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Volumn 23, Issue 36, 2003, Pages 11453-11460

Oxidative Stress is Responsible for Deficient Survival and Dendritogenesis in Purkinje Neurons from Ataxia-Telangiectasia Mutated Mutant Mice

Author keywords

Ataxia telangiectasia; Atm mutant mice; Cell cultures; Neurodegeneration; Oxidative stress; Purkinje neurons

Indexed keywords

ATM PROTEIN; ISOINDOLE DERIVATIVE; ISOINDOLE NITROXIDE; UNCLASSIFIED DRUG;

EID: 0347479231     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.23-36-11453.2003     Document Type: Article
Times cited : (119)

References (47)
  • 7
    • 0034236760 scopus 로고    scopus 로고
    • Synthesis, single crystal X-ray structure and W-band (95 GHz) EPR spectroscopy of a new anionic isoindoline aminoxyl: Synthesis and characterization of some derivatives
    • Bottle SE, Gillies DG, Hughes DL, Micallef AS, Smirnov A, Sutcliffe LH (2000) Synthesis, single crystal X-ray structure and W-band (95 GHz) EPR spectroscopy of a new anionic isoindoline aminoxyl: synthesis and characterization of some derivatives. J Chem Soc Perkins 227:1285-1291.
    • (2000) J Chem Soc Perkins , vol.227 , pp. 1285-1291
    • Bottle, S.E.1    Gillies, D.G.2    Hughes, D.L.3    Micallef, A.S.4    Smirnov, A.5    Sutcliffe, L.H.6
  • 11
    • 0031791601 scopus 로고    scopus 로고
    • An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting
    • Furuya S, Makino A, Hirabayashi Y (1998) An improved method for culturing cerebellar Purkinje cells with differentiated dendrites under a mixed monolayer setting. Brain Res Protoc 3:192-198.
    • (1998) Brain Res Protoc , vol.3 , pp. 192-198
    • Furuya, S.1    Makino, A.2    Hirabayashi, Y.3
  • 13
    • 0035905742 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: Chronic activation of damage-responsive functions is reduced by alpha-lipoic acid
    • Gatei M, Shkedy D, Khanna KK, Uzie T, Shiloh Y, Pandita TK, Lavin MF, Rotman G (2001) Ataxia-telangiectasia: chronic activation of damage-responsive functions is reduced by alpha-lipoic acid. Oncogene 20:289-294.
    • (2001) Oncogene , vol.20 , pp. 289-294
    • Gatei, M.1    Shkedy, D.2    Khanna, K.K.3    Uzie, T.4    Shiloh, Y.5    Pandita, T.K.6    Lavin, M.F.7    Rotman, G.8
  • 14
    • 0028636504 scopus 로고
    • New directions for free radical cancer research and medical applications
    • Hahn SM, Krishna CM, Michell JB (1994) New directions for free radical cancer research and medical applications. Adv Exp Med Biol 336:241-251.
    • (1994) Adv Exp Med Biol , vol.336 , pp. 241-251
    • Hahn, S.M.1    Krishna, C.M.2    Michell, J.B.3
  • 15
    • 0032524070 scopus 로고    scopus 로고
    • Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system
    • Herzog KH, Chong MJ, Kapsetaki M, Morgan JI, McKinnon PJ (1998) Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science 280:1089-1091.
    • (1998) Science , vol.280 , pp. 1089-1091
    • Herzog, K.H.1    Chong, M.J.2    Kapsetaki, M.3    Morgan, J.I.4    McKinnon, P.J.5
  • 16
    • 0032444904 scopus 로고    scopus 로고
    • Free radicals in disease
    • Hogg N (1998) Free radicals in disease. Semin Reprod Endocrinol 16:241-248.
    • (1998) Semin Reprod Endocrinol , vol.16 , pp. 241-248
    • Hogg, N.1
  • 17
    • 0035266308 scopus 로고    scopus 로고
    • Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
    • Kamsler A, Daily D, Hockman A, Stern N, Shiloh Y, Rotman G, Barzilai A (2001) Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice. Cancer Res 61:1849-1854.
    • (2001) Cancer Res , vol.61 , pp. 1849-1854
    • Kamsler, A.1    Daily, D.2    Hockman, A.3    Stern, N.4    Shiloh, Y.5    Rotman, G.6    Barzilai, A.7
  • 18
    • 0346657235 scopus 로고    scopus 로고
    • Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms
    • Khanna KK, Yan J, Watters D, Hobson K, Beamish H, Spring K, Shiloh Y, Gatti RA, Lavin MF (1997) Cellular localisation of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms. J Biol Chem 272:9483-9495.
    • (1997) J Biol Chem , vol.272 , pp. 9483-9495
    • Khanna, K.K.1    Yan, J.2    Watters, D.3    Hobson, K.4    Beamish, H.5    Spring, K.6    Shiloh, Y.7    Gatti, R.A.8    Lavin, M.F.9
  • 20
    • 0030730292 scopus 로고    scopus 로고
    • Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia
    • Kuljis RO, Xu Y, Aguila MC, Baltimore D (1997) Degeneration of neurons, synapses, and neuropil and glial activation in a murine Atm knockout model of ataxia-telangiectasia. Proc Natl Acad Sci USA 94:12688-12693.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 12688-12693
    • Kuljis, R.O.1    Xu, Y.2    Aguila, M.C.3    Baltimore, D.4
  • 21
    • 0030933152 scopus 로고    scopus 로고
    • The genetic defect in ataxia-telangiectasia
    • Lavin MF, Shiloh Y (1997) The genetic defect in ataxia-telangiectasia. Annu Rev Immunol 15:177-202.
    • (1997) Annu Rev Immunol , vol.15 , pp. 177-202
    • Lavin, M.F.1    Shiloh, Y.2
  • 22
    • 0034732630 scopus 로고    scopus 로고
    • A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity
    • Miranda KM, Espey MG, Wink DA (2000) A discussion of the chemistry of oxidative and nitrosative stress in cytotoxicity. J Inorg Biochem 79:237-240.
    • (2000) J Inorg Biochem , vol.79 , pp. 237-240
    • Miranda, K.M.1    Espey, M.G.2    Wink, D.A.3
  • 23
    • 0033826520 scopus 로고    scopus 로고
    • Role for mitochondrial oxidants as regulators of cellular metabolism
    • Nemoto S, Takeda K, Yu ZX, Ferrans VJ, Finkel T (2000) Role for mitochondrial oxidants as regulators of cellular metabolism. Mol Cell Biol 20:7311-7318.
    • (2000) Mol Cell Biol , vol.20 , pp. 7311-7318
    • Nemoto, S.1    Takeda, K.2    Yu, Z.X.3    Ferrans, V.J.4    Finkel, T.5
  • 24
    • 0018888601 scopus 로고
    • Mitogen receptor redistribution defects and concomitant absence of blastogenesis in ataxia-telangiectasia T lymphocytes
    • O'Connor RD, Linthicum DS (1980) Mitogen receptor redistribution defects and concomitant absence of blastogenesis in ataxia-telangiectasia T lymphocytes. Clin Immunol Immunopathol 15:66-75.
    • (1980) Clin Immunol Immunopathol , vol.15 , pp. 66-75
    • O'Connor, R.D.1    Linthicum, D.S.2
  • 25
    • 0032555458 scopus 로고    scopus 로고
    • Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development
    • Oka A, Takashima S (1998) Expression of the ataxia-telangiectasia gene (ATM) product in human cerebellar neurons during development. Neurosci Lett 252:195-198.
    • (1998) Neurosci Lett , vol.252 , pp. 195-198
    • Oka, A.1    Takashima, S.2
  • 26
    • 0035478788 scopus 로고    scopus 로고
    • Integrating stress-response and cell-cycle checkpoint pathways
    • Pearce AK, Humphrey TC (2001) Integrating stress-response and cell-cycle checkpoint pathways. Trends Cell Biol 11:426-433.
    • (2001) Trends Cell Biol , vol.11 , pp. 426-433
    • Pearce, A.K.1    Humphrey, T.C.2
  • 27
    • 0034722098 scopus 로고    scopus 로고
    • Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons
    • Pong K, Doctrow SR, Baudry M (2000) Prevention of 1-methyl-4-phenylpyridinium- and 6-hydroxydopamine-induced nitration of tyrosine hydroxylase and neurotoxicity by EUK-134, a superoxide dismutase and catalase mimetic, in cultured dopaminergic neurons. Brain Res 881:182-189.
    • (2000) Brain Res , vol.881 , pp. 182-189
    • Pong, K.1    Doctrow, S.R.2    Baudry, M.3
  • 28
    • 0034853453 scopus 로고    scopus 로고
    • Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons
    • Pong K, Doctrow SR, Huffman K, Adinolfi CA, Baudry M (2001) Attenuation of staurosporine-induced apoptosis, oxidative stress, and mitochondrial dysfunction by synthetic superoxide dismutase and catalase mimetics, in cultured cortical neurons. Exp Neurol 171:84-97.
    • (2001) Exp Neurol , vol.171 , pp. 84-97
    • Pong, K.1    Doctrow, S.R.2    Huffman, K.3    Adinolfi, C.A.4    Baudry, M.5
  • 29
    • 0031991097 scopus 로고    scopus 로고
    • Loss of ROS - A radical response
    • Przedborski S, Schon EA (1998) Loss of ROS - a radical response. Nat Genet 18:99-100.
    • (1998) Nat Genet , vol.18 , pp. 99-100
    • Przedborski, S.1    Schon, E.A.2
  • 30
    • 0035011079 scopus 로고    scopus 로고
    • Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia
    • Quick KL, Dugan LL (2001) Superoxide stress identifies neurons at risk in a model of ataxia-telangiectasia. Ann Neurol 49:627-635.
    • (2001) Ann Neurol , vol.49 , pp. 627-635
    • Quick, K.L.1    Dugan, L.L.2
  • 31
    • 0033578309 scopus 로고    scopus 로고
    • EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology
    • Rong Y, Doctrow SR, Tocco G, Baudry B (1999) EUK-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology. Neurobiology 96:9897-9902.
    • (1999) Neurobiology , vol.96 , pp. 9897-9902
    • Rong, Y.1    Doctrow, S.R.2    Tocco, G.3    Baudry, B.4
  • 32
    • 0031259793 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress?
    • Rotman G, Shiloh Y (1997) Ataxia-telangiectasia: is ATM a sensor of oxidative damage and stress? BioEssays 19:911-917.
    • (1997) BioEssays , vol.19 , pp. 911-917
    • Rotman, G.1    Shiloh, Y.2
  • 34
    • 0001183734 scopus 로고
    • Ataxia-telangiectasia (208900, 208910, 208920)
    • (Vinkin PJ, Bruyn W, Klawans HL, eds). New York: Alan R. Liss
    • Sedgwick RP, Boder E (1991) Ataxia-telangiectasia (208900, 208910, 208920). In: Hereditary neuropathies and spinocerebellar atrophies (Vinkin PJ, Bruyn W, Klawans HL, eds), pp 347-423. New York: Alan R. Liss.
    • (1991) Hereditary Neuropathies and Spinocerebellar Atrophies , pp. 347-423
    • Sedgwick, R.P.1    Boder, E.2
  • 35
    • 0034798285 scopus 로고    scopus 로고
    • ATM: Genome stability, neuronal development, and cancer cross paths
    • Shiloh Y, Kastan MB (2001) ATM: genome stability, neuronal development, and cancer cross paths. Adv Cancer Res 83:209-254.
    • (2001) Adv Cancer Res , vol.83 , pp. 209-254
    • Shiloh, Y.1    Kastan, M.B.2
  • 36
    • 0020400388 scopus 로고
    • Colony-forming ability of ataxia-telangiectasia skin fibroblasts is an indicator of their early senescence and increased demand for growth factors
    • Shiloh Y, Tabor E, Becker Y (1982) Colony-forming ability of ataxia-telangiectasia skin fibroblasts is an indicator of their early senescence and increased demand for growth factors. Exp Cell Res 140:91-99.
    • (1982) Exp Cell Res , vol.140 , pp. 91-99
    • Shiloh, Y.1    Tabor, E.2    Becker, Y.3
  • 37
    • 0032543723 scopus 로고    scopus 로고
    • Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia
    • Soares HD, Morgan JI, McKinnon PJ (1998) Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia. Neuroscience 86:1045-1054.
    • (1998) Neuroscience , vol.86 , pp. 1045-1054
    • Soares, H.D.1    Morgan, J.I.2    McKinnon, P.J.3
  • 40
    • 0037016764 scopus 로고    scopus 로고
    • Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice
    • Stern N, Hochman A, Zemach N, Weizman N, Hammel I, Shiloh Y, Rotman G, Barzilai A (2002) Accumulation of DNA damage and reduced levels of nicotine adenine dinucleotide in the brains of Atm-deficient mice. J Biol Chem 277:602-608.
    • (2002) J Biol Chem , vol.277 , pp. 602-608
    • Stern, N.1    Hochman, A.2    Zemach, N.3    Weizman, N.4    Hammel, I.5    Shiloh, Y.6    Rotman, G.7    Barzilai, A.8
  • 41
    • 0037414761 scopus 로고    scopus 로고
    • Identifcation of a novel protein kinase mediating Akt survival signaling to the ATM protein
    • Suzuki A, Kasakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H (2003) Identifcation of a novel protein kinase mediating Akt survival signaling to the ATM protein. J Biol Chem 278:48-53.
    • (2003) J Biol Chem , vol.278 , pp. 48-53
    • Suzuki, A.1    Kasakai, G.2    Kishimoto, A.3    Lu, J.4    Ogura, T.5    Lavin, M.F.6    Esumi, H.7
  • 42
    • 0035873398 scopus 로고    scopus 로고
    • Pyruvate released by astrocytes protects neurons from copper-catalyzed cysteine neurotoxicity
    • Wang XF, Cynader MS (2001) Pyruvate released by astrocytes protects neurons from copper-catalyzed cysteine neurotoxicity. J Neurosci 21:3322-3331.
    • (2001) J Neurosci , vol.21 , pp. 3322-3331
    • Wang, X.F.1    Cynader, M.S.2
  • 44
    • 0037470193 scopus 로고    scopus 로고
    • Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains
    • Weizman N, Shiloh Y, Barzilai A (2003) Contribution of the Atm protein to maintaining cellular homeostasis evidenced by continuous activation of the AP-1 pathway in Atm-deficient brains. J Biol Chem 278:6741-6747.
    • (2003) J Biol Chem , vol.278 , pp. 6741-6747
    • Weizman, N.1    Shiloh, Y.2    Barzilai, A.3
  • 45
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu Y, Ashley T, Brainerd EE, Bronson RT, Meyn MS, Baltimore D (1996) Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev 10:2411-2422.
    • (1996) Genes Dev , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 46
    • 0033662156 scopus 로고    scopus 로고
    • Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
    • Yang DQ, Kastan MB (2000) Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1. Nat Cell Biol 2:893-898.
    • (2000) Nat Cell Biol , vol.2 , pp. 893-898
    • Yang, D.Q.1    Kastan, M.B.2
  • 47


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.