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Volumn 198, Issue 3, 2012, Pages 295-304

Loss of ATM kinase activity leads to embryonic lethality in mice

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; ATM PROTEIN; IMMUNOGLOBULIN; PHOSPHOTRANSFERASE;

EID: 84866445314     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201204035     Document Type: Article
Times cited : (89)

References (78)
  • 1
    • 33646795891 scopus 로고    scopus 로고
    • Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex
    • Adams, K.E., A.L. Medhurst, D.A. Dart, and N.D. Lakin. 2006. Recruitment of ATR to sites of ionising radiation-induced DNA damage requires ATM and components of the MRN protein complex. Oncogene. 25:3894-3904. http://dx.doi.org/10.1038/sj.onc.1209426
    • (2006) Oncogene , vol.25 , pp. 3894-3904
    • Adams, K.E.1    Medhurst, A.L.2    Dart, D.A.3    Lakin, N.D.4
  • 2
    • 0037472924 scopus 로고    scopus 로고
    • DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
    • Bakkenist, C.J., and M.B. Kastan. 2003. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature. 421: 499-506. http://dx.doi.org/10.1038/nature01368
    • (2003) Nature , vol.421 , pp. 499-506
    • Bakkenist, C.J.1    Kastan, M.B.2
  • 5
    • 67749147223 scopus 로고    scopus 로고
    • Modeling ATM mutant proteins from missense changes confirms retained kinase activity
    • Barone, G., A. Groom, A. Reiman, V. Srinivasan, P.J. Byrd, and A.M. Taylor. 2009. Modeling ATM mutant proteins from missense changes confirms retained kinase activity. Hum. Mutat. 30:1222-1230. http://dx.doi.org/10.1002/humu.21034
    • (2009) Hum. Mutat , vol.30 , pp. 1222-1230
    • Barone, G.1    Groom, A.2    Reiman, A.3    Srinivasan, V.4    Byrd, P.J.5    Taylor, A.M.6
  • 7
    • 78649938817 scopus 로고    scopus 로고
    • ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage
    • Bensimon, A., A. Schmidt, Y. Ziv, R. Elkon, S.Y. Wang, D.J. Chen, R. Aebersold, and Y. Shiloh. 2010. ATM-dependent and -independent dynamics of the nuclear phosphoproteome after DNA damage. Sci. Signal. 3:rs3. http://dx.doi.org/10.1126/scisignal.2001034
    • (2010) Sci. Signal , vol.3
    • Bensimon, A.1    Schmidt, A.2    Ziv, Y.3    Elkon, R.4    Wang, S.Y.5    Chen, D.J.6    Aebersold, R.7    Shiloh, Y.8
  • 10
    • 0037335861 scopus 로고    scopus 로고
    • Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance
    • Brown, E.J., and D. Baltimore. 2003. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17:615-628. http://dx.doi.org/10.1101/gad.1067403
    • (2003) Genes Dev , vol.17 , pp. 615-628
    • Brown, E.J.1    Baltimore, D.2
  • 11
    • 33645532464 scopus 로고    scopus 로고
    • Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair
    • Bryant, H.E., and T. Helleday. 2006. Inhibition of poly (ADP-ribose) polymerase activates ATM which is required for subsequent homologous recombination repair. Nucleic Acids Res. 34:1685-1691. http://dx.doi.org/10.1093/nar/gkl108
    • (2006) Nucleic Acids Res , vol.34 , pp. 1685-1691
    • Bryant, H.E.1    Helleday, T.2
  • 12
    • 52949109260 scopus 로고    scopus 로고
    • Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
    • Buis, J., Y. Wu, Y. Deng, J. Leddon, G. Westfield, M. Eckersdorff, J.M. Sekiguchi, S. Chang, and D.O. Ferguson. 2008. Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation. Cell. 135:85-96. http://dx.doi.org/10.1016/j.cell.2008.08.015
    • (2008) Cell , vol.135 , pp. 85-96
    • Buis, J.1    Wu, Y.2    Deng, Y.3    Leddon, J.4    Westfield, G.5    Eckersdorff, M.6    Sekiguchi, J.M.7    Chang, S.8    Ferguson, D.O.9
  • 18
    • 68949221567 scopus 로고    scopus 로고
    • A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency
    • Cao, L., X. Xu, S.F. Bunting, J. Liu, R.H. Wang, L.L. Cao, J.J. Wu, T.N. Peng, J. Chen, A. Nussenzweig, et al. 2009. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol. Cell. 35:534-541. http://dx.doi.org/10.1016/j.molcel.2009.06.037
    • (2009) Mol. Cell , vol.35 , pp. 534-541
    • Cao, L.1    Xu, X.2    Bunting, S.F.3    Liu, J.4    Wang, R.H.5    Cao, L.L.6    Wu, J.J.7    Peng, T.N.8    Chen, J.9    Nussenzweig, A.10
  • 20
    • 58149312946 scopus 로고    scopus 로고
    • Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo
    • Daniel, J.A., M. Pellegrini, J.H. Lee, T.T. Paull, L. Feigenbaum, and A. Nussenzweig. 2008. Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo. J. Cell Biol. 183:777-783. http://dx.doi.org/10.1083/jcb.200805154
    • (2008) J. Cell Biol , vol.183 , pp. 777-783
    • Daniel, J.A.1    Pellegrini, M.2    Lee, J.H.3    Paull, T.T.4    Feigenbaum, L.5    Nussenzweig, A.6
  • 21
    • 77955434227 scopus 로고    scopus 로고
    • Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks
    • Davis, A.J., S. So, and D.J. Chen. 2010. Dynamics of the PI3K-like protein kinase members ATM and DNA-PKcs at DNA double strand breaks. Cell Cycle. 9:2529-2536.
    • (2010) Cell Cycle , vol.9 , pp. 2529-2536
    • Davis, A.J.1    So, S.2    Chen, D.J.3
  • 23
    • 35848938279 scopus 로고    scopus 로고
    • The NBS1-ATM connection revisited
    • Difilippantonio, S., and A. Nussenzweig. 2007. The NBS1-ATM connection revisited. Cell Cycle. 6:2366-2370. http://dx.doi.org/10.4161/cc.6.19.4758
    • (2007) Cell Cycle , vol.6 , pp. 2366-2370
    • Difilippantonio, S.1    Nussenzweig, A.2
  • 26
    • 57049132043 scopus 로고    scopus 로고
    • 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
    • Dimitrova, N., Y.C. Chen, D.L. Spector, and T. de Lange. 2008. 53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility. Nature. 456:524-528. http://dx.doi.org/10.1038/nature07433
    • (2008) Nature , vol.456 , pp. 524-528
    • Dimitrova, N.1    Chen, Y.C.2    Spector, D.L.3    de Lange, T.4
  • 28
    • 79959267641 scopus 로고    scopus 로고
    • Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination
    • Gapud, E.J., and B.P. Sleckman. 2011. Unique and redundant functions of ATM and DNA-PKcs during V(D)J recombination. Cell Cycle. 10:1928-1935. http://dx.doi.org/10.4161/cc.10.12.16011
    • (2011) Cell Cycle , vol.10 , pp. 1928-1935
    • Gapud, E.J.1    Sleckman, B.P.2
  • 30
    • 33744827665 scopus 로고    scopus 로고
    • p53-independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc
    • Gladdy, R.A., L.M. Nutter, T. Kunath, J.S. Danska, and C.J. Guidos. 2006. p53-independent apoptosis disrupts early organogenesis in embryos lacking both ataxia-telangiectasia mutated and Prkdc. Mol. Cancer Res. 4: 311-318. http://dx.doi.org/10.1158/1541-7786.MCR-05-0258
    • (2006) Mol. Cancer Res. , vol.4 , pp. 311-318
    • Gladdy, R.A.1    Nutter, L.M.2    Kunath, T.3    Danska, J.S.4    Guidos, C.J.5
  • 31
    • 0035125901 scopus 로고    scopus 로고
    • Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis
    • Gurley, K.E., and C.J. Kemp. 2001. Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis. Curr. Biol. 11:191-194. http://dx.doi.org/10.1016/S0960-9822(01)00048-3
    • (2001) Curr. Biol. , vol.11 , pp. 191-194
    • Gurley, K.E.1    Kemp, C.J.2
  • 32
  • 33
    • 3242891383 scopus 로고    scopus 로고
    • PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development
    • Huber, A., P. Bai, J.M. de Murcia, and G. de Murcia. 2004. PARP-1, PARP-2 and ATM in the DNA damage response: functional synergy in mouse development. DNA Repair (Amst.). 3:1103-1108. http://dx.doi.org/10.1016/j.dnarep.2004.06.002
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1103-1108
    • Huber, A.1    Bai, P.2    de Murcia, J.M.3    de Murcia, G.4
  • 34
    • 84857189416 scopus 로고    scopus 로고
    • Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations
    • Jacquemin, V., G. Rieunier, S. Jacob, D. Bellanger, C.D. d'Enghien, A. Laugé, D. Stoppa-Lyonnet, and M.H. Stern. 2012. Underexpression and abnormal localization of ATM products in ataxia telangiectasia patients bearing ATM missense mutations. Eur. J. Hum. Genet. 20:305-312. http://dx.doi.org/10.1038/ejhg.2011.196
    • (2012) Eur. J. Hum. Genet , vol.20 , pp. 305-312
    • Jacquemin, V.1    Rieunier, G.2    Jacob, S.3    Bellanger, D.4    d'Enghien, C.D.5    Laugé, A.6    Stoppa-Lyonnet, D.7    Stern, M.H.8
  • 35
    • 30344463835 scopus 로고    scopus 로고
    • ATM-and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
    • Jazayeri, A., J. Falck, C. Lukas, J. Bartek, G.C. Smith, J. Lukas, and S.P. Jackson. 2006. ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat. Cell Biol. 8:37-45. http://dx.doi.org/10.1038/ncb1337
    • (2006) Nat. Cell Biol. , vol.8 , pp. 37-45
    • Jazayeri, A.1    Falck, J.2    Lukas, C.3    Bartek, J.4    Smith, G.C.5    Lukas, J.6    Jackson, S.P.7
  • 37
    • 33747614605 scopus 로고    scopus 로고
    • Involvement of novel autophosphorylation sites in ATM activation
    • Kozlov, S.V., M.E. Graham, C. Peng, P. Chen, P.J. Robinson, and M.F. Lavin. 2006. Involvement of novel autophosphorylation sites in ATM activation. EMBO J. 25:3504-3514. http://dx.doi.org/10.1038/sj.emboj.7601231
    • (2006) EMBO J. , vol.25 , pp. 3504-3514
    • Kozlov, S.V.1    Graham, M.E.2    Peng, C.3    Chen, P.4    Robinson, P.J.5    Lavin, M.F.6
  • 40
    • 52449114574 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer
    • Lavin, M.F. 2008. Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer. Nat. Rev. Mol. Cell Biol. 9:759-769. http://dx.doi.org/10.1038/nrm2514
    • (2008) Nat. Rev. Mol. Cell Biol. , vol.9 , pp. 759-769
    • Lavin, M.F.1
  • 41
    • 17644409069 scopus 로고    scopus 로고
    • ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
    • Lee, J.H., and T.T. Paull. 2005. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science. 308:551-554. http://dx.doi.org/10.1126/science.1108297
    • (2005) Science , vol.308 , pp. 551-554
    • Lee, J.H.1    Paull, T.T.2
  • 42
    • 0034729226 scopus 로고    scopus 로고
    • Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients
    • Li, A., and M. Swift. 2000. Mutations at the ataxia-telangiectasia locus and clinical phenotypes of A-T patients. Am. J. Med. Genet. 92:170-177. http://dx.doi.org/10.1002/(SICI)1096-8628(20000529)92:3<170::AID-AJMG3>3.0.CO;2-#
    • (2000) Am. J. Med. Genet , vol.92 , pp. 170-177
    • Li, A.1    Swift, M.2
  • 43
    • 78649443528 scopus 로고    scopus 로고
    • The ATR barrier to replication-born DNA damage
    • López-Contreras, A.J., and O. Fernandez-Capetillo. 2010. The ATR barrier to replication-born DNA damage. DNA Repair (Amst.). 9:1249-1255. http://dx.doi.org/10.1016/j.dnarep.2010.09.012
    • (2010) DNA Repair (Amst. ) , vol.9 , pp. 1249-1255
    • López-Contreras, A.J.1    Fernandez-Capetillo, O.2
  • 46
    • 33748065304 scopus 로고    scopus 로고
    • Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition
    • McCabe, N., N.C. Turner, C.J. Lord, K. Kluzek, A. Bialkowska, S. Swift, S. Giavara, M.J. O'Connor, A.N. Tutt, M.Z. Zdzienicka, et al. 2006. Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res. 66:8109-8115. http://dx.doi.org/10.1158/0008-5472.CAN-06-0140
    • (2006) Cancer Res , vol.66 , pp. 8109-8115
    • McCabe, N.1    Turner, N.C.2    Lord, C.J.3    Kluzek, K.4    Bialkowska, A.5    Swift, S.6    Giavara, S.7    O'Connor, M.J.8    Tutt, A.N.9    Zdzienicka, M.Z.10
  • 47
    • 0035131124 scopus 로고    scopus 로고
    • Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development
    • Ménisser-de Murcia, J., M. Mark, O. Wendling, A. Wynshaw-Boris, and G. de Murcia. 2001. Early embryonic lethality in PARP-1 Atm double-mutant mice suggests a functional synergy in cell proliferation during development. Mol. Cell. Biol. 21:1828-1832. http://dx.doi.org/10.1128/MCB.21.5.1828-1832.2001
    • (2001) Mol. Cell. Biol , vol.21 , pp. 1828-1832
    • Ménisser-de Murcia, J.1    Mark, M.2    Wendling, O.3    Wynshaw-Boris, A.4    de Murcia, G.5
  • 49
    • 33646777679 scopus 로고    scopus 로고
    • Rapid activation of ATR by ionizing radiation requires ATM and Mre11
    • Myers, J.S., and D. Cortez. 2006. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J. Biol. Chem. 281:9346-9350. http://dx.doi.org/10.1074/jbc.M513265200
    • (2006) J. Biol. Chem. , vol.281 , pp. 9346-9350
    • Myers, J.S.1    Cortez, D.2
  • 53
    • 41649120947 scopus 로고    scopus 로고
    • Interplay between ATM and ATR in the regulation of common fragile site stability
    • Ozeri-Galai, E., M. Schwartz, A. Rahat, and B. Kerem. 2008. Interplay between ATM and ATR in the regulation of common fragile site stability. Oncogene. 27:2109-2117. http://dx.doi.org/10.1038/sj.onc.1210849
    • (2008) Oncogene , vol.27 , pp. 2109-2117
    • Ozeri-Galai, E.1    Schwartz, M.2    Rahat, A.3    Kerem, B.4
  • 54
    • 0036105322 scopus 로고    scopus 로고
    • Alternative end joining during switch recombination in patients with ataxia-telangiectasia
    • Pan, Q., C. Petit-Frére, A. Lähdesmäki, H. Gregorek, K.H. Chrzanowska, and L. Hammarström. 2002. Alternative end joining during switch recombination in patients with ataxia-telangiectasia. Eur. J. Immunol. 32: 1300-1308. http://dx.doi.org/10.1002/1521-4141(200205)32:5<1300:AID-IMMU1300>3.0.CO;2-L
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1300-1308
    • Pan, Q.1    Petit-Frére, C.2    Lähdesmäki, A.3    Gregorek, H.4    Chrzanowska, K.H.5    Hammarström, L.6
  • 55
    • 33748648775 scopus 로고    scopus 로고
    • Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo
    • Pellegrini, M., A. Celeste, S. Difilippantonio, R. Guo, W. Wang, L. Feigenbaum, and A. Nussenzweig. 2006. Autophosphorylation at serine 1987 is dispensable for murine Atm activation in vivo. Nature. 443:222-225. http://dx.doi.org/10.1038/nature05112
    • (2006) Nature , vol.443 , pp. 222-225
    • Pellegrini, M.1    Celeste, A.2    Difilippantonio, S.3    Guo, R.4    Wang, W.5    Feigenbaum, L.6    Nussenzweig, A.7
  • 56
    • 0035893363 scopus 로고    scopus 로고
    • Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells
    • Pierce, A.J., P. Hu, M. Han, N. Ellis, and M. Jasin. 2001. Ku DNA end-binding protein modulates homologous repair of double-strand breaks in mammalian cells. Genes Dev. 15:3237-3242. http://dx.doi.org/10.1101/gad.946401
    • (2001) Genes Dev , vol.15 , pp. 3237-3242
    • Pierce, A.J.1    Hu, P.2    Han, M.3    Ellis, N.4    Jasin, M.5
  • 57
    • 54749148734 scopus 로고    scopus 로고
    • Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation
    • Rainey, M.D., M.E. Charlton, R.V. Stanton, and M.B. Kastan. 2008. Transient inhibition of ATM kinase is sufficient to enhance cellular sensitivity to ionizing radiation. Cancer Res. 68:7466-7474. http://dx.doi.org/10.1158/0008-5472.CAN-08-0763
    • (2008) Cancer Res. , vol.68 , pp. 7466-7474
    • Rainey, M.D.1    Charlton, M.E.2    Stanton, R.V.3    Kastan, M.B.4
  • 58
    • 8644238314 scopus 로고    scopus 로고
    • ATM is required for efficient recombination between immunoglobulin switch regions
    • Reina-San-Martin, B., H.T. Chen, A. Nussenzweig, and M.C. Nussenzweig. 2004. ATM is required for efficient recombination between immunoglobulin switch regions. J. Exp. Med. 200:1103-1110. http://dx.doi.org/10.1084/jem.20041162
    • (2004) J. Exp. Med , vol.200 , pp. 1103-1110
    • Reina-San-Martin, B.1    Chen, H.T.2    Nussenzweig, A.3    Nussenzweig, M.C.4
  • 59
    • 0030818183 scopus 로고    scopus 로고
    • B lymphocyte-specific, Cremediated mutagenesis in mice
    • Rickert, R.C., J. Roes, and K. Rajewsky. 1997. B lymphocyte-specific, Cremediated mutagenesis in mice. Nucleic Acids Res. 25:1317-1318. http://dx.doi.org/10.1093/nar/25.6.1317
    • (1997) Nucleic Acids Res. , vol.25 , pp. 1317-1318
    • Rickert, R.C.1    Roes, J.2    Rajewsky, K.3
  • 62
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: safeguarding genome integrity
    • Shiloh, Y. 2003. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer. 3:155-168. http://dx.doi.org/10.1038/nrc1011
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 63
    • 76149146422 scopus 로고    scopus 로고
    • Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites
    • So, S., A.J. Davis, and D.J. Chen. 2009. Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites. J. Cell Biol. 187:977-990. http://dx.doi.org/10.1083/jcb.200906064
    • (2009) J. Cell Biol. , vol.187 , pp. 977-990
    • So, S.1    Davis, A.J.2    Chen, D.J.3
  • 64
  • 65
    • 42649123314 scopus 로고    scopus 로고
    • Mechanism and regulation of class switch recombination
    • Stavnezer, J., J.E. Guikema, and C.E. Schrader. 2008. Mechanism and regulation of class switch recombination. Annu. Rev. Immunol. 26:261-292. http://dx.doi.org/10.1146/annurev.immunol.26.021607.090248
    • (2008) Annu. Rev. Immunol , vol.26 , pp. 261-292
    • Stavnezer, J.1    Guikema, J.E.2    Schrader, C.E.3
  • 66
    • 78951474460 scopus 로고    scopus 로고
    • The MRE11 complex: starting from the ends
    • Stracker, T.H., and J.H. Petrini. 2011. The MRE11 complex: starting from the ends. Nat. Rev. Mol. Cell Biol. 12:90-103. http://dx.doi.org/10.1038/nrm3047
    • (2011) Nat. Rev. Mol. Cell Biol , vol.12 , pp. 90-103
    • Stracker, T.H.1    Petrini, J.H.2
  • 67
    • 26244435498 scopus 로고    scopus 로고
    • Molecular pathology of ataxia telangiectasia
    • Taylor, A.M., and P.J. Byrd. 2005. Molecular pathology of ataxia telangiectasia. J. Clin. Pathol. 58:1009-1015. http://dx.doi.org/10.1136/jcp.2005.026062
    • (2005) J. Clin. Pathol , vol.58 , pp. 1009-1015
    • Taylor, A.M.1    Byrd, P.J.2
  • 68
    • 0142136826 scopus 로고    scopus 로고
    • Requirement of the MRN complex for ATM activation by DNA damage
    • Uziel, T., Y. Lerenthal, L. Moyal, Y. Andegeko, L. Mittelman, and Y. Shiloh. 2003. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J. 22:5612-5621. http://dx.doi.org/10.1093/emboj/cdg541
    • (2003) EMBO J , vol.22 , pp. 5612-5621
    • Uziel, T.1    Lerenthal, Y.2    Moyal, L.3    Andegeko, Y.4    Mittelman, L.5    Shiloh, Y.6
  • 70
    • 44349157094 scopus 로고    scopus 로고
    • Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity
    • White, J.S., S. Choi, and C.J. Bakkenist. 2008. Irreversible chromosome damage accumulates rapidly in the absence of ATM kinase activity. Cell Cycle. 7:1277-1284. http://dx.doi.org/10.4161/cc.7.9.5961
    • (2008) Cell Cycle , vol.7 , pp. 1277-1284
    • White, J.S.1    Choi, S.2    Bakkenist, C.J.3
  • 72
    • 37349096996 scopus 로고    scopus 로고
    • Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
    • Xie, A., A. Hartlerode, M. Stucki, S. Odate, N. Puget, A. Kwok, G. Nagaraju, C. Yan, F.W. Alt, J. Chen, et al. 2007. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol. Cell. 28:1045-1057. http://dx.doi.org/10.1016/j.molcel.2007.12.005
    • (2007) Mol. Cell , vol.28 , pp. 1045-1057
    • Xie, A.1    Hartlerode, A.2    Stucki, M.3    Odate, S.4    Puget, N.5    Kwok, A.6    Nagaraju, G.7    Yan, C.8    Alt, F.W.9    Chen, J.10
  • 73
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu, Y., T. Ashley, E.E. Brainerd, R.T. Bronson, M.S. Meyn, and D. Baltimore. 1996. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10:2411-2422. http://dx.doi.org/10.1101/gad.10.19.2411
    • (1996) Genes Dev. , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 74
    • 0041660878 scopus 로고    scopus 로고
    • A simple two-step'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragments
    • Yang, Y., and S.K. Sharan. 2003. A simple two-step, 'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragments. Nucleic Acids Res. 31:e80. http://dx.doi.org/10.1093/nar/gng080
    • (2003) Nucleic Acids Res. , vol.31
    • Yang, Y.1    Sharan, S.K.2
  • 75
    • 35748967571 scopus 로고    scopus 로고
    • Rapid activation of ATM on DNA flanking double-strand breaks
    • You, Z., J.M. Bailis, S.A. Johnson, S.M. Dilworth, and T. Hunter. 2007. Rapid activation of ATM on DNA flanking double-strand breaks. Nat. Cell Biol. 9:1311-1318. http://dx.doi.org/10.1038/ncb1651
    • (2007) Nat. Cell Biol , vol.9 , pp. 1311-1318
    • You, Z.1    Bailis, J.M.2    Johnson, S.A.3    Dilworth, S.M.4    Hunter, T.5
  • 77
    • 48249121979 scopus 로고    scopus 로고
    • Complementary functions of ATM and H2AX in development and suppression of genomic instability
    • Zha, S., J. Sekiguchi, J.W. Brush, C.H. Bassing, and F.W. Alt. 2008. Complementary functions of ATM and H2AX in development and suppression of genomic instability. Proc. Natl. Acad. Sci. USA. 105:9302- 9306. http://dx.doi.org/10.1073/pnas.0803520105
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 9302-9306
    • Zha, S.1    Sekiguchi, J.2    Brush, J.W.3    Bassing, C.H.4    Alt, F.W.5
  • 78
    • 79955519714 scopus 로고    scopus 로고
    • Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair
    • Zhang, S., H. Yajima, H. Huynh, J. Zheng, E. Callen, H.T. Chen, N. Wong, S. Bunting, Y.F. Lin, M. Li, et al. 2011. Congenital bone marrow failure in DNA-PKcs mutant mice associated with deficiencies in DNA repair. J. Cell Biol. 193:295-305. http://dx.doi.org/10.1083/jcb.201009074
    • (2011) J. Cell Biol. , vol.193 , pp. 295-305
    • Zhang, S.1    Yajima, H.2    Huynh, H.3    Zheng, J.4    Callen, E.5    Chen, H.T.6    Wong, N.7    Bunting, S.8    Lin, Y.F.9    Li, M.10


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