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Volumn 24, Issue 12, 2014, Pages 1947-1953

Insulin and insulin-like growth factor receptors in the brain: Physiological and pathological aspects

Author keywords

Alzheimer's disease; Diabetes; Insulin; Insulin receptors; Insulin like growth factor 1 (IGF 1)

Indexed keywords

GLUCOSE; INSULIN; INSULIN RECEPTOR; SOMATOMEDIN B; SOMATOMEDIN C; SOMATOMEDIN; SOMATOMEDIN RECEPTOR;

EID: 84903701668     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2014.01.020     Document Type: Review
Times cited : (132)

References (50)
  • 1
    • 0034656167 scopus 로고    scopus 로고
    • Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus
    • Aberg M.A., Aberg N.D., Hedbacker H., Oscarsson J., Eriksson P.S. Peripheral infusion of IGF-I selectively induces neurogenesis in the adult rat hippocampus. J. Neurosci. 2000, 20:2896-2903.
    • (2000) J. Neurosci. , vol.20 , pp. 2896-2903
    • Aberg, M.A.1    Aberg, N.D.2    Hedbacker, H.3    Oscarsson, J.4    Eriksson, P.S.5
  • 2
    • 84862829155 scopus 로고    scopus 로고
    • Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2
    • Alberini C.M., Chen D.Y. Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2. Trends Neurosci. 2012, 35:274-283.
    • (2012) Trends Neurosci. , vol.35 , pp. 274-283
    • Alberini, C.M.1    Chen, D.Y.2
  • 4
    • 0027423419 scopus 로고
    • Role of insulin-like growth factors in embryonic and postnatal growth
    • Baker J., Liu J.P., Robertson E.J., Efstratiadis A. Role of insulin-like growth factors in embryonic and postnatal growth. Cell 1993, 75:73-82.
    • (1993) Cell , vol.75 , pp. 73-82
    • Baker, J.1    Liu, J.P.2    Robertson, E.J.3    Efstratiadis, A.4
  • 6
    • 67349093525 scopus 로고    scopus 로고
    • Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests
    • Bates K.A., Verdile G., Li Q.X., Ames D., Hudson P., Masters C.L., Martins R.N. Clearance mechanisms of Alzheimer's amyloid-beta peptide: implications for therapeutic design and diagnostic tests. Mol. Psychiatry 2009, 14:469-486.
    • (2009) Mol. Psychiatry , vol.14 , pp. 469-486
    • Bates, K.A.1    Verdile, G.2    Li, Q.X.3    Ames, D.4    Hudson, P.5    Masters, C.L.6    Martins, R.N.7
  • 7
    • 0025028901 scopus 로고
    • Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression
    • Bondy C.A., Werner H., Roberts C.T., LeRoith D. Cellular pattern of insulin-like growth factor-I (IGF-I) and type I IGF receptor gene expression in early organogenesis: comparison with IGF-II gene expression. Mol. Endocrinol. 1990, 4:1386-1398.
    • (1990) Mol. Endocrinol. , vol.4 , pp. 1386-1398
    • Bondy, C.A.1    Werner, H.2    Roberts, C.T.3    LeRoith, D.4
  • 8
    • 0026556829 scopus 로고
    • Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II
    • Bondy C.A., Werner H., Roberts C.T., LeRoith D. Cellular pattern of type-I insulin-like growth factor receptor gene expression during maturation of the rat brain: comparison with insulin-like growth factors I and II. Neuroscience 1992, 46:909-923.
    • (1992) Neuroscience , vol.46 , pp. 909-923
    • Bondy, C.A.1    Werner, H.2    Roberts, C.T.3    LeRoith, D.4
  • 9
    • 18144446836 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor I mediates effects of exercise on the brain
    • Carro E., Nunez A., Busiguina S., Torres-Aleman I. Circulating insulin-like growth factor I mediates effects of exercise on the brain. J. Neurosci. 2000, 20:2926-2933.
    • (2000) J. Neurosci. , vol.20 , pp. 2926-2933
    • Carro, E.1    Nunez, A.2    Busiguina, S.3    Torres-Aleman, I.4
  • 10
    • 33748438509 scopus 로고    scopus 로고
    • Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?
    • Carro E., Trejo J.L., Spuch C., Bohl D., Heard J.M., Torres-Aleman I. Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer's-like neuropathology in rodents: new cues into the human disease?. Neurobiol. Aging 2006, 27:1618-1631.
    • (2006) Neurobiol. Aging , vol.27 , pp. 1618-1631
    • Carro, E.1    Trejo, J.L.2    Spuch, C.3    Bohl, D.4    Heard, J.M.5    Torres-Aleman, I.6
  • 12
    • 0024213009 scopus 로고
    • Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes
    • Clark A., Wells C.A., Buley I.D., Cruickshank J.K., Vanhegan R.I., Matthews D.R., et al. Islet amyloid, increased A-cells, reduced B-cells and exocrine fibrosis: quantitative changes in the pancreas in type 2 diabetes. Diabetes Res. 1988, 9:151-159.
    • (1988) Diabetes Res. , vol.9 , pp. 151-159
    • Clark, A.1    Wells, C.A.2    Buley, I.D.3    Cruickshank, J.K.4    Vanhegan, R.I.5    Matthews, D.R.6
  • 13
    • 0036551775 scopus 로고    scopus 로고
    • Mutant mouse models of insulin-like growth factor actions in the central nervous system
    • D'Ercole A.J., Ye P., O'Kusky J.R. Mutant mouse models of insulin-like growth factor actions in the central nervous system. Neuropeptides 2002, 36:209-220.
    • (2002) Neuropeptides , vol.36 , pp. 209-220
    • D'Ercole, A.J.1    Ye, P.2    O'Kusky, J.R.3
  • 15
    • 0032903670 scopus 로고    scopus 로고
    • Apoptotic cell death of proliferating neuroepithelial cells in the embryonic retina is prevented by insulin
    • Díaz B., Pimentel B., de Pablo F., de La Rosa E.J. Apoptotic cell death of proliferating neuroepithelial cells in the embryonic retina is prevented by insulin. Eur. J. Neurosci. 1999, 11:1624-1632.
    • (1999) Eur. J. Neurosci. , vol.11 , pp. 1624-1632
    • Díaz, B.1    Pimentel, B.2    de Pablo, F.3    de La Rosa, E.J.4
  • 16
    • 0026515010 scopus 로고
    • Modulation of rat brain insulin receptor kinase activity in diabetes
    • Gupta G., Azam M., Baquer N.Z. Modulation of rat brain insulin receptor kinase activity in diabetes. Neurochem. Int. 1992, 20:487-492.
    • (1992) Neurochem. Int. , vol.20 , pp. 487-492
    • Gupta, G.1    Azam, M.2    Baquer, N.Z.3
  • 17
    • 9644307899 scopus 로고    scopus 로고
    • Melanocortin-independent effects of leptin on hepatic glucose fluxes
    • Gutierrez-Juarez R., Obici S., Rossetti L. Melanocortin-independent effects of leptin on hepatic glucose fluxes. J. Biol. Chem. 2004, 279:49704-49715.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49704-49715
    • Gutierrez-Juarez, R.1    Obici, S.2    Rossetti, L.3
  • 18
    • 84859526987 scopus 로고    scopus 로고
    • Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women
    • Hallschmid M., Higgs S., Thienel M., Ott V., Lehnert H. Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women. Diabetes 2012, 61:782-789.
    • (2012) Diabetes , vol.61 , pp. 782-789
    • Hallschmid, M.1    Higgs, S.2    Thienel, M.3    Ott, V.4    Lehnert, H.5
  • 19
    • 0018090354 scopus 로고
    • Insulin receptors are widely distributed in the central nervous system of the rat
    • Havrankova J., Roth J., Brownstein M. Insulin receptors are widely distributed in the central nervous system of the rat. Nature 1978, 272:827-829.
    • (1978) Nature , vol.272 , pp. 827-829
    • Havrankova, J.1    Roth, J.2    Brownstein, M.3
  • 21
    • 0036398986 scopus 로고    scopus 로고
    • The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes
    • Kaidanovich O., Eldar-Finkelman H. The role of glycogen synthase kinase-3 in insulin resistance and type 2 diabetes. Expert Opin. Ther. Targets 2002, 6:555-561.
    • (2002) Expert Opin. Ther. Targets , vol.6 , pp. 555-561
    • Kaidanovich, O.1    Eldar-Finkelman, H.2
  • 22
    • 54949143977 scopus 로고    scopus 로고
    • Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism
    • Kappeler L., De Magalhaes Filho C., Dupont J., Leneuve P., Cervera P., Périn L., et al. Brain IGF-1 receptors control mammalian growth and lifespan through a neuroendocrine mechanism. PLoS Biol. 2008, 6(10):e254.
    • (2008) PLoS Biol. , vol.6 , Issue.10 , pp. e254
    • Kappeler, L.1    De Magalhaes Filho, C.2    Dupont, J.3    Leneuve, P.4    Cervera, P.5    Périn, L.6
  • 23
    • 67649742213 scopus 로고    scopus 로고
    • Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials
    • Kopf D., Frolich L. Risk of incident Alzheimer's disease in diabetic patients: a systematic review of prospective trials. J. Alzheimer's Dis. 2009, 16:677-685.
    • (2009) J. Alzheimer's Dis. , vol.16 , pp. 677-685
    • Kopf, D.1    Frolich, L.2
  • 24
    • 58149175658 scopus 로고    scopus 로고
    • Insulin regulates P-glycoprotein in rat brain microvessel endothelial cells via an insulin receptor-mediated PKC/NF-kappaB pathway but not a PI3K/Akt pathway
    • Liu H., Yang H., Wang D., Liu Y., Liu X., Li Y., et al. Insulin regulates P-glycoprotein in rat brain microvessel endothelial cells via an insulin receptor-mediated PKC/NF-kappaB pathway but not a PI3K/Akt pathway. Eur. J. Pharmacol. 2009, 602:277-282.
    • (2009) Eur. J. Pharmacol. , vol.602 , pp. 277-282
    • Liu, H.1    Yang, H.2    Wang, D.3    Liu, Y.4    Liu, X.5    Li, Y.6
  • 25
    • 0027496895 scopus 로고
    • Mice carrying null mutations of the genes encoding insulin-like growth factor-I (Igf-1) and type 1 IGF receptor (Igf1r)
    • Liu J.P., Baker J., Perkins A.S., Robertson E.J., Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor-I (Igf-1) and type 1 IGF receptor (Igf1r). Cell 1993, 75:59-72.
    • (1993) Cell , vol.75 , pp. 59-72
    • Liu, J.P.1    Baker, J.2    Perkins, A.S.3    Robertson, E.J.4    Efstratiadis, A.5
  • 27
    • 36749033116 scopus 로고    scopus 로고
    • Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR
    • Luca S., Yau W.M., Leapman R., Tycko R. Peptide conformation and supramolecular organization in amylin fibrils: constraints from solid-state NMR. Biochemistry 2007, 46:13505-13522.
    • (2007) Biochemistry , vol.46 , pp. 13505-13522
    • Luca, S.1    Yau, W.M.2    Leapman, R.3    Tycko, R.4
  • 28
    • 66249130052 scopus 로고    scopus 로고
    • Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors
    • Marks D.R., Tucker K., Cavallin M.A., Mast T.G., Fadool D.A. Awake intranasal insulin delivery modifies protein complexes and alters memory, anxiety, and olfactory behaviors. J Neurosci. 2009, 29:6734-6751.
    • (2009) J Neurosci. , vol.29 , pp. 6734-6751
    • Marks, D.R.1    Tucker, K.2    Cavallin, M.A.3    Mast, T.G.4    Fadool, D.A.5
  • 29
    • 33750495607 scopus 로고    scopus 로고
    • Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death
    • Mielke J.G., Taghibiglou C., Wang Y.T. Endogenous insulin signaling protects cultured neurons from oxygen-glucose deprivation-induced cell death. Neuroscience 2006, 143:165-173.
    • (2006) Neuroscience , vol.143 , pp. 165-173
    • Mielke, J.G.1    Taghibiglou, C.2    Wang, Y.T.3
  • 30
    • 0036913187 scopus 로고    scopus 로고
    • Hypothalamic insulin signaling is required for inhibition of glucose production
    • Obici S., Zhang B.B., Karkanias G., Rossetti L. Hypothalamic insulin signaling is required for inhibition of glucose production. Nat. Med. 2002, 8:1376-1382.
    • (2002) Nat. Med. , vol.8 , pp. 1376-1382
    • Obici, S.1    Zhang, B.B.2    Karkanias, G.3    Rossetti, L.4
  • 31
    • 84857985148 scopus 로고    scopus 로고
    • The cellular and signaling networks linking the immun system and metabolism in disease
    • Osborn O., Olefsky J.M. The cellular and signaling networks linking the immun system and metabolism in disease. Nat. Med. 2012, 18:363-374.
    • (2012) Nat. Med. , vol.18 , pp. 363-374
    • Osborn, O.1    Olefsky, J.M.2
  • 33
    • 42949114366 scopus 로고    scopus 로고
    • Aging of the brain, neurotrophin signaling and Alzheimer's disease: is IGF1-R the common culprit?
    • Puglielli L. Aging of the brain, neurotrophin signaling and Alzheimer's disease: is IGF1-R the common culprit?. Neurobiol. Aging 2008, 29:795-811.
    • (2008) Neurobiol. Aging , vol.29 , pp. 795-811
    • Puglielli, L.1
  • 34
    • 33644591150 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine
    • Rivera E.J., Goldin A., Fulmer N., Tavares R., Wands J.R., de la Monte S.M. Insulin and insulin-like growth factor expression and function deteriorate with progression of Alzheimer's disease: link to brain reductions in acetylcholine. J. Alzheimer's Dis. 2005, 8:247-268.
    • (2005) J. Alzheimer's Dis. , vol.8 , pp. 247-268
    • Rivera, E.J.1    Goldin, A.2    Fulmer, N.3    Tavares, R.4    Wands, J.R.5    de la Monte, S.M.6
  • 35
    • 28844432459 scopus 로고    scopus 로고
    • The insulin-like growth factor system and its pleiotropic functions in brain
    • Russo V.C., Gluckman P.D., Feldman E.L., Werther G.A. The insulin-like growth factor system and its pleiotropic functions in brain. Endocr. Rev. 2005, 26:916-943.
    • (2005) Endocr. Rev. , vol.26 , pp. 916-943
    • Russo, V.C.1    Gluckman, P.D.2    Feldman, E.L.3    Werther, G.A.4
  • 36
    • 79951754336 scopus 로고    scopus 로고
    • Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential
    • Sato N., Takeda S., Uchio-Yamada K., Ueda H., Fujisawa T., Rakugi H., Morishita R. Role of insulin signaling in the interaction between Alzheimer disease and diabetes mellitus: a missing link to therapeutic potential. Curr. Aging Sci. 2011, 4:118-127.
    • (2011) Curr. Aging Sci. , vol.4 , pp. 118-127
    • Sato, N.1    Takeda, S.2    Uchio-Yamada, K.3    Ueda, H.4    Fujisawa, T.5    Rakugi, H.6    Morishita, R.7
  • 37
    • 47849123972 scopus 로고    scopus 로고
    • Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults
    • Reger M.A., Watson G.S., Green P.S., Baker L.D., Cholerton B., Fishel M.A., et al. Intranasal insulin administration dose-dependently modulates verbal memory and plasma amyloid-beta in memory-impaired older adults. J. Alzheimer's Dis. 2008, 13:323-331.
    • (2008) J. Alzheimer's Dis. , vol.13 , pp. 323-331
    • Reger, M.A.1    Watson, G.S.2    Green, P.S.3    Baker, L.D.4    Cholerton, B.5    Fishel, M.A.6
  • 38
    • 80054850926 scopus 로고    scopus 로고
    • Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism
    • Scherer T., Buettner C. Yin and Yang of hypothalamic insulin and leptin signaling in regulating white adipose tissue metabolism. Rev. Endocr. Metab. Disord. 2011, 12:235-243.
    • (2011) Rev. Endocr. Metab. Disord. , vol.12 , pp. 235-243
    • Scherer, T.1    Buettner, C.2
  • 39
    • 0023644894 scopus 로고
    • Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture
    • Shemer J., Raizada M.K., Masters B.A., Ota A., LeRoith D. Insulin-like growth factor I receptors in neuronal and glial cells. Characterization and biological effects in primary culture. J. Biol. Chem. 1987, 262:7693-7699.
    • (1987) J. Biol. Chem. , vol.262 , pp. 7693-7699
    • Shemer, J.1    Raizada, M.K.2    Masters, B.A.3    Ota, A.4    LeRoith, D.5
  • 41
    • 57649210178 scopus 로고    scopus 로고
    • Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions
    • Suzuki T., Nakaya T. Regulation of amyloid beta-protein precursor by phosphorylation and protein interactions. J. Biol. Chem. 2008, 283:29633-29637.
    • (2008) J. Biol. Chem. , vol.283 , pp. 29633-29637
    • Suzuki, T.1    Nakaya, T.2
  • 42
    • 84859718265 scopus 로고    scopus 로고
    • Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    • Talbot K., Wang H.Y., Kazi H., Han L.Y., Bakshi K.P., Stucky A., et al. Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline. J. Clin. Investig. 2012, 122:1316-1338.
    • (2012) J. Clin. Investig. , vol.122 , pp. 1316-1338
    • Talbot, K.1    Wang, H.Y.2    Kazi, H.3    Han, L.Y.4    Bakshi, K.P.5    Stucky, A.6
  • 43
    • 77949741721 scopus 로고    scopus 로고
    • Towards a comprehensive neurobiology of IGF-I
    • Torres-Aleman I. Towards a comprehensive neurobiology of IGF-I. Dev. Neurobiol. 2010, 70:384-396.
    • (2010) Dev. Neurobiol. , vol.70 , pp. 384-396
    • Torres-Aleman, I.1
  • 44
    • 36549062949 scopus 로고    scopus 로고
    • Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects
    • Trejo J.L., Piriz J., Llorens-Martin M.V., Fernandez A.M., Bolós M., LeRoith D., et al. Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects. Mol. Psychiatry 2007, 12:1118-1128.
    • (2007) Mol. Psychiatry , vol.12 , pp. 1118-1128
    • Trejo, J.L.1    Piriz, J.2    Llorens-Martin, M.V.3    Fernandez, A.M.4    Bolós, M.5    LeRoith, D.6
  • 45
    • 0025847968 scopus 로고
    • Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects
    • Unger J.W., Livingston J.N., Moss A.M. Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects. Prog. Neurobiol. 1991, 36:343-362.
    • (1991) Prog. Neurobiol. , vol.36 , pp. 343-362
    • Unger, J.W.1    Livingston, J.N.2    Moss, A.M.3
  • 47
    • 33748471099 scopus 로고    scopus 로고
    • Inflammation in Alzheimer disease: driving force, bystander or beneficial response?
    • Wyss-Coray T. Inflammation in Alzheimer disease: driving force, bystander or beneficial response?. Nat. Med. 2006, 1:1005-1015.
    • (2006) Nat. Med. , vol.1 , pp. 1005-1015
    • Wyss-Coray, T.1
  • 48
    • 0027391758 scopus 로고
    • The cellular and physiological actions of insulin in the central nervous system
    • Wozniak M., Rydzewski B., Baker S.P., Raizada M.K. The cellular and physiological actions of insulin in the central nervous system. Neurochem. Int. 1993, 22:1-10.
    • (1993) Neurochem. Int. , vol.22 , pp. 1-10
    • Wozniak, M.1    Rydzewski, B.2    Baker, S.P.3    Raizada, M.K.4
  • 49
    • 27544492807 scopus 로고    scopus 로고
    • Control of aging and longevity by IGF-I signaling
    • Yang J., Anzo M., Cohen P. Control of aging and longevity by IGF-I signaling. Exp. Gerontol. 2005, 40:867-872.
    • (2005) Exp. Gerontol. , vol.40 , pp. 867-872
    • Yang, J.1    Anzo, M.2    Cohen, P.3
  • 50
    • 84883733870 scopus 로고    scopus 로고
    • Molecular links between Alzheimer's disease and diabetes mellitus
    • Yang Y., Song W. Molecular links between Alzheimer's disease and diabetes mellitus. Neuroscience 2013, 250:140-150.
    • (2013) Neuroscience , vol.250 , pp. 140-150
    • Yang, Y.1    Song, W.2


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