ATM activation by oxidative stress

Science

Volumn 330, Issue 6003, 2010, Pages 517-521

  Guo, Zhi ^a   Kozlov, Sergei ^b   Lavin, Martin F ^b   Person, Maria D ^a   Paull, Tanya T ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; DIMER; ATM PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYSTEINE; DISULFIDE; DNA BINDING PROTEIN; HYDROGEN PEROXIDE; MRE11A PROTEIN, HUMAN; NBN PROTEIN, HUMAN; NUCLEAR PROTEIN; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; PROTEIN SERINE THREONINE KINASE; RAD50 PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN;

CELL ORGANELLE; ENZYME ACTIVITY; MITOCHONDRIAL DNA; OXIDATION; PROTEIN;

ARTICLE; AUTOPHOSPHORYLATION; DENSITY GRADIENT CENTRIFUGATION; DISULFIDE BOND; DOUBLE STRANDED DNA BREAK; GENE DELETION; HUMAN; IMMUNOPRECIPITATION; OXIDATION; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; ANIMAL; ATAXIA TELANGIECTASIA; DNA REPAIR; ENZYME ACTIVATION; ENZYMOLOGY; GENETICS; METABOLISM; MUTATION;

ATAXIA TELANGIECTASIA;

ANIMALS; ATAXIA TELANGIECTASIA; ATAXIA TELANGIECTASIA MUTATED PROTEINS; CELL CYCLE PROTEINS; CYSTEINE; DISULFIDES; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; DNA REPAIR ENZYMES; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HUMANS; HYDROGEN PEROXIDE; MUTATION; NUCLEAR PROTEINS; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 77958191599     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1192912     Document Type: Article

References (33)

1. Y. Shiloh, Nat. Rev. Cancer 3, 155 (2003).
2. A. Barzilai, G. Rotman, Y. Shiloh, DNA Repair (Amst.) 1, 3 (2002).
3. R. Reliene, R. H. Schiestl, J. Nutr. 137 (suppl.), 229S (2007).
4. R. Reliene, S. M. Fleming, M. F. Chesselet, R. H. Schiestl, Food Chem. Toxicol. 46, 1371 (2008).
5. K. Ito et al., Nature 431, 997 (2004).
6. Z. Bencokova et al., Mol. Cell. Biol. 29, 526 (2009).
7. M. Sasaki, H. Ikeda, Y. Sato, Y. Nakanuma, Free Radic. Res. 42, 625 (2008).
8. M. Kobayashi et al., Genes Cells 11, 779 (2006).
9. R. E. Shackelford et al., J. Biol. Chem. 276, 21951 (2001).
10. E. U. Kurz, P. Douglas, S. P. Lees-Miller, J. Biol. Chem. 279, 53272 (2004).
11. Materials and methods are available as supporting material on Science Online.
12. T. Uziel et al., EMBO J. 22, 5612 (2003).
13. J.-H. Lee, T. T. Paull, Science 308, 551 (2005); published online 24 March 2005 (10.1126/science.1108297).
14. G. S. Stewart et al., Cell 99, 577 (1999).
15. T. H. Stracker, C. T. Carson, M. D. Weitzman, Nature 418, 348 (2002).
16. C. J. Bakkenist, M. B. Kastan, Nature 421, 499 (2003).
17. N. S. Kosower, E. M. Kosower, Methods Enzymol. 251, 123 (1995).
18. Y. Kim et al., J. Neurochem. 101, 1316 (2007).
19. O. Vos, G. A. Grant, L. Budke, Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 29, 513 (1976).
20. J. H. Lee, T. T. Paull, Methods Enzymol. 408, 529 (2006).
21. M. Toyoshima et al., Am. J. Med. Genet. 75, 141 (1998).
22. S. Gilad et al., Am. J. Hum. Genet. 62, 551 (1998).
23. L. Chessa et al., Am. J. Med. Genet. 42, 741 (1992).
24. D. Watters et al., J. Biol. Chem. 274, 34277 (1999).
25. G. C. Smith et al., Proc. Natl. Acad. Sci. U.S.A. 96, 11134 (1999).
26. S. Matsuoka et al., Proc. Natl. Acad. Sci. U.S.A. 97, 10389 (2000).
27. D. W. Chan et al., J. Biol. Chem. 275, 7803 (2000).
28. S. Banin et al., Science 281, 1674 (1998).
29. C. E. Canman et al., Science 281, 1677 (1998).
30. D. HaMai, S. C. Bondy, Neurochem. Int. 44, 223 (2004).
31. M. L. Circu, T. Y. Aw, Free Radic. Biol. Med. 48, 749 (2010).
32. S. Matsuoka et al., Science 316, 1160 (2007).
33. We are grateful to members of the Paull laboratory as well as to M. Weitzman for cell lines; to D. Johnson, G. Georgiou, J. Huibregtse, and K. Dalby for discussion; and to C. Walker for communication of data in press. This work was supported by NIH grant CA132813 (Paull laboratory), NHMRC 569591 (Lavin laboratory), and NIEHS 007784 (ICMB mass spectrometry core facility).