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Volumn 8, Issue 3, 1996, Pages 412-418

Phosphatidylinositol 3-kinase related kinases

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE;

EID: 0030175487     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0952-7915(96)80132-4     Document Type: Article
Times cited : (58)

References (69)
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    • 2-M phase in S. cerevisiae. Mec1p is a homolog of the human ATM protein, which is mutated in AT. Like AT cells, yeast cells with mutations in MEC1 perform damage-resistant DNA synthesis, and incur higher rates of mutation and cytotoxicity following exposure to ionizing radiation and other genotoxic agents.
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    • of outstanding interest. The authors report the isolation of a cDNA encoding the entire open reading frame of the S. cerevisiae TEL1 gene. The deduced amino acid sequence indicates that Tel1p is a member of the family of PI3K-related kinases, and the closest known homolog of the human ATM protein. Interestingly, mutations in TEL1, but not in MEC1, TOR1 or TOR2, result in telomere shortening in yeast. Thus, Tel1p apparently executes a specialized function related to telomere metabolism in these cells.
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    • of special interest. This paper shows that insulin stimulation induces the phosphorylation of PHAS-I via a rapamycin-sensitive signaling pathway in 3T3-L1 adipocytes. Phosphorylation of PHAS-I relieves a negative inhibitory constraint on eukaryotic initiation factor (eIF)-4E binding to mRNA cap sites, and thereby facilitates a rate-limiting step in the stimulation of protein synthesis by insulin and other growth factors. These results suggest that mTor is an upstream component of a pathway leading to eIF-4E-dependent translation initiation in mammalian cells.
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