOSPITAL   (Norway)

^d UNIVERSITY OF OSLO   (Norway)

^e UNIVERSITY OF COPENHAGEN   (Denmark)

^f HARVARD MEDICAL SCHOOL   (United States)

^g UNIVERSITY OF NEW SOUTH WALES   (Australia)

^h JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; BRAIN DERIVED NEUROTROPHIC FACTOR; CALBINDIN; CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; MITOFUSIN 2; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NEUROTROPHIC FACTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; POSTSYNAPTIC DENSITY PROTEIN 95; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SYNAPSIN I; OLAPARIB; PHTHALAZINE DERIVATIVE; PIPERAZINE DERIVATIVE;

AMNESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA TELANGIECTASIA; AUTOPHOSPHORYLATION; CAENORHABDITIS ELEGANS; CELL AGING; CITRIC ACID CYCLE; CONTROLLED STUDY; DEACETYLATION; DISEASE SEVERITY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA REPAIR; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; LIFESPAN; MITOPHAGY; MOUSE; NEUROLOGIC DISEASE; NEUROMUSCULAR DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; ANIMAL BEHAVIOR; CELL CULTURE; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENE SILENCING; HEALTH; HOMEOSTASIS; LONGEVITY; METABOLISM; METABOLOMICS; NERVE CELL; PATHOLOGY; PHENOTYPE; PROTEOMICS; SPRAGUE DAWLEY RAT; ULTRASTRUCTURE;

ANIMALS; ATAXIA TELANGIECTASIA; ATAXIA TELANGIECTASIA MUTATED PROTEINS; BEHAVIOR, ANIMAL; CAENORHABDITIS ELEGANS; CELLS, CULTURED; DISEASE MODELS, ANIMAL; DNA REPAIR; GENE KNOCKDOWN TECHNIQUES; HEALTH; HOMEOSTASIS; LONGEVITY; METABOLOMICS; MICE; MITOCHONDRIAL DEGRADATION; NAD; NEURONS; PHENOTYPE; PHTHALAZINES; PIPERAZINES; PROTEOMICS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; SIRTUIN 1;

EID: 84992343671     PISSN: 15504131     EISSN: 19327420     Source Type: Journal    
DOI: 10.1016/j.cmet.2016.09.004     Document Type: Article

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