-
2
-
-
0033821266
-
The molecular basis and clinical management of ataxia telangiectasia
-
Spacey SD, Gatti RA, Bebb G. 2000. The molecular basis and clinical management of ataxia telangiectasia. Can. J. Neurol. Sci. 27:184-91
-
(2000)
Can. J. Neurol. Sci.
, vol.27
, pp. 184-191
-
-
Spacey, S.D.1
Gatti, R.A.2
Bebb, G.3
-
4
-
-
52449114574
-
Ataxia-telangiectasia: From a rare disorder to a paradigm for cell signalling and cancer
-
Lavin MF. 2008. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 9:759-69
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 759-769
-
-
Lavin, M.F.1
-
6
-
-
0029057336
-
A single ataxia telangiectasia gene with a product similar to PI-3 kinase
-
Savitsky K, Bar-Shira A, Gilad S, Rotman G, Ziv Y, et al. 1995. A single ataxia telangiectasia gene with a product similar to PI-3 kinase. Science 268:1749-53
-
(1995)
Science
, vol.268
, pp. 1749-1753
-
-
Savitsky, K.1
Bar-Shira, A.2
Gilad, S.3
Rotman, G.4
Ziv, Y.5
-
7
-
-
0024205754
-
Localization of an ataxia-telangiectasia gene to chromosome 11q22-23
-
Gatti RA, Berkel I, Boder E, Braedt G, Charmley P, et al. 1988. Localization of an ataxia-telangiectasia gene to chromosome 11q22-23. Nature 336:577-80
-
(1988)
Nature
, vol.336
, pp. 577-580
-
-
Gatti, R.A.1
Berkel, I.2
Boder, E.3
Braedt, G.4
Charmley, P.5
-
8
-
-
0028827312
-
The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
-
Savitsky K, Sfez S, Tagle DA, Ziv Y, Sartiel A, et al. 1995. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species. Hum. Mol. Genet. 4:2025-32
-
(1995)
Hum. Mol. Genet.
, vol.4
, pp. 2025-2032
-
-
Savitsky, K.1
Sfez, S.2
Tagle, D.A.3
Ziv, Y.4
Sartiel, A.5
-
9
-
-
0031016990
-
ATM gene product phosphorylates IκB-α
-
Jung M, Kondratyev A, Lee SA, Dimtchev A, Dritschilo A. 1997. ATM gene product phosphorylates IκB-α. Cancer Res. 57:24-27
-
(1997)
Cancer Res.
, vol.57
, pp. 24-27
-
-
Jung, M.1
Kondratyev, A.2
Lee, S.A.3
Dimtchev, A.4
Dritschilo, A.5
-
10
-
-
68249113593
-
Common mechanisms of PIKK regulation
-
Lovejoy CA, Cortez D. 2009. Common mechanisms of PIKK regulation. DNA Repair 8:1004-8
-
(2009)
DNA Repair
, vol.8
, pp. 1004-1008
-
-
Lovejoy, C.A.1
Cortez, D.2
-
11
-
-
0033621392
-
Substrate specificities and identification of putative substrates of ATM kinase family members
-
Kim ST, Lim DS, Canman CE, Kastan MB. 1999. Substrate specificities and identification of putative substrates of ATM kinase family members. J. Biol. Chem. 274:37538-43
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37538-37543
-
-
Kim, S.T.1
Lim, D.S.2
Canman, C.E.3
Kastan, M.B.4
-
12
-
-
3242882820
-
PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways
-
Abraham RT. 2004. PI 3-kinase related kinases: 'big' players in stress-induced signaling pathways. DNA Repair 3:883-87
-
(2004)
DNA Repair
, vol.3
, pp. 883-887
-
-
Abraham, R.T.1
-
13
-
-
80054736907
-
Structural basis for activation and inhibition of class i phosphoinositide 3-kinases
-
Vadas O, Burke JE, Zhang X, Berndt A, Williams RL. 2011. Structural basis for activation and inhibition of class I phosphoinositide 3-kinases. Sci. Signal. 4:re2
-
(2011)
Sci. Signal
, vol.4
, pp. re2
-
-
Vadas, O.1
Burke, J.E.2
Zhang, X.3
Berndt, A.4
Williams, R.L.5
-
14
-
-
70350324640
-
Emerging common themes in regulation of PIKKs and PI3Ks
-
Lempiainen H, Halazonetis TD. 2009. Emerging common themes in regulation of PIKKs and PI3Ks. EMBO J. 28:3067-73
-
(2009)
EMBO J.
, vol.28
, pp. 3067-3073
-
-
Lempiainen, H.1
Halazonetis, T.D.2
-
15
-
-
0037462453
-
TheATRs, ATMs, and TOR sare giant HEAT repeat proteins
-
Perry J, Kleckner N. 2003. TheATRs, ATMs, and TOR sare giant HEAT repeat proteins. Cell 112:151-55
-
(2003)
Cell
, vol.112
, pp. 151-155
-
-
Perry, J.1
Kleckner, N.2
-
16
-
-
0035946941
-
Comparison of ARM and HEAT protein repeats
-
Andrade MA, Petosa C, O'Donoghue SI, Müller CW, Bork P. 2001. Comparison of ARM and HEAT protein repeats. J. Mol. Biol. 309:1-18
-
(2001)
J. Mol. Biol.
, vol.309
, pp. 1-18
-
-
Andrade, M.A.1
Petosa, C.2
O'donoghue, S.I.3
Müller, C.W.4
Bork, P.5
-
18
-
-
34948899943
-
Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template
-
Williams RS, Williams JS, Tainer JA. 2007. Mre11-Rad50-Nbs1 is a keystone complex connecting DNA repair machinery, double-strand break signaling, and the chromatin template. Biochem. Cell Biol. 85:509-20
-
(2007)
Biochem. Cell Biol.
, vol.85
, pp. 509-520
-
-
Williams, R.S.1
Williams, J.S.2
Tainer, J.A.3
-
19
-
-
78649451417
-
Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection
-
Paull TT. 2010. Making the best of the loose ends: Mre11/Rad50 complexes and Sae2 promote DNA double-strand break resection. DNA Repair 9:1283-91
-
(2010)
DNA Repair
, vol.9
, pp. 1283-1291
-
-
Paull, T.T.1
-
20
-
-
80755187806
-
Double-strand break end resection and repair pathway choice
-
Symington LS, Gautier J. 2011. Double-strand break end resection and repair pathway choice. Annu. Rev. Genet. 45:247-71
-
(2011)
Annu. Rev. Genet.
, vol.45
, pp. 247-271
-
-
Symington, L.S.1
Gautier, J.2
-
21
-
-
84919421154
-
The Mre11/Rad50/Nbs1 complex: Recent insights into catalytic activities and ATP-driven conformational changes
-
Paull TT, Deshpande RA. 2014. The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes. Exp. Cell Res. 329:139-47
-
(2014)
Exp. Cell Res.
, vol.329
, pp. 139-147
-
-
Paull, T.T.1
Deshpande, R.A.2
-
22
-
-
0033544724
-
TheDNAdouble-strand break repair gene hMre11 is mutated in individuals with an ataxia-telangiectasia-like disorder
-
Stewart GS, Maser RS, Stankovic T, Bressan DA, Kaplan MI, et al. 1999. TheDNAdouble-strand break repair gene hMre11 is mutated in individuals with an ataxia-telangiectasia-like disorder. Cell 99:577-87
-
(1999)
Cell
, vol.99
, pp. 577-587
-
-
Stewart, G.S.1
Maser, R.S.2
Stankovic, T.3
Bressan, D.A.4
Kaplan, M.I.5
-
24
-
-
0033594904
-
Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation
-
Luo G, Yao MS, Bender CF, Mills M, Bladl AR, et al. 1999. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. PNAS 96:7376-81
-
(1999)
PNAS
, vol.96
, pp. 7376-7381
-
-
Luo, G.1
Yao, M.S.2
Bender, C.F.3
Mills, M.4
Bladl, A.R.5
-
25
-
-
0030749867
-
Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells
-
Xiao Y, Weaver DT. 1997. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 25:2985-91
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 2985-2991
-
-
Xiao, Y.1
Weaver, D.T.2
-
26
-
-
0035936554
-
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
-
Zhu J, Petersen S, Tessarollo L, Nussenzweig A. 2001. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11:105-9
-
(2001)
Curr. Biol.
, vol.11
, pp. 105-109
-
-
Zhu, J.1
Petersen, S.2
Tessarollo, L.3
Nussenzweig, A.4
-
27
-
-
3242889151
-
Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis
-
Taylor AM, Groom A, Byrd PJ. 2004. Ataxia-telangiectasia-like disorder (ATLD)-its clinical presentation and molecular basis. DNA Repair 3:1219-25
-
(2004)
DNA Repair
, vol.3
, pp. 1219-1225
-
-
Taylor, A.M.1
Groom, A.2
Byrd, P.J.3
-
28
-
-
0142136826
-
Requirement of the MRN complex for ATM activation by DNA damage
-
Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. 2003. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22:5612-21
-
(2003)
EMBO J.
, vol.22
, pp. 5612-5621
-
-
Uziel, T.1
Lerenthal, Y.2
Moyal, L.3
Andegeko, Y.4
Mittelman, L.5
Shiloh, Y.6
-
29
-
-
0033485758
-
Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells
-
Yamaguchi-Iwai Y, Sonoda E, Sasaki MS, Morrison C, Haraguchi T, et al. 1999. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J. 18:6619-29
-
(1999)
EMBO J.
, vol.18
, pp. 6619-6629
-
-
Yamaguchi-Iwai, Y.1
Sonoda, E.2
Sasaki, M.S.3
Morrison, C.4
Haraguchi, T.5
-
30
-
-
58249101175
-
Rad50 is dispensable for the maintenance and viability of postmitotic tissues
-
Adelman CA, De S, Petrini JH. 2009. Rad50 is dispensable for the maintenance and viability of postmitotic tissues. Mol. Cell. Biol. 29:483-92
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 483-492
-
-
Adelman, C.A.1
De S Petrini, J.H.2
-
31
-
-
0031466618
-
Ataxia-telangiectasia and theNijmegen breakage syndrome: Related disorders but genes apart
-
Shiloh Y. 1997. Ataxia-telangiectasia and theNijmegen breakage syndrome: related disorders but genes apart. Annu. Rev. Genet. 31:635-62
-
(1997)
Annu. Rev. Genet.
, vol.31
, pp. 635-662
-
-
Shiloh, Y.1
-
32
-
-
0032076190
-
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome
-
Varon R, Vissinga C, Platzer M, Cerosaletti KM, Chrzanowska KH, et al. 1998. Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell 93:467-76
-
(1998)
Cell
, vol.93
, pp. 467-476
-
-
Varon, R.1
Vissinga, C.2
Platzer, M.3
Cerosaletti, K.M.4
Chrzanowska, K.H.5
-
33
-
-
33749678963
-
Ataxia-telangiectasia and related diseases
-
Frappart PO, McKinnon PJ. 2006. Ataxia-telangiectasia and related diseases. Neuromol. Med. 8:495-511
-
(2006)
Neuromol. Med.
, vol.8
, pp. 495-511
-
-
Frappart, P.O.1
McKinnon, P.J.2
-
34
-
-
79951852632
-
Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly
-
Matsumoto Y, Miyamoto T, Sakamoto H, Izumi H, Nakazawa Y, et al. 2011. Two unrelated patients with MRE11A mutations and Nijmegen breakage syndrome-like severe microcephaly. DNA Repair 10:314-21
-
(2011)
DNA Repair
, vol.10
, pp. 314-321
-
-
Matsumoto, Y.1
Miyamoto, T.2
Sakamoto, H.3
Izumi, H.4
Nakazawa, Y.5
-
35
-
-
65149095154
-
Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder
-
Waltes R, Kalb R, Gatei M, Kijas AW, Stumm M, et al. 2009. Human RAD50 deficiency in a Nijmegen breakage syndrome-like disorder. Am. J. Hum. Genet. 84:605-16
-
(2009)
Am. J. Hum. Genet.
, vol.84
, pp. 605-616
-
-
Waltes, R.1
Kalb, R.2
Gatei, M.3
Kijas, A.W.4
Stumm, M.5
-
36
-
-
0033563229
-
Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex
-
Paull TT, Gellert M. 1999. Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex. Genes Dev. 13:1276-88
-
(1999)
Genes Dev.
, vol.13
, pp. 1276-1288
-
-
Paull, T.T.1
Gellert, M.2
-
37
-
-
0242413320
-
Regulation ofMre11/Rad50 by Nbs1: Effects on nucleotide-dependentDNAbinding and association with ATLDmutant complexes
-
Lee J-H, Ghirlando R, Bhaskara V, Hoffmeyer MR, Gu J, Paull TT. 2003. Regulation ofMre11/Rad50 by Nbs1: effects on nucleotide-dependentDNAbinding and association with ATLDmutant complexes. J. Biol. Chem. 278:45171-81
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 45171-45181
-
-
Lee, J.-H.1
Ghirlando, R.2
Bhaskara, V.3
Hoffmeyer, M.R.4
Gu, J.5
Paull, T.T.6
-
38
-
-
0034066847
-
Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation
-
Cerosaletti KM, Desai-Mehta A, Yeo TC, Kraakman-Van Der Zwet M, Zdzienicka MZ, Concannon P. 2000. Retroviral expression of the NBS1 gene in cultured Nijmegen breakage syndrome cells restores normal radiation sensitivity and nuclear focus formation. Mutagenesis 15:281-86
-
(2000)
Mutagenesis
, vol.15
, pp. 281-286
-
-
Cerosaletti, K.M.1
Desai-Mehta, A.2
Yeo, T.C.3
Kraakman-Van Der Zwet, M.4
Zdzienicka, M.Z.5
Concannon, P.6
-
39
-
-
0034997651
-
Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization
-
Desai-Mehta A, Cerosaletti KM, Concannon P. 2001. Distinct functional domains of nibrin mediate Mre11 binding, focus formation, and nuclear localization. Mol. Cell. Biol. 21:2184-91
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2184-2191
-
-
Desai-Mehta, A.1
Cerosaletti, K.M.2
Concannon, P.3
-
40
-
-
84888774584
-
Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms
-
Regal JA, Festerling TA, Buis JM, Ferguson DO. 2013. Disease-associated MRE11 mutants impact ATM/ATR DNA damage signaling by distinct mechanisms. Hum. Mol. Genet. 22:5146-59
-
(2013)
Hum. Mol. Genet.
, vol.22
, pp. 5146-5159
-
-
Regal, J.A.1
Festerling, T.A.2
Buis, J.M.3
Ferguson, D.O.4
-
41
-
-
58849135489
-
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS
-
Shull ER, Lee Y, Nakane H, Stracker TH, Zhao J, et al. 2009. Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev. 23:171-80
-
(2009)
Genes Dev.
, vol.23
, pp. 171-180
-
-
Shull, E.R.1
Lee, Y.2
Nakane, H.3
Stracker, T.H.4
Zhao, J.5
-
42
-
-
29144450333
-
The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: Implications for the Mre11 complex as a DNA damage sensor
-
Morales M, Theunissen JW, Kim CF, Kitagawa R, Kastan MB, Petrini JH. 2005. The Rad50S allele promotes ATM-dependent DNA damage responses and suppresses ATM deficiency: implications for the Mre11 complex as a DNA damage sensor. Genes Dev. 19:3043-54
-
(2005)
Genes Dev.
, vol.19
, pp. 3043-3054
-
-
Morales, M.1
Theunissen, J.W.2
Kim, C.F.3
Kitagawa, R.4
Kastan, M.B.5
Petrini, J.H.6
-
43
-
-
84896820650
-
The Rad50 hook domain regulates DNA damage signaling and tumorigenesis
-
Roset R, Inagaki A, Hohl M, Brenet F, Lafrance-Vanasse J, et al. 2014. The Rad50 hook domain regulates DNA damage signaling and tumorigenesis. Genes Dev. 28:451-62
-
(2014)
Genes Dev.
, vol.28
, pp. 451-462
-
-
Roset, R.1
Inagaki, A.2
Hohl, M.3
Brenet, F.4
Lafrance-Vanasse, J.5
-
44
-
-
0025334351
-
Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination
-
Alani E, Padmore R, Kleckner N. 1990. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Cell 61:419-36
-
(1990)
Cell
, vol.61
, pp. 419-436
-
-
Alani, E.1
Padmore, R.2
Kleckner, N.3
-
45
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist CJ, Kastan MB. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421:499-506
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
46
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S, Ballif BA, Smogorzewska A, McDonald ER 3rd, Hurov KE, et al. 2007. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316:1160-66
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald, E.R.4
Hurov, K.E.5
-
47
-
-
78649938817
-
ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage
-
Bensimon A, Schmidt A, Ziv Y, Elkon R, Wang SY, et al. 2010. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci. Signal. 3:rs3
-
(2010)
Sci. Signal
, vol.3
, pp. rs3
-
-
Bensimon, A.1
Schmidt, A.2
Ziv, Y.3
Elkon, R.4
Wang, S.Y.5
-
48
-
-
84875423827
-
The ATM protein kinase: Regulating the cellular response to genotoxic stress, and more
-
Shiloh Y, Ziv Y. 2013. The ATM protein kinase: regulating the cellular response to genotoxic stress, and more. Nat. Rev. Mol. Cell Biol. 14:197-210
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 197-210
-
-
Shiloh, Y.1
Ziv, Y.2
-
49
-
-
34447551681
-
Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair
-
Berkovich E, Monnat RJ Jr., Kastan MB. 2007. Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat. Cell Biol. 9:683-90
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 683-690
-
-
Berkovich, E.1
Monnat, R.J.2
Kastan, M.B.3
-
50
-
-
33747614605
-
Involvement of novel autophosphorylation sites in ATM activation
-
Kozlov SV, Graham ME, Peng C, Chen P, Robinson PJ, Lavin MF. 2006. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 25:3504-14
-
(2006)
EMBO J.
, vol.25
, pp. 3504-3514
-
-
Kozlov, S.V.1
Graham, M.E.2
Peng, C.3
Chen, P.4
Robinson, P.J.5
Lavin, M.F.6
-
51
-
-
33748648775
-
Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
-
Pellegrini M, Celeste A, Difilippantonio S, Guo R, Wang W, et al. 2006. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature 443:222-25
-
(2006)
Nature
, vol.443
, pp. 222-225
-
-
Pellegrini, M.1
Celeste, A.2
Difilippantonio, S.3
Guo, R.4
Wang, W.5
-
52
-
-
58149312946
-
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo
-
Daniel JA, Pellegrini M, Lee JH, Paull TT, Feigenbaum L, Nussenzweig A. 2008. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J. Cell Biol. 183:777-83
-
(2008)
J. Cell Biol.
, vol.183
, pp. 777-783
-
-
Daniel, J.A.1
Pellegrini, M.2
Lee, J.H.3
Paull, T.T.4
Feigenbaum, L.5
Nussenzweig, A.6
-
53
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee JH, Paull TT. 2005. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308:551-54
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
54
-
-
33745058037
-
Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex
-
Dupre A, Boyer-Chatenet L, Gautier J. 2006. Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex. Nat. Struct. Mol. Biol. 13:451-57
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 451-457
-
-
Dupre, A.1
Boyer-Chatenet, L.2
Gautier, J.3
-
55
-
-
20744436198
-
ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1
-
You Z, Chahwan C, Bailis J, Hunter T, Russell P. 2005. ATM activation and its recruitment to damaged DNA require binding to the C terminus of Nbs1. Mol. Cell. Biol. 25:5363-79
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5363-5379
-
-
You, Z.1
Chahwan, C.2
Bailis, J.3
Hunter, T.4
Russell, P.5
-
56
-
-
76149146422
-
Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
-
So S, Davis AJ, Chen DJ. 2009. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J. Cell Biol. 187:977-90
-
(2009)
J. Cell Biol.
, vol.187
, pp. 977-990
-
-
So, S.1
Davis, A.J.2
Chen, D.J.3
-
57
-
-
24944516931
-
A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM
-
Sun Y, Jiang X, Chen S, Fernandes N, Price BD. 2005. A role for the Tip60 histone acetyltransferase in the acetylation and activation of ATM. PNAS 102:13182-87
-
(2005)
PNAS
, vol.102
, pp. 13182-13187
-
-
Sun, Y.1
Jiang, X.2
Chen, S.3
Fernandes, N.4
Price, B.D.5
-
59
-
-
84878677036
-
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling
-
Kaidi A, Jackson SP. 2013. KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling. Nature 498:70-74
-
(2013)
Nature
, vol.498
, pp. 70-74
-
-
Kaidi, A.1
Jackson, S.P.2
-
60
-
-
79960467426
-
ATR autophosphorylation as a molecular switch for checkpoint activation
-
Liu S, Shiotani B, Lahiri M, Marechal A, Tse A, et al. 2011. ATR autophosphorylation as a molecular switch for checkpoint activation. Mol. Cell 43:192-202
-
(2011)
Mol. Cell
, vol.43
, pp. 192-202
-
-
Liu, S.1
Shiotani, B.2
Lahiri, M.3
Marechal, A.4
Tse, A.5
-
61
-
-
2242484657
-
Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase
-
Douglas P, Sapkota GP, Morrice N, Yu Y, Goodarzi AA, et al. 2002. Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase. Biochem. J. 368:243-51
-
(2002)
Biochem. J.
, vol.368
, pp. 243-251
-
-
Douglas, P.1
Sapkota, G.P.2
Morrice, N.3
Yu, Y.4
Goodarzi, A.A.5
-
62
-
-
1842431822
-
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex
-
Lee JH, Paull TT. 2004. Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex. Science 304:93-96
-
(2004)
Science
, vol.304
, pp. 93-96
-
-
Lee, J.H.1
Paull, T.T.2
-
63
-
-
61649093808
-
Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks
-
Shiotani B, Zou L. 2009. Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks. Mol. Cell 33:547-58
-
(2009)
Mol. Cell
, vol.33
, pp. 547-558
-
-
Shiotani, B.1
Zou, L.2
-
64
-
-
0033613099
-
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM
-
Smith GC, Cary RB, Lakin ND, Hann BC, Teo SH, et al. 1999. Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM. PNAS 96:11134-39
-
(1999)
PNAS
, vol.96
, pp. 11134-11139
-
-
Smith, G.C.1
Cary, R.B.2
Lakin, N.D.3
Hann, B.C.4
Teo, S.H.5
-
65
-
-
84896125249
-
ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling
-
Deshpande RA, Williams GJ, Limbo O, Williams RS, Kuhnlein J, et al. 2014. ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling. EMBO J. 33:482-500
-
(2014)
EMBO J.
, vol.33
, pp. 482-500
-
-
Deshpande, R.A.1
Williams, G.J.2
Limbo, O.3
Williams, R.S.4
Kuhnlein, J.5
-
66
-
-
84888082048
-
Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET
-
Cannon B, Kuhnlein J, Yang SH, Cheng A, Schindler D, et al. 2013. Visualization of local DNA unwinding by Mre11/Rad50/Nbs1 using single-molecule FRET. PNAS 110:18868-73
-
(2013)
PNAS
, vol.110
, pp. 18868-18873
-
-
Cannon, B.1
Kuhnlein, J.2
Yang, S.H.3
Cheng, A.4
Schindler, D.5
-
67
-
-
19344371406
-
Mre11 assembles linear DNA fragments into DNA damage signaling complexes
-
Costanzo V, Paull TT, Gottesman M, Gautier J. 2004. Mre11 assembles linear DNA fragments into DNA damage signaling complexes. PLOS Biol. 2:e110
-
(2004)
PLOS Biol.
, vol.2
, pp. e110
-
-
Costanzo, V.1
Paull, T.T.2
Gottesman, M.3
Gautier, J.4
-
68
-
-
84877124011
-
Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex
-
Lee JH, Mand MR, Deshpande RA, Kinoshita E, Yang SH, et al. 2013. Ataxia telangiectasia-mutated (ATM) kinase activity is regulated by ATP-driven conformational changes in the Mre11/Rad50/Nbs1 (MRN) complex. J. Biol. Chem. 288:12840-51
-
(2013)
J. Biol. Chem.
, vol.288
, pp. 12840-12851
-
-
Lee, J.H.1
Mand, M.R.2
Deshpande, R.A.3
Kinoshita, E.4
Yang, S.H.5
-
69
-
-
0018065032
-
Human disorders showing increased sensitivity to the induction of genetic damage
-
Arlett CF, Lehmann AR. 1978. Human disorders showing increased sensitivity to the induction of genetic damage. Annu. Rev. Genet. 12:95-115
-
(1978)
Annu. Rev. Genet.
, vol.12
, pp. 95-115
-
-
Arlett, C.F.1
Lehmann, A.R.2
-
70
-
-
0035851090
-
Nuclear retention of ATM at sites of DNA double strand breaks
-
Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G. 2001. Nuclear retention of ATM at sites of DNA double strand breaks. J. Biol. Chem. 276:38224-30
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 38224-38230
-
-
Andegeko, Y.1
Moyal, L.2
Mittelman, L.3
Tsarfaty, I.4
Shiloh, Y.5
Rotman, G.6
-
71
-
-
35748967571
-
Rapid activation of ATM on DNA flanking double-strand breaks
-
You Z, Bailis JM, Johnson SA, Dilworth SM, Hunter T. 2007. Rapid activation of ATM on DNA flanking double-strand breaks. Nat. Cell Biol. 9:1311-18
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 1311-1318
-
-
You, Z.1
Bailis, J.M.2
Johnson, S.A.3
Dilworth, S.M.4
Hunter, T.5
-
72
-
-
15844394846
-
Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage
-
Falck J, Coates J, Jackson SP. 2005. Conserved modes of recruitment of ATM, ATR and DNA-PKcs to sites of DNA damage. Nature 434:605-11
-
(2005)
Nature
, vol.434
, pp. 605-611
-
-
Falck, J.1
Coates, J.2
Jackson, S.P.3
-
73
-
-
33644538562
-
Active role for nibrin in the kinetics of atm activation
-
Cerosaletti K, Wright J, Concannon P. 2006. Active role for nibrin in the kinetics of atm activation. Mol. Cell. Biol. 26:1691-99
-
(2006)
Mol. Cell. Biol.
, vol.26
, pp. 1691-1699
-
-
Cerosaletti, K.1
Wright, J.2
Concannon, P.3
-
74
-
-
0032085295
-
The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks
-
Paull TT, Gellert M. 1998. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1:969-79
-
(1998)
Mol. Cell
, vol.1
, pp. 969-979
-
-
Paull, T.T.1
Gellert, M.2
-
75
-
-
53549093050
-
The P. Furiosus Mre11/Rad50 complex promotes 5′ strand resection at a DNA double-strand break
-
Hopkins B, Paull TT. 2008. The P. furiosus Mre11/Rad50 complex promotes 5′ strand resection at a DNA double-strand break. Cell 135:250-60
-
(2008)
Cell
, vol.135
, pp. 250-260
-
-
Hopkins, B.1
Paull, T.T.2
-
76
-
-
0032555480
-
Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95
-
Trujillo KM, Yuan SS, Lee EY, Sung P. 1998. Nuclease activities in a complex of human recombination and DNA repair factors Rad50, Mre11, and p95. J. Biol. Chem. 273:21447-50
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 21447-21450
-
-
Trujillo, K.M.1
Yuan, S.S.2
Lee, E.Y.3
Sung, P.4
-
77
-
-
27544491633
-
DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50/Mre11 complex
-
Trujillo KM, Sung P. 2001. DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50/Mre11 complex. J. Biol. Chem. 13:13
-
(2001)
J. Biol. Chem.
, vol.13
, pp. 13
-
-
Trujillo, K.M.1
Sung, P.2
-
78
-
-
52949109260
-
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
-
Buis J, Wu Y, Deng Y, Leddon J, Westfield G, et al. 2008. Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell 135:85-96
-
(2008)
Cell
, vol.135
, pp. 85-96
-
-
Buis, J.1
Wu, Y.2
Deng, Y.3
Leddon, J.4
Westfield, G.5
-
79
-
-
84892369333
-
DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities
-
Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, et al. 2014. DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol. Cell 53:7-18
-
(2014)
Mol. Cell
, vol.53
, pp. 7-18
-
-
Shibata, A.1
Moiani, D.2
Arvai, A.S.3
Perry, J.4
Harding, S.M.5
-
80
-
-
47949121598
-
Mre11-Rad50-Nbs1 dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity
-
Jazayeri A, Balestrini A, Garner E, Haber JE, Costanzo V. 2008. Mre11-Rad50-Nbs1 dependent processing of DNA breaks generates oligonucleotides that stimulate ATM activity. EMBO J. 27:1953-62
-
(2008)
EMBO J.
, vol.27
, pp. 1953-1962
-
-
Jazayeri, A.1
Balestrini, A.2
Garner, E.3
Haber, J.E.4
Costanzo, V.5
-
81
-
-
0034964498
-
A DNA damage response pathway controlled by Tel1 and the Mre11 complex
-
Usui T, Ogawa H, Petrini JH. 2001. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell 7:1255-66
-
(2001)
Mol. Cell
, vol.7
, pp. 1255-1266
-
-
Usui, T.1
Ogawa, H.2
Petrini, J.H.3
-
82
-
-
78751536258
-
Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks
-
Limbo O, Porter-Goff ME, Rhind N, Russell P. 2011. Mre11 nuclease activity and Ctp1 regulate Chk1 activation by Rad3ATR and Tel1ATM checkpoint kinases at double-strand breaks. Mol. Cell. Biol. 31:573-83
-
(2011)
Mol. Cell. Biol.
, vol.31
, pp. 573-583
-
-
Limbo, O.1
Porter-Goff, M.E.2
Rhind, N.3
Russell, P.4
-
83
-
-
0029150855
-
TEL1, an S. Cerevisiae homolog of the human genemutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1
-
Morrow DM, Tagle DA, Shiloh Y, Collins FS, Hieter P. 1995. TEL1, an S. cerevisiae homolog of the human genemutated in ataxia telangiectasia, is functionally related to the yeast checkpoint gene MEC1. Cell 82:831-40
-
(1995)
Cell
, vol.82
, pp. 831-840
-
-
Morrow, D.M.1
Tagle, D.A.2
Shiloh, Y.3
Collins, F.S.4
Hieter, P.5
-
84
-
-
80455173885
-
The Rad 50 coiled-coil domain is indispensable for Mre11 complex functions
-
Hohl M, Kwon Y, Galvan SM, Xue X, Tous C, et al. 2011. The Rad 50 coiled-coil domain is indispensable for Mre11 complex functions. Nat. Struct. Mol. Biol. 18:1124-31
-
(2011)
Nat. Struct. Mol. Biol.
, vol.18
, pp. 1124-1131
-
-
Hohl, M.1
Kwon, Y.2
Galvan, S.M.3
Xue, X.4
Tous, C.5
-
85
-
-
33746841423
-
Rad50S alleles of the Mre11 complex: Questions answered and questions raised
-
Usui T, Petrini JH, Morales M. 2006. Rad50S alleles of the Mre11 complex: questions answered and questions raised. Exp. Cell Res. 312:2694-99
-
(2006)
Exp. Cell Res.
, vol.312
, pp. 2694-2699
-
-
Usui, T.1
Petrini, J.H.2
Morales, M.3
-
86
-
-
70349850935
-
PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin
-
Di Virgilio M, Ying CY, Gautier J. 2009. PIKK-dependent phosphorylation of Mre11 induces MRN complex inactivation by disassembly from chromatin. DNA Repair 8:1311-20
-
(2009)
DNA Repair
, vol.8
, pp. 1311-1320
-
-
Di Virgilio, M.1
Ying, C.Y.2
Gautier, J.3
-
87
-
-
80052424280
-
ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control
-
Gatei M, Jakob B, Chen P, Kijas AW, Becherel OJ, et al. 2011. ATM protein-dependent phosphorylation of Rad50 protein regulates DNA repair and cell cycle control. J. Biol. Chem. 286:31542-56
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 31542-31556
-
-
Gatei, M.1
Jakob, B.2
Chen, P.3
Kijas, A.W.4
Becherel, O.J.5
-
88
-
-
84904761846
-
RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress
-
Gatei M, Kijas AW, Biard D, Dork T, Lavin MF. 2014. RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress. Hum. Mol. Genet. 23:4232-48
-
(2014)
Hum. Mol. Genet.
, vol.23
, pp. 4232-4248
-
-
Gatei, M.1
Kijas, A.W.2
Biard, D.3
Dork, T.4
Lavin, M.F.5
-
89
-
-
12444254801
-
Distinct functions ofNijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage
-
Lee JH, Xu B, Lee CH, Ahn JY, Song MS, et al. 2003. Distinct functions ofNijmegen breakage syndrome in ataxia telangiectasia mutated-dependent responses to DNA damage. Mol. Cancer Res. 1:674-81
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 674-681
-
-
Lee, J.H.1
Xu, B.2
Lee, C.H.3
Ahn, J.Y.4
Song, M.S.5
-
90
-
-
0034106722
-
ATM-dependent phosphorylation of nibrin in response to radiation exposure
-
Gatei M, Young D, Cerosaletti KM, Desai-Mehta A, Spring K, et al. 2000. ATM-dependent phosphorylation of nibrin in response to radiation exposure. Nat. Genet. 25:115-19
-
(2000)
Nat. Genet.
, vol.25
, pp. 115-119
-
-
Gatei, M.1
Young, D.2
Cerosaletti, K.M.3
Desai-Mehta, A.4
Spring, K.5
-
91
-
-
0034713393
-
Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products
-
Zhao S, Weng YC, Yuan SS, Lin YT, Hsu HC, et al. 2000. Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products. Nature 405:473-77
-
(2000)
Nature
, vol.405
, pp. 473-477
-
-
Zhao, S.1
Weng, Y.C.2
Yuan, S.S.3
Lin, Y.T.4
Hsu, H.C.5
-
92
-
-
0034611728
-
ATM phosphorylates p95/Nbs1 in an S-phase checkpoint pathway
-
Lim DS, Kim ST, Xu B, Maser RS, Lin J, et al. 2000. ATM phosphorylates p95/Nbs1 in an S-phase checkpoint pathway. Nature 404:613-17
-
(2000)
Nature
, vol.404
, pp. 613-617
-
-
Lim, D.S.1
Kim, S.T.2
Xu, B.3
Maser, R.S.4
Lin, J.5
-
93
-
-
80053102728
-
Point mutation at the Nbs1 threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage
-
Li T, Wang ZQ. 2011. Point mutation at the Nbs1 threonine 278 site does not affect mouse development, but compromises the Chk2 and Smc1 phosphorylation after DNA damage. Mech. Ageing Dev. 132:382-88
-
(2011)
Mech. Ageing Dev.
, vol.132
, pp. 382-388
-
-
Li, T.1
Wang, Z.Q.2
-
94
-
-
0034953719
-
Chk2 activation dependence on Nbs1 after DNA damage
-
Buscemi G, Savio C, Zannini L, Micciche F, Masnada D, et al. 2001. Chk2 activation dependence on Nbs1 after DNA damage. Mol. Cell. Biol. 21:5214-22
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5214-5222
-
-
Buscemi, G.1
Savio, C.2
Zannini, L.3
Micciche, F.4
Masnada, D.5
-
95
-
-
0036500690
-
SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
-
Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J. 2002. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev. 16:571-82
-
(2002)
Genes Dev.
, vol.16
, pp. 571-582
-
-
Yazdi, P.T.1
Wang, Y.2
Zhao, S.3
Patel, N.4
Lee, E.Y.5
Qin, J.6
-
96
-
-
0347990555
-
Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM
-
Bai Y, Murnane JP. 2003. Telomere instability in a human tumor cell line expressing NBS1 with mutations at sites phosphorylated by ATM. Mol. Cancer Res. 1:1058-69
-
(2003)
Mol. Cancer Res.
, vol.1
, pp. 1058-1069
-
-
Bai, Y.1
Murnane, J.P.2
-
97
-
-
36148985345
-
TheMre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells
-
Lee AY, Liu E, WuX. 2007. TheMre11/Rad50/Nbs1 complex plays an important role in the prevention of DNA rereplication in mammalian cells. J. Biol. Chem. 282:32243-55
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 32243-32255
-
-
Lee, A.Y.1
Liu, E.2
Wu, X.3
-
98
-
-
84860740820
-
Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1
-
Wu J, Zhang X, Zhang L, Wu CY, Rezaeian AH, et al. 2012. Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. Mol. Cell 46:351-61
-
(2012)
Mol. Cell
, vol.46
, pp. 351-361
-
-
Wu, J.1
Zhang, X.2
Zhang, L.3
Wu, C.Y.4
Rezaeian, A.H.5
-
99
-
-
84862000281
-
A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons
-
Li R, Yang YG, Gao Y, Wang ZQ, Tong WM. 2012. A distinct response to endogenous DNA damage in the development of Nbs1-deficient cortical neurons. Cell Res. 22:859-72
-
(2012)
Cell Res.
, vol.22
, pp. 859-872
-
-
Li, R.1
Yang, Y.G.2
Gao, Y.3
Wang, Z.Q.4
Tong, W.M.5
-
100
-
-
18844394291
-
An essential function for NBS1 in the prevention of ataxia and cerebellar defects
-
Frappart PO, Tong WM, Demuth I, Radovanovic I, Herceg Z, et al. 2005. An essential function for NBS1 in the prevention of ataxia and cerebellar defects. Nat. Med. 11:538-44
-
(2005)
Nat. Med.
, vol.11
, pp. 538-544
-
-
Frappart, P.O.1
Tong, W.M.2
Demuth, I.3
Radovanovic, I.4
Herceg, Z.5
-
101
-
-
15844426692
-
Atm-deficient mice: A paradigm of ataxia telangiectasia
-
Barlow C, Hirotsune S, Paylor R, Liyanage M, Eckhaus M, et al. 1996. Atm-deficient mice: a paradigm of ataxia telangiectasia. Cell 86:159-71
-
(1996)
Cell
, vol.86
, pp. 159-171
-
-
Barlow, C.1
Hirotsune, S.2
Paylor, R.3
Liyanage, M.4
Eckhaus, M.5
-
102
-
-
0029844048
-
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
-
Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10:2411-22
-
(1996)
Genes Dev.
, vol.10
, pp. 2411-2422
-
-
Xu, Y.1
Ashley, T.2
Brainerd, E.E.3
Bronson, R.T.4
Meyn, M.S.5
Baltimore, D.6
-
103
-
-
12944316603
-
ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
-
Barlow C, Ribaut-Barassin C, Zwingman TA, Pope AJ, Brown KD, et al. 2000. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation. PNAS 97:871-76
-
(2000)
PNAS
, vol.97
, pp. 871-876
-
-
Barlow, C.1
Ribaut-Barassin, C.2
Zwingman, T.A.3
Pope, A.J.4
Brown, K.D.5
-
104
-
-
0029848286
-
Pleiotropic defects in ataxiatelangiectasia protein-deficient mice
-
Elson A, Wang Y, Daugherty CJ, Morton CC, Zhou F, et al. 1996. Pleiotropic defects in ataxiatelangiectasia protein-deficient mice. PNAS 93:13084-89
-
(1996)
PNAS
, vol.93
, pp. 13084-13089
-
-
Elson, A.1
Wang, Y.2
Daugherty, C.J.3
Morton, C.C.4
Zhou, F.5
-
105
-
-
0030730292
-
Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia
-
Kuljis RO, Xu Y, Aguila MC, Baltimore D. 1997. Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia. PNAS 94:12688-93
-
(1997)
PNAS
, vol.94
, pp. 12688-12693
-
-
Kuljis, R.O.1
Xu, Y.2
Aguila, M.C.3
Baltimore, D.4
-
106
-
-
0036012789
-
ATM deficiency and oxidative stress: A new dimension of defective response to DNA damage
-
Barzilai A, Rotman G, Shiloh Y. 2002. ATM deficiency and oxidative stress: a new dimension of defective response to DNA damage. DNA Repair 1:3-25
-
(2002)
DNA Repair
, vol.1
, pp. 3-25
-
-
Barzilai, A.1
Rotman, G.2
Shiloh, Y.3
-
107
-
-
0031259793
-
Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress?
-
Rotman G, Shiloh Y. 1997. Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress? Bioessays 19:911-17
-
(1997)
Bioessays
, vol.19
, pp. 911-917
-
-
Rotman, G.1
Shiloh, Y.2
-
108
-
-
0035266308
-
Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
-
Kamsler A, Daily D, Hochman A, Stern N, Shiloh Y, et al. 2001. Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. Cancer Res. 61:1849-54
-
(2001)
Cancer Res.
, vol.61
, pp. 1849-1854
-
-
Kamsler, A.1
Daily, D.2
Hochman, A.3
Stern, N.4
Shiloh, Y.5
-
109
-
-
0035011079
-
Superoxide stress identifies neurons at risk in a model of ataxiatelangiectasia
-
Quick KL, Dugan LL. 2001. Superoxide stress identifies neurons at risk in a model of ataxiatelangiectasia. Ann. Neurol. 49:627-35
-
(2001)
Ann. Neurol.
, vol.49
, pp. 627-635
-
-
Quick, K.L.1
Dugan, L.L.2
-
110
-
-
0025107807
-
Response of fibroblast cultures from ataxia-telangiectasia patients to oxidative stress
-
Yi M, Rosin MP, Anderson CK. 1990. Response of fibroblast cultures from ataxia-telangiectasia patients to oxidative stress. Cancer Lett. 54:43-50
-
(1990)
Cancer Lett
, vol.54
, pp. 43-50
-
-
Yi, M.1
Rosin, M.P.2
Anderson, C.K.3
-
111
-
-
0028020158
-
Response of fibroblast cultures from ataxia-telangiectasia patients to reactive oxygen species generated during inflammatory reactions
-
Ward AJ, Olive PL, Burr AH, Rosin MP. 1994. Response of fibroblast cultures from ataxia-telangiectasia patients to reactive oxygen species generated during inflammatory reactions. Environ. Mol. Mutagen. 24:103-11
-
(1994)
Environ. Mol. Mutagen
, vol.24
, pp. 103-111
-
-
Ward, A.J.1
Olive, P.L.2
Burr, A.H.3
Rosin, M.P.4
-
112
-
-
0035877581
-
The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts
-
Shackelford RE, Innes CL, Sieber SO, Heinloth AN, Leadon SA, Paules RS. 2001. The Ataxia telangiectasia gene product is required for oxidative stress-induced G1 and G2 checkpoint function in human fibroblasts. J. Biol. Chem. 276:21951-59
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 21951-21959
-
-
Shackelford, R.E.1
Innes, C.L.2
Sieber, S.O.3
Heinloth, A.N.4
Leadon, S.A.5
Paules, R.S.6
-
113
-
-
0000202516
-
Circulation and energy metabolism of the brain
-
ed. S Brady, G Siegel, RW Albers, D Price, Philadelphia: Lippincott-Raven
-
Clarke DD, Solokoff L. 2006. Circulation and energy metabolism of the brain. In Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, ed. S Brady, G Siegel, RW Albers, D Price, pp. 637-70. Philadelphia: Lippincott-Raven
-
(2006)
Basic Neurochemistry: Molecular, Cellular, and Medical Aspects
, pp. 637-670
-
-
Clarke, D.D.1
Solokoff, L.2
-
114
-
-
11144234525
-
Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species
-
Kurz EU, Douglas P, Lees-Miller SP. 2004. Doxorubicin activates ATM-dependent phosphorylation of multiple downstream targets in part through the generation of reactive oxygen species. J. Biol. Chem. 279:53272-81
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 53272-53281
-
-
Kurz, E.U.1
Douglas, P.2
Lees-Miller, S.P.3
-
115
-
-
33845969499
-
Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes
-
Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, et al. 2007. Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes. J. Immunol. 178:103-10
-
(2007)
J. Immunol
, vol.178
, pp. 103-110
-
-
Ito, K.1
Takubo, K.2
Arai, F.3
Satoh, H.4
Matsuoka, S.5
-
116
-
-
7244250309
-
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
-
Ito K, Hirao A, Arai F, Matsuoka S, Takubo K, et al. 2004. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 431:997-1002
-
(2004)
Nature
, vol.431
, pp. 997-1002
-
-
Ito, K.1
Hirao, A.2
Arai, F.3
Matsuoka, S.4
Takubo, K.5
-
117
-
-
67649794703
-
Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes
-
Kim J, Wong PK. 2009. Oxidative stress is linked to ERK1/2-p16 signaling-mediated growth defect in ATM-deficient astrocytes. J. Biol. Chem. 284:14396-404
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 14396-14404
-
-
Kim, J.1
Wong, P.K.2
-
118
-
-
33846121630
-
Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice
-
Reliene R, Schiestl RH. 2007. Antioxidants suppress lymphoma and increase longevity in Atm-deficient mice. J. Nutr. 137:S229-32
-
(2007)
J. Nutr
, vol.137
, pp. S229-S232
-
-
Reliene, R.1
Schiestl, R.H.2
-
119
-
-
77958191599
-
ATM activation by oxidative stress
-
Guo Z, Kozlov S, Lavin MF, Person MD, Paull TT. 2010. ATM activation by oxidative stress. Science 330:517-21
-
(2010)
Science
, vol.330
, pp. 517-521
-
-
Guo, Z.1
Kozlov, S.2
Lavin, M.F.3
Person, M.D.4
Paull, T.T.5
-
120
-
-
58249095024
-
ATM activation and signaling under hypoxic conditions
-
Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. 2009. ATM activation and signaling under hypoxic conditions. Mol. Cell. Biol. 29:526-37
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 526-537
-
-
Bencokova, Z.1
Kaufmann, M.R.2
Pires, I.M.3
Lecane, P.S.4
Giaccia, A.J.5
Hammond, E.M.6
-
121
-
-
0034682786
-
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor 1αduring hypoxia: A mechanism of O2 sensing
-
Chandel NS, McClintock DS, Feliciano CE, Wood TM, Melendez JA, et al. 2000. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor 1αduring hypoxia: a mechanism of O2 sensing. J. Biol. Chem. 275:25130-38
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 25130-25138
-
-
Chandel, N.S.1
McClintock, D.S.2
Feliciano, C.E.3
Wood, T.M.4
Melendez, J.A.5
-
122
-
-
34248158282
-
Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status
-
Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, et al. 2007. Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status. Cancer Res. 67:3010-17
-
(2007)
Cancer Res.
, vol.67
, pp. 3010-3017
-
-
Hunt, C.R.1
Pandita, R.K.2
Laszlo, A.3
Higashikubo, R.4
Agarwal, M.5
-
123
-
-
0026549535
-
Heterogeneity in ataxia-telangiectasia: Classical phenotype associated with intermediate cellular radiosensitivity
-
Chessa L, Petrinelli P, Antonelli A, Fiorilli M, Elli R, et al. 1992. Heterogeneity in ataxia-telangiectasia: classical phenotype associated with intermediate cellular radiosensitivity. Am. J.Med. Genet. 42:741-46
-
(1992)
Am. J.Med. Genet.
, vol.42
, pp. 741-746
-
-
Chessa, L.1
Petrinelli, P.2
Antonelli, A.3
Fiorilli, M.4
Elli, R.5
-
124
-
-
17344370225
-
Genotype-phenotype relationships in ataxia-telangiectasia and variants
-
Gilad S, Chessa L, Khosravi R, Russell P, Galanty Y, et al. 1998. Genotype-phenotype relationships in ataxia-telangiectasia and variants. Am. J. Hum. Genet. 62:551-61
-
(1998)
Am. J. Hum. Genet.
, vol.62
, pp. 551-561
-
-
Gilad, S.1
Chessa, L.2
Khosravi, R.3
Russell, P.4
Galanty, Y.5
-
125
-
-
0031963040
-
Ataxia-telangiectasia without immunodeficiency: Novel point mutations within and adjacent to the phosphatidylinositol 3-kinase-like domain
-
Toyoshima M, Hara T, Zhang H, Yamamoto T, Akaboshi S, et al. 1998. Ataxia-telangiectasia without immunodeficiency: novel point mutations within and adjacent to the phosphatidylinositol 3-kinase-like domain. Am. J. Med. Genet. 75:141-14
-
(1998)
Am. J. Med. Genet.
, vol.75
, pp. 141-214
-
-
Toyoshima, M.1
Hara, T.2
Zhang, H.3
Yamamoto, T.4
Akaboshi, S.5
-
126
-
-
78650378982
-
ATM activation in the presence of oxidative stress
-
Guo Z, Deshpande R, Paull TT. 2010. ATM activation in the presence of oxidative stress. Cell Cycle 9:4805-11
-
(2010)
Cell Cycle
, vol.9
, pp. 4805-4811
-
-
Guo, Z.1
Deshpande, R.2
Paull, T.T.3
-
127
-
-
79953721149
-
Cytoplasmic ATM protein kinase: An emerging therapeutic target for diabetes, cancer and neuronal degeneration
-
Yang DQ, Halaby MJ, Li Y, Hibma JC, Burn P. 2011. Cytoplasmic ATM protein kinase: an emerging therapeutic target for diabetes, cancer and neuronal degeneration. Drug Discov. Today 16:332-38
-
(2011)
Drug Discov. Today
, vol.16
, pp. 332-338
-
-
Yang, D.Q.1
Halaby, M.J.2
Li, Y.3
Hibma, J.C.4
Burn, P.5
-
128
-
-
84856893251
-
Mitochondrial dysfunction in ataxia telangiectasia
-
Valentin-Vega YA, Maclean KH, Tait-Mulder J, Milasta S, Steeves M, et al. 2011. Mitochondrial dysfunction in ataxia telangiectasia. Blood 119:1490-500
-
(2011)
Blood
, vol.119
, pp. 1490-1500
-
-
Valentin-Vega, Y.A.1
Maclean, K.H.2
Tait-Mulder, J.3
Milasta, S.4
Steeves, M.5
-
129
-
-
0033607810
-
Localization of a portion of extranuclear ATM to peroxisomes
-
Watters D, Kedar P, Spring K, Bjorkman J, Chen P, et al. 1999. Localization of a portion of extranuclear ATM to peroxisomes. J. Biol. Chem. 274:34277-82
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 34277-34282
-
-
Watters, D.1
Kedar, P.2
Spring, K.3
Bjorkman, J.4
Chen, P.5
-
130
-
-
8244245266
-
Cellular localisation of the ataxiatelangiectasia (ATM) gene product and discrimination between mutated and normal forms
-
Watters D, Khanna KK, Beamish H, Birrell G, Spring K, et al. 1997. Cellular localisation of the ataxiatelangiectasia (ATM) gene product and discrimination between mutated and normal forms. Oncogene 14:1911-21
-
(1997)
Oncogene
, vol.14
, pp. 1911-1921
-
-
Watters, D.1
Khanna, K.K.2
Beamish, H.3
Birrell, G.4
Spring, K.5
-
131
-
-
73849140503
-
Crystal structure of DNA-PKcs reveals a large openring cradle comprised of HEAT repeats
-
Sibanda BL, Chirgadze DY, Blundell TL. 2010. Crystal structure of DNA-PKcs reveals a large openring cradle comprised of HEAT repeats. Nature 463:118-21
-
(2010)
Nature
, vol.463
, pp. 118-121
-
-
Sibanda, B.L.1
Chirgadze, D.Y.2
Blundell, T.L.3
-
132
-
-
84900404387
-
Structural insights into NHEJ: Building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time
-
Williams GJ, Hammel M, Radhakrishnan SK, Ramsden D, Lees-Miller SP, Tainer JA. 2014. Structural insights into NHEJ: building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time. DNA Repair 17:110-20
-
(2014)
DNA Repair
, vol.17
, pp. 110-120
-
-
Williams, G.J.1
Hammel, M.2
Radhakrishnan, S.K.3
Ramsden, D.4
Lees-Miller, S.P.5
Tainer, J.A.6
-
133
-
-
84877761058
-
MTOR kinase structure, mechanism and regulation
-
Yang H, Rudge DG, Koos JD, Vaidialingam B, Yang HJ, Pavletich NP. 2013. mTOR kinase structure, mechanism and regulation. Nature 497:217-23
-
(2013)
Nature
, vol.497
, pp. 217-223
-
-
Yang, H.1
Rudge, D.G.2
Koos, J.D.3
Vaidialingam, B.4
Yang, H.J.5
Pavletich, N.P.6
-
134
-
-
51849114713
-
Activation of ATR and related PIKKs
-
Mordes DA, Cortez D. 2008. Activation of ATR and related PIKKs. Cell Cycle 7:2809-12
-
(2008)
Cell Cycle
, vol.7
, pp. 2809-2812
-
-
Mordes, D.A.1
Cortez, D.2
-
136
-
-
84878797603
-
Epigenetic silencing mediates mitochondria stressinduced longevity
-
Schroeder EA, Raimundo N, Shadel GS. 2013. Epigenetic silencing mediates mitochondria stressinduced longevity. Cell Metab. 17:954-64
-
(2013)
Cell Metab
, vol.17
, pp. 954-964
-
-
Schroeder, E.A.1
Raimundo, N.2
Shadel, G.S.3
-
137
-
-
84859778293
-
MTOR signaling in growth control and disease
-
Laplante M, Sabatini DM. 2012. mTOR signaling in growth control and disease. Cell 149:274-93
-
(2012)
Cell
, vol.149
, pp. 274-293
-
-
Laplante, M.1
Sabatini, D.M.2
-
138
-
-
84856078168
-
Deconvoluting mTOR biology
-
Weber, JD, Gutmann DH. 2012. Deconvoluting mTOR biology. Cell Cycle 11:236-48
-
(2012)
Cell Cycle
, vol.11
, pp. 236-248
-
-
Weber, J.D.1
Gutmann, D.H.2
-
139
-
-
0030472725
-
Analysis of the ATM protein in wild-type and ataxia telangiectasia cells
-
Lakin ND, Weber P, Stankovic T, Rottinghaus ST, Taylor AM, Jackson SP. 1996. Analysis of the ATM protein in wild-type and ataxia telangiectasia cells. Oncogene 13:2707-16
-
(1996)
Oncogene
, vol.13
, pp. 2707-2716
-
-
Lakin, N.D.1
Weber, P.2
Stankovic, T.3
Rottinghaus, S.T.4
Taylor, A.M.5
Jackson, S.P.6
-
140
-
-
57649137958
-
Isolation of hyperactive mutants of mammalian target of rapamycin
-
Ohne Y, Takahara T, Hatakeyama R, Matsuzaki T, Noda M, et al. 2008. Isolation of hyperactive mutants of mammalian target of rapamycin. J. Biol. Chem. 283:31861-70
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 31861-31870
-
-
Ohne, Y.1
Takahara, T.2
Hatakeyama, R.3
Matsuzaki, T.4
Noda, M.5
-
141
-
-
33847651745
-
Point mutations in
-
TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells
-
Urano J, Sato T, Matsuo T, Otsubo Y, Yamamoto M, Tamanoi F. 2007. Point mutations in TOR confer Rheb-independent growth in fission yeast and nutrient-independent mammalian TOR signaling in mammalian cells. PNAS 104:3514-19
-
(2007)
PNAS
, vol.104
, pp. 3514-3519
-
-
Urano, J.1
Sato, T.2
Matsuo, T.3
Otsubo, Y.4
Yamamoto, M.5
Tamanoi, F.6
-
142
-
-
37549028467
-
Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response
-
Baldo V, Testoni V, Lucchini G, Longhese MP. 2008. Dominant TEL1-hy mutations compensate for Mec1 lack of functions in the DNA damage response. Mol. Cell. Biol. 28:358-75
-
(2008)
Mol. Cell. Biol.
, vol.28
, pp. 358-375
-
-
Baldo, V.1
Testoni, V.2
Lucchini, G.3
Longhese, M.P.4
-
143
-
-
10044225999
-
Autophosphorylation of ataxiatelangiectasia mutated is regulated by protein phosphatase 2A
-
Goodarzi AA, Jonnalagadda JC, Douglas P, Young D, Ye R, et al. 2004. Autophosphorylation of ataxiatelangiectasia mutated is regulated by protein phosphatase 2A. EMBO J. 23:4451-61
-
(2004)
EMBO J.
, vol.23
, pp. 4451-4461
-
-
Goodarzi, A.A.1
Jonnalagadda, J.C.2
Douglas, P.3
Young, D.4
Ye, R.5
-
144
-
-
77649178662
-
Repo-Man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation
-
Peng A, Lewellyn AL, Schiemann WP, Maller JL. 2010. Repo-Man controls a protein phosphatase 1-dependent threshold for DNA damage checkpoint activation. Curr. Biol. 20:387-96
-
(2010)
Curr. Biol.
, vol.20
, pp. 387-396
-
-
Peng, A.1
Lewellyn, A.L.2
Schiemann, W.P.3
Maller, J.L.4
-
145
-
-
0030925222
-
Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner
-
Fiscella M, Zhang H, Fan S, Sakaguchi K, Shen S, et al. 1997. Wip1, a novel human protein phosphatase that is induced in response to ionizing radiation in a p53-dependent manner. PNAS 94:6048-53
-
(1997)
PNAS
, vol.94
, pp. 6048-6053
-
-
Fiscella, M.1
Zhang, H.2
Fan, S.3
Sakaguchi, K.4
Shen, S.5
-
146
-
-
33748150967
-
Wip1 phosphatasemodulates ATM-dependent signaling pathways
-
Shreeram S, Demidov ON, Hee WK, Yamaguchi H, Onishi N, et al. 2006. Wip1 phosphatasemodulates ATM-dependent signaling pathways. Mol. Cell 23:757-64
-
(2006)
Mol. Cell
, vol.23
, pp. 757-764
-
-
Shreeram, S.1
Demidov, O.N.2
Hee, W.K.3
Yamaguchi, H.4
Onishi, N.5
-
147
-
-
1842483852
-
Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p1Arf pathway
-
Bulavin DV, Phillips C, Nannenga B, Timofeev O, Donehower LA, et al. 2004. Inactivation of the Wip1 phosphatase inhibits mammary tumorigenesis through p38 MAPK-mediated activation of the p16Ink4a-p1Arf pathway. Nat. Genet. 36:343-50
-
(2004)
Nat. Genet.
, vol.36
, pp. 343-350
-
-
Bulavin, D.V.1
Phillips, C.2
Nannenga, B.3
Timofeev, O.4
Donehower, L.A.5
-
148
-
-
42949171936
-
Recurrent initiation: A mechanism for triggering p53 pulses in response to DNA damage
-
Batchelor E, Mock CS, Bhan I, Loewer A, Lahav G. 2008. Recurrent initiation: a mechanism for triggering p53 pulses in response to DNA damage. Mol. Cell 30:277-89
-
(2008)
Mol. Cell
, vol.30
, pp. 277-289
-
-
Batchelor, E.1
Mock, C.S.2
Bhan, I.3
Loewer, A.4
Lahav, G.5
-
149
-
-
1042301303
-
Requirement of protein phosphatase 5 in DNA damage- induced ATM activation
-
Ali A, Zhang J, Bao S, Liu I, Otterness D, et al. 2004. Requirement of protein phosphatase 5 in DNA damage- induced ATM activation. Genes Dev. 18:249-54
-
(2004)
Genes Dev.
, vol.18
, pp. 249-254
-
-
Ali, A.1
Zhang, J.2
Bao, S.3
Liu, I.4
Otterness, D.5
-
150
-
-
34447525646
-
Mice lacking protein phosphatase 5 are defective in ataxia telangiectasiamutated (ATM)-mediated cell cycle arrest
-
Yong W, Bao S, Chen H, Li D, Sanchez ER, Shou W. 2007. Mice lacking protein phosphatase 5 are defective in ataxia telangiectasiamutated (ATM)-mediated cell cycle arrest. J. Biol. Chem. 282:14690-94
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 14690-14694
-
-
Yong, W.1
Bao, S.2
Chen, H.3
Li, D.4
Sanchez, E.R.5
Shou, W.6
-
151
-
-
30744465308
-
MDC1 maintains genomic stability by participating in the amplification ofATM-dependentDNA damage signals
-
Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, et al. 2006. MDC1 maintains genomic stability by participating in the amplification ofATM-dependentDNA damage signals. Mol. Cell 21:187-200
-
(2006)
Mol. Cell
, vol.21
, pp. 187-200
-
-
Lou, Z.1
Minter-Dykhouse, K.2
Franco, S.3
Gostissa, M.4
Rivera, M.A.5
-
152
-
-
29244434544
-
MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks
-
Stucki M, Clapperton JA, Mohammad D, Yaffe MB, Smerdon SJ, Jackson SP. 2005. MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell 123:1213-26
-
(2005)
Cell
, vol.123
, pp. 1213-1226
-
-
Stucki, M.1
Clapperton, J.A.2
Mohammad, D.3
Yaffe, M.B.4
Smerdon, S.J.5
Jackson, S.P.6
-
153
-
-
48649100438
-
Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage
-
Chapman JR, Jackson SP. 2008. Phospho-dependent interactions between NBS1 and MDC1 mediate chromatin retention of the MRN complex at sites of DNA damage. EMBO Rep. 9:795-801
-
(2008)
EMBO Rep.
, vol.9
, pp. 795-801
-
-
Chapman, J.R.1
Jackson, S.P.2
-
154
-
-
42449086413
-
Phosphorylation of SDT repeats in the MDC1Nterminus triggers retention ofNBS1 at the DNA damage-modified chromatin
-
Melander F, Bekker-Jensen S, Falck J, Bartek J, Mailand N, Lukas J. 2008. Phosphorylation of SDT repeats in the MDC1Nterminus triggers retention ofNBS1 at the DNA damage-modified chromatin. J. Cell Biol. 181:213-26
-
(2008)
J. Cell Biol.
, vol.181
, pp. 213-226
-
-
Melander, F.1
Bekker-Jensen, S.2
Falck, J.3
Bartek, J.4
Mailand, N.5
Lukas, J.6
-
155
-
-
42449115711
-
Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin
-
Spycher C, Miller ES, Townsend K, Pavic L, Morrice NA, et al. 2008. Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. J. Cell Biol. 181:227-40
-
(2008)
J. Cell Biol.
, vol.181
, pp. 227-240
-
-
Spycher, C.1
Miller, E.S.2
Townsend, K.3
Pavic, L.4
Morrice, N.A.5
-
156
-
-
49649089537
-
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks
-
Wu L, Luo K, Lou Z, Chen J. 2008. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. PNAS 105:11200-5
-
(2008)
PNAS
, vol.105
, pp. 11200-11205
-
-
Wu, L.1
Luo, K.2
Lou, Z.3
Chen, J.4
-
157
-
-
34748900520
-
Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos
-
Peng A, Lewellyn AL, Maller JL. 2007. Undamaged DNA transmits and enhances DNA damage checkpoint signals in early embryos. Mol. Cell. Biol. 27:6852-62
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6852-6862
-
-
Peng, A.1
Lewellyn, A.L.2
Maller, J.L.3
-
158
-
-
84898902550
-
Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks
-
Wang Q, Alexander P, Goldstein M, Wakeman TP, Sun T, et al. 2014. Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks. EMBO J. 33:862-77
-
(2014)
EMBO J.
, vol.33
, pp. 862-877
-
-
Wang, Q.1
Alexander, P.2
Goldstein, M.3
Wakeman, T.P.4
Sun, T.5
-
159
-
-
84903446359
-
DNA double-strand breaks promote methylation of histoneH3on lysine 9 and transient formation of repressive chromatin
-
Ayrapetov MK, Gursoy-Yuzugullu O, Xu C, Xu Y, Price BD. 2014. DNA double-strand breaks promote methylation of histoneH3on lysine 9 and transient formation of repressive chromatin. PNAS 111:9169-74
-
(2014)
PNAS
, vol.111
, pp. 9169-9174
-
-
Ayrapetov, M.K.1
Gursoy-Yuzugullu, O.2
Xu, C.3
Xu, Y.4
Price, B.D.5
-
160
-
-
84899849011
-
SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint
-
Carvalho S, Vitor AC, Sridhara SC, Martins FB, Raposo AC, et al. 2014. SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint. eLife 3:e02482
-
(2014)
ELife
, vol.3
, pp. e02482
-
-
Carvalho, S.1
Vitor, A.C.2
Sridhara, S.C.3
Martins, F.B.4
Raposo, A.C.5
-
161
-
-
84884510464
-
The chromatin remodeling protein BRG1 modulates BRCA1 response to UV irradiation by regulating ATR/ATM activation
-
Zhang L, Chen H, Gong M, Gong F. 2013. The chromatin remodeling protein BRG1 modulates BRCA1 response to UV irradiation by regulating ATR/ATM activation. Front. Oncol. 3:7
-
(2013)
Front. Oncol
, vol.3
, pp. 7
-
-
Zhang, L.1
Chen, H.2
Gong, M.3
Gong, F.4
-
162
-
-
71949103959
-
Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation
-
Ray A, Mir SN, Wani G, Zhao Q, Battu A, et al. 2009. Human SNF5/INI1, a component of the human SWI/SNF chromatin remodeling complex, promotes nucleotide excision repair by influencing ATM recruitment and downstream H2AX phosphorylation. Mol. Cell. Biol. 29:6206-19
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 6206-6219
-
-
Ray, A.1
Mir, S.N.2
Wani, G.3
Zhao, Q.4
Battu, A.5
-
163
-
-
34547907083
-
RSC functions as an early double-strand-break sensor in the cell's response to DNA damage
-
Liang B, Qiu J, Ratnakumar K, Laurent BC. 2007. RSC functions as an early double-strand-break sensor in the cell's response to DNA damage. Curr. Biol. 17:1432-37
-
(2007)
Curr. Biol.
, vol.17
, pp. 1432-1437
-
-
Liang, B.1
Qiu, J.2
Ratnakumar, K.3
Laurent, B.C.4
-
164
-
-
33748367886
-
Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting γ-H2AX induction
-
Park JH, Park EJ, Lee HS, Kim SJ, Hur SK, et al. 2006. Mammalian SWI/SNF complexes facilitate DNA double-strand break repair by promoting γ-H2AX induction. EMBO J. 25:3986-97
-
(2006)
EMBO J.
, vol.25
, pp. 3986-3997
-
-
Park, J.H.1
Park, E.J.2
Lee, H.S.3
Kim, S.J.4
Hur, S.K.5
-
165
-
-
20344365811
-
Involvement of human MOF in ATM function
-
Gupta A, Sharma GG, Young CS, Agarwal M, Smith ER, et al. 2005. Involvement of human MOF in ATM function. Mol. Cell. Biol. 25:5292-305
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5292-5305
-
-
Gupta, A.1
Sharma, G.G.2
Young, C.S.3
Agarwal, M.4
Smith, E.R.5
-
166
-
-
58149328408
-
Activation of ATM depends on chromatin interactions occurring before induction of DNA damage
-
Kim YC, Gerlitz G, Furusawa T, Catez F, Nussenzweig A, et al. 2009. Activation of ATM depends on chromatin interactions occurring before induction of DNA damage. Nat. Cell Biol. 11:92-96
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 92-96
-
-
Kim, Y.C.1
Gerlitz, G.2
Furusawa, T.3
Catez, F.4
Nussenzweig, A.5
-
167
-
-
45849117573
-
Activation of the cellular DNA damage response in the absence of DNA lesions
-
Soutoglou E, Misteli T. 2008. Activation of the cellular DNA damage response in the absence of DNA lesions. Science 320:1507-10
-
(2008)
Science
, vol.320
, pp. 1507-1510
-
-
Soutoglou, E.1
Misteli, T.2
-
168
-
-
77953837463
-
TransientATMkinase inhibition disruptsDNA damage-induced sister chromatid exchange
-
White JS, Choi S, Bakkenist CJ. 2010. TransientATMkinase inhibition disruptsDNA damage-induced sister chromatid exchange. Sci. Signal. 3:ra44
-
(2010)
Sci. Signal
, vol.3
, pp. ra44
-
-
White, J.S.1
Choi, S.2
Bakkenist, C.J.3
-
169
-
-
84866445314
-
Loss of ATM kinase activity leads to embryonic lethality in mice
-
Daniel JA, Pellegrini M, Lee BS, Guo Z, Filsuf D, et al. 2012. Loss of ATM kinase activity leads to embryonic lethality in mice. J. Cell Biol. 198:295-304
-
(2012)
J. Cell Biol.
, vol.198
, pp. 295-304
-
-
Daniel, J.A.1
Pellegrini, M.2
Lee, B.S.3
Guo, Z.4
Filsuf, D.5
-
170
-
-
84866459934
-
Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice
-
Yamamoto K, Wang Y, Jiang W, Liu X, Dubois RL, et al. 2012. Kinase-dead ATM protein causes genomic instability and early embryonic lethality in mice. J. Cell Biol. 198:305-13
-
(2012)
J. Cell Biol.
, vol.198
, pp. 305-313
-
-
Yamamoto, K.1
Wang, Y.2
Jiang, W.3
Liu, X.4
Dubois, R.L.5
-
171
-
-
34250813133
-
ATMIN defines an NBS1-independent pathway of ATM signalling
-
Kanu N, Behrens A. 2007. ATMIN defines an NBS1-independent pathway of ATM signalling. EMBO J. 26:2933-41
-
(2007)
EMBO J.
, vol.26
, pp. 2933-2941
-
-
Kanu, N.1
Behrens, A.2
-
172
-
-
84871692987
-
Competition between NBS1 and ATMIN controls ATM signaling pathway choice
-
Zhang T, Penicud K, Bruhn C, Loizou JI, Kanu N, et al. 2012. Competition between NBS1 and ATMIN controls ATM signaling pathway choice. Cell Rep. 2:1498-504
-
(2012)
Cell Rep.
, vol.2
, pp. 1498-1504
-
-
Zhang, T.1
Penicud, K.2
Bruhn, C.3
Loizou, J.I.4
Kanu, N.5
-
173
-
-
84906313836
-
UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function
-
Zhang T, Cronshaw J, Kanu N, Snijders AP, Behrens A. 2014. UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function. PNAS 111:12091-96
-
(2014)
PNAS
, vol.111
, pp. 12091-12096
-
-
Zhang, T.1
Cronshaw, J.2
Kanu, N.3
Snijders, A.P.4
Behrens, A.5
-
174
-
-
76349099135
-
53BP1 promotes ATM activity through direct interactions with the MRN complex
-
Lee JH, Goodarzi AA, Jeggo PA, Paull TT. 2010. 53BP1 promotes ATM activity through direct interactions with the MRN complex. EMBO J. 29:574-85
-
(2010)
EMBO J.
, vol.29
, pp. 574-585
-
-
Lee, J.H.1
Goodarzi, A.A.2
Jeggo, P.A.3
Paull, T.T.4
-
175
-
-
84881614943
-
Functional activation of ATM by the prostate cancer suppressor NKX3.1
-
Bowen C, Ju JH, Lee JH, Paull TT, Gelmann EP. 2013. Functional activation of ATM by the prostate cancer suppressor NKX3.1. Cell Rep. 4:516-29
-
(2013)
Cell Rep.
, vol.4
, pp. 516-529
-
-
Bowen, C.1
Ju, J.H.2
Lee, J.H.3
Paull, T.T.4
Gelmann, E.P.5
-
176
-
-
84857415007
-
Homeobox B9 induces epithelialto- mesenchymal transition-associated radioresistance by accelerating DNA damage responses
-
Chiba N, Comaills V, Shiotani B, Takahashi F, Shimada T, et al. 2012. Homeobox B9 induces epithelialto- mesenchymal transition-associated radioresistance by accelerating DNA damage responses. PNAS 109:2760-65
-
(2012)
PNAS
, vol.109
, pp. 2760-2765
-
-
Chiba, N.1
Comaills, V.2
Shiotani, B.3
Takahashi, F.4
Shimada, T.5
-
177
-
-
84875417035
-
Novel Smad proteins localize to IR-induced double-strand breaks: Interplay between TGFβ and ATM pathways
-
Wang M, Saha J, Hada M, Anderson JA, Pluth JM, et al. 2013. Novel Smad proteins localize to IR-induced double-strand breaks: interplay between TGFβ and ATM pathways. Nucleic Acids Res. 41:933-42
-
(2013)
Nucleic Acids Res.
, vol.41
, pp. 933-942
-
-
Wang, M.1
Saha, J.2
Hada, M.3
Anderson, J.A.4
Pluth, J.M.5
-
178
-
-
84925027472
-
Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair
-
Park S, Kang JM, Kim SJ, Kim H, Hong S, et al. 2014. Smad7 enhances ATM activity by facilitating the interaction between ATM and Mre11-Rad50-Nbs1 complex in DNA double-strand break repair. Cell. Mol. Life Sci. 72:583-96
-
(2014)
Cell. Mol. Life Sci.
, vol.72
, pp. 583-596
-
-
Park, S.1
Kang, J.M.2
Kim, S.J.3
Kim, H.4
Hong, S.5
-
179
-
-
45849103487
-
Aven-dependent activation of ATM following DNA damage
-
Guo JY, Yamada A, Kajino T, Wu JQ, Tang W, et al. 2008. Aven-dependent activation of ATM following DNA damage. Curr. Biol. 18:933-42
-
(2008)
Curr. Biol.
, vol.18
, pp. 933-942
-
-
Guo, J.Y.1
Yamada, A.2
Kajino, T.3
Wu, J.Q.4
Tang, W.5
-
180
-
-
84890906106
-
TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster
-
Hong ST, Choi KW. 2013. TCTP directly regulates ATM activity to control genome stability and organ development in Drosophila melanogaster. Nat. Commun. 4:2986
-
(2013)
Nat. Commun.
, vol.4
, pp. 2986
-
-
Hong, S.T.1
Choi, K.W.2
-
181
-
-
84859958882
-
Role of the translationally controlled tumor protein in DNA damage sensing and repair
-
Zhang J, de Toledo SM, Pandey BN, Guo G, Pain D, et al. 2012. Role of the translationally controlled tumor protein in DNA damage sensing and repair. PNAS 109:e926-33
-
(2012)
PNAS
, vol.109
, pp. e926-e933
-
-
Zhang, J.1
De Toledo, S.M.2
Pandey, B.N.3
Guo, G.4
Pain, D.5
-
182
-
-
84884507712
-
Ribosomal S6 kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway
-
Lim HC, Xie L, Zhang W, Li R, Chen ZC, et al. 2013. Ribosomal S6 kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway. PLOS ONE 8:e74334
-
(2013)
PLOS ONE
, vol.8
, pp. e74334
-
-
Lim, H.C.1
Xie, L.2
Zhang, W.3
Li, R.4
Chen, Z.C.5
-
183
-
-
84890849140
-
Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11
-
Chen C, Zhang L, Huang NJ, Huang B, Kornbluth S. 2013. Suppression of DNA-damage checkpoint signaling by Rsk-mediated phosphorylation of Mre11. PNAS 110:20605-10
-
(2013)
PNAS
, vol.110
, pp. 20605-20610
-
-
Chen, C.1
Zhang, L.2
Huang, N.J.3
Huang, B.4
Kornbluth, S.5
-
184
-
-
34848928166
-
Chronic treatment with resveratrol induces redox stressand ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells
-
Heiss EH, Schilder YD, Dirsch VM. 2007. Chronic treatment with resveratrol induces redox stressand ataxia telangiectasia-mutated (ATM)-dependent senescence in p53-positive cancer cells. J. Biol. Chem. 282:26759-66
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 26759-26766
-
-
Heiss, E.H.1
Schilder, Y.D.2
Dirsch, V.M.3
-
185
-
-
27744485649
-
Resveratrol causes Cdc2-Tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells
-
Tyagi A, Singh RP, Agarwal C, Siriwardana S, Sclafani RA, Agarwal R. 2005. Resveratrol causes Cdc2-Tyr15 phosphorylation via ATM/ATR-Chk1/2-Cdc25C pathway as a central mechanism for S phase arrest in human ovarian carcinoma Ovcar-3 cells. Carcinogenesis 26:1978-87
-
(2005)
Carcinogenesis
, vol.26
, pp. 1978-1987
-
-
Tyagi, A.1
Singh, R.P.2
Agarwal, C.3
Siriwardana, S.4
Sclafani, R.A.5
Agarwal, R.6
-
186
-
-
40949127382
-
Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner
-
Gatz SA, Keimling M, Baumann C, Dork T, Debatin K-M, et al. 2008. Resveratrol modulates DNA double-strand break repair pathways in an ATM/ATR-p53- and -Nbs1-dependent manner. Carcinogenesis 29:519-27
-
(2008)
Carcinogenesis
, vol.29
, pp. 519-527
-
-
Gatz, S.A.1
Keimling, M.2
Baumann, C.3
Dork, T.4
Debatin, K.-M.5
-
187
-
-
84903220507
-
Direct activation of ATM by resveratrol under oxidizing conditions
-
Lee JH, Guo Z, Myler LR, Zheng S, Paull TT. 2014. Direct activation of ATM by resveratrol under oxidizing conditions. PLOS ONE 9:e97969
-
(2014)
PLOS ONE
, vol.9
, pp. e97969
-
-
Lee, J.H.1
Guo, Z.2
Myler, L.R.3
Zheng, S.4
Paull, T.T.5
-
188
-
-
46749136505
-
Resveratrol: One molecule, many targets
-
Pirola L, Fröjdö S. 2008. Resveratrol: one molecule, many targets. IUBMB Life 60:323-32
-
(2008)
IUBMB Life
, vol.60
, pp. 323-332
-
-
Pirola, L.1
Fröjdö, S.2
-
190
-
-
0028800996
-
PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints
-
Keith CT, Schreiber SL. 1995. PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints. Science 270:50-51
-
(1995)
Science
, vol.270
, pp. 50-51
-
-
Keith, C.T.1
Schreiber, S.L.2
-
191
-
-
84865592978
-
Amino acids and mTORC1: From lysosomes to disease
-
Efeyan A, Zoncu R, Sabatini DM. 2012. Amino acids and mTORC1: from lysosomes to disease. Trends Mol. Med. 18:524-33
-
(2012)
Trends Mol. Med.
, vol.18
, pp. 524-533
-
-
Efeyan, A.1
Zoncu, R.2
Sabatini, D.M.3
-
192
-
-
74049134920
-
Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex
-
Hammel M, Yu Y, Mahaney BL, Cai B, Ye R, et al. 2010. Ku and DNA-dependent protein kinase dynamic conformations and assembly regulate DNA binding and the initial non-homologous end joining complex. J. Biol. Chem. 285:1414-23
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 1414-1423
-
-
Hammel, M.1
Yu, Y.2
Mahaney, B.L.3
Cai, B.4
Ye, R.5
|