-
1
-
-
1842431822
-
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
-
15064416
-
J.H.Lee, T.T.Paull. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 2004; 304:93-6; PMID:15064416; http://dx.doi.org/10.1126/science.1091496
-
(2004)
Science
, vol.304
, pp. 93-96
-
-
Lee, J.H.1
Paull, T.T.2
-
2
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
15790808
-
J.H.Lee, T.T.Paull. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 2005; 308:551-4; PMID:15790808; http://dx.doi.org/10.1126/science.1108297
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
3
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
14532133
-
T.Uziel, Y.Lerenthal, L.Moyal, Y.Andegeko, L.Mittelman, Y.Shiloh. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 2003; 22:5612-21; PMID:14532133; http://dx.doi.org/10.1093/emboj/cdg541
-
(2003)
EMBO J
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
4
-
-
84875423827
-
The ATM protein kinase: regulating the cellular response to genotoxic stress, and more
-
Y.Shiloh, Y.Ziv. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat Rev Mol Cell Biol 2013; 14:197-210; http://dx.doi.org/10.1038/nrm3546
-
(2013)
Nat Rev Mol Cell Biol
, vol.14
, pp. 197-210
-
-
Shiloh, Y.1
Ziv, Y.2
-
5
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
12556884
-
C.J.Bakkenist, M.B.Kastan. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421:499-506; PMID:12556884; http://dx.doi.org/10.1038/nature01368
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
6
-
-
34447551681
-
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
-
17486112
-
E.Berkovich, R.J.Monnat, Jr, M.B.Kastan. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol 2007; 9:683-90; PMID:17486112; http://dx.doi.org/10.1038/ncb1599
-
(2007)
Nat Cell Biol
, vol.9
, pp. 683-690
-
-
Berkovich, E.1
Monnat, R.J.2
Kastan, M.B.3
-
7
-
-
78649938817
-
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage
-
21139141
-
A.Bensimon, A.Schmidt, Y.Ziv, R.Elkon, S.Y.Wang, D.J.Chen, R.Aebersold, Y.Shiloh. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci Signal 2010; 3:rs3; PMID:21139141
-
(2010)
Sci Signal
, vol.3
, pp. rs3
-
-
Bensimon, A.1
Schmidt, A.2
Ziv, Y.3
Elkon, R.4
Wang, S.Y.5
Chen, D.J.6
Aebersold, R.7
Shiloh, Y.8
-
8
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
17525332
-
S.Matsuoka, B.A.Ballif, A.Smogorzewska, E.R.McDonald, 3rd, K.E.Hurov, J.Luo, C.E.Bakalarski, Z.Zhao, N.Solimini, Y.Lerenthal, et al. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316:1160-6; PMID:17525332; http://dx.doi.org/10.1126/science.1140321
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
-
9
-
-
84899834860
-
ATM specifically mediates repair of double-strand breaks with blocked DNA ends
-
24572510
-
A.Alvarez-Quilon, A.Serrano-Benitez, J.A.Lieberman, C.Quintero, D.Sanchez-Gutierrez, L.M.Escudero, F.Cortes-Ledesma. ATM specifically mediates repair of double-strand breaks with blocked DNA ends. Nat Commun 2014; 5:3347; PMID:24572510; http://dx.doi.org/10.1038/ncomms4347
-
(2014)
Nat Commun
, vol.5
, pp. 3347
-
-
Alvarez-Quilon, A.1
Serrano-Benitez, A.2
Lieberman, J.A.3
Quintero, C.4
Sanchez-Gutierrez, D.5
Escudero, L.M.6
Cortes-Ledesma, F.7
-
10
-
-
4444339751
-
ATM and ataxia telangiectasia
-
15289825
-
P.J.McKinnon. ATM and ataxia telangiectasia. EMBO Reports 2004; 5:772-6; PMID:15289825; http://dx.doi.org/10.1038/sj.embor.7400210
-
(2004)
EMBO Reports
, vol.5
, pp. 772-776
-
-
McKinnon, P.J.1
-
11
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
19847258
-
S.P.Jackson, J.Bartek. The DNA-damage response in human biology and disease. Nature 2009; 461:1071-8; PMID:19847258; http://dx.doi.org/10.1038/nature08467
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
12
-
-
84924384551
-
Mechanisms of ATM Activation
-
25580527
-
T.T.Paull. Mechanisms of ATM Activation. Ann Rev Biochem 2015; 84:711-38; PMID:25580527; http://dx.doi.org/10.1146/annurev-biochem-060614-034335
-
(2015)
Ann Rev Biochem
, vol.84
, pp. 711-738
-
-
Paull, T.T.1
-
13
-
-
68249113593
-
Common mechanisms of PIKK regulation
-
19464237
-
C.A.Lovejoy, D.Cortez. Common mechanisms of PIKK regulation. DNA Repair 2009; 8:1004-8; PMID:19464237; http://dx.doi.org/10.1016/j.dnarep.2009.04.006
-
(2009)
DNA Repair
, vol.8
, pp. 1004-1008
-
-
Lovejoy, C.A.1
Cortez, D.2
-
14
-
-
70350324640
-
Emerging common themes in regulation of PIKKs and PI3Ks
-
19779456
-
H.Lempiainen, T.D.Halazonetis. Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J 2009; 28:3067-73; PMID:19779456; http://dx.doi.org/10.1038/emboj.2009.281
-
(2009)
EMBO J
, vol.28
, pp. 3067-3073
-
-
Lempiainen, H.1
Halazonetis, T.D.2
-
15
-
-
0034193150
-
FAT: a novel domain in PIK-related kinases
-
10782091
-
R.Bosotti, A.Isacchi, E.L.Sonnhammer. FAT: a novel domain in PIK-related kinases. Trends Biochem Sci 2000; 25:225-7; PMID:10782091; http://dx.doi.org/10.1016/S0968-0004(00)01563-2
-
(2000)
Trends Biochem Sci
, vol.25
, pp. 225-227
-
-
Bosotti, R.1
Isacchi, A.2
Sonnhammer, E.L.3
-
16
-
-
0037462453
-
The ATRs, ATMs, and TORs are giant HEAT repeat proteins
-
12553904
-
J.Perry, N.Kleckner. The ATRs, ATMs, and TORs are giant HEAT repeat proteins. Cell 2003; 112:151-5; PMID:12553904; http://dx.doi.org/10.1016/S0092-8674(03)00033-3
-
(2003)
Cell
, vol.112
, pp. 151-155
-
-
Perry, J.1
Kleckner, N.2
-
17
-
-
0035946941
-
Comparison of ARM and HEAT protein repeats
-
11491282
-
M.A.Andrade, C.Petosa, S.I.O'Donoghue, C.W.Muller, P.Bork. Comparison of ARM and HEAT protein repeats. J Mol Biol 2001; 309:1-18; PMID:11491282; http://dx.doi.org/10.1006/jmbi.2001.4624
-
(2001)
J Mol Biol
, vol.309
, pp. 1-18
-
-
Andrade, M.A.1
Petosa, C.2
O'Donoghue, S.I.3
Muller, C.W.4
Bork, P.5
-
18
-
-
84901982905
-
Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits
-
I.Piazza, A.Rutkowska, A.Ori, M.Walczak, J.Metz, V.Pelechano, M.Beck, C.H.Haering. Association of condensin with chromosomes depends on DNA binding by its HEAT-repeat subunits. Nat Structural Mol Biol 2014; 21:560-8; http://dx.doi.org/10.1038/nsmb.2831
-
(2014)
Nat Structural Mol Biol
, vol.21
, pp. 560-568
-
-
Piazza, I.1
Rutkowska, A.2
Ori, A.3
Walczak, M.4
Metz, J.5
Pelechano, V.6
Beck, M.7
Haering, C.H.8
-
19
-
-
78549243696
-
An unprecedented nucleic acid capture mechanism for excision of DNA damage
-
20927102
-
E.H.Rubinson, A.S.Gowda, T.E.Spratt, B.Gold, B.F.Eichman. An unprecedented nucleic acid capture mechanism for excision of DNA damage. Nature 2010; 468:406-11; PMID:20927102; http://dx.doi.org/10.1038/nature09428
-
(2010)
Nature
, vol.468
, pp. 406-411
-
-
Rubinson, E.H.1
Gowda, A.S.2
Spratt, T.E.3
Gold, B.4
Eichman, B.F.5
-
20
-
-
33745058037
-
Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex
-
A.Dupre, L.Boyer-Chatenet, J.Gautier. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat Structural Mol Biol 2006; 13:451-7; http://dx.doi.org/10.1038/nsmb1090
-
(2006)
Nat Structural Mol Biol
, vol.13
, pp. 451-457
-
-
Dupre, A.1
Boyer-Chatenet, L.2
Gautier, J.3
-
21
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
15758953
-
J.Falck, J.Coates, S.P.Jackson. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 2005; 434:605-11; PMID:15758953; http://dx.doi.org/10.1038/nature03442
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
22
-
-
34250813133
-
ATMIN defines an NBS1-independent pathway of ATM signalling
-
17525732
-
N.Kanu, A.Behrens. ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J 2007; 26:2933-41; PMID:17525732; http://dx.doi.org/10.1038/sj.emboj.7601733
-
(2007)
EMBO J
, vol.26
, pp. 2933-2941
-
-
Kanu, N.1
Behrens, A.2
-
23
-
-
84881614943
-
Functional activation of ATM by the prostate cancer suppressor NKX3.1
-
23890999
-
C.Bowen, J.H.Ju, J.H.Lee, T.T.Paull, E.P.Gelmann. Functional activation of ATM by the prostate cancer suppressor NKX3.1. Cell Reports 2013; 4:516-29; PMID:23890999; http://dx.doi.org/10.1016/j.celrep.2013.06.039
-
(2013)
Cell Reports
, vol.4
, pp. 516-529
-
-
Bowen, C.1
Ju, J.H.2
Lee, J.H.3
Paull, T.T.4
Gelmann, E.P.5
-
24
-
-
84877761058
-
mTOR kinase structure, mechanism and regulation
-
23636326
-
H.Yang, D.G.Rudge, J.D.Koos, B.Vaidialingam, H.J.Yang, N.P.Pavletich. mTOR kinase structure, mechanism and regulation. Nature 2013; 497:217-23; PMID:23636326; http://dx.doi.org/10.1038/nature12122
-
(2013)
Nature
, vol.497
, pp. 217-223
-
-
Yang, H.1
Rudge, D.G.2
Koos, J.D.3
Vaidialingam, B.4
Yang, H.J.5
Pavletich, N.P.6
-
25
-
-
84952950121
-
Architecture of human mTOR complex 1
-
26678875
-
C.H.Aylett, E.Sauer, S.Imseng, D.Boehringer, M.N.Hall, N.Ban, T.Maier. Architecture of human mTOR complex 1. Science 2016; 351:48-52; PMID:26678875; http://dx.doi.org/; http://dx.doi.org/10.1126/science.aaa3870
-
(2016)
Science
, vol.351
, pp. 48-52
-
-
Aylett, C.H.1
Sauer, E.2
Imseng, S.3
Boehringer, D.4
Hall, M.N.5
Ban, N.6
Maier, T.7
-
26
-
-
73849140503
-
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats
-
20023628
-
B.L.Sibanda, D.Y.Chirgadze, T.L.Blundell. Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats. Nature 2010; 463:118-21; PMID:20023628; http://dx.doi.org/10.1038/nature08648
-
(2010)
Nature
, vol.463
, pp. 118-121
-
-
Sibanda, B.L.1
Chirgadze, D.Y.2
Blundell, T.L.3
-
27
-
-
33745217811
-
Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1
-
J.H.Lee, T.T.Paull. Purification and biochemical characterization of ataxia-telangiectasia mutated and Mre11/Rad50/Nbs1. Methods Enzymol 2006; 408:529-39; http://dx.doi.org/10.1016/S0076-6879(06)08033-5
-
(2006)
Methods Enzymol
, vol.408
, pp. 529-539
-
-
Lee, J.H.1
Paull, T.T.2
-
28
-
-
80052199786
-
Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies
-
21450809
-
E.P.Morris, A.Rivera-Calzada, P.C.da Fonseca, O.Llorca, L.H.Pearl, L.Spagnolo. Evidence for a remodelling of DNA-PK upon autophosphorylation from electron microscopy studies. Nucleic Acids Res 2011; 39:5757-67; PMID:21450809; http://dx.doi.org/10.1093/nar/gkr146
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 5757-5767
-
-
Morris, E.P.1
Rivera-Calzada, A.2
da Fonseca, P.C.3
Llorca, O.4
Pearl, L.H.5
Spagnolo, L.6
-
29
-
-
58149312946
-
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo
-
19047460
-
J.A.Daniel, M.Pellegrini, J.H.Lee, T.T.Paull, L.Feigenbaum, A.Nussenzweig. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J Cell Biol 2008; 183:777-83; PMID:19047460; http://dx.doi.org/10.1083/jcb.200805154
-
(2008)
J Cell Biol
, vol.183
, pp. 777-783
-
-
Daniel, J.A.1
Pellegrini, M.2
Lee, J.H.3
Paull, T.T.4
Feigenbaum, L.5
Nussenzweig, A.6
-
30
-
-
33748648775
-
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
-
16906133
-
M.Pellegrini, A.Celeste, S.Difilippantonio, R.Guo, W.Wang, L.Feigenbaum, A.Nussenzweig. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature 2006; 443:222-5; PMID:16906133; http://dx.doi.org/10.1038/nature05112
-
(2006)
Nature
, vol.443
, pp. 222-225
-
-
Pellegrini, M.1
Celeste, A.2
Difilippantonio, S.3
Guo, R.4
Wang, W.5
Feigenbaum, L.6
Nussenzweig, A.7
-
31
-
-
20744436198
-
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
-
15964794
-
Z.You, C.Chahwan, J.Bailis, T.Hunter, P.Russell. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol Cell Biol 2005; 25:5363-79; PMID:15964794; http://dx.doi.org/10.1128/MCB.25.13.5363-5379.2005
-
(2005)
Mol Cell Biol
, vol.25
, pp. 5363-5379
-
-
You, Z.1
Chahwan, C.2
Bailis, J.3
Hunter, T.4
Russell, P.5
-
32
-
-
78650378982
-
ATM activation in the presence of oxidative stress
-
21150274
-
Z.Guo, R.Deshpande, T.T.Paull. ATM activation in the presence of oxidative stress. Cell Cycle 2010; 9:4805-11; PMID:21150274; http://dx.doi.org/10.4161/cc.9.24.14323
-
(2010)
Cell Cycle
, vol.9
, pp. 4805-4811
-
-
Guo, Z.1
Deshpande, R.2
Paull, T.T.3
-
33
-
-
77958191599
-
ATM activation by oxidative stress
-
20966255
-
Z.Guo, S.Kozlov, M.F.Lavin, M.D.Person, T.T.Paull. ATM activation by oxidative stress. Science 2010; 330:517-21; PMID:20966255; http://dx.doi.org/10.1126/science.1192912
-
(2010)
Science
, vol.330
, pp. 517-521
-
-
Guo, Z.1
Kozlov, S.2
Lavin, M.F.3
Person, M.D.4
Paull, T.T.5
-
34
-
-
0038339042
-
Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA
-
12813460
-
O.Llorca, A.Rivera-Calzada, J.Grantham, K.R.Willison. Electron microscopy and 3D reconstructions reveal that human ATM kinase uses an arm-like domain to clamp around double-stranded DNA. Oncogene 2003; 22:3867-74; PMID:12813460; http://dx.doi.org/10.1038/sj.onc.1206649
-
(2003)
Oncogene
, vol.22
, pp. 3867-3874
-
-
Llorca, O.1
Rivera-Calzada, A.2
Grantham, J.3
Willison, K.R.4
-
35
-
-
33845332754
-
EMAN2: an extensible image processing suite for electron microscopy
-
G.Tang, L.Peng, P.R.Baldwin, D.S.Mann, W.Jiang, I.Rees, S.J.Ludtke. EMAN2: an extensible image processing suite for electron microscopy. J Structural Biol 2007; 157:38-46; http://dx.doi.org/10.1016/j.jsb.2006.05.009
-
(2007)
J Structural Biol
, vol.157
, pp. 38-46
-
-
Tang, G.1
Peng, L.2
Baldwin, P.R.3
Mann, D.S.4
Jiang, W.5
Rees, I.6
Ludtke, S.J.7
-
36
-
-
84868444740
-
RELION: implementation of a Bayesian approach to cryo-EM structure determination
-
S.H.Scheres. RELION: implementation of a Bayesian approach to cryo-EM structure determination. J Structural Biol 2012; 180:519-30; http://dx.doi.org/10.1016/j.jsb.2012.09.006
-
(2012)
J Structural Biol
, vol.180
, pp. 519-530
-
-
Scheres, S.H.1
-
37
-
-
84868498215
-
SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles
-
D.Elmlund, H.Elmlund. SIMPLE: Software for ab initio reconstruction of heterogeneous single-particles. J Structural Biol 2012; 180:420-7; http://dx.doi.org/10.1016/j.jsb.2012.07.010
-
(2012)
J Structural Biol
, vol.180
, pp. 420-427
-
-
Elmlund, D.1
Elmlund, H.2
-
38
-
-
0142042865
-
Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy
-
14568533
-
P.B.Rosenthal, R.Henderson. Optimal determination of particle orientation, absolute hand, and contrast loss in single-particle electron cryomicroscopy. J Mol Biol 2003; 333:721-45; PMID:14568533; http://dx.doi.org/10.1016/j.jmb.2003.07.013
-
(2003)
J Mol Biol
, vol.333
, pp. 721-745
-
-
Rosenthal, P.B.1
Henderson, R.2
-
39
-
-
4444221565
-
UCSF Chimera–a visualization system for exploratory research and analysis
-
E.F.Pettersen, T.D.Goddard, C.C.Huang, G.S.Couch, D.M.Greenblatt, E.C.Meng, T.E.Ferrin. UCSF Chimera–a visualization system for exploratory research and analysis. J Computational Chem 2004; 25:1605-12; http://dx.doi.org/10.1002/jcc.20084
-
(2004)
J Computational Chem
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
40
-
-
84862862508
-
Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps
-
22696409
-
G.Pintilie, W.Chiu. Comparison of Segger and other methods for segmentation and rigid-body docking of molecular components in cryo-EM density maps. Biopolymers 2012; 97:742-60; PMID:22696409; http://dx.doi.org/10.1002/bip.22074
-
(2012)
Biopolymers
, vol.97
, pp. 742-760
-
-
Pintilie, G.1
Chiu, W.2
|