메뉴 건너뛰기




Volumn 15, Issue 8, 2016, Pages 1117-1124

Structure of the human dimeric ATM kinase

Author keywords

ataxia telangiectasia; ATM kinase; DNA damage; DNA damage response; electron microscopy (EM); PIKK; post translational modification (PTM)

Indexed keywords

ATM PROTEIN; DIMER; MAMMALIAN TARGET OF RAPAMYCIN; PROTEIN SUBUNIT;

EID: 84964556605     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2016.1158362     Document Type: Article
Times cited : (40)

References (40)
  • 1
    • 1842431822 scopus 로고    scopus 로고
    • Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
    • 15064416
    • J.H.Lee, T.T.Paull. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004; 304:93-6; PMID:15064416; http://dx.doi.org/10.1126/science.1091496
    • (2004) Science , vol.304 , pp. 93-96
    • Lee, J.H.1    Paull, T.T.2
  • 2
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • 15790808
    • J.H.Lee, T.T.Paull. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 2005; 308:551-4; PMID:15790808; http://dx.doi.org/10.1126/science.1108297
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 3
    • 0142136826 scopus 로고    scopus 로고
    • Requirement of the MRN complex for ATM activation by DNA damage
    • 14532133
    • T.Uziel, Y.Lerenthal, L.Moyal, Y.Andegeko, L.Mittelman, Y.Shiloh. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 2003; 22:5612-21; PMID:14532133; http://dx.doi.org/10.1093/emboj/cdg541
    • (2003) EMBO J , vol.22 , pp. 5612-5621
    • Uziel, T.1    Lerenthal, Y.2    Moyal, L.3    Andegeko, Y.4    Mittelman, L.5    Shiloh, Y.6
  • 4
    • 84875423827 scopus 로고    scopus 로고
    • The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
    • Y.Shiloh, Y.Ziv. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 2013; 14:197-210; http://dx.doi.org/10.1038/nrm3546
    • (2013) Nat Rev Mol Cell Biol , vol.14 , pp. 197-210
    • Shiloh, Y.1    Ziv, Y.2
  • 5
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • 12556884
    • C.J.Bakkenist, M.B.Kastan. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421:499-506; PMID:12556884; http://dx.doi.org/10.1038/nature01368
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 6
    • 34447551681 scopus 로고    scopus 로고
    • Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
    • 17486112
    • E.Berkovich, R.J.Monnat, Jr, M.B.Kastan. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 2007; 9:683-90; PMID:17486112; http://dx.doi.org/10.1038/ncb1599
    • (2007) Nat Cell Biol , vol.9 , pp. 683-690
    • Berkovich, E.1    Monnat, R.J.2    Kastan, M.B.3
  • 10
    • 4444339751 scopus 로고    scopus 로고
    • ATM and ataxia telangiectasia
    • 15289825
    • P.J.McKinnon. ATM and ataxia telangiectasia. EMBO Reports 2004; 5:772-6; PMID:15289825; http://dx.doi.org/10.1038/sj.embor.7400210
    • (2004) EMBO Reports , vol.5 , pp. 772-776
    • McKinnon, P.J.1
  • 11
    • 70350504453 scopus 로고    scopus 로고
    • The DNA-damage response in human biology and disease
    • 19847258
    • S.P.Jackson, J.Bartek. The DNA-damage response in human biology and disease. Nature 2009; 461:1071-8; PMID:19847258; http://dx.doi.org/10.1038/nature08467
    • (2009) Nature , vol.461 , pp. 1071-1078
    • Jackson, S.P.1    Bartek, J.2
  • 12
    • 84924384551 scopus 로고    scopus 로고
    • Mechanisms of ATM Activation
    • 25580527
    • T.T.Paull. Mechanisms of ATM Activation. Ann Rev Biochem 2015; 84:711-38; PMID:25580527; http://dx.doi.org/10.1146/annurev-biochem-060614-034335
    • (2015) Ann Rev Biochem , vol.84 , pp. 711-738
    • Paull, T.T.1
  • 13
    • 68249113593 scopus 로고    scopus 로고
    • Common mechanisms of PIKK regulation
    • 19464237
    • C.A.Lovejoy, D.Cortez. Common mechanisms of PIKK regulation. DNA Repair 2009; 8:1004-8; PMID:19464237; http://dx.doi.org/10.1016/j.dnarep.2009.04.006
    • (2009) DNA Repair , vol.8 , pp. 1004-1008
    • Lovejoy, C.A.1    Cortez, D.2
  • 14
    • 70350324640 scopus 로고    scopus 로고
    • Emerging common themes in regulation of PIKKs and PI3Ks
    • 19779456
    • H.Lempiainen, T.D.Halazonetis. Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J 2009; 28:3067-73; PMID:19779456; http://dx.doi.org/10.1038/emboj.2009.281
    • (2009) EMBO J , vol.28 , pp. 3067-3073
    • Lempiainen, H.1    Halazonetis, T.D.2
  • 15
    • 0034193150 scopus 로고    scopus 로고
    • FAT: a novel domain in PIK-related kinases
    • 10782091
    • R.Bosotti, A.Isacchi, E.L.Sonnhammer. FAT: a novel domain in PIK-related kinases. Trends Biochem Sci 2000; 25:225-7; PMID:10782091; http://dx.doi.org/10.1016/S0968-0004(00)01563-2
    • (2000) Trends Biochem Sci , vol.25 , pp. 225-227
    • Bosotti, R.1    Isacchi, A.2    Sonnhammer, E.L.3
  • 16
    • 0037462453 scopus 로고    scopus 로고
    • The ATRs, ATMs, and TORs are giant HEAT repeat proteins
    • 12553904
    • J.Perry, N.Kleckner. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell 2003; 112:151-5; PMID:12553904; http://dx.doi.org/10.1016/S0092-8674(03)00033-3
    • (2003) Cell , vol.112 , pp. 151-155
    • Perry, J.1    Kleckner, N.2
  • 17
    • 0035946941 scopus 로고    scopus 로고
    • Comparison of ARM and HEAT protein repeats
    • 11491282
    • M.A.Andrade, C.Petosa, S.I.O'Donoghue, C.W.Muller, P.Bork. Comparison of ARM and HEAT protein repeats. J Mol Biol 2001; 309:1-18; PMID:11491282; http://dx.doi.org/10.1006/jmbi.2001.4624
    • (2001) J Mol Biol , vol.309 , pp. 1-18
    • Andrade, M.A.1    Petosa, C.2    O'Donoghue, S.I.3    Muller, C.W.4    Bork, P.5
  • 19
    • 78549243696 scopus 로고    scopus 로고
    • An unprecedented nucleic acid capture mechanism for excision of DNA damage
    • 20927102
    • E.H.Rubinson, A.S.Gowda, T.E.Spratt, B.Gold, B.F.Eichman. An unprecedented nucleic acid capture mechanism for excision of DNA damage. Nature 2010; 468:406-11; PMID:20927102; http://dx.doi.org/10.1038/nature09428
    • (2010) Nature , vol.468 , pp. 406-411
    • Rubinson, E.H.1    Gowda, A.S.2    Spratt, T.E.3    Gold, B.4    Eichman, B.F.5
  • 20
    • 33745058037 scopus 로고    scopus 로고
    • Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex
    • A.Dupre, L.Boyer-Chatenet, J.Gautier. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Structural Mol Biol 2006; 13:451-7; http://dx.doi.org/10.1038/nsmb1090
    • (2006) Nat Structural Mol Biol , vol.13 , pp. 451-457
    • Dupre, A.1    Boyer-Chatenet, L.2    Gautier, J.3
  • 21
    • 15844394846 scopus 로고    scopus 로고
    • Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
    • 15758953
    • J.Falck, J.Coates, S.P.Jackson. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005; 434:605-11; PMID:15758953; http://dx.doi.org/10.1038/nature03442
    • (2005) Nature , vol.434 , pp. 605-611
    • Falck, J.1    Coates, J.2    Jackson, S.P.3
  • 22
    • 34250813133 scopus 로고    scopus 로고
    • ATMIN defines an NBS1-independent pathway of ATM signalling
    • 17525732
    • N.Kanu, A.Behrens. ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J 2007; 26:2933-41; PMID:17525732; http://dx.doi.org/10.1038/sj.emboj.7601733
    • (2007) EMBO J , vol.26 , pp. 2933-2941
    • Kanu, N.1    Behrens, A.2
  • 23
    • 84881614943 scopus 로고    scopus 로고
    • Functional activation of ATM by the prostate cancer suppressor NKX3.1
    • 23890999
    • C.Bowen, J.H.Ju, J.H.Lee, T.T.Paull, E.P.Gelmann. Functional activation of ATM by the prostate cancer suppressor NKX3.1. Cell Reports 2013; 4:516-29; PMID:23890999; http://dx.doi.org/10.1016/j.celrep.2013.06.039
    • (2013) Cell Reports , vol.4 , pp. 516-529
    • Bowen, C.1    Ju, J.H.2    Lee, J.H.3    Paull, T.T.4    Gelmann, E.P.5
  • 24
  • 26
    • 73849140503 scopus 로고    scopus 로고
    • Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
    • 20023628
    • B.L.Sibanda, D.Y.Chirgadze, T.L.Blundell. Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature 2010; 463:118-21; PMID:20023628; http://dx.doi.org/10.1038/nature08648
    • (2010) Nature , vol.463 , pp. 118-121
    • Sibanda, B.L.1    Chirgadze, D.Y.2    Blundell, T.L.3
  • 27
    • 33745217811 scopus 로고    scopus 로고
    • Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1
    • J.H.Lee, T.T.Paull. Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1. Methods Enzymol 2006; 408:529-39; http://dx.doi.org/10.1016/S0076-6879(06)08033-5
    • (2006) Methods Enzymol , vol.408 , pp. 529-539
    • Lee, J.H.1    Paull, T.T.2
  • 28
    • 80052199786 scopus 로고    scopus 로고
    • Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies
    • 21450809
    • E.P.Morris, A.Rivera-Calzada, P.C.da Fonseca, O.Llorca, L.H.Pearl, L.Spagnolo. Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Res 2011; 39:5757-67; PMID:21450809; http://dx.doi.org/10.1093/nar/gkr146
    • (2011) Nucleic Acids Res , vol.39 , pp. 5757-5767
    • Morris, E.P.1    Rivera-Calzada, A.2    da Fonseca, P.C.3    Llorca, O.4    Pearl, L.H.5    Spagnolo, L.6
  • 29
    • 58149312946 scopus 로고    scopus 로고
    • Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo
    • 19047460
    • J.A.Daniel, M.Pellegrini, J.H.Lee, T.T.Paull, L.Feigenbaum, A.Nussenzweig. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol 2008; 183:777-83; PMID:19047460; http://dx.doi.org/10.1083/jcb.200805154
    • (2008) J Cell Biol , vol.183 , pp. 777-783
    • Daniel, J.A.1    Pellegrini, M.2    Lee, J.H.3    Paull, T.T.4    Feigenbaum, L.5    Nussenzweig, A.6
  • 30
    • 33748648775 scopus 로고    scopus 로고
    • Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
    • 16906133
    • M.Pellegrini, A.Celeste, S.Difilippantonio, R.Guo, W.Wang, L.Feigenbaum, A.Nussenzweig. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature 2006; 443:222-5; PMID:16906133; http://dx.doi.org/10.1038/nature05112
    • (2006) Nature , vol.443 , pp. 222-225
    • Pellegrini, M.1    Celeste, A.2    Difilippantonio, S.3    Guo, R.4    Wang, W.5    Feigenbaum, L.6    Nussenzweig, A.7
  • 31
    • 20744436198 scopus 로고    scopus 로고
    • ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
    • 15964794
    • Z.You, C.Chahwan, J.Bailis, T.Hunter, P.Russell. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 2005; 25:5363-79; PMID:15964794; http://dx.doi.org/10.1128/MCB.25.13.5363-5379.2005
    • (2005) Mol Cell Biol , vol.25 , pp. 5363-5379
    • You, Z.1    Chahwan, C.2    Bailis, J.3    Hunter, T.4    Russell, P.5
  • 32
    • 78650378982 scopus 로고    scopus 로고
    • ATM activation in the presence of oxidative stress
    • 21150274
    • Z.Guo, R.Deshpande, T.T.Paull. ATM activation in the presence of oxidative stress. Cell Cycle 2010; 9:4805-11; PMID:21150274; http://dx.doi.org/10.4161/cc.9.24.14323
    • (2010) Cell Cycle , vol.9 , pp. 4805-4811
    • Guo, Z.1    Deshpande, R.2    Paull, T.T.3
  • 33
    • 77958191599 scopus 로고    scopus 로고
    • ATM activation by oxidative stress
    • 20966255
    • Z.Guo, S.Kozlov, M.F.Lavin, M.D.Person, T.T.Paull. ATM activation by oxidative stress. Science 2010; 330:517-21; PMID:20966255; http://dx.doi.org/10.1126/science.1192912
    • (2010) Science , vol.330 , pp. 517-521
    • Guo, Z.1    Kozlov, S.2    Lavin, M.F.3    Person, M.D.4    Paull, T.T.5
  • 34
    • 0038339042 scopus 로고    scopus 로고
    • Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA
    • 12813460
    • O.Llorca, A.Rivera-Calzada, J.Grantham, K.R.Willison. Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA. Oncogene 2003; 22:3867-74; PMID:12813460; http://dx.doi.org/10.1038/sj.onc.1206649
    • (2003) Oncogene , vol.22 , pp. 3867-3874
    • Llorca, O.1    Rivera-Calzada, A.2    Grantham, J.3    Willison, K.R.4
  • 36
    • 84868444740 scopus 로고    scopus 로고
    • RELION: implementation of a Bayesian approach to cryo-EM structure determination
    • S.H.Scheres. RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Structural Biol 2012; 180:519-30; http://dx.doi.org/10.1016/j.jsb.2012.09.006
    • (2012) J Structural Biol , vol.180 , pp. 519-530
    • Scheres, S.H.1
  • 37
    • 84868498215 scopus 로고    scopus 로고
    • SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles
    • D.Elmlund, H.Elmlund. SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles. J Structural Biol 2012; 180:420-7; http://dx.doi.org/10.1016/j.jsb.2012.07.010
    • (2012) J Structural Biol , vol.180 , pp. 420-427
    • Elmlund, D.1    Elmlund, H.2
  • 38
    • 0142042865 scopus 로고    scopus 로고
    • Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy
    • 14568533
    • P.B.Rosenthal, R.Henderson. Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy. J Mol Biol 2003; 333:721-45; PMID:14568533; http://dx.doi.org/10.1016/j.jmb.2003.07.013
    • (2003) J Mol Biol , vol.333 , pp. 721-745
    • Rosenthal, P.B.1    Henderson, R.2
  • 40
    • 84862862508 scopus 로고    scopus 로고
    • Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps
    • 22696409
    • G.Pintilie, W.Chiu. Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps. Biopolymers 2012; 97:742-60; PMID:22696409; http://dx.doi.org/10.1002/bip.22074
    • (2012) Biopolymers , vol.97 , pp. 742-760
    • Pintilie, G.1    Chiu, W.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.