-
1
-
-
84938483122
-
Damage in chromatin: Preparing the chromatin landscape for base excision repair
-
Rodriguez, Y.; Hinz, J.M.; Smerdon, M.J. Accessing DNA damage in chromatin: Preparing the chromatin landscape for base excision repair. DNA Repair 2015, 32, 113-119.
-
(2015)
DNA Repair
, vol.32
, pp. 113-119
-
-
Rodriguez, Y.1
Hinz, J.M.2
Smerdon, M.J.3
Accessing, D.4
-
2
-
-
84903124095
-
Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair
-
Zhao, Y.; Brickner, J.R.; Majid, M.C.; Mosammaparast, N. Crosstalk between ubiquitin and other post-translational modifications on chromatin during double-strand break repair. Trends Cell Biol. 2014, 24, 426-434.
-
(2014)
Trends Cell Biol
, vol.24
, pp. 426-434
-
-
Zhao, Y.1
Brickner, J.R.2
Majid, M.C.3
Mosammaparast, N.4
-
3
-
-
0026377650
-
Interaction between ionizing radiation and supercoiled DNA within human tumor cells
-
Vaughan, A.T.; Milner, A.M.; Gordon, D.G.; Schwartz, J.L. Interaction between ionizing radiation and supercoiled DNA within human tumor cells. Cancer Res. 1991, 51, 3857-3861.
-
(1991)
Cancer Res
, vol.51
, pp. 3857-3861
-
-
Vaughan, A.T.1
Milner, A.M.2
Gordon, D.G.3
Schwartz, J.L.4
-
4
-
-
69949123856
-
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1
-
Ahel, D.; Horejsi, Z.; Wiechens, N.; Polo, S.E.; Garcia-Wilson, E.; Ahel, I.; Flynn, H.; Skehel, M.; West, S.C.; Jackson, S.P. et al. Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science 2009, 325, 1240-1243.
-
(2009)
Science
, vol.325
, pp. 1240-1243
-
-
Ahel, D.1
Horejsi, Z.2
Wiechens, N.3
Polo, S.E.4
Garcia-Wilson, E.5
Ahel, I.6
Flynn, H.7
Skehel, M.8
West, S.C.9
Jackson, S.P.10
-
5
-
-
69549083315
-
Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler
-
Gottschalk, A.J.; Timinszky, G.; Kong, S.E.; Jin, J.; Cai, Y.; Swanson, S.K.; Washburn, M.P.; Florens, L.; Ladurner, A.G.; Conaway, J.W. et al. Poly(ADP-ribosyl)ation directs recruitment and activation of an ATP-dependent chromatin remodeler. Proc. Natl. Acad. Sci. USA 2009, 106, 13770-13774.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 13770-13774
-
-
Gottschalk, A.J.1
Timinszky, G.2
Kong, S.E.3
Jin, J.4
Cai, Y.5
Swanson, S.K.6
Washburn, M.P.7
Florens, L.8
Ladurner, A.G.9
Conaway, J.W.10
-
6
-
-
77956379478
-
The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage
-
Larsen, D.H.; Poinsignon, C.; Gudjonsson, T.; Dinant, C.; Payne, M.R.; Hari, F.J.; Danielsen, J.M.R.; Menard, P.; Sand, J.C.; Stucki, M. et al. The chromatin-remodeling factor CHD4 coordinates signaling and repair after DNA damage. J. Cell Biol. 2010, 190, 731-740.
-
(2010)
J. Cell Biol
, vol.190
, pp. 731-740
-
-
Larsen, D.H.1
Poinsignon, C.2
Gudjonsson, T.3
Dinant, C.4
Payne, M.R.5
Hari, F.J.6
Danielsen, J.7
Menard, P.8
Sand, J.C.9
Stucki, M.10
-
7
-
-
80053555789
-
More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance
-
Lukas, J.; Lukas, C.; Bartek, J. More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance. Nat. Cell Biol. 2011, 13, 1161-1169.
-
(2011)
Nat. Cell Biol
, vol.13
, pp. 1161-1169
-
-
Lukas, J.1
Lukas, C.2
Bartek, J.3
-
8
-
-
84919451538
-
Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin
-
Kakarougkas, A.; Ismail, A.; Chambers, A.L.; Riballo, E.; Herbert, A.D.; Kunzel, J.; Lobrich, M.; Jeggo, P.A.; Downs, J.A. Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin. Mol. Cell 2014, 55, 723-732.
-
(2014)
Mol. Cell
, vol.55
, pp. 723-732
-
-
Kakarougkas, A.1
Ismail, A.2
Chambers, A.L.3
Riballo, E.4
Herbert, A.D.5
Kunzel, J.6
Lobrich, M.7
Jeggo, P.A.8
Downs, J.A.9
-
9
-
-
77953720192
-
ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks
-
Shanbhag, N.M.; Rafalska-Metcalf, I.U.; Balane-Bolivar, C.; Janicki, S.M.; Greenberg, R.A. ATM-dependent chromatin changes silence transcription in cis to DNA double-strand breaks. Cell 2010, 141, 970-981.
-
(2010)
Cell
, vol.141
, pp. 970-981
-
-
Shanbhag, N.M.1
Rafalska-Metcalf, I.U.2
Balane-Bolivar, C.3
Janicki, S.M.4
Greenberg, R.A.5
-
10
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou, E.P.; Pilch, D.R.; Orr, A.H.; Ivanova, V.S.; Bonner, W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 1998, 273, 5858-5868.
-
(1998)
J. Biol. Chem
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
11
-
-
0037711771
-
Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
-
Celeste, A.; Fernandez-Capetillo, O.; Kruhlak, M.J.; Pilch, D.R.; Staudt, D.W.; Lee, A.; Bonner, R.F.; Bonner, W.M.; Nussenzweig, A. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat. Cell Biol. 2003, 5, 675-679.
-
(2003)
Nat. Cell Biol
, vol.5
, pp. 675-679
-
-
Celeste, A.1
Fernandez-Capetillo, O.2
Kruhlak, M.J.3
Pilch, D.R.4
Staudt, D.W.5
Lee, A.6
Bonner, R.F.7
Bonner, W.M.8
Nussenzweig, A.9
-
12
-
-
63849187827
-
Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions
-
Cook, P.J.; Ju, B.G.; Telese, F.; Wang, X.; Glass, C.K.; Rosenfeld, M.G. Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions. Nature 2009, 455, 591-596.
-
(2009)
Nature
, vol.455
, pp. 591-596
-
-
Cook, P.J.1
Ju, B.G.2
Telese, F.3
Wang, X.4
Glass, C.K.5
Rosenfeld, M.G.6
-
13
-
-
58149242430
-
Wstf regulates the H2AX DNA damage response via a novel tyrosine kinase activity
-
Xiao, A.; Li, H.; Shechter, D.; Ahn, S.H.; Fabrizio, L.A.; Erdjument-Bromage, H.; Ishibe-Murakami, S.; Wang, B.; Tempst, P.; Hofmann, K. et al. Wstf regulates the H2AX DNA damage response via a novel tyrosine kinase activity. Nature 2009, 457, 57-62.
-
(2009)
Nature
, vol.457
, pp. 57-62
-
-
Xiao, A.1
Li, H.2
Shechter, D.3
Ahn, S.H.4
Fabrizio, L.A.5
Erdjument-Bromage, H.6
Ishibe-Murakami, S.7
Wang, B.8
Tempst, P.9
Hofmann, K.10
-
14
-
-
79952235291
-
Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications
-
Polo, S.E.; Jackson, S.P. Dynamics of DNA damage response proteins at DNA breaks: A focus on protein modifications. Genes Dev. 2011, 25, 409-433.
-
(2011)
Genes Dev
, vol.25
, pp. 409-433
-
-
Polo, S.E.1
Jackson, S.P.2
-
15
-
-
84919401699
-
ATM: Expanding roles as a chief guardian of genome stability. Exp. Cell
-
Shiloh, Y. ATM: Expanding roles as a chief guardian of genome stability. Exp. Cell. Res. 2014, 329, 154-161.
-
(2014)
Res
, vol.329
, pp. 154-161
-
-
Shiloh, Y.1
-
16
-
-
65549129613
-
Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin
-
Savic, V.; Yin, B.; Maas, N.L.; Bredemeyer, A.L.; Carpenter, A.C.; Helmink, B.A.; Yang-Iott, K.S.; Sleckman, B.P.; Bassing, C.H. Formation of dynamic gamma-H2AX domains along broken DNA strands is distinctly regulated by ATM and MDC1 and dependent upon H2AX densities in chromatin. Mol. Cell 2009, 34, 298-310.
-
(2009)
Mol. Cell
, vol.34
, pp. 298-310
-
-
Savic, V.1
Yin, B.2
Maas, N.L.3
Bredemeyer, A.L.4
Carpenter, A.C.5
Helmink, B.A.6
Yang-Iott, K.S.7
Sleckman, B.P.8
Bassing, C.H.9
-
17
-
-
77953495958
-
Tip60: Connecting chromatin to DNA damage signaling
-
Sun, Y.; Jiang, X.; Price, B.D. Tip60: Connecting chromatin to DNA damage signaling. Cell Cycle 2010, 9, 930-936.
-
(2010)
Cell Cycle
, vol.9
, pp. 930-936
-
-
Sun, Y.1
Jiang, X.2
Price, B.D.3
-
18
-
-
84903446359
-
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin
-
Ayrapetov, M.K.; Gursoy-Yuzugullu, O.; Xu, C.; Xu, Y.; Price, B.D. DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin. Proc. Natl. Acad. Sci. USA 2014, 111, 9169-9174.
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 9169-9174
-
-
Ayrapetov, M.K.1
Gursoy-Yuzugullu, O.2
Xu, C.3
Xu, Y.4
Price, B.D.5
-
19
-
-
9244252580
-
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
-
Huyen, Y.; Zgheib, O.; Ditullio, R.A., Jr.; Gorgoulis, V.G.; Zacharatos, P.; Petty, T.J.; Sheston, E.A.; Mellert, H.S.; Stavridi, E.S.; Halazonetis, T.D. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 2004, 432, 406-411.
-
(2004)
Nature
, vol.432
, pp. 406-411
-
-
Huyen, Y.1
Zgheib, O.2
Ditullio, R.A.3
Gorgoulis, V.G.4
Zacharatos, P.5
Petty, T.J.6
Sheston, E.A.7
Mellert, H.S.8
Stavridi, E.S.9
Halazonetis, T.D.10
-
20
-
-
79551665780
-
Mmset regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites
-
Pei, H.; Zhang, L.; Luo, K.; Qin, Y.; Chesi, M.; Fei, F.; Bergsagel, P.L.; Wang, L.; You, Z.; Lou, Z. Mmset regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites. Nature 2011, 470, 124-128.
-
(2011)
Nature
, vol.470
, pp. 124-128
-
-
Pei, H.1
Zhang, L.2
Luo, K.3
Qin, Y.4
Chesi, M.5
Fei, F.6
Bergsagel, P.L.7
Wang, L.8
You, Z.9
Lou, Z.10
-
21
-
-
80052697814
-
The ubiquitin- and sumo-dependent signaling response to DNA double-strand breaks
-
Bekker-Jensen, S.; Mailand, N. The ubiquitin- and sumo-dependent signaling response to DNA double-strand breaks. FEBSLett. 2011, 555, 2914-2919.
-
(2011)
Febslett
, vol.555
, pp. 2914-2919
-
-
Bekker-Jensen, S.1
Mailand, N.2
-
22
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
Mailand, N.; Bekker-Jensen, S.; Faustrup, H.; Melander, F.; Bartek, J.; Lukas, C.; Lukas, J. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 2007, 131, 887-900.
-
(2007)
Cell
, vol.131
, pp. 887-900
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
Lukas, J.7
-
23
-
-
84933073669
-
Ubiquitylation, neddylation and the DNA damage response
-
Brown, J.S.; Jackson, S.P. Ubiquitylation, neddylation and the DNA damage response. Open Biol. 2015, doi:10.1098/rsob.150018.
-
(2015)
Open Biol
-
-
Brown, J.S.1
Jackson, S.P.2
-
24
-
-
78649449767
-
The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax
-
Goodarzi, A.A.; Jeggo, P.; Lobrich, M. The influence of heterochromatin on DNA double strand break repair: Getting the strong, silent type to relax. DNA Repair 2010, 9, 1273-1282.
-
(2010)
DNA Repair
, vol.9
, pp. 1273-1282
-
-
Goodarzi, A.A.1
Jeggo, P.2
Lobrich, M.3
-
25
-
-
84942937470
-
DNA end resection: Nucleases team up with the right partners to initiate homologous recombination
-
Cejka, P. DNA end resection: Nucleases team up with the right partners to initiate homologous recombination. J. Biol. Chem. 2015, doi:10.1074/jbc.R115.675942.
-
(2015)
J. Biol. Chem
-
-
Cejka, P.1
-
26
-
-
84877321963
-
Microhomology-mediated end joining and homologous recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells
-
Truong, L.N.; Li, Y.; Shi, L.Z.; Hwang, P.Y.; He, J.; Wang, H.; Razavian, N.; Berns, M.W.; Wu, X. Microhomology-mediated end joining and homologous recombination share the initial end resection step to repair DNA double-strand breaks in mammalian cells. Proc. Natl. Acad. Sci. USA 2013, 110, 7720-7725.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 7720-7725
-
-
Truong, L.N.1
Li, Y.2
Shi, L.Z.3
Hwang, P.Y.4
He, J.5
Wang, H.6
Razavian, N.7
Berns, M.W.8
Wu, X.9
-
27
-
-
0037159220
-
The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation
-
Merkle, D.; Douglas, P.; Moorhead, G.B.; Leonenko, Z.; Yu, Y.; Cramb, D.; Bazett-Jones, D.P.; Lees-Miller, S.P. The DNA-dependent protein kinase interacts with DNA to form a protein-DNA complex that is disrupted by phosphorylation. Biochemistry 2002, 41, 12706-12714.
-
(2002)
Biochemistry
, vol.41
, pp. 12706-12714
-
-
Merkle, D.1
Douglas, P.2
Moorhead, G.B.3
Leonenko, Z.4
Yu, Y.5
Cramb, D.6
Bazett-Jones, D.P.7
Lees-Miller, S.P.8
-
28
-
-
84922384279
-
PAXX, a paralog of XRCC4 and Xlf, interacts with Ku to promote DNA double-strand break repair
-
Ochi, T.; Blackford, A.N.; Coates, J.; Jhujh, S.; Mehmood, S.; Tamura, N.; Travers, J.; Wu, Q.; Draviam, V.M.; Robinson, C.V. et al. PAXX, a paralog of XRCC4 and Xlf, interacts with Ku to promote DNA double-strand break repair. Science 2015, 347, 185-188.
-
(2015)
Science
, vol.347
, pp. 185-188
-
-
Ochi, T.1
Blackford, A.N.2
Coates, J.3
Jhujh, S.4
Mehmood, S.5
Tamura, N.6
Travers, J.7
Wu, Q.8
Draviam, V.M.9
Robinson, C.V.10
-
29
-
-
84891396638
-
DNA-dependent protein kinase regulates DNA end resection in concert with mre11-rad50-nbs1 (MRN) and ataxia telangiectasia-mutated (ATM)
-
Zhou, Y.; Paull, T.T. DNA-dependent protein kinase regulates DNA end resection in concert with mre11-rad50-nbs1 (MRN) and ataxia telangiectasia-mutated (ATM). J. Biol. Chem. 2013, 255, 37112-37125.
-
(2013)
J. Biol. Chem
, vol.255
, pp. 37112-37125
-
-
Zhou, Y.1
Paull, T.T.2
-
30
-
-
79956004104
-
HSSB1 interacts directly with the mrn complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity
-
Richard, D.J.; Cubeddu, L.; Urquhart, A.J.; Bain, A.; Bolderson, E.; Menon, D.; White, M.F.; Khanna, K.K. hSSB1 interacts directly with the mrn complex stimulating its recruitment to DNA double-strand breaks and its endo-nuclease activity. Nucleic Acids Res. 2011, 39, 3643-3651.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 3643-3651
-
-
Richard, D.J.1
Cubeddu, L.2
Urquhart, A.J.3
Bain, A.4
Bolderson, E.5
Menon, D.6
White, M.F.7
Khanna, K.K.8
-
31
-
-
84861843272
-
CDK targeting of nbs1 promotes DNA-end resection, replication restart and homologous recombination
-
Falck, J.; Forment, J.V.; Coates, J.; Mistrik, M.; Lukas, J.; Bartek, J.; Jackson, S.P. CDK targeting of nbs1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Rep. 2012, 13, 561-568.
-
(2012)
EMBO Rep
, vol.13
, pp. 561-568
-
-
Falck, J.1
Forment, J.V.2
Coates, J.3
Mistrik, M.4
Lukas, J.5
Bartek, J.6
Jackson, S.P.7
-
33
-
-
84924402458
-
Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein
-
Sarangi, P.; Steinacher, R.; Altmannova, V.; Fu, Q.; Paull, T.T.; Krejci, L.; Whitby, M.C.; Zhao, X. Sumoylation influences DNA break repair partly by increasing the solubility of a conserved end resection protein. PLoS Genet. 2015, doi:10.1371/journal.pgen.1004899.
-
(2015)
Plos Genet
-
-
Sarangi, P.1
Steinacher, R.2
Altmannova, V.3
Fu, Q.4
Paull, T.T.5
Krejci, L.6
Whitby, M.C.7
Zhao, X.8
-
34
-
-
84904070920
-
Mof phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice
-
Gupta, A.; Hunt, C.R.; Hegde, M.L.; Chakraborty, S.; Chakraborty, S.; Udayakumar, D.; Horikoshi, N.; Singh, M.; Ramnarain, D.B.; Hittelman, W.N. et al. Mof phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice. Cell Rep. 2014, 5, 177-189.
-
(2014)
Cell Rep
, vol.5
, pp. 177-189
-
-
Gupta, A.1
Hunt, C.R.2
Hegde, M.L.3
Chakraborty, S.4
Chakraborty, S.5
Udayakumar, D.6
Horikoshi, N.7
Singh, M.8
Ramnarain, D.B.9
Hittelman, W.N.10
-
35
-
-
84876877091
-
A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice
-
Escribano-Diaz, C.; Orthwein, A.; Fradet-Turcotte, A.; Xing, M.; Young, J.T.; Tkac, J.; Cook, M.A.; Rosebrock, A.P.; Munro, M.; Canny, M.D. et al. A cell cycle-dependent regulatory circuit composed of 53BP1-RIF1 and BRCA1-CtIP controls DNA repair pathway choice. Mol. cell 2013, 49, 872-883.
-
(2013)
Mol. Cell
, vol.49
, pp. 872-883
-
-
Escribano-Diaz, C.1
Orthwein, A.2
Fradet-Turcotte, A.3
Xing, M.4
Young, J.T.5
Tkac, J.6
Cook, M.A.7
Rosebrock, A.P.8
Munro, M.9
Canny, M.D.10
-
36
-
-
0036276388
-
The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling
-
D'Amours, D.; Jackson, S.P. The Mre11 complex: At the crossroads of DNA repair and checkpoint signalling. Nat. Rev. Mol. Cell Biol. 2002, 3, 317-327.
-
(2002)
Nat. Rev. Mol. Cell Biol
, vol.3
, pp. 317-327
-
-
D'amours, D.1
Jackson, S.P.2
-
37
-
-
0142186242
-
The mrn complex: Coordinating and mediating the response to broken chromosomes
-
Van den Bosch, M.; Bree, R.T.; Lowndes, N.F. The mrn complex: Coordinating and mediating the response to broken chromosomes. EMBO Rep. 2003, 4, 844-849.
-
(2003)
EMBO Rep
, vol.4
, pp. 844-849
-
-
Van Den Bosch, M.1
Bree, R.T.2
Lowndes, N.F.3
-
38
-
-
65149095154
-
Human RAD50 deficiency in a nijmegen breakage syndrome-like disorder
-
Waltes, R.; Kalb, R.; Gatei, M.; Kijas, A.W.; Stumm, M.; Sobeck, A.; Wieland, B.; Varon, R.; Lerenthal, Y.; Lavin, M.F. et al. Human RAD50 deficiency in a nijmegen breakage syndrome-like disorder. Am. J. Hum. Genet. 2009, 54, 605-616.
-
(2009)
Am. J. Hum. Genet
, vol.54
, pp. 605-616
-
-
Waltes, R.1
Kalb, R.2
Gatei, M.3
Kijas, A.W.4
Stumm, M.5
Sobeck, A.6
Wieland, B.7
Varon, R.8
Lerenthal, Y.9
Lavin, M.F.10
-
39
-
-
0033544724
-
The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder
-
Stewart, G.S.; Maser, R.S.; Stankovic, T.; Bressan, D.A.; Kaplan, M.I.; Jaspers, N.G.; Raams, A.; Byrd, P.J.; Petrini, J.H.; Taylor, A.M. The DNA double-strand break repair gene hMRE11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 1999, 99, 577-587.
-
(1999)
Cell
, vol.99
, pp. 577-587
-
-
Stewart, G.S.1
Maser, R.S.2
Stankovic, T.3
Bressan, D.A.4
Kaplan, M.I.5
Jaspers, N.G.6
Raams, A.7
Byrd, P.J.8
Petrini, J.H.9
Taylor, A.M.10
-
40
-
-
0032076248
-
The hMRE11/hRAD50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response
-
Carney, J.P.; Maser, R.S.; Olivares, H.; Davis, E.M.; le Beau, M.; Yates, J.R.; Hays, L.; Morgan, W.F.; Petrini, J.H. The hMRE11/hRAD50 protein complex and Nijmegen breakage syndrome: Linkage of double-strand break repair to the cellular DNA damage response. Cell 1998, 93, 477-486.
-
(1998)
Cell
, vol.93
, pp. 477-486
-
-
Carney, J.P.1
Maser, R.S.2
Olivares, H.3
Davis, E.M.4
Le Beau, M.5
Yates, J.R.6
Hays, L.7
Morgan, W.F.8
Petrini, J.H.9
-
41
-
-
84924910336
-
Interdependence of the RAD50 hook and globular domain functions
-
Hohl, M.; Kochanczyk, T.; Tous, C.; Aguilera, A.; Krezel, A.; Petrini, J.H. Interdependence of the RAD50 hook and globular domain functions. Mol. Cell 2015, 57, 479-491.
-
(2015)
Mol. Cell
, vol.57
, pp. 479-491
-
-
Hohl, M.1
Kochanczyk, T.2
Tous, C.3
Aguilera, A.4
Krezel, A.5
Petrini, J.H.6
-
42
-
-
84938991065
-
Envisioning the dynamics and flexibility of MRE11-RAD50-NBS1 complex to decipher its roles in DNA replication and repair
-
Lafrance-Vanasse, J.; Williams, G.J.; Tainer, J.A. Envisioning the dynamics and flexibility of MRE11-RAD50-NBS1 complex to decipher its roles in DNA replication and repair. Prog. Biophys. Mol. Biol. 2015, 117, 182-193.
-
(2015)
Prog. Biophys. Mol. Biol
, vol.117
, pp. 182-193
-
-
Lafrance-Vanasse, J.1
Williams, G.J.2
Tainer, J.A.3
-
43
-
-
84896125249
-
ATP-driven RAD50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
-
Deshpande, R.A.; Williams, G.J.; Limbo, O.; Williams, R.S.; Kuhnlein, J.; Lee, J.H.; Classen, S.; Guenther, G.; Russell, P.; Tainer, J.A. et al. ATP-driven RAD50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. 2014, 33, 482-500.
-
(2014)
EMBO J
, vol.33
, pp. 482-500
-
-
Deshpande, R.A.1
Williams, G.J.2
Limbo, O.3
Williams, R.S.4
Kuhnlein, J.5
Lee, J.H.6
Classen, S.7
Guenther, G.8
Russell, P.9
Tainer, J.A.10
-
44
-
-
52949109260
-
MRE11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
-
Buis, J.; Wu, Y.; Deng, Y.; Leddon, J.; Westfield, G.; Eckersdorff, M.; Sekiguchi, J.M.; Chang, S.; Ferguson, D.O. MRE11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 2008, 135, 85-96.
-
(2008)
Cell
, vol.135
, pp. 85-96
-
-
Buis, J.1
Wu, Y.2
Deng, Y.3
Leddon, J.4
Westfield, G.5
Eckersdorff, M.6
Sekiguchi, J.M.7
Chang, S.8
Ferguson, D.O.9
-
45
-
-
84877124011
-
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the MRE11/RAD50/NBS1 (MRN) complex
-
Lee, J.H.; Mand, M.R.; Deshpande, R.A.; Kinoshita, E.; Yang, S.H.; Wyman, C.; Paull, T.T. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the MRE11/RAD50/NBS1 (MRN) complex. J. Biol. Chem. 2013, 255, 12840-12851.
-
(2013)
J. Biol. Chem
, vol.255
, pp. 12840-12851
-
-
Lee, J.H.1
Mand, M.R.2
Deshpande, R.A.3
Kinoshita, E.4
Yang, S.H.5
Wyman, C.6
Paull, T.T.7
-
46
-
-
84924384551
-
Mechanisms of ATM activation
-
Paull, T.T. Mechanisms of ATM activation. Annu. Rev. Biochem. 2015, 54, 711-738.
-
(2015)
Annu. Rev. Biochem
, vol.54
, pp. 711-738
-
-
Paull, T.T.1
-
47
-
-
52449114574
-
Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer
-
Lavin, M.F. Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 2008, 9, 759-769.
-
(2008)
Nat. Rev. Mol. Cell Biol
, vol.9
, pp. 759-769
-
-
Lavin, M.F.1
-
48
-
-
0034749425
-
DNA damage-dependent nuclear dynamics of the MRE11 complex
-
Mirzoeva, O.K.; Petrini, J.H. DNA damage-dependent nuclear dynamics of the MRE11 complex. Mol. Cell. Biol. 2001, 21, 281-288.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 281-288
-
-
Mirzoeva, O.K.1
Petrini, J.H.2
-
49
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel, T.; Lerenthal, Y.; Moyal, L.; Andegeko, Y.; Mittelman, L.; Shiloh, Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 2003, 22, 5612-5621.
-
(2003)
EMBO J
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
50
-
-
0345732687
-
The MRE11 complex is required for ATM activation and the G2/M checkpoint
-
Carson, C.T.; Schwartz, R.A.; Stracker, T.H.; Lilley, C.E.; Lee, D.V.; Weitzman, M.D. The MRE11 complex is required for ATM activation and the G2/M checkpoint. EMBO J. 2003, 22, 6610-6620.
-
(2003)
EMBO J
, vol.22
, pp. 6610-6620
-
-
Carson, C.T.1
Schwartz, R.A.2
Stracker, T.H.3
Lilley, C.E.4
Lee, D.V.5
Weitzman, M.D.6
-
51
-
-
0033607810
-
Localization of a portion of extranuclear ATM to peroxisomes
-
Watters, D.; Kedar, P.; Spring, K.; Bjorkman, J.; Chen, P.; Gatei, M.; Birrell, G.; Garrone, B.; Srinivasa, P.; Crane, D.I. et al. Localization of a portion of extranuclear ATM to peroxisomes. J. Biol. Chem. 1999, 274, 34277-34282.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 34277-34282
-
-
Watters, D.1
Kedar, P.2
Spring, K.3
Bjorkman, J.4
Chen, P.5
Gatei, M.6
Birrell, G.7
Garrone, B.8
Srinivasa, P.9
Crane, D.I.10
-
52
-
-
84862630341
-
A new role for ATM: Regulating mitochondrial function and mitophagy
-
Valentin-Vega, Y.A.; Kastan, M.B. A new role for ATM: Regulating mitochondrial function and mitophagy. Autophagy 2012, 5, 840-841.
-
(2012)
Autophagy
, vol.5
, pp. 840-841
-
-
Valentin-Vega, Y.A.1
Kastan, M.B.2
-
53
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist, C.J.; Kastan, M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003, 421, 499-506.
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
54
-
-
33747614605
-
Involvement of novel autophosphorylation sites in ATM activation
-
Kozlov, S.V.; Graham, M.E.; Peng, C.; Chen, P.; Robinson, P.J.; Lavin, M.F. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 2006, 25, 3504-3514.
-
(2006)
EMBO J
, vol.25
, pp. 3504-3514
-
-
Kozlov, S.V.1
Graham, M.E.2
Peng, C.3
Chen, P.4
Robinson, P.J.5
Lavin, M.F.6
-
55
-
-
79953183356
-
Autophosphorylation and ATM activation: Additional sites add to the complexity
-
Kozlov, S.V.; Graham, M.E.; Jakob, B.; Tobias, F.; Kijas, A.W.; Tanuji, M.; Chen, P.; Robinson, P.J.; Taucher-Scholz, G.; Suzuki, K. et al. Autophosphorylation and ATM activation: Additional sites add to the complexity. J. Biol. Chem. 2011, 256, 9107-9119.
-
(2011)
J. Biol. Chem
, vol.256
, pp. 9107-9119
-
-
Kozlov, S.V.1
Graham, M.E.2
Jakob, B.3
Tobias, F.4
Kijas, A.W.5
Tanuji, M.6
Chen, P.7
Robinson, P.J.8
Taucher-Scholz, G.9
Suzuki, K.10
-
56
-
-
33748648775
-
Autophosphorylation at serine 1987 is dispensable for murine ATM activation in vivo
-
Pellegrini, M.; Celeste, A.; Difilippantonio, S.; Guo, R.; Wang, W.; Feigenbaum, L.; Nussenzweig, A. Autophosphorylation at serine 1987 is dispensable for murine ATM activation in vivo. Nature 2006, 443, 222-225.
-
(2006)
Nature
, vol.443
, pp. 222-225
-
-
Pellegrini, M.1
Celeste, A.2
Difilippantonio, S.3
Guo, R.4
Wang, W.5
Feigenbaum, L.6
Nussenzweig, A.7
-
57
-
-
58149312946
-
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo
-
Daniel, J.A.; Pellegrini, M.; Lee, J.H.; Paull, T.T.; Feigenbaum, L.; Nussenzweig, A. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J. Biol. Chem. 2008, 153, 777-783.
-
(2008)
J. Biol. Chem
, vol.153
, pp. 777-783
-
-
Daniel, J.A.1
Pellegrini, M.2
Lee, J.H.3
Paull, T.T.4
Feigenbaum, L.5
Nussenzweig, A.6
-
58
-
-
33745058037
-
Two-step activation of ATM by DNA and the MRE11-RAD50-NBS1 complex
-
Dupre, A.; Boyer-Chatenet, L.; Gautier, J. Two-step activation of ATM by DNA and the MRE11-RAD50-NBS1 complex. Nat. Struct. Mol. Biol. 2006, 13, 451-457.
-
(2006)
Nat. Struct. Mol. Biol
, vol.13
, pp. 451-457
-
-
Dupre, A.1
Boyer-Chatenet, L.2
Gautier, J.3
-
59
-
-
36949026694
-
Activation and regulation of ATM kinase activity in response to DNA double-strand breaks
-
Lee, J.H.; Paull, T.T. Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene 2007, 26, 7741-7748.
-
(2007)
Oncogene
, vol.26
, pp. 7741-7748
-
-
Lee, J.H.1
Paull, T.T.2
-
60
-
-
37549028411
-
DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity
-
Sun, Y.; Xu, Y.; Roy, K.; Price, B.D. DNA damage-induced acetylation of lysine 3016 of ATM activates ATM kinase activity. Mol. Cell. Biol. 2007, 27, 8502-8509.
-
(2007)
Mol. Cell. Biol
, vol.27
, pp. 8502-8509
-
-
Sun, Y.1
Xu, Y.2
Roy, K.3
Price, B.D.4
-
61
-
-
84878677036
-
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
-
Kaidi, A.; Jackson, S.P. KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 2013, 495, 70-74.
-
(2013)
Nature
, vol.495
, pp. 70-74
-
-
Kaidi, A.1
Jackson, S.P.2
-
62
-
-
79960034248
-
Chfr and RNF8 synergistically regulate ATM activation
-
Wu, J.; Chen, Y.; Lu, L.Y.; Wu, Y.; Paulsen, M.T.; Ljungman, M.; Ferguson, D.O.; Yu, X. Chfr and RNF8 synergistically regulate ATM activation. Nat. Struct. Mol. Biol. 2011, 15, 761-768.
-
(2011)
Nat. Struct. Mol. Biol
, vol.15
, pp. 761-768
-
-
Wu, J.1
Chen, Y.2
Lu, L.Y.3
Wu, Y.4
Paulsen, M.T.5
Ljungman, M.6
Ferguson, D.O.7
Yu, X.8
-
63
-
-
84962385367
-
The core spliceosome as target and effector of non-canonical ATM signalling
-
Tresini, M.; Warmerdam, D.O.; Kolovos, P.; Snijder, L.; Vrouwe, M.G.; Demmers, J.A.; van IJcken, W.F.J.; Grosveld, F.G.; Medema, R.H.; Hoeijmakers, J.H. et al. The core spliceosome as target and effector of non-canonical ATM signalling. Nature 2015, 523, 53-58.
-
(2015)
Nature
, vol.523
, pp. 53-58
-
-
Tresini, M.1
Warmerdam, D.O.2
Kolovos, P.3
Snijder, L.4
Vrouwe, M.G.5
Demmers, J.A.6
Van Ijcken, W.7
Grosveld, F.G.8
Medema, R.H.9
Hoeijmakers, J.H.10
-
64
-
-
84878527709
-
Pathogenesis of ataxia-telangiectasia: The next generation of ATM functions
-
Ambrose, M.; Gatti, R.A. Pathogenesis of ataxia-telangiectasia: The next generation of ATM functions. Blood 2013, 121, 4036-4045.
-
(2013)
Blood
, vol.121
, pp. 4036-4045
-
-
Ambrose, M.1
Gatti, R.A.2
-
65
-
-
44949238447
-
The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle
-
Biton, S.; Barzilai, A.; Shiloh, Y. The neurological phenotype of ataxia-telangiectasia: Solving a persistent puzzle. DNA Repair 2008, 7, 1028-1038.
-
(2008)
DNA Repair
, vol.7
, pp. 1028-1038
-
-
Biton, S.1
Barzilai, A.2
Shiloh, Y.3
-
66
-
-
38449117827
-
Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia
-
Lavin, M.F.; Gueven, N.; Bottle, S.; Gatti, R.A. Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia. Br. Med. Bull. 2007, doi:10.1093/bmb/ldm012.
-
(2007)
Br. Med. Bull
-
-
Lavin, M.F.1
Gueven, N.2
Bottle, S.3
Gatti, R.A.4
-
67
-
-
0028827312
-
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
-
Savitsky, K.; Sfez, S.; Tagle, D.A.; Ziv, Y.; Sartiel, A.; Collins, F.S.; Shiloh, Y.; Rotman, G. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 1995, 4, 2025-2032.
-
(1995)
Hum. Mol. Genet
, vol.4
, pp. 2025-2032
-
-
Savitsky, K.1
Sfez, S.2
Tagle, D.A.3
Ziv, Y.4
Sartiel, A.5
Collins, F.S.6
Shiloh, Y.7
Rotman, G.8
-
68
-
-
0031259793
-
Hypothesis: Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress?
-
Rotman, G.; Shiloh, Y. Hypothesis: Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress? Cell Mol. Biol. 1997, 19, 911-917.
-
(1997)
Cell Mol. Biol
, vol.19
, pp. 911-917
-
-
Rotman, G.1
Shiloh, Y.2
-
69
-
-
79952721979
-
Efficacy of very-low-dose betamethasone on neurological symptoms in ataxia-telangiectasia
-
Broccoletti, T.; del Giudice, E.; Cirillo, E.; Vigliano, I.; Giardino, G.; Ginocchio, V.M.; Bruscoli, S.; Riccardi, C.; Pignata, C. Efficacy of very-low-dose betamethasone on neurological symptoms in ataxia-telangiectasia. Eur. J. Neurol. 2011, 15, 564-570.
-
(2011)
Eur. J. Neurol
, vol.15
, pp. 564-570
-
-
Broccoletti, T.1
Del Giudice, E.2
Cirillo, E.3
Vigliano, I.4
Giardino, G.5
Ginocchio, V.M.6
Bruscoli, S.7
Riccardi, C.8
Pignata, C.9
-
70
-
-
39149088014
-
Steroid-induced improvement of neurological signs in ataxia-telangiectasia patients
-
Broccoletti, T.; del Giudice, E.; Amorosi, S.; Russo, I.; di Bonito, M.; Imperati, F.; Romano, A.; Pignata, C. Steroid-induced improvement of neurological signs in ataxia-telangiectasia patients. Eur. J. Neurol. 2008, 15, 223-228.
-
(2008)
Eur. J. Neurol
, vol.15
, pp. 223-228
-
-
Broccoletti, T.1
Del Giudice, E.2
Amorosi, S.3
Russo, I.4
Di Bonito, M.5
Imperati, F.6
Romano, A.7
Pignata, C.8
-
71
-
-
84892158748
-
Intra-erythrocyte infusion of dexamethasone reduces neurological symptoms in ataxia teleangiectasia patients: Results of a phase 2 trial
-
Chessa, L.; Leuzzi, V.; Plebani, A.; Soresina, A.; Micheli, R.; D'Agnano, D.; Venturi, T.; Molinaro, A.; Fazzi, E.; Marini, M. et al. Intra-erythrocyte infusion of dexamethasone reduces neurological symptoms in ataxia teleangiectasia patients: Results of a phase 2 trial. Orphanet J. Rare Dis. 2014, doi:10.1186/1750-1172-9-5.
-
(2014)
Orphanet J. Rare Dis
-
-
Chessa, L.1
Leuzzi, V.2
Plebani, A.3
Soresina, A.4
Micheli, R.5
D'agnano, D.6
Venturi, T.7
Molinaro, A.8
Fazzi, E.9
Marini, M.10
-
72
-
-
84875370751
-
Steroid treatment in ataxia-telangiectasia induces alterations of functional magnetic resonance imaging during prono-supination task
-
Quarantelli, M.; Giardino, G.; Prinster, A.; Aloj, G.; Carotenuto, B.; Cirillo, E.; Marsili, A.; Salvatore, E.; del Giudice, E.; Pignata, C. Steroid treatment in ataxia-telangiectasia induces alterations of functional magnetic resonance imaging during prono-supination task. Eur. J. Paediatr. Neurol. 2013, 17, 135-140.
-
(2013)
Eur. J. Paediatr. Neurol
, vol.17
, pp. 135-140
-
-
Quarantelli, M.1
Giardino, G.2
Prinster, A.3
Aloj, G.4
Carotenuto, B.5
Cirillo, E.6
Marsili, A.7
Salvatore, E.8
Del Giudice, E.9
Pignata, C.10
-
73
-
-
77957279926
-
Evaluation and management of pulmonary disease in ataxia-telangiectasia
-
McGrath-Morrow, S.A.; Gower, W.A.; Rothblum-Oviatt, C.; Brody, A.S.; Langston, C.; Fan, L.L.; Lefton-Greif, M.A.; Crawford, T.O.; Troche, M.; Sandlund, J.T. et al. Evaluation and management of pulmonary disease in ataxia-telangiectasia. Pediatr. Pulm. 2010, 45, 847-859.
-
(2010)
Pediatr. Pulm
, vol.45
, pp. 847-859
-
-
McGrath-Morrow, S.A.1
Gower, W.A.2
Rothblum-Oviatt, C.3
Brody, A.S.4
Langston, C.5
Fan, L.L.6
Lefton-Greif, M.A.7
Crawford, T.O.8
Troche, M.9
Sandlund, J.T.10
-
74
-
-
0036012789
-
ATM deficiency and oxidative stress: A new dimension of defective response to DNA damage
-
Barzilai, A.; Rotman, G.; Shiloh, Y. ATM deficiency and oxidative stress: A new dimension of defective response to DNA damage. DNA Repair 2002, 1, 3-25.
-
(2002)
DNA Repair
, vol.1
, pp. 3-25
-
-
Barzilai, A.1
Rotman, G.2
Shiloh, Y.3
-
75
-
-
84922986861
-
DNA damage primes the type I interferon system via the cytosolic DNA sensor sting to promote anti-microbial innate immunity
-
Hartlova, A.; Erttmann, S.F.; Raffi, F.A.; Schmalz, A.M.; Resch, U.; Anugula, S.; Lienenklaus, S.; Nilsson, L.M.; Kroger, A.; Nilsson, J.A. et al. DNA damage primes the type I interferon system via the cytosolic DNA sensor sting to promote anti-microbial innate immunity. Immunity 2015, 42, 332-343.
-
(2015)
Immunity
, vol.42
, pp. 332-343
-
-
Hartlova, A.1
Erttmann, S.F.2
Raffi, F.A.3
Schmalz, A.M.4
Resch, U.5
Anugula, S.6
Lienenklaus, S.7
Nilsson, L.M.8
Kroger, A.9
Nilsson, J.A.10
-
76
-
-
84933680056
-
DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function
-
Yu, Q.; Katlinskaya, Y.V.; Carbone, C.J.; Zhao, B.; Katlinski, K.V.; Zheng, H.; Guha, M.; Li, N.; Chen, Q.; Yang, T. et al. DNA-damage-induced type I interferon promotes senescence and inhibits stem cell function. Cell Rep. 2015, 11, 785-797.
-
(2015)
Cell Rep
, vol.11
, pp. 785-797
-
-
Yu, Q.1
Katlinskaya, Y.V.2
Carbone, C.J.3
Zhao, B.4
Katlinski, K.V.5
Zheng, H.6
Guha, M.7
Li, N.8
Chen, Q.9
Yang, T.10
-
77
-
-
0033578411
-
Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs
-
Barlow, C.; Dennery, P.A.; Shigenaga, M.K.; Smith, M.A.; Morrow, J.D.; Roberts, L.J.,; Wynshaw-Boris, A.; Levine, R.L. Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs. Proc. Natl. Acad. Sci. USA 1999, 96, 9915-9919.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 9915-9919
-
-
Barlow, C.1
Dennery, P.A.2
Shigenaga, M.K.3
Smith, M.A.4
Morrow, J.D.5
Roberts, L.J.6
Wynshaw-Boris, A.7
Levine, R.L.8
-
78
-
-
0347479231
-
Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice
-
Chen, P.; Peng, C.; Luff, J.; Spring, K.; Watters, D.; Bottle, S.; Furuya, S.; Lavin, M.F. Oxidative stress is responsible for deficient survival and dendritogenesis in purkinje neurons from ataxia-telangiectasia mutated mutant mice. J. Neurosci.2003, 23, 11453-11460.
-
(2003)
J. Neurosci
, vol.23
, pp. 11453-11460
-
-
Chen, P.1
Peng, C.2
Luff, J.3
Spring, K.4
Watters, D.5
Bottle, S.6
Furuya, S.7
Lavin, M.F.8
-
79
-
-
33747371969
-
Dramatic extension of tumor latency and correction of neurobehavioral phenotype in ATM-mutant mice with a nitroxide antioxidant
-
Gueven, N.; Luff, J.; Peng, C.; Hosokawa, K.; Bottle, S.E.; Lavin, M.F. Dramatic extension of tumor latency and correction of neurobehavioral phenotype in ATM-mutant mice with a nitroxide antioxidant. Free Radical Biol. Med. 2006, 41, 992-1000.
-
(2006)
Free Radical Biol. Med
, vol.41
, pp. 992-1000
-
-
Gueven, N.1
Luff, J.2
Peng, C.3
Hosokawa, K.4
Bottle, S.E.5
Lavin, M.F.6
-
80
-
-
4444349506
-
Cancer chemoprevention by the antioxidant tempol in ATM-deficient mice
-
Schubert, R.; Erker, L.; Barlow, C.; Yakushiji, H.; Larson, D.; Russo, A.; Mitchell, J.B.; Wynshaw-Boris, A. Cancer chemoprevention by the antioxidant tempol in ATM-deficient mice. Hum. Mol. Genet. 2004, 13, 1793-1802.
-
(2004)
Hum. Mol. Genet
, vol.13
, pp. 1793-1802
-
-
Schubert, R.1
Erker, L.2
Barlow, C.3
Yakushiji, H.4
Larson, D.5
Russo, A.6
Mitchell, J.B.7
Wynshaw-Boris, A.8
-
81
-
-
33846121630
-
Antioxidants suppress lymphoma and increase longevity in ATM-deficient mice
-
Reliene, R.; Schiestl, R.H. Antioxidants suppress lymphoma and increase longevity in ATM-deficient mice. J. Nutr. 2007, 137, S229-S232.
-
(2007)
J. Nutr
, vol.137
, pp. S229-S232
-
-
Reliene, R.1
Schiestl, R.H.2
-
82
-
-
84856673305
-
Activation of amp-activated protein kinase in cerebella of ATM-/-mice is attributable to accumulation of reactive oxygen species
-
Kuang, X.; Yan, M.; Ajmo, J.M.; Scofield, V.L.; Stoica, G.; Wong, P.K. Activation of amp-activated protein kinase in cerebella of ATM-/-mice is attributable to accumulation of reactive oxygen species. Biochem. Biophys. Res. Commun. 2012, 415, 267-272.
-
(2012)
Biochem. Biophys. Res. Commun
, vol.415
, pp. 267-272
-
-
Kuang, X.1
Yan, M.2
Ajmo, J.M.3
Scofield, V.L.4
Stoica, G.5
Wong, P.K.6
-
83
-
-
0035011079
-
Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia
-
Quick, K.L.; Dugan, L.L. Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia. Ann. Neurol. 2001, 49, 627-635.
-
(2001)
Ann. Neurol
, vol.49
, pp. 627-635
-
-
Quick, K.L.1
Dugan, L.L.2
-
84
-
-
84926033805
-
ATM prevents dsb formation by coordinating ssb repair and cell cycle progression
-
Khoronenkova, S.V.; Dianov, G.L. ATM prevents dsb formation by coordinating ssb repair and cell cycle progression. Proc. Natl. Acad. Sci. USA 2015, 112, 3997-4002.
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 3997-4002
-
-
Khoronenkova, S.V.1
Dianov, G.L.2
-
85
-
-
0035877581
-
The ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts
-
Shackelford, R.E.; Innes, C.L.; Sieber, S.O.; Heinloth, A.N.; Leadon, S.A.; Paules, R.S. The ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J. Biol. Chem. 2001, 276, 21951-21959.
-
(2001)
J. Biol. Chem
, vol.276
, pp. 21951-21959
-
-
Shackelford, R.E.1
Innes, C.L.2
Sieber, S.O.3
Heinloth, A.N.4
Leadon, S.A.5
Paules, R.S.6
-
86
-
-
78650378982
-
ATM activation in the presence of oxidative stress
-
Guo, Z.; Deshpande, R.; Paull, T.T. ATM activation in the presence of oxidative stress. Cell cycle 2010, 9, 4805-4811.
-
(2010)
Cell Cycle
, vol.9
, pp. 4805-4811
-
-
Guo, Z.1
Deshpande, R.2
Paull, T.T.3
-
87
-
-
77955494878
-
Redox regulation of transglutaminase 2 activity
-
Stamnaes, J.; Pinkas, D.M.; Fleckenstein, B.; Khosla, C.; Sollid, L.M. Redox regulation of transglutaminase 2 activity. J. Biol. Chem. 2010, 255, 25402-25409.
-
(2010)
J. Biol. Chem
, vol.255
, pp. 25402-25409
-
-
Stamnaes, J.1
Pinkas, D.M.2
Fleckenstein, B.3
Khosla, C.4
Sollid, L.M.5
-
88
-
-
84870877138
-
Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease
-
Wei, P.C.; Hsieh, Y.H.; Su, M.I.; Jiang, X.; Hsu, P.H.; Lo, W.T.; Weng, J.Y.; Jeng, Y.M.; Wang, J.M.; Chen, P.L. et al. Loss of the oxidative stress sensor NPGPx compromises GRP78 chaperone activity and induces systemic disease. Mol. Cell 2012, 45, 747-759.
-
(2012)
Mol. Cell
, vol.45
, pp. 747-759
-
-
Wei, P.C.1
Hsieh, Y.H.2
Su, M.I.3
Jiang, X.4
Hsu, P.H.5
Lo, W.T.6
Weng, J.Y.7
Jeng, Y.M.8
Wang, J.M.9
Chen, P.L.10
-
89
-
-
77958191599
-
ATM activation by oxidative stress
-
Guo, Z.; Kozlov, S.; Lavin, M.F.; Person, M.D.; Paull, T.T. ATM activation by oxidative stress. Science 2010, 330, 517-521.
-
(2010)
Science
, vol.330
, pp. 517-521
-
-
Guo, Z.1
Kozlov, S.2
Lavin, M.F.3
Person, M.D.4
Paull, T.T.5
-
90
-
-
84903220507
-
Direct activation of ATM by resveratrol under oxidizing conditions
-
Lee, J.H.; Guo, Z.; Myler, L.R.; Zheng, S.; Paull, T.T. Direct activation of ATM by resveratrol under oxidizing conditions. PLoS ONE 2014, doi:10.1371/journal.pone.0097969.
-
(2014)
Plos ONE
-
-
Lee, J.H.1
Guo, Z.2
Myler, L.R.3
Zheng, S.4
Paull, T.T.5
-
91
-
-
23044462591
-
Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association
-
Young, D.B.; Jonnalagadda, J.; Gatei, M.; Jans, D.A.; Meyn, S.; Khanna, K.K. Identification of domains of ataxia-telangiectasia mutated required for nuclear localization and chromatin association. J. Biol. Chem. 2005, 250, 27587-27594.
-
(2005)
J. Biol. Chem
, vol.250
, pp. 27587-27594
-
-
Young, D.B.1
Jonnalagadda, J.2
Gatei, M.3
Jans, D.A.4
Meyn, S.5
Khanna, K.K.6
-
92
-
-
58249095024
-
ATM activation and signaling under hypoxic conditions
-
Bencokova, Z.; Kaufmann, M.R.; Pires, I.M.; Lecane, P.S.; Giaccia, A.J.; Hammond, E.M. ATM activation and signaling under hypoxic conditions. Mol. Cell. Biol. 2009, 29, 526-537.
-
(2009)
Mol. Cell. Biol
, vol.29
, pp. 526-537
-
-
Bencokova, Z.1
Kaufmann, M.R.2
Pires, I.M.3
Lecane, P.S.4
Giaccia, A.J.5
Hammond, E.M.6
-
93
-
-
84942982653
-
ATM functions at the peroxisome to induce pexophagy in response to ROS
-
Zhang, J.; Tripathi, D.N.; Jing, J.; Alexander, A.; Kim, J.; Powell, R.T.; Dere, R.; Tait-Mulder, J.; Lee, J.H.; Paull, T.T. et al. ATM functions at the peroxisome to induce pexophagy in response to ROS. Nat. Cell Biol. 2015, doi:10.1038/ncb3230.
-
(2015)
Nat. Cell Biol
-
-
Zhang, J.1
Tripathi, D.N.2
Jing, J.3
Alexander, A.4
Kim, J.5
Powell, R.T.6
Dere, R.7
Tait-Mulder, J.8
Lee, J.H.9
Paull, T.T.10
-
94
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka, S.; Ballif, B.A.; Smogorzewska, A.; McDonald, E.R., 3rd; Hurov, K.E.; Luo, J.; Bakalarski, C.E.; Zhao, Z.; Solimini, N.; Lerenthal, Y. et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007, 316, 1160-1166.
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
-
95
-
-
78649938817
-
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage
-
Bensimon, A.; Schmidt, A.; Ziv, Y.; Elkon, R.; Wang, S.Y.; Chen, D.J.; Aebersold, R.; Shiloh, Y. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci. Signal 2010, doi:10.1126/scisignal.2001034.
-
(2010)
Sci. Signal
-
-
Bensimon, A.1
Schmidt, A.2
Ziv, Y.3
Elkon, R.4
Wang, S.Y.5
Chen, D.J.6
Aebersold, R.7
Shiloh, Y.8
-
96
-
-
84860325854
-
Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response
-
Beli, P.; Lukashchuk, N.; Wagner, S.A.; Weinert, B.T.; Olsen, J.V.; Baskcomb, L.; Mann, M.; Jackson, S.P.; Choudhary, C. Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response. Mol. Cell 2012, 46, 212-225.
-
(2012)
Mol. Cell
, vol.46
, pp. 212-225
-
-
Beli, P.1
Lukashchuk, N.2
Wagner, S.A.3
Weinert, B.T.4
Olsen, J.V.5
Baskcomb, L.6
Mann, M.7
Jackson, S.P.8
Choudhary, C.9
-
97
-
-
72449147303
-
In neurons modulates synaptic function
-
Li, J.; Han, Y.R.; Plummer, M.R.; Herrup, K. Cytoplasmic ATM in neurons modulates synaptic function. Curr. Biol. 2009, 19, 2091-2096.
-
(2009)
Curr. Biol
, vol.19
, pp. 2091-2096
-
-
Li, J.1
Han, Y.R.2
Plummer, M.R.3
Herrup, K.4
Cytoplasmic, A.5
-
98
-
-
78650873841
-
ATM-mediated nusap phosphorylation induces mitotic arrest
-
Xie, P.; Li, L.; Xing, G.; Tian, C.; Yin, Y.; He, F.; Zhang, L. ATM-mediated nusap phosphorylation induces mitotic arrest. Biochem. Biophys. Res. Commun. 2011, 404, 413-418.
-
(2011)
Biochem. Biophys. Res. Commun
, vol.404
, pp. 413-418
-
-
Xie, P.1
Li, L.2
Xing, G.3
Tian, C.4
Yin, Y.5
He, F.6
Zhang, L.7
-
99
-
-
79957547966
-
The protein kinase landscape of the DNA damage response
-
Bensimon, A.; Aebersold, R.; Shiloh, Y. Beyond ATM: The protein kinase landscape of the DNA damage response. FEBS Lett. 2011, 555, 1625-1639.
-
(2011)
FEBS Lett
, vol.555
, pp. 1625-1639
-
-
Bensimon, A.1
Aebersold, R.2
Shiloh, Y.3
Beyond, A.4
-
100
-
-
84938982424
-
The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis
-
Jette, N.; Lees-Miller, S.P. The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis. Prog. Biophys. Mol. Biol. 2015, 117, 194-205.
-
(2015)
Prog. Biophys. Mol. Biol
, vol.117
, pp. 194-205
-
-
Jette, N.1
Lees-Miller, S.P.2
-
101
-
-
84900458715
-
DNA-PK: A dynamic enzyme in a versatile DSB repair pathway
-
Davis, A.J.; Chen, B.P.; Chen, D.J. DNA-PK: A dynamic enzyme in a versatile DSB repair pathway. DNA Repair 2014, 17, 21-29.
-
(2014)
DNA Repair
, vol.17
, pp. 21-29
-
-
Davis, A.J.1
Chen, B.P.2
Chen, D.J.3
-
102
-
-
84891301320
-
Causes and consequences of replication stress
-
Zeman, M.K.; Cimprich, K.A. Causes and consequences of replication stress. Nat. Cell Biol. 2014, 16, 2-9.
-
(2014)
Nat. Cell Biol
, vol.16
, pp. 2-9
-
-
Zeman, M.K.1
Cimprich, K.A.2
-
103
-
-
84874217508
-
Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay
-
Yamashita, A. Role of SMG-1-mediated Upf1 phosphorylation in mammalian nonsense-mediated mRNA decay. Genes cells 2013, 15, 161-175.
-
(2013)
Genes Cells
, vol.15
, pp. 161-175
-
-
Yamashita, A.1
-
104
-
-
83255185785
-
A novel role for hSMG-1 in stress granule formation
-
Brown, J.A.; Roberts, T.L.; Richards, R.; Woods, R.; Birrell, G.; Lim, Y.C.; Ohno, S.; Yamashita, A.; Abraham, R.T.; Gueven, N. et al. A novel role for hSMG-1 in stress granule formation. Mol. Cell. Biol. 2011, 31, 4417-4429.
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 4417-4429
-
-
Brown, J.A.1
Roberts, T.L.2
Richards, R.3
Woods, R.4
Birrell, G.5
Lim, Y.C.6
Ohno, S.7
Yamashita, A.8
Abraham, R.T.9
Gueven, N.10
-
105
-
-
84872842115
-
SMG1 haploinsufficiency predisposes to tumor formation and inflammation
-
Roberts, T.L.; Ho, U.; Luff, J.; Lee, C.S.; Apte, S.H.; MacDonald, K.P.; Raggat, L.J.; Pettit, A.R.; Morrow, C.A.; Waters, M.J. et al. SMG1 haploinsufficiency predisposes to tumor formation and inflammation. Proc. Natl. Acad. Sci. USA 2013, 110, E285-E294.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
-
-
Roberts, T.L.1
Ho, U.2
Luff, J.3
Lee, C.S.4
Apte, S.H.5
Macdonald, K.P.6
Raggat, L.J.7
Pettit, A.R.8
Morrow, C.A.9
Waters, M.J.10
-
106
-
-
84928381121
-
MTOR signaling in protein translation regulation: Implications in cancer genesis and therapeutic interventions
-
Showkat, M.; Beigh, M.A.; Andrabi, K.I. mTOR signaling in protein translation regulation: Implications in cancer genesis and therapeutic interventions. Biochem. Mol. Biol. Int. 2014, doi:10.1155/2014/686984.
-
(2014)
Biochem. Mol. Biol. Int
-
-
Showkat, M.1
Beigh, M.A.2
Andrabi, K.I.3
-
107
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck, J.; Coates, J.; Jackson, S.P. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005, 434, 605-611.
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
108
-
-
20744436198
-
ATM activation and its recruitment to damaged DNA require binding to the C terminus of nbs1
-
You, Z.; Chahwan, C.; Bailis, J.; Hunter, T.; Russell, P. ATM activation and its recruitment to damaged DNA require binding to the C terminus of nbs1. Mol. Cell. Biol. 2005, 25, 5363-5379.
-
(2005)
Mol. Cell. Biol
, vol.25
, pp. 5363-5379
-
-
You, Z.1
Chahwan, C.2
Bailis, J.3
Hunter, T.4
Russell, P.5
-
109
-
-
34247483506
-
ATM activation and DNA damage response
-
Lavin, M.F.; Kozlov, S. ATM activation and DNA damage response. Cell Cycle 2007, 6, 931-942.
-
(2007)
Cell Cycle
, vol.6
, pp. 931-942
-
-
Lavin, M.F.1
Kozlov, S.2
-
110
-
-
0034713393
-
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
-
Zhao, S.; Weng, Y.C.; Yuan, S.S.; Lin, Y.T.; Hsu, H.C.; Lin, S.C.; Gerbino, E.; Song, M.H.; Zdzienicka, M.Z.; Gatti, R.A. et al. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 2000, 405, 473-477.
-
(2000)
Nature
, vol.405
, pp. 473-477
-
-
Zhao, S.1
Weng, Y.C.2
Yuan, S.S.3
Lin, Y.T.4
Hsu, H.C.5
Lin, S.C.6
Gerbino, E.7
Song, M.H.8
Zdzienicka, M.Z.9
Gatti, R.A.10
-
111
-
-
0034611728
-
ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway
-
Lim, D.S.; Kim, S.T.; Xu, B.; Maser, R.S.; Lin, J.; Petrini, J.H.; Kastan, M.B. ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway. Nature 2000, 404, 613-617.
-
(2000)
Nature
, vol.404
, pp. 613-617
-
-
Lim, D.S.1
Kim, S.T.2
Xu, B.3
Maser, R.S.4
Lin, J.5
Petrini, J.H.6
Kastan, M.B.7
-
112
-
-
0034713466
-
ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response
-
Wu, X.; Ranganathan, V.; Weisman, D.S.; Heine, W.F.; Ciccone, D.N.; O'Neill, T.B.; Crick, K.E.; Pierce, K.A.; Lane, W.S.; Rathbun, G. et al. ATM phosphorylation of Nijmegen breakage syndrome protein is required in a DNA damage response. Nature 2000, 405, 477-482.
-
(2000)
Nature
, vol.405
, pp. 477-482
-
-
Wu, X.1
Ranganathan, V.2
Weisman, D.S.3
Heine, W.F.4
Ciccone, D.N.5
O'neill, T.B.6
Crick, K.E.7
Pierce, K.A.8
Lane, W.S.9
Rathbun, G.10
-
113
-
-
0034106722
-
ATM-dependent phosphorylation of nibrin in response to radiation exposure
-
Gatei, M.; Young, D.; Cerosaletti, K.M.; Desai-Mehta, A.; Spring, K.; Kozlov, S.; Lavin, M.F.; Gatti, R.A.; Concannon, P.; Khanna, K. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 2000, 25, 115-119.
-
(2000)
Nat. Genet
, vol.25
, pp. 115-119
-
-
Gatei, M.1
Young, D.2
Cerosaletti, K.M.3
Desai-Mehta, A.4
Spring, K.5
Kozlov, S.6
Lavin, M.F.7
Gatti, R.A.8
Concannon, P.9
Khanna, K.10
-
114
-
-
12444254801
-
Distinct functions of nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage
-
Lee, J.H.; Xu, B.; Lee, C.H.; Ahn, J.Y.; Song, M.S.; Lee, H.; Canman, C.E.; Lee, J.S.; Kastan, M.B.; Lim, D.S. Distinct functions of nijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol. Cancer Res. 2003, 1, 674-681.
-
(2003)
Mol. Cancer Res
, vol.1
, pp. 674-681
-
-
Lee, J.H.1
Xu, B.2
Lee, C.H.3
Ahn, J.Y.4
Song, M.S.5
Lee, H.6
Canman, C.E.7
Lee, J.S.8
Kastan, M.B.9
Lim, D.S.10
-
115
-
-
80053102728
-
Point mutation at the Nbs1 threonine 278 site does not affect mouse development, but compromises the Chk2 and SMC1 phosphorylation after DNA damage
-
Li, T.; Wang, Z.Q. Point mutation at the Nbs1 threonine 278 site does not affect mouse development, but compromises the Chk2 and SMC1 phosphorylation after DNA damage. Mech. Ageing Dev. 2011, 132, 382-388.
-
(2011)
Mech. Ageing Dev
, vol.132
, pp. 382-388
-
-
Li, T.1
Wang, Z.Q.2
-
116
-
-
0032484084
-
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase
-
Matsuoka, S.; Huang, M.; Elledge, S.J. Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. Science 1998, 252, 1893-1897.
-
(1998)
Science
, vol.252
, pp. 1893-1897
-
-
Matsuoka, S.1
Huang, M.2
Elledge, S.J.3
-
117
-
-
0034953719
-
Chk2 activation dependence on Nbs1 after DNA damage
-
Buscemi, G.; Savio, C.; Zannini, L.; Micciche, F.; Masnada, D.; Nakanishi, M.; Tauchi, H.; Komatsu, K.; Mizutani, S.; Khanna, K. et al. Chk2 activation dependence on Nbs1 after DNA damage. Mol. Cell. Biol. 2001, 21, 5214-5222.
-
(2001)
Mol. Cell. Biol
, vol.21
, pp. 5214-5222
-
-
Buscemi, G.1
Savio, C.2
Zannini, L.3
Micciche, F.4
Masnada, D.5
Nakanishi, M.6
Tauchi, H.7
Komatsu, K.8
Mizutani, S.9
Khanna, K.10
-
118
-
-
0036500690
-
SMC1 is a downstream effector in the ATM/Nbs1 branch of the human S-phase checkpoint
-
Yazdi, P.T.; Wang, Y.; Zhao, S.; Patel, N.; Lee, E.Y.; Qin, J. SMC1 is a downstream effector in the ATM/Nbs1 branch of the human S-phase checkpoint. Genes Dev. 2002, 16, 571-582.
-
(2002)
Genes Dev
, vol.16
, pp. 571-582
-
-
Yazdi, P.T.1
Wang, Y.2
Zhao, S.3
Patel, N.4
Lee, E.Y.5
Qin, J.6
-
119
-
-
50349086574
-
Regulation of intra-S phase checkpoint by Ionizing Radiation (IR)-dependent and IR-independent phosphorylation of SMC3
-
Luo, H.; Li, Y.; Mu, J.J.; Zhang, J.; Tonaka, T.; Hamamori, Y.; Jung, S.Y.; Wang, Y.; Qin, J. Regulation of intra-S phase checkpoint by Ionizing Radiation (IR)-dependent and IR-independent phosphorylation of SMC3. J. Biol. Chem. 2008, 253, 19176-19183.
-
(2008)
J. Biol. Chem
, vol.253
, pp. 19176-19183
-
-
Luo, H.1
Li, Y.2
Mu, J.J.3
Zhang, J.4
Tonaka, T.5
Hamamori, Y.6
Jung, S.Y.7
Wang, Y.8
Qin, J.9
-
120
-
-
0347990555
-
Telomere instability in a human tumor cell line expressing Nbs1 with mutations at sites phosphorylated by ATM
-
Bai, Y.; Murnane, J.P. Telomere instability in a human tumor cell line expressing Nbs1 with mutations at sites phosphorylated by ATM. Mol. Cancer Res. 2003, 1, 1058-1069.
-
(2003)
Mol. Cancer Res
, vol.1
, pp. 1058-1069
-
-
Bai, Y.1
Murnane, J.P.2
-
121
-
-
31144471460
-
The role of Nbs1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control
-
Zhang, Y.; Zhou, J.; Lim, C.U. The role of Nbs1 in DNA double strand break repair, telomere stability, and cell cycle checkpoint control. Cell Res. 2006, 16, 45-54.
-
(2006)
Cell Res
, vol.16
, pp. 45-54
-
-
Zhang, Y.1
Zhou, J.2
Lim, C.U.3
-
122
-
-
0035954284
-
Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires Nbs and telomerase catalytic subunit
-
Ranganathan, V.; Heine, W.F.; Ciccone, D.N.; Rudolph, K.L.; Wu, X.; Chang, S.; Hai, H.; Ahearn, I.M.; Livingston, D.M.; Resnick, I. et al. Rescue of a telomere length defect of Nijmegen breakage syndrome cells requires Nbs and telomerase catalytic subunit. Curr. Biol. 2001, 11, 962-966.
-
(2001)
Curr. Biol
, vol.11
, pp. 962-966
-
-
Ranganathan, V.1
Heine, W.F.2
Ciccone, D.N.3
Rudolph, K.L.4
Wu, X.5
Chang, S.6
Hai, H.7
Ahearn, I.M.8
Livingston, D.M.9
Resnick, I.10
-
123
-
-
34249048548
-
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis
-
Difilippantonio, S.; Celeste, A.; Kruhlak, M.J.; Lee, Y.; Difilippantonio, M.J.; Feigenbaum, L.; Jackson, S.P.; McKinnon, P.J.; Nussenzweig, A. Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J. Exp. Med. 2007, 204, 1003-1011.
-
(2007)
J. Exp. Med
, vol.204
, pp. 1003-1011
-
-
Difilippantonio, S.1
Celeste, A.2
Kruhlak, M.J.3
Lee, Y.4
Difilippantonio, M.J.5
Feigenbaum, L.6
Jackson, S.P.7
McKinnon, P.J.8
Nussenzweig, A.9
-
124
-
-
0025874254
-
Chromosome instability and X-ray hypersensitivity in a microcephalic and growth-retarded child
-
Barbi, G.; Scheres, J.M.; Schindler, D.; Taalman, R.D.; Rodens, K.; Mehnert, K.; Muller, M.; Seyschab, H. Chromosome instability and X-ray hypersensitivity in a microcephalic and growth-retarded child. Am. J. Med. Genet 1991, 40, 44-50.
-
(1991)
Am. J. Med. Genet
, vol.40
, pp. 44-50
-
-
Barbi, G.1
Scheres, J.M.2
Schindler, D.3
Taalman, R.D.4
Rodens, K.5
Mehnert, K.6
Muller, M.7
Seyschab, H.8
-
125
-
-
84927761261
-
Human RAD50 makes a functional DNA-binding complex
-
Kinoshita, E.; van Rossum-Fikkert, S.; Sanchez, H.; Kertokalio, A.; Wyman, C. Human RAD50 makes a functional DNA-binding complex. Biochim. 2015, 113, 47-53.
-
(2015)
Biochim
, vol.113
, pp. 47-53
-
-
Kinoshita, E.1
Van Rossum-Fikkert, S.2
Sanchez, H.3
Kertokalio, A.4
Wyman, C.5
-
126
-
-
34250743173
-
Systematic discovery of in vivo phosphorylation networks
-
Linding, R.; Jensen, L.J.; Ostheimer, G.J.; van Vugt, M.A.; Jorgensen, C.; Miron, I.M.; Diella, F.; Colwill, K.; Taylor, L.; Elder, K. et al. Systematic discovery of in vivo phosphorylation networks. Cell 2007, 129, 1415-1426.
-
(2007)
Cell
, vol.129
, pp. 1415-1426
-
-
Linding, R.1
Jensen, L.J.2
Ostheimer, G.J.3
Van Vugt, M.A.4
Jorgensen, C.5
Miron, I.M.6
Diella, F.7
Colwill, K.8
Taylor, L.9
Elder, K.10
-
127
-
-
80052424280
-
ATM protein-dependent phosphorylation of RAD50 protein regulates DNA repair and cell cycle control
-
Gatei, M.; Jakob, B.; Chen, P.; Kijas, A.W.; Becherel, O.J.; Gueven, N.; Birrell, G.; Lee, J.H.; Paull, T.T.; Lerenthal, Y. et al. ATM protein-dependent phosphorylation of RAD50 protein regulates DNA repair and cell cycle control. J. Biol. Chem. 2011, 256, 31542-31556.
-
(2011)
J. Biol. Chem
, vol.256
, pp. 31542-31556
-
-
Gatei, M.1
Jakob, B.2
Chen, P.3
Kijas, A.W.4
Becherel, O.J.5
Gueven, N.6
Birrell, G.7
Lee, J.H.8
Paull, T.T.9
Lerenthal, Y.10
-
128
-
-
68249135624
-
Multiple functions of MRN in end-joining pathways during isotype class switching
-
Dinkelmann, M.; Spehalski, E.; Stoneham, T.; Buis, J.; Wu, Y.; Sekiguchi, J.M.; Ferguson, D.O. Multiple functions of MRN in end-joining pathways during isotype class switching. Nat. Struct. Mol. Biol. 2009, 16, 808-813.
-
(2009)
Nat. Struct. Mol. Biol
, vol.16
, pp. 808-813
-
-
Dinkelmann, M.1
Spehalski, E.2
Stoneham, T.3
Buis, J.4
Wu, Y.5
Sekiguchi, J.M.6
Ferguson, D.O.7
-
129
-
-
35648986560
-
Ctp1/CtIP and the mrn complex collaborate in the initial steps of homologous recombination
-
Takeda, S.; Nakamura, K.; Taniguchi, Y.; Paull, T.T. Ctp1/CtIP and the mrn complex collaborate in the initial steps of homologous recombination. Mol. Cell 2007, 25, 351-352.
-
(2007)
Mol. Cell
, vol.25
, pp. 351-352
-
-
Takeda, S.1
Nakamura, K.2
Taniguchi, Y.3
Paull, T.T.4
-
130
-
-
85012082578
-
The mre11-rad50-nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and RAD3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment
-
Olson, E.; Nievera, C.J.; Lee, A.Y.; Chen, L.; Wu, X. The mre11-rad50-nbs1 complex acts both upstream and downstream of ataxia telangiectasia mutated and RAD3-related protein (ATR) to regulate the S-phase checkpoint following UV treatment. Nat. Struct. Mol. Biol. 2007, 252, 22939-22952.
-
(2007)
Nat. Struct. Mol. Biol
, vol.252
, pp. 22939-22952
-
-
Olson, E.1
Nievera, C.J.2
Lee, A.Y.3
Chen, L.4
Wu, X.5
-
131
-
-
33646777679
-
Rapid activation of ATR by ionizing radiation requires ATM and MRE11
-
Myers, J.S.; Cortez, D. Rapid activation of ATR by ionizing radiation requires ATM and MRE11. J. Biol. Chem. 2006, 251, 9346-9350.
-
(2006)
J. Biol. Chem
, vol.251
, pp. 9346-9350
-
-
Myers, J.S.1
Cortez, D.2
-
132
-
-
13244287780
-
Nbs1 is required for ATR-dependent phosphorylation events
-
Stiff, T.; Reis, C.; Alderton, G.K.; Woodbine, L.; O'Driscoll, M.; Jeggo, P.A. Nbs1 is required for ATR-dependent phosphorylation events. EMBO J. 2005, 24, 199-208.
-
(2005)
EMBO J
, vol.24
, pp. 199-208
-
-
Stiff, T.1
Reis, C.2
Alderton, G.K.3
Woodbine, L.4
O'driscoll, M.5
Jeggo, P.A.6
-
133
-
-
84876097735
-
Role for the mrn complex in ATR activation via TOPBP1 recruitment
-
Duursma, A.M.; Driscoll, R.; Elias, J.E.; Cimprich, K.A. A role for the mrn complex in ATR activation via TOPBP1 recruitment. Mol. Cell 2013, 50, 116-122.
-
(2013)
Mol. Cell
, vol.50
, pp. 116-122
-
-
Duursma, A.M.1
Driscoll, R.2
Elias, J.E.3
Cimprich, K.4
-
134
-
-
84904761846
-
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress
-
Gatei, M.; Kijas, A.W.; Biard, D.; Dork, T.; Lavin, M.F. RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress. Hum. Mol. Genet. 2014, 23, 4232-4248.
-
(2014)
Hum. Mol. Genet
, vol.23
, pp. 4232-4248
-
-
Gatei, M.1
Kijas, A.W.2
Biard, D.3
Dork, T.4
Lavin, M.F.5
-
135
-
-
38349078295
-
Nbs1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse
-
Manthey, K.C.; Opiyo, S.; Glanzer, J.G.; Dimitrova, D.; Elliott, J.; Oakley, G.G. Nbs1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse. J. Cell Sci. 2007, 120, 4221-4229.
-
(2007)
J. Cell Sci
, vol.120
, pp. 4221-4229
-
-
Manthey, K.C.1
Opiyo, S.2
Glanzer, J.G.3
Dimitrova, D.4
Elliott, J.5
Oakley, G.G.6
-
136
-
-
34248579748
-
The carboxy terminus of nbs1 is required for induction of apoptosis by the Mre11 complex
-
Stracker, T.H.; Morales, M.; Couto, S.S.; Hussein, H.; Petrini, J.H. The carboxy terminus of nbs1 is required for induction of apoptosis by the Mre11 complex. Nature 2007, 447, 218-221.
-
(2007)
Nature
, vol.447
, pp. 218-221
-
-
Stracker, T.H.1
Morales, M.2
Couto, S.S.3
Hussein, H.4
Petrini, J.H.5
-
137
-
-
84908028845
-
DNA repair: Making the cut
-
Symington, L.S. DNA repair: Making the cut. Nature 2014, 514, 39-40.
-
(2014)
Nature
, vol.514
, pp. 39-40
-
-
Symington, L.S.1
-
138
-
-
79953803622
-
ABC ATPase signature helices in RAD50 link nucleotide state to MRE11 interface for DNA repair
-
Williams, G.J.; Williams, R.S.; Williams, J.S.; Moncalian, G.; Arvai, A.S.; Limbo, O.; Guenther, G.; SilDas, S.; Hammel, M.; Russell, P. et al. ABC ATPase signature helices in RAD50 link nucleotide state to MRE11 interface for DNA repair. Nat. Struct. Mol. Biol. 2011, 15, 423-431.
-
(2011)
Nat. Struct. Mol. Biol
, vol.15
, pp. 423-431
-
-
Williams, G.J.1
Williams, R.S.2
Williams, J.S.3
Moncalian, G.4
Arvai, A.S.5
Limbo, O.6
Guenther, G.7
Sildas, S.8
Hammel, M.9
Russell, P.10
-
139
-
-
79956301873
-
Crystal structure of the MRE11-RAD50-ATPgammas complex: Understanding the interplay between MRE11 and RAD50
-
Lim, H.S.; Kim, J.S.; Park, Y.B.; Gwon, G.H.; Cho, Y. Crystal structure of the MRE11-RAD50-ATPgammas complex: Understanding the interplay between MRE11 and RAD50. Genes Dev. 2011, 25, 1091-1104.
-
(2011)
Genes Dev
, vol.25
, pp. 1091-1104
-
-
Lim, H.S.1
Kim, J.S.2
Park, Y.B.3
Gwon, G.H.4
Cho, Y.5
-
140
-
-
84861801547
-
Phosphositeanalyzer: A bioinformatic platform for deciphering phospho proteomes using kinase predictions retrieved from networkin
-
Bennetzen, M.V.; Cox, J.; Mann, M.; Andersen, J.S. Phosphositeanalyzer: A bioinformatic platform for deciphering phospho proteomes using kinase predictions retrieved from networkin. J. Proteome Res. 2012, 11, 3480-3486.
-
(2012)
J. Proteome Res
, vol.11
, pp. 3480-3486
-
-
Bennetzen, M.V.1
Cox, J.2
Mann, M.3
Andersen, J.S.4
-
141
-
-
0033538496
-
The nijmegen breakage syndrome protein is essential for MRE11 phosphorylation upon DNA damage
-
Dong, Z.; Zhong, Q.; Chen, P.L. The nijmegen breakage syndrome protein is essential for MRE11 phosphorylation upon DNA damage. J. Biol. Chem. 1999, 274, 19513-19516.
-
(1999)
J. Biol. Chem
, vol.274
, pp. 19513-19516
-
-
Dong, Z.1
Zhong, Q.2
Chen, P.L.3
-
142
-
-
0037102708
-
Neocarzinostatin induces mre11 phosphorylation and focus formation through an ATM- and Nbs1-dependent mechanism
-
Yuan, S.S.; Chang, H.L.; Hou, M.F.; Chan, T.F.; Kao, Y.H.; Wu, Y.C.; Su, J.H. Neocarzinostatin induces mre11 phosphorylation and focus formation through an ATM- and Nbs1-dependent mechanism. Toxicol. 2002, 177, 123-130.
-
(2002)
Toxicol
, vol.177
, pp. 123-130
-
-
Yuan, S.S.1
Chang, H.L.2
Hou, M.F.3
Chan, T.F.4
Kao, Y.H.5
Wu, Y.C.6
Su, J.H.7
-
143
-
-
70349850935
-
PIKK-dependent phosphorylation of MRE11 induces mrn complex inactivation by disassembly from chromatin
-
Di Virgilio, M.; Ying, C.Y.; Gautier, J. PIKK-dependent phosphorylation of MRE11 induces mrn complex inactivation by disassembly from chromatin. DNA Repair 2009, 5, 1311-1320.
-
(2009)
DNA Repair
, vol.5
, pp. 1311-1320
-
-
Di Virgilio, M.1
Ying, C.Y.2
Gautier, J.3
-
144
-
-
84949032464
-
ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through exonuclease 1
-
Kijas, A.W.; Lim, Y.C.; Bolderson, E.; Cerosaletti, K.; Gatei, M.; Jakob, B.; Tobias, F.; Taucher-Scholz, G.; Gueven, N.; Oakley, G. et al. ATM-dependent phosphorylation of MRE11 controls extent of resection during homology directed repair by signalling through exonuclease 1. Nucleic Acids Res. 2015, 43, 8352-8367.
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 8352-8367
-
-
Kijas, A.W.1
Lim, Y.C.2
Bolderson, E.3
Cerosaletti, K.4
Gatei, M.5
Jakob, B.6
Tobias, F.7
Taucher-Scholz, G.8
Gueven, N.9
Oakley, G.10
-
145
-
-
79951688343
-
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair
-
Nimonkar, A.V.; Genschel, J.; Kinoshita, E.; Polaczek, P.; Campbell, J.L.; Wyman, C.; Modrich, P.; Kowalczykowski, S.C. BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair. Genes Dev. 2011, 25, 350-362.
-
(2011)
Genes Dev
, vol.25
, pp. 350-362
-
-
Nimonkar, A.V.1
Genschel, J.2
Kinoshita, E.3
Polaczek, P.4
Campbell, J.L.5
Wyman, C.6
Modrich, P.7
Kowalczykowski, S.C.8
-
146
-
-
80855144827
-
Bidirectional resection of DNA double-strand breaks by MRE11 and EXO1
-
Garcia, V.; Phelps, S.E.; Gray, S.; Neale, M.J. Bidirectional resection of DNA double-strand breaks by MRE11 and EXO1. Nature 2011, 479, 241-244.
-
(2011)
Nature
, vol.479
, pp. 241-244
-
-
Garcia, V.1
Phelps, S.E.2
Gray, S.3
Neale, M.J.4
-
147
-
-
51949118680
-
Checkpoint-dependent phosphorylation of EXO1 modulates the DNA damage response
-
Morin, I.; Ngo, H.P.; Greenall, A.; Zubko, M.K.; Morrice, N.; Lydall, D. Checkpoint-dependent phosphorylation of EXO1 modulates the DNA damage response. EMBO J. 2008, 27, 2400-2410.
-
(2008)
EMBO J
, vol.27
, pp. 2400-2410
-
-
Morin, I.1
Ngo, H.P.2
Greenall, A.3
Zubko, M.K.4
Morrice, N.5
Lydall, D.6
-
148
-
-
77951251067
-
Phosphorylation of EXO1 modulates homologous recombination repair of DNA double-strand breaks
-
Bolderson, E.; Tomimatsu, N.; Richard, D.J.; Boucher, D.; Kumar, R.; Pandita, T.K.; Burma, S.; Khanna, K.K. Phosphorylation of EXO1 modulates homologous recombination repair of DNA double-strand breaks. Nucleic Acids Res. 2010, 35, 1821-1831.
-
(2010)
Nucleic Acids Res
, vol.35
, pp. 1821-1831
-
-
Bolderson, E.1
Tomimatsu, N.2
Richard, D.J.3
Boucher, D.4
Kumar, R.5
Pandita, T.K.6
Burma, S.7
Khanna, K.K.8
|