The interrelations between malfunctioning DNA damage response (DDR) and the functionality of the neuro-glio-vascular unit

DNA Repair

Volumn 12, Issue 8, 2013, Pages 543-557

  Barzilai, Ari ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Ataxia telangiectasia; DNA damage response; Genomic instability diseases; Glial cells; Neuro glio vascular unit; Neurodgenerative diseases

Indexed keywords

SEMAPHORIN;

ARTICLE; BRAIN BLOOD VESSEL; CELL DAMAGE; DEGENERATIVE DISEASE; DNA DAMAGE; DNA DAMAGE RESPONSE; DNA DOUBLE STRAND BREAK REPAIR; DNA SINGLE STRAND BREAK REPAIR; EXCISION REPAIR; GLIA; GLIA CELL; MISMATCH REPAIR; PRIORITY JOURNAL;

ATAXIA-TELANGIECTASIA; DNA DAMAGE RESPONSE; GENOMIC INSTABILITY DISEASES; GLIAL CELLS; NEURO-GLIO-VASCULAR UNIT; NEURODGENERATIVE DISEASES;

ANIMALS; ASTROCYTES; BRAIN; DISEASE MODELS, ANIMAL; DNA DAMAGE; DNA REPAIR; HUMANS; NERVE DEGENERATION; NEURODEGENERATIVE DISEASES; NEUROGLIA; NEURONS; SEMAPHORINS;

ATAXIA TELANGIECTASIA;

EID: 84881028628     PISSN: 15687864     EISSN: 15687856     Source Type: Journal    
DOI: 10.1016/j.dnarep.2013.04.007     Document Type: Article

References (237)

1. Pena-Casanova J., Sanchez-Benavides G., de Sola-Llopis S., Manero-Borras R.M., Casals-Coll M. Neuropsychology of Alzheimer's disease. Arch. Med. Res. 2012.
2. Deutch A.Y. Striatal plasticity in parkinsonism: dystrophic changes in medium spiny neurons and progression in Parkinson's disease. J. Neural. Transm. Suppl. 2006, 67-70.
3. Palau F., Espinos C. Autosomal recessive cerebellar ataxias. Orphanet J. Rare Dis. 2006, 1:47.
4. Digweed M., Sperling K. Nijmegen breakage syndrome: clinical manifestation of defective response to DNA double-strand breaks. DNA Repair 2004, 3:1207-1217.
5. Kasai M., Nakamura K., Meguro K. Alzheimer's disease in Japan and other countries: review of epidemiological studies in the last 10 years. Brain Nerve=Shinkei kenkyu no shinpo 2010, 62:667-678.
6. Prasad K.N., Cole W.C., Prasad K.C. Risk factors for Alzheimer's disease: role of multiple antioxidants, non-steroidal anti-inflammatory and cholinergic agents alone or in combination in prevention and treatment. J. Am. Coll. Nutr. 2002, 21:506-522.
7. Wong K.K., Raffel D.M., Koeppe R.A., Frey K.A., Bohnen N.I., Gilman S. Pattern of cardiac sympathetic denervation in idiopathic Parkinson disease studied with 11C Hydroxyephedrine PET. Radiology 2012, 265:240-247.
8. Czornak K., Chughtai S., Chrzanowska K.H. Mystery of DNA repair: the role of the MRN complex and ATM kinase in DNA damage repair. J. Appl. Genet. 2008, 49:383-396.
9. Giaume C., Kirchhoff F., Matute C., Reichenbach A., Verkhratsky A. Glia: the fulcrum of brain diseases. Cell Death Differ. 2007, 14:1324-1335.
10. Curin Y., Ritz M.F., Andriantsitohaina R. Cellular mechanisms of the protective effect of polyphenols on the neurovascular unit in strokes. Cardiovasc. Hematol. Agents Med. Chem. 2006, 4:277-288.
11. Lifshitz F.D.V. Animal models for cerebrovascular impairment and its relevance in vascular dementia. Cognitive Impairment: Causes, Diagnosis and Treatments 2009, 1-20. Nova Biomedical, New York. L. ML (Ed.).
12. Kettenmann H., Verkhratsky A. Neuroglia: the 150 years after. Trends Neurosci. 2008, 31:653-659.
13. Hanisch U.K., Kettenmann H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci. 2007, 10:1387-1394.
14. Streit W.J. Microglial senescence: does the brain's immune system have an expiration date?. Trends Neurosci. 2006, 29:506-510.
15. Nimmerjahn A. Astrocytes going live: advances and challenges. J. Physiol. 2009, 587:1639-1647.
16. Farfara D., Lifshitz V., Frenkel D. Neuroprotective and neurotoxic properties of glial cells in the pathogenesis of Alzheimer's disease. J. Cell. Mol. Med. 2008, 12:762-780.
17. Ilieva H., Polymenidou M., Cleveland D.W. Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyond. J. Cell Biol. 2009, 187:761-772.
18. Barzilai A., Biton S., Shiloh Y. The role of the DNA damage response in neuronal development, organization and maintenance. DNA Repair 2008, 7:1010-1027.
19. Rutten B.P., Korr H., Steinbusch H.W., Schmitz C. The aging brain: less neurons could be better. Mech. Ageing Dev. 2003, 124:349-355.
20. Rutten B.P., Schmitz C., Gerlach O.H., Oyen H.M., de Mesquita E.B., Steinbusch H.W., Korr H. The aging brain: accumulation of DNA damage or neuron loss?. Neurobiol. Aging 2007, 28:91-98.
21. Anttinen A., Koulu L., Nikoskelainen E., Portin R., Kurki T., Erkinjuntti M., Jaspers N.G., Raams A., Green M.H., Lehmann A.R., Wing J.F., Arlett C.F., Marttila R.J. Neurological symptoms and natural course of xeroderma pigmentosum. Brain: J. Neurol. 2008, 131:1979-1989.
22. McKinnon P.J. DNA repair deficiency and neurological disease, Nature reviews. Neuroscience 2009, 10:100-112.
23. Rass U., Ahel I., West S.C. Defective DNA repair and neurodegenerative disease. Cell 2007, 130:991-1004.
24. Brooks P.J., Cheng T.F., Cooper L. Do all of the neurologic diseases in patients with DNA repair gene mutations result from the accumulation of DNA damage?. DNA Repair 2008, 7:834-848.
25. Kraemer K.H., Patronas N.J., Schiffmann R., Brooks B.P., Tamura D., DiGiovanna J.J. Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship. Neuroscience 2007, 145:1388-1396.
26. Niedernhofer L.J. Nucleotide excision repair deficient mouse models and neurological disease. DNA Repair 2008, 7:1180-1189.
27. Weinfeld M., Mani R.S., Abdou I., Aceytuno R.D., Glover J.N. Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair. Trends Biochem. Sci. 2011, 36:262-271.
28. Tahbaz N., Subedi S., Weinfeld M. Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair. Nucleic Acids Res. 2012, 40:3484-3495.
29. Wiederhold L., Leppard J.B., Kedar P., Karimi-Busheri F., Rasouli-Nia A., Weinfeld M., Tomkinson A.E., Izumi T., Prasad R., Wilson S.H., Mitra S., Hazra T.K. AP endonuclease-independent DNA base excision repair in human cells. Mol. Cell 2004, 15:209-220.
30. Bandaru V., Sunkara S., Wallace S.S., Bond J.P. A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII. DNA Repair 2002, 1:517-529.
31. Das A., Wiederhold L., Leppard J.B., Kedar P., Prasad R., Wang H., Boldogh I., Karimi-Busheri F., Weinfeld M., Tomkinson A.E., Wilson S.H., Mitra S., Hazra T.K., N.E.I.L2-initiated, APE-independent repair of oxidized bases in DNA: evidence for a repair complex in human cells DNA Repair 2006, 5:1439-1448.
32. Dobson C.J., Allinson S.L. The phosphatase activity of mammalian polynucleotide kinase takes precedence over its kinase activity in repair of single strand breaks. Nucleic Acids Res. 2006, 34:2230-2237.
33. Freschauf G.K., Karimi-Busheri F., Ulaczyk-Lesanko A., Mereniuk T.R., Ahrens A., Koshy J.M., Rasouli-Nia A., Pasarj P., Holmes C.F., Rininsland F., Hall D.G., Weinfeld M. Identification of a small molecule inhibitor of the human DNA repair enzyme polynucleotide kinase/phosphatase. Cancer Res. 2009, 69:7739-7746.
34. Chappell C., Hanakahi L.A., Karimi-Busheri F., Weinfeld M., West S.C. Involvement of human polynucleotide kinase in double-strand break repair by non-homologous end joining. EMBO J. 2002, 21:2827-2832.
35. Karimi-Busheri F., Rasouli-Nia A., Allalunis-Turner J., Weinfeld M. Human polynucleotide kinase participates in repair of DNA double-strand breaks by nonhomologous end joining but not homologous recombination. Cancer Res. 2007, 67:6619-6625.
36. Shen J., Gilmore E.C., Marshall C.A., Haddadin M., Reynolds J.J., Eyaid W., Bodell A., Barry B., Gleason D., Allen K., Ganesh V.S., Chang B.S., Grix A., Hill R.S., Topcu M., Caldecott K.W., Barkovich A.J., Walsh C.A. Mutations in PNKP cause microcephaly, seizures and defects in DNA repair. Nat. Genet. 2010, 42:245-249.
37. Ciccia A., Elledge S.J. The DNA damage response: making it safe to play with knives. Mol. Cell 2010, 40:179-204.
38. Jackson S.P., Bartek J. The DNA-damage response in human biology and disease. Nature 2009, 461:1071-1078.
39. Giglia-Mari G., Zotter A., Vermeulen W. DNA damage response. Cold Spring Harbor Perspect. Biol. 2011, 3:a000745.
40. Hawkins A.J., Golding S.E., Khalil A., Valerie K. DNA double-strand break - induced pro-survival signaling. Radiother. Oncol.: J. Eur Soc Ther. Radiol. Oncol. 2011, 101:13-17.
41. Jeppesen D.K., Bohr V.A., Stevnsner T. DNA repair deficiency in neurodegeneration. Prog. Neurobiol. 2011, 94:166-200.
42. Lindahl T. Instability and decay of the primary structure of DNA. Nature 1993, 362:709-715.
43. Jena N.R. DNA damage by reactive species: mechanisms, mutation and repair. J. Biosci. 2012, 37:503-517.
44. Rashi-Elkeles S., Elkon R., Shavit S., Lerenthal Y., Linhart C., Kupershtein A., Amariglio N., Rechavi G., Shamir R., Shiloh Y. Transcriptional modulation induced by ionizing radiation: p53 remains a central player. Mol. Oncol. 2011, 5:336-348.
45. Roos W.P., Kaina B. DNA damage-induced apoptosis: from specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett. 2012.
46. Musich P.R., Zou Y. DNA-damage accumulation and replicative arrest in Hutchinson-Gilford progeria syndrome. Biochem. Soc. Trans. 2011, 39:1764-1769.
47. Al-Ejeh F., Kumar R., Wiegmans A., Lakhani S.R., Brown M.P., Khanna K.K. Harnessing the complexity of DNA-damage response pathways to improve cancer treatment outcomes. Oncogene 2010, 29:6085-6098.
48. Kruman I.I., Wersto R.P., Cardozo-Pelaez F., Smilenov L., Chan S.L., Chrest F.J., Emokpae R., Gorospe M., Mattson M.P. Cell cycle activation linked to neuronal cell death initiated by DNA damage. Neuron 2004, 41:549-561.
49. Kruman I.I. Why do neurons enter the cell cycle?. Cell Cycle 2004, 3:769-773.
50. Spyropoulou A., Piperi C., Adamopoulos C., Papavassiliou A.G. Deregulated chromatin remodeling in the pathobiology of brain tumors. Neuromol. Med. 2012.
51. Diderich K., Alanazi M., Hoeijmakers J.H. Premature aging and cancer in nucleotide excision repair-disorders. DNA Repair 2011, 10:772-780.
52. Hsieh P., Yamane K. DNA mismatch repair: molecular mechanism, cancer, and ageing. Mech. Ageing Dev. 2008, 129:391-407.
53. Iyer R.R., Pluciennik A., Burdett V., Modrich P.L. DNA mismatch repair: functions and mechanisms. Chem. Rev. 2006, 106:302-323.
54. Modrich P. Strand-specific mismatch repair in mammalian cells. J. Biol. Chem. 1997, 272:24727-24730.
55. Pena-Diaz J., Jiricny J. Mammalian mismatch repair: error-free or error-prone?. Trends Biochem. Sci. 2012, 37:206-214.
56. Caldecott K.W. Single-strand break repair and genetic disease. Nat. Rev. Genet. 2008, 9:619-631.
57. Caldecott K.W. DNA single-strand breaks and neurodegeneration. DNA Repair 2004, 3:875-882.
58. Caldecott K.W. Mammalian single-strand break repair: mechanisms and links with chromatin. DNA Repair 2007, 6:443-453.
59. Harrison J.C., Haber J.E. Surviving the breakup: the DNA damage checkpoint. Annu. Rev. Genet. 2006, 40:209-235.
60. Bassing C.H., Alt F.W. The cellular response to general and programmed DNA double strand breaks. DNA Repair 2004, 3:781-796.
61. Lieber M.R., Ma Y., Pannicke U., Schwarz K. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair 2004, 3:817-826.
62. Wyman C., Kanaar R. DNA double-strand break repair: all's well that ends well. Annu. Rev. Genet. 2006, 40:363-383.
63. Bekker-Jensen S., Mailand N. Assembly and function of DNA double-strand break repair foci in mammalian cells. DNA Repair (Amsterdam) 2010, 9:1219-1228.
64. Thompson L.H. Recognition, signaling, and repair of DNA double-strand breaks produced by ionizing radiation in mammalian cells: the molecular choreography. Mutat. Res. 2012, 751:158-246.
65. Biton S., Barzilai A., Shiloh Y. The neurological phenotype of ataxia-telangiectasia: solving a persistent puzzle. DNA Repair 2008, 7:1028-1038.
66. Symington L.S., Gautier J. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 2011, 45:247-271.
67. Bekker-Jensen S., Mailand N. The ubiquitin- and SUMO-dependent signaling response to DNA double-strand breaks. FEBS Lett. 2011, 585:2914-2919.
68. van Attikum H., Gasser S.M. Crosstalk between histone modifications during the DNA damage response. Trends Cell Biol. 2009, 19:207-217.
69. Li J., Han Y.R., Plummer M.R., Herrup K. Cytoplasmic ATM in neurons modulates synaptic function. Current Biol. 2009, 19:2091-2096.
70. Levine-Small N., Yekutieli Z., Aljadeff J., Boccaletti S., Ben-Jacob E., Barzilai A. Reduced synchronization persistence in neural networks derived from atm-deficient mice. Front. Neurosci. 2011, 5:46.
71. Chiesa N., Barlow C., Wynshaw-Boris A., Strata P., Tempia F. Atm-deficient mice Purkinje cells show age-dependent defects in calcium spike bursts and calcium currents. Neuroscience 2000, 96:575-583.
72. Barzilai A. The neuro-glial-vascular interrelations in genomic instability symptoms. Mech. Ageing Dev. 2011, 132:395-404.
73. Verkhratsky A., Parpura V. Recent advances in (patho)physiology of astroglia. Acta Pharmacol. Sin. 2010, 31:1044-1054.
74. Miller R., Raff M., Fibrous protoplasmic astrocytes are biochemically and developmentally distinct. J. Neurosci. 1984, 4:585-592.
75. + channels and gap junction coupling. Glia 2012, 60:1192-1202.
76. Raff M.C., Lillien L.E., Richardson W.D., Burne J.F., Noble M.D. Platelet-derived growth factor from astrocytes drives the clock that times oligodendrocyte development in culture. Nature 1988, 333:562-565.
77. Rudge J.S. Astrocyte-derived neurotrophic factors. Astrocytes: Pharmacology and Function 1993, 267-305. Academic Press, San Diego, CA. S. Murphy (Ed.).
78. Kreft M., Bak L.K., Waagepetersen H.S., Schousboe A. Aspects of astrocyte energy metabolism, amino acid neurotransmitter homoeostasis and metabolic compartmentation. ASN Neuro 2012, 4.
79. Sidoryk-Wegrzynowicz M., Wegrzynowicz M., Lee E., Bowman A.B., Aschner M. Role of astrocytes in brain function and disease. Toxicol. Pathol. 2011, 39:115-123.
80. Zelenina M. Regulation of brain aquaporins. Neurochem. Int. 2010, 57:468-488.
81. Rose C. Effect of ammonia on astrocytic glutamate uptake/release mechanisms. J. Neurochem. 2006, 97(Suppl 1):11-15.
82. Losi G., Cammarota M., Carmignoto G. The role of astroglia in the epileptic brain. Front. Pharmacol. 2012, 3:132.
83. Perea G., Navarrete M., Araque A. Tripartite synapses: astrocytes process and control synaptic information. Trends Neurosci. 2009, 32:421-431.
84. Ullian E.M., Sapperstein S.K., Christopherson K.S., Barres B.A. Control of synapse number by glia. Science 2001, 291:657-661.
85. Christopherson K.S., Ullian E.M., Stokes C.C., Mullowney C.E., Hell J.W., Agah A., Lawler J., Mosher D.F., Bornstein P., Barres B.A. Thrombospondins are astrocyte-secreted proteins that promote CNS synaptogenesis. Cell 2005, 120:421-433.
86. Duffy A.M., Fitzgerald M.L., Chan J., Robinson D.C., Milner T.A., Mackie K., Pickel V.M. Acetylcholine alpha7 nicotinic and dopamine D2 receptors are targeted to many of the same postsynaptic dendrites and astrocytes in the rodent prefrontal cortex. Synapse 2011, 65:1350-1367.
87. Saab A.S., Neumeyer A., Jahn H.M., Cupido A., Simek A.A., Boele H.J., Scheller A., Le Meur K., Gotz M., Monyer H., Sprengel R., Rubio M.E., Deitmer J.W., De Zeeuw C.I., Kirchhoff F. Bergmann glial AMPA receptors are required for fine motor coordination. Science 2012, 337:749-753.
88. Iram T.a.F.D. Targeting the role of astrocytes in the progression of Alzheimer's disease. Curr. Signal Transduct. Ther. 2012, 7:20-27.
89. De Pittà M., Goldberg M., Volman V., Berry H., Ben-Jacob E. Glutamate regulation of calcium and oscillating and pulsating dynamics in astrocytes. J. Biol. Phys. 2009, 35:383-411.
90. De Pittà M., Volman V., Berry H., Ben-Jacob E. A tale of two stories: astrocyte regulation of synaptic depression and facilitation. PLoS Comput. Biol. 2011, 7:e1002293.
91. 2+ as a signalling route. ASN Neuro 2012, 4.
92. Scemes E., Giaume C. Astrocyte calcium waves: what they are and what they do. Glia 2006, 54:716-725.
93. Goldberg M., De Pittà M., Volman V., Berry H., Ben-Jacob E. Nonlinear gap junctions enable long-distance propagation of pulsating calcium waves in astrocyte networks. PLoS Comput. Biol. 2010, 6:e1000909.
94. Naus C.C., Bechberger J.F., Zhang Y., Venance L., Yamasaki H., Juneja S.C., Kidder G.M., Giaume C. Altered gap junctional communication, intercellular signaling, and growth in cultured astrocytes deficient in connexin 43. J. Neurosci. Res. 1997, 49:528-540.
95. Scemes E., Dermietzel R., Spray D.C. Calcium waves between astrocytes from Cx43 knockout mice. Glia 1998, 24:65-73.
96. Guan X., Cravatt B.F., Ehring G.R., Hall J.E., Boger D.L., Lerner R.A., Gilula N.B. The sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission in glial cells. J. Cell Biol. 1997, 139:1785-1792.
97. Zanotti S., Charles A. Extracellular calcium sensing by glial cells: low extracellular calcium induces intracellular calcium release and intercellular signaling. J. Neurochem. 1997, 69:594-602.
98. Cotrina M.L., Lin J.H., Alves-Rodrigues A., Liu S., Li J., Azmi-Ghadimi H., Kang J., Naus C.C., Nedergaard M. Connexins regulate calcium signaling by controlling ATP release. Proc. Natl. Acad. Sci. U S A 1998, 95:15735-15740.
99. Honda S., Sasaki Y., Ohsawa K., Imai Y., Nakamura Y., Inoue K., Kohsaka S. Extracellular ATP or ADP induce chemotaxis of cultured microglia through Gi/o-coupled P2Y receptors. J. Neurosci.: Off. J. Soc. Neurosci. 2001, 21:1975-1982.
100. Norenberg W., Cordes A., Blohbaum G., Frohlich R., Illes P. Coexistence of purino- and pyrimidinoceptors on activated rat microglial cells. Br. J. Pharmacol. 1997, 121:1087-1098.
101. Suzuki T., Hide I., Ido K., Kohsaka S., Inoue K., Nakata Y. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J. Neurosci.: Off. J. Soc. Neurosci. 2004, 24:1-7.
102. Davalos D., Grutzendler J., Yang G., Kim J.V., Zuo Y., Jung S., Littman D.R., Dustin M.L., Gan W.B. ATP mediates rapid microglial response to local brain injury in vivo. Nat. Neurosci. 2005, 8:752-758.
103. 2+ waves trigger responses in microglial cells in brain slices. FASEB J. 2002, 16:255-257.
104. Verderio C., Matteoli M. ATP mediates calcium signaling between astrocytes and microglial cells: modulation by IFN-gamma. J. Immunol. 2001, 166:6383-6391.
105. Fiacco T.A., McCarthy K.D. Astrocyte calcium elevations: properties, propagation, and effects on brain signaling. Glia 2006, 54:676-690.
106. 2+ signaling and the microvasculature in experimental mice models of Alzheimer's disease. Ann. N.Y. Acad. Sci. 2007, 1097:40-50.
107. Kuchibhotla K.V., Lattarulo C.R., Hyman B.T., Bacskai B.J. Synchronous hyperactivity and intercellular calcium waves in astrocytes in Alzheimer mice. Science 2009, 323:1211-1215.
108. Abramov A.Y., Canevari L., Duchen M.R. Changes in intracellular calcium and glutathione in astrocytes as the primary mechanism of amyloid neurotoxicity. J. Neurosci.: Off. J. Soc. Neurosci. 2003, 23:5088-5095.
109. Casley C.S., Lakics V., Lee H.G., Broad L.M., Day T.A., Cluett T., Smith M.A., O'Neill M.J., Kingston A.E. Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-beta peptide. Brain Res. 2009, 1260:65-75.
110. Chow S.K., Yu D., Macdonald C.L., Buibas M., Silva G.A. Amyloid beta-peptide directly induces spontaneous calcium transients, delayed intercellular calcium waves and gliosis in rat cortical astrocytes. ASN Neuro 2010, 2:e00026.
111. 2+ levels in cultured rat astrocytes. Neurosci. Lett. 1998, 243:121-124.
112. Haughey N.J., Mattson M.P. Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes. Neuromol. Med. 2003, 3:173-180.
113. Perea G., Araque A. Astrocytes potentiate transmitter release at single hippocampal synapses. Science 2007, 317:1083-1086.
114. Gordon G.R., Iremonger K.J., Kantevari S., Ellis-Davies G.C., MacVicar B.A., Bains J.S. Astrocyte-mediated distributed plasticity at hypothalamic glutamate synapses. Neuron 2009, 64:391-403.
115. Zonta M., Angulo M.C., Gobbo S., Rosengarten B., Hossmann K.A., Pozzan T., Carmignoto G. Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nat. Neurosci. 2003, 6:43-50.
116. Takano T., Tian G.F., Peng W., Lou N., Libionka W., Han X., Nedergaard M. Astrocyte-mediated control of cerebral blood flow. Nat. Neurosci. 2006, 9:260-267.
117. Arizono M., Bannai H., Nakamura K., Niwa F., Enomoto M., Matsu-Ura T., Miyamoto A., Sherwood M.W., Nakamura T., Mikoshiba K. Receptor-selective diffusion barrier enhances sensitivity of astrocytic processes to metabotropic glutamate receptor stimulation. Sci. Signal. 2012, 5:ra27.
118. Fernandez-Capetillo O., Lee A., Nussenzweig M., Nussenzweig A. H2AX: the histone guardian of the genome. DNA Repair 2004, 3:959-967.
119. Lee M.S., Edwards R.A., Thede G.L., Glover J.N. Structure of the BRCT repeat domain of MDC1 and its specificity for the free COOH-terminal end of the gamma-H2AX histone tail. J. Biol. Chem. 2005, 280:32053-32056.
120. Adams B.R., Golding S.E., Rao R.R., Valerie K. Dynamic dependence on ATR and ATM for double-strand break repair in human embryonic stem cells and neural descendants. PloS One 2010, 5:e10001.
121. + tumor-derived cells. Neuro-oncology 2011, 13:487-499.
122. Burma S., Chen B.P., Murphy M., Kurimasa A., Chen D.J. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J. Biol. Chem. 2001, 276:42462-42467.
123. Girard P.M., Riballo E., Begg A.C., Waugh A., Jeggo P.A. Nbs1 promotes ATM dependent phosphorylation events including those required for G1/S arrest. Oncogene 2002, 21:4191-4199.
124. Dar I., Yosha G., Elfassy R., Galron R., Wang Z.Q., Shiloh Y., Barzilai A. Investigation of the functional link between ATM and NBS1 in the DNA damage response in the mouse cerebellum. J. Biol. Chem. 2011, 286:15361-15376.
125. Schneider L., Fumagalli M., d'Adda di Fagagna F. Terminally differentiated astrocytes lack DNA damage response signaling and are radioresistant but retain DNA repair proficiency. Cell Death Differ. 2012, 19:582-591.
126. Harrison J.F., Rinne M.L., Kelley M.R., Druzhyna N.M., Wilson G.L., Ledoux S.P. Altering DNA base excision repair: use of nuclear and mitochondrial-targeted N-methylpurine DNA glycosylase to sensitize astroglia to chemotherapeutic agents. Glia 2007, 55:1416-1425.
127. Ahel I., Rass U., El-Khamisy S.F., Katyal S., Clements P.M., McKinnon P.J., Caldecott K.W., West S.C. The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature 2006, 443:713-716.
128. Date H., Onodera O., Tanaka H., Iwabuchi K., Uekawa K., Igarashi S., Koike R., Hiroi T., Yuasa T., Awaya Y., Sakai T., Takahashi T., Nagatomo H., Sekijima Y., Kawachi I., Takiyama Y., Nishizawa M., Fukuhara N., Saito K., Sugano S., Tsuji S. Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Nat. Genet. 2001, 29:184-188.
129. Moreira M.C., Barbot C., Tachi N., Kozuka N., Uchida E., Gibson T., Mendonca P., Costa M., Barros J., Yanagisawa T., Watanabe M., Ikeda Y., Aoki M., Nagata T., Coutinho P., Sequeiros J., Koenig M. The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin. Nat. Genet. 2001, 29:189-193.
130. Reynolds J.J., El-Khamisy S.F., Katyal S., Clements P., McKinnon P.J., Caldecott K.W. Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Mol. Cell. Biol. 2009, 29:1354-1362.
131. Yamamoto A., Nakamura Y., Kobayashi N., Iwamoto T., Yoshioka A., Kuniyasu H., Kishimoto T., Mori T. Neurons and astrocytes exhibit lower activities of global genome nucleotide excision repair than do fibroblasts. DNA Repair 2007, 6:649-657.
132. Attwell D., Laughlin S.B. An energy budget for signaling in the grey matter of the brain. J. Cereb. Blood Flow Metab. Off. J. Int. Soc. Cereb. Blood Flow Metabolism 2001, 21:1133-1145.
133. Wallace D.C., Fan W., Procaccio V. Mitochondrial energetics and therapeutics. Annu. Rev. Pathol. 2010, 5:297-348.
134. Leloup C., Casteilla L., Carriere A., Galinier A., Benani A., Carneiro L., Penicaud L. Balancing mitochondrial redox signaling: a key point in metabolic regulation. Antioxid. Redox Signal. 2011, 14:519-530.
135. Contreras L., Drago I., Zampese E., Pozzan T. Mitochondria: the calcium connection. Biochim. Biophys. Acta 2010, 1797:607-618.
136. Borutaite V. Mitochondria as decision-makers in cell death. Environ. Mol. Mutagen. 2010, 51:406-416.
137. Attardi G., Schatz G. Biogenesis of mitochondria. Annu. Rev. Cell Biol. 1988, 4:289-333.
138. Yakes F.M., Van Houten B. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress. Proc. Natl. Acad. Sci. U S A 1997, 94:514-519.
139. Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proc. Natl. Acad. Sci. U S A. 1993, 90:7915-7922.
140. Barzilai A. The contribution of the DNA damage response to neuronal viability. Antioxd. Redox Signal. 2007, 9:211-218.
141. Bogenhagen D.F., Pinz K.G., Perez-Jannotti R.M. Enzymology of mitochondrial base excision repair. Prog. Nucleic Acid Res. Mol. Biol. 2001, 68:257-271.
142. Bohr V.A. Repair of oxidative DNA damage in nuclear and mitochondrial DNA, and some changes with aging in mammalian cells. Free Radic. Biol. Med. 2002, 32:804-812.
143. Bohr V.A., Anson R.M. Mitochondrial DNA repair pathways. J. Bioenerg. Biomembr. 1999, 31:391-398.
144. Karahalil B., Hogue B.A., de Souza-Pinto N.C., Bohr V.A. Base excision repair capacity in mitochondria and nuclei: tissue-specific variations. FASEB J. 2002, 16:1895-1902.
145. Ledoux S.P., Shen C.C., Grishko V.I., Fields P.A., Gard A.L., Wilson G.L. Glial cell-specific differences in response to alkylation damage. Glia 1998, 24:304-312.
146. Loor G., Kondapalli J., Schriewer J.M., Chandel N.S., Vanden Hoek T.L., Schumacker P.T. Menadione triggers cell death through ROS-dependent mechanisms involving PARP activation without requiring apoptosis. Free Radic. Biol. Med. 2010, 49:1925-1936.
147. LeDoux S.P., Druzhyna N.M., Hollensworth S.B., Harrison J.F., Wilson G.L. Mitochondrial DNA repair: a critical player in the response of cells of the CNS to genotoxic insults. Neuroscience 2007, 145:1249-1259.
148. Hollensworth S.B., Shen C., Sim J.E., Spitz D.R., Wilson G.L., LeDoux S.P. Glial cell type-specific responses to menadione-induced oxidative stress. Free Radic. Biol. Med. 2000, 28:1161-1174.
149. Gros-Louis F., Gaspar C., Rouleau G.A. Genetics of familial and sporadic amyotrophic lateral sclerosis. Biochim. Biophys. Acta 2006, 1762:956-972.
150. Julien J.P., Kriz J. Transgenic mouse models of amyotrophic lateral sclerosis. Biochim. Biophys. Acta 2006, 1762:1013-1024.
151. Clement A.M., Nguyen M.D., Roberts E.A., Garcia M.L., Boillee S., Rule M., McMahon A.P., Doucette W., Siwek D., Ferrante R.J., Brown R.H., Julien J.P., Goldstein L.S., Cleveland D.W. Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 2003, 302:113-117.
152. Galron R., Gruber R., Lifshitz V., Lu H., Kirshner M., Ziv N., Wang Z.Q., Shiloh Y., Barzilai A., Frenkel D. Astrocyte dysfunction associated with cerebellar attrition in a nijmegen breakage syndrome animal model. J. Mol. Neurosci. 2011, 45:202-211.
153. Gobbel G.T., Bellinzona M., Vogt A.R., Gupta N., Fike J.R., Chan P.H. Response of postmitotic neurons to X-irradiation: implications for the role of DNA damage in neuronal apoptosis. J. Neurosci.: Off. J. Soc. Neurosci. 1998, 18:147-155.
154. Eilam R., Peter Y., Elson A., Rotman G., Shiloh Y., Groner Y., Segal M. Selective loss of dopaminergic nigro-striatal neurons in brains of Atm-deficient mice. Proc. Natl. Acad. Sci. U S A 1998, 95:12653-12656.
155. Eilam R., Peter Y., Groner Y., Segal M. Late degeneration of nigro-striatal neurons in ATM-/- mice. Neuroscience 2003, 121:83-98.
156. Oberheim N.A., Wang X., Goldman S., Nedergaard M. Astrocytic complexity distinguishes the human brain. Trends Neurosci. 2006, 29:547-553.
157. Sherwood C.C., Stimpson C.D., Raghanti M.A., Wildman D.E., Uddin M., Grossman L.I., Goodman M., Redmond J.C., Bonar C.J., Erwin J.M., Hof P.R. Evolution of increased glia-neuron ratios in the human frontal cortex. Proc. Natl. Acad. Sci. U S A 2006, 103:13606-13611.
158. Haydon P.G., Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol. Rev. 2006, 86:1009-1031.
159. Verkhratsky A. Calcium ions and integration in neural circuits. Acta Physiol. (Oxf) 2006, 187:357-369.
160. Volterra A., Meldolesi J. Astrocytes, from brain glue to communication elements: the revolution continues. Nat. Rev. Neurosci. 2005, 6:626-640.
161. Buffo A., Rite I., Tripathi P., Lepier A., Colak D., Horn A.P., Mori T., Gotz M. Origin and progeny of reactive gliosis: a source of multipotent cells in the injured brain. Proc. Natl. Acad. Sci. U S A 2008, 105:3581-3586.
162. Horner P.J., Power A.E., Kempermann G., Kuhn H.G., Palmer T.D., Winkler J., Thal L.J., Gage F.H. Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J. Neurosci. 2000, 20:2218-2228.
163. Johansson C.B., Momma S., Clarke D.L., Risling M., Lendahl U., Frisen J. Identification of a neural stem cell in the adult mammalian central nervous system. Cell 1999, 96:25-34.
164. Ohori Y., Yamamoto S., Nagao M., Sugimori M., Yamamoto N., Nakamura K., Nakafuku M. Growth factor treatment and genetic manipulation stimulate neurogenesis and oligodendrogenesis by endogenous neural progenitors in the injured adult spinal cord. J. Neurosci. 2006, 26:11948-11960.
165. Seifert G., Schilling K., Steinhauser C. Astrocyte dysfunction in neurological disorders: a molecular perspective. Nat. Rev. Neurosci. 2006, 7:194-206.
166. Bachoo R.M., Kim R.S., Ligon K.L., Maher E.A., Brennan C., Billings N., Chan S., Li C., Rowitch D.H., Wong W.H., DePinho R.A. Molecular diversity of astrocytes with implications for neurological disorders. Proc. Natl. Acad. Sci. U S A 2004, 101:8384-8389.
167. Maragakis N.J., Rothstein J.D. Mechanisms of disease: astrocytes in neurodegenerative disease, nature clinical practice. Neurology 2006, 2:679-689.
168. Myung N.H., Zhu X., Kruman I.I., Castellani R.J., Petersen R.B., Siedlak S.L., Perry G., Smith M.A., Lee H.G. Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes. Age (Dordr) 2008, 30:209-215.
169. Wallace D.C. A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine. Annu. Rev. Genet. 2005, 39:359-407.
170. Sullivan P.G., Brown M.R. Mitochondrial aging and dysfunction in Alzheimer's disease. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005, 29:407-410.
171. Baranes K., Raz-Prag D., Nitzan A., Galron R., Ashery-Padan R., Rotenstreich Y., Assaf Y., Shiloh Y., Wang Z.Q., Barzilai A., Solomon A.S. Conditional inactivation of the NBS1 gene in the mouse central nervous system leads to neurodegeneration and disorganization of the visual system. Exp. Neurol. 2009, 218:24-32.
172. Houtsmuller A.B., Rademakers S., Nigg A.L., Hoogstraten D., Hoeijmakers J.H., Vermeulen W. Action of DNA repair endonuclease ERCC1/XPF in living cells. Science 1999, 284:958-961.
173. Ahmad A., Robinson A.R., Duensing A., van Drunen E., Beverloo H.B., Weisberg D.B., Hasty P., Hoeijmakers J.H., Niedernhofer L.J. ERCC1-XPF endonuclease facilitates DNA double-strand break repair. Mol. Cell. Biol. 2008, 28:5082-5092.
174. Bergstralh D.T., Sekelsky J. Interstrand crosslink repair: can XPF-ERCC1 be let off the hook?. Trends Genet. 2008, 24:70-76.
175. Bhagwat N., Olsen A.L., Wang A.T., Hanada K., Stuckert P., Kanaar R., D'Andrea A., Niedernhofer L.J., McHugh P.J. XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair. Mol. Cell. Biol. 2009, 29:6427-6437.
176. Niedernhofer L.J., Garinis G.A., Raams A., Lalai A.S., Robinson A.R., Appeldoorn E., Odijk H., Oostendorp R., Ahmad A., van Leeuwen W., Theil A.F., Vermeulen W., van der Horst G.T., Meinecke P., Kleijer W.J., Vijg J., Jaspers N.G., Hoeijmakers J.H. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 2006, 444:1038-1043.
177. Zhu X.D., Niedernhofer L., Kuster B., Mann M., Hoeijmakers J.H., de Lange T. ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNA-containing double minute chromosomes. Mol. Cell 2003, 12:1489-1498.
178. de Waard M.C., van der Pluijm I., Zuiderveen Borgesius N., Comley L.H., Haasdijk E.D., Rijksen Y., Ridwan Y., Zondag G., Hoeijmakers J.H., Elgersma Y., Gillingwater T.H., Jaarsma D. Age-related motor neuron degeneration in DNA repair-deficient Ercc1 mice. Acta Neuropathol. (Berl.) 2010, 120:461-475.
179. Weidenheim K.M., Dickson D.W., Rapin I. Neuropathology of Cockayne syndrome: evidence for impaired development, premature aging, and
180. Meshulam L., Galron R., Kanner S., De Pitta M., Bonifazi P., Goldin M., Frenkel D., Ben-Jacob E., Barzilai A. The role of the neuro-astro-vascular unit in the etiology of ataxia telangiectasia. Front. Pharmacol. 2012, 3:157.
181. Gleckman A.M., Jiang Z., Liu Y., Smith T.W. Neuronal and glial DNA fragmentation in Pick's disease. Acta Neuropathol. (Berl.) 1999, 98:55-61.
182. Claassen D.A., Lahue R.S. Expansions of CAG.CTG repeats in immortalized human astrocytes. Hum. Mol. Genet. 2007, 16:3088-3096.
183. Frappart P.O., Tong W.M., Demuth I., Radovanovic I., Herceg Z., Aguzzi A., Digweed M., Wang Z.Q. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat. Med. 2005, 11:538-544.
184. Assaf Y., Galron R., Shapira I., Nitzan A., Blumenfeld-Katzir T., Solomon A.S., Holdengreber V., Wang Z.Q., Shiloh Y., Barzilai A. MRI evidence of white matter damage in a mouse model of Nijmegen breakage syndrome. Exp. Neurol. 2008, 209:181-191.
185. Hardin-Pouzet H., Krakowski M., Bourbonniere L., Didier-Bazes M., Tran E., Owens T. Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis. Glia 1997, 20:79-85.
186. El Khoury J., Toft M., Hickman S.E., Means T.K., Terada K., Geula C., Luster A.D. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 2007, 13:432-438.
187. Kalehua A.N., Nagel J.E., Whelchel L.M., Gides J.J., Pyle R.S., Smith R.J., Kusiak J.W., Taub D.D. Monocyte chemoattractant protein-1 and macrophage inflammatory protein-2 are involved in both excitotoxin-induced neurodegeneration and regeneration. Exp. Cell Res. 2004, 297:197-211.
188. Kirshner M., Galron R., Frenkel D., Mandelbaum G., Shiloh Y., Wang Z.Q., Barzilai A. Malfunctioning DNA damage response (DDR) leads to the degeneration of nigro-striatal pathway in mouse brain. J. Mol. Neurosci. 2012, 46:554-568.
189. Petersen A.J., Rimkus S.A., Wassarman D.A. ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila. Proc. Natl. Acad Sci. U S A 2012, 109:E656-E664.
190. Van Vactor D.V., Lorenz L.J. Neural development: the semantics of axon guidance. Curr. Biol. 1999, 9:R201-R204.
191. Luo Y., Shepherd I., Li J., Renzi M.J., Chang S., Raper J.A. A family of molecules related to collapsin in the embryonic chick nervous system. Neuron 1995, 14:1131-1140.
192. Messersmith E.K., Leonardo E.D., Shatz C.J., Tessier-Lavigne M., Goodman C.S., Kolodkin A.L. Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. Neuron 1995, 14:949-959.
193. Gagliardini V., Fankhauser C. Semaphorin III can induce death in sensory neurons. Mol. Cell. Neurosci. 1999, 14:301-316.
194. Shirvan A., Kimron M., Holdengreber V., Ziv I., Ben-Shaul Y., Melamed S., Melamed E., Barzilai A., Solomon A.S. Anti-semaphorin 3A antibodies rescue retinal ganglion cells from cell death following optic nerve axotomy. J. Biol. Chem. 2002, 277:49799-49807.
195. Shirvan A., Ziv I., Fleminger G., Shina R., He Z., Brudo I., Melamed E., Barzilai A. Semaphorins as mediators of neuronal apoptosis. J. Neurochem. 1999, 73:961-971.
196. Raper J.A. Semaphorins and their receptors in vertebrates and invertebrates. Curr. Opin. Neurobiol. 2000, 10:88-94.
197. Charrier E., Reibel S., Rogemond V., Aguera M., Thomasset N., Honnorat J. Collapsin response mediator proteins (CRMPs): involvement in nervous system development and adult neurodegenerative disorders. Mol. Neurobiol. 2003, 28:51-64.
198. De Winter F., Oudega M., Lankhorst A.J., Hamers F.P., Blits B., Ruitenberg M.J., Pasterkamp R.J., Gispen W.H., Verhaagen J. Injury-induced class 3 semaphorin expression in the rat spinal cord. Exp. Neurol. 2002, 175:61-75.
199. Nitzan A., Kermer P., Shirvan A., Bahr M., Barzilai A., Solomon A.S. Examination of cellular and molecular events associated with optic nerve axotomy. Glia 2006, 54:545-556.
200. Ochi K., Mori T., Toyama Y., Nakamura Y., Arakawa H. Identification of semaphorin3B as a direct target of p53. Neoplasia 2002, 4:82-87.
201. Attwell D., Buchan A.M., Charpak S., Lauritzen M., Macvicar B.A., Newman E.A. Glial and neuronal control of brain blood flow. Nature 2010, 468:232-243.
202. Petzold G.C., Murthy V.N. Role of astrocytes in neurovascular coupling. Neuron 2011, 71:782-797.
203. Zlokovic B.V. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron 2008, 57:178-201.
204. Ronaldson P.T., Davis T.P. Blood-brain barrier integrity and glial support: mechanisms that can be targeted for novel therapeutic approaches in stroke. Curr. Pharm. Des. 2012, 18:3624-3644.
205. Nag S. Morphology and properties of astrocytes. Methods Mol. Biol. 2011, 686:69-100.
206. Zlokovic B.V. Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders. Nat. Rev. Neurosci. 2011, 12:723-738.
207. Ehrlich P. Das Sauerstoff-Bedürfnis des Organismus. Eine farbenanalytische Studie 1885, Verlag von August Hirschwald, Berlin.
208. Goldmann E. Vitalfärbungen am Zentralnervensystem. Beitrag zur Physio-Pathologie des Plexus Choroideus und der Hirnhäute. Physikalisch-Mathematische Classe 1913, 1:1-64.
209. Lewandowski M. Zur Lehre von der Cerebrospinalflüssigkeit. Z. Klein Forsch. 1900, 40:480-494.
210. Wolburg H., Noell S., Mack A., Wolburg-Buchholz K., Fallier-Becker P. Brain endothelial cells and the glio-vascular complex. Cell Tissue Res. 2009, 335:75-96.
211. Bechmann I., Galea I., Perry V.H. What is the blood-brain barrier (not)?. Trends Immunol. 2007, 28:5-11.
212. Mathiisen T.M., Lehre K.P., Danbolt N.C., Ottersen O.P. The perivascular astroglial sheath provides a complete covering of the brain microvessels: an electron microscopic 3D reconstruction. Glia 2010, 58:1094-1103.
213. Nielsen S., Nagelhus E.A., Amiry-Moghaddam M., Bourque C., Agre P., Ottersen O.P. Specialized membrane domains for water transport in glial cells: high-resolution immunogold cytochemistry of aquaporin-4 in rat brain. J. Neurosci: Off. J. Soc. Neurosci. 1997, 17:171-180.
214. Petzold G.C., Albeanu D.F., Sato T.F., Murthy V.N. Coupling of neural activity to blood flow in olfactory glomeruli is mediated by astrocytic pathways. Neuron 2008, 58:897-910.
215. Simard M., Arcuino G., Takano T., Liu Q.S., Nedergaard M. Signaling at the gliovascular interface. J. Neurosci.: Off. J. Soc. Neurosci. 2003, 23:9254-9262.
216. Zacchigna S., Lambrechts D., Carmeliet P. Neurovascular signalling defects in neurodegeneration. Nat. Rev. Neurosci. 2008, 9:169-181.
217. Lafuente J.V., Ortuzar N., Bengoetxea H., Bulnes S., Argandona E.G. Vascular endothelial growth factor and other angioglioneurins: key molecules in brain development and restoration. Int. Rev. Neurobiol. 2012, 102:317-346.
218. Argandona E.G., Bengoetxea H., Ortuzar N., Bulnes S., Rico-Barrio I., Lafuente J.V. Vascular endothelial growth factor: adaptive changes in the neuroglialvascular unit. Curr. Neurovasc. Res. 2012, 9:72-81.
219. Moore C.I., Cao R. The hemo-neural hypothesis: on the role of blood flow in information processing. J. Neurophysiol. 2008, 99:2035-2047.
220. Forstl H., Howard R. Recent studies on dementia senilis and brain disorders caused by atheromatous vascular disease: by A. Alzheimer, 1898. Alzheimer Dis. Assoc. Disord. 1991, 5:257-264.
221. Baldwin R.C., O'Brien J. Vascular basis of late-onset depressive disorder. Br. J. Psychiatry 2002, 180:157-160.
222. McKimmie C.S., Graham G.J. Astrocytes modulate the chemokine network in a pathogen-specific manner. Biochem. Biophys. Res. Commun. 2010, 394:1006-1011.
223. Johnson N.A., Jahng G.H., Weiner M.W., Miller B.L., Chui H.C., Jagust W.J., Gorno-Tempini M.L., Schuff N. Pattern of cerebral hypoperfusion in Alzheimer disease and mild cognitive impairment measured with arterial spin-labeling MR imaging: initial experience. Radiology 2005, 234:851-859.
224. Ruitenberg A., den Heijer T., Bakker S.L., van Swieten J.C., Koudstaal P.J., Hofman A., Breteler M.M. Cerebral hypoperfusion and clinical onset of dementia: the Rotterdam Study. Ann. Neurol. 2005, 57:789-794.
225. Chow N., Bell R.D., Deane R., Streb J.W., Chen J., Brooks A., Van Nostrand W., Miano J.M., Zlokovic B.V. Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype. Proc. Natl. Acad. Sci. U S A 2007, 104:823-828.
226. Roman G.C. Vascular dementia: distinguishing characteristics, treatment, and prevention. J. Am. Geriatr. Soc. 2003, 51:S296-S304.
227. Bigler E.D., Kerr B., Victoroff J., Tate D.F., Breitner J.C. White matter lesions, quantitative magnetic resonance imaging, and dementia. Alzheimer Dis. Assoc. Disord. 2002, 16:161-170.
228. Raz-Prag D., Galron R., Segev-Amzaleg N., Solomon A.S., Shiloh Y., Barzilai A., Frenkel D. A role for vascular deficiency in retinal pathology in a mouse model of ataxia-telangiectasia. Am. J. Pathol. 2011, 179:1533-1541.
229. Okuno Y., Nakamura-Ishizu A., Otsu K., Suda T., Kubota Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat. Med. 2012, 18:1208-1216.
230. Alitalo K. A radical view of pathological vasculature. Cell Metab. 2012, 16:287-288.
231. Fruttiger M. Development of the retinal vasculature. Angiogenesis 2007, 10:77-88.
232. Antonetti D.A., Barber A.J., Khin S., Lieth E., Tarbell J.M., Gardner T.W. Vascular permeability in experimental diabetes is associated with reduced endothelial occludin content: vascular endothelial growth factor decreases occludin in retinal endothelial cells. Penn State Retina Research Group. Diabetes 1998, 47:1953-1959.
233. Tyagi N., Roberts A.M., Dean W.L., Tyagi S.C., Lominadze D. Fibrinogen induces endothelial cell permeability. Mol. Cell. Biochem. 2008, 307:13-22.
234. Viswanathan A., Chabriat H. Cerebral microhemorrhage. Stroke 2006, 37:550-555.
235. Li P., Hu X., Gan Y., Gao Y., Liang W., Chen J. Mechanistic insight into DNA damage and repair in ischemic stroke: exploiting the base excision repair pathway as a model of neuroprotection. Antioxid Redox Signal. 2011, 14:1905-1918.
236. Ascoli G.A., Alonso-Nanclares L., Anderson S.A., Barrionuevo G., Benavides-Piccione R., Burkhalter A., Buzsáki G., DeFelipe J., Fairén A., Feldmeyer D., Fishell G., Fregnac Y., Freund T.F., Gardner D., Gardner E.P., Goldberg J.H., Helmstaedter M., Hestrin S., Karube F., Kisvárday Z.F., Lambolez B., Lewis D.A., Marin O., Markram H., Muñoz A., Packer A., Petersen C.C.H., Rockland K.S., Rossier J., Rudy B., Somogyi P., Staiger J.F., Tamas G., Thomson A.M., Toledo-Rodriguez M., Wang.Y., West D.C., Yuste R. Petilla terminology: nomenclature of features of GABAergic interneurons of the cerebral cortex. Nat. Rev. Neurosci. 2008, 9:557-568.
237. Giaume C., Koulakoff A., Roux L., Holcman D., Rouach N. Astroglial networks: a step further in neuroglial and gliovascular interactions. Nat. Rev. Neurosci. 2010, 11:87-99.