Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice

Cancer Research

Volumn 61, Issue 5, 2001, Pages 1849-1854

  Kamsler, A ^a   Daily, D ^a   Hochman, A ^a   Stern, N ^a   Shiloh, Y ^a   Rotman, G ^a   Barzilai, A ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ATM PROTEIN; CATALASE; GENE PRODUCT; MANGANESE SUPEROXIDE DISMUTASE; REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE; THIOREDOXIN;

ANIMAL TISSUE; ARTICLE; ATAXIA TELANGIECTASIA; CEREBELLUM; CLINICAL FEATURE; CONTROLLED STUDY; GENE INACTIVATION; NERVE DEGENERATION; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; ATAXIA TELANGIECTASIA; CATALASE; CELL CYCLE PROTEINS; CEREBELLUM; CYSTEINE; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; GLUTATHIONE; LIPID PEROXIDATION; MICE; NERVE TISSUE PROTEINS; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SUPEROXIDE DISMUTASE; TELENCEPHALON; THIOREDOXIN; TUMOR SUPPRESSOR PROTEINS;

EID: 0035266308     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (56)

1. Ataxia-telangiectasia
2. A single ataxiatelangiectasia gene with a product similar to PI-3 kinase
3. The complete sequence of the coding region of the ATM gene reveals similarity to cell cycle regulators in different species
4. Multiple ATM-dependent pathways
5. At the crossroads of DNA damage response, cell cycle control, genome stability, and cancer
6. ATM-deficient mice: A paradigm of ataxia telangiectasia
7. Pleiotropic defects in ataxia-telangiectasia protein-deficient mice
8. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
9. Radiosensitivity and oxidative signaling in ataxia telangiectasia: An update
10. Splitting the ATM
11. Free radicals as mediators of tissue injury and disease
12. Biological origin of free radicals and mechanisms of antioxidant protection
13. Role of reactive oxygen species: Signaling and regulation of cellular function
14. An essential role for free radicals and derived species in signal transduction
15. Redox regulation of cellular signaling
16. Cellular defenses against damage from reactive oxygen species
17. Antioxidant enzymes and their implications in pathophysiologic processes
18. Glutathione S-transferase: Genetics and role in toxicology
19. Thioredoxin and glutaredoxin systems
20. Thioltransferases
21. The ATM gene and protein: Possible roles in genome surveillance, checkpoint controls, and cellular defense against oxidative stress
22. Ataxia-telangiectasia: Is ATM a sensor of oxidative damage and stress?
23. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
24. Assay and inhibition of spinach superoxide dismutase
25. Assays for glutathione peroxidase
26. Glutathione S-transferases
27. Glutathione reductase
28. Further studies on the properties and assay of glucose 6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase of rat liver
29. Rat liver thioredoxin: Purification and characterization
30. Differential susceptibility of plasma proteins to oxidative modification: Examination by Western blot immunoassay
31. Adult T cell leukemia-derived factor/human thioredoxin protects endothelial F-2 cell injury caused by activated neutrophils or hydrogen peroxide
32. Oxidative stress induces adult T cell leukemia derived factor/thioredoxin in the rat retina
33. Induction of ADF/TRX by oxidative stress in keratinocytes and lymphoid cells
34. Loss of the ataxia-telangiectasia gene product causes oxidative damage in target organs
35. Superoxide dismutase activity and chromosome damage in cultured chromosome instability syndrome cells
36. Deficiency in the catalase activity of xeroderma pigmantosum cell and simian virus 40-transformed human cell extracts
37. Localization of a portion of extranuclear ATM to peroxisome
38. Anti-oxidative capacity in patients with ataxia-telangiectasia
39. Protective roles for ATM in cellular response to oxidative stress
40. Nitric oxide: A neuronal messenger
41. Free radicals in disease
42. Nitric oxide and cell death
43. Molecular and biochemical aspects of Bloom's syndrome
44. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage
45. Cogenital disorders sharing oxidative stress and cancer proneness as phenotypic hallmark: Prospects for joint research in pharmacology
46. Low catalase activity in xeroderma pigmentosum fibroblasts and SV40-transformed human cell lines is directly related to decreased intracellular levels of the cofactor
47. Analysis of the ATM protein in wild-type and ataxia telangiectasia cells
48. The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage
49. Cellular localization of the ataxia-telangiectasia (ATM) gene product and discrimination between mutated and normal forms
50. Expression of the ataxia telagiectasia gene (ATM) product in human cerebellar neurons during development
51. ATM is a cytoplasmic protein in mouse brain required to prevent lysosomal accumulation
52. Involvement of glutathione peroxidase and catalase in the disposal of exogenous hydrogen peroxide by cultured astroglia cells
53. Oxidative alterations in Alzheimer's disease
54. Prospects for new restorative and neuroprotective treatments in Parkinson's disease
55. Selective loss of dopaminergic nigro-striatal neurons in brains of ATM-deficient mice
56. Etiology and pathogenesis of Parkinson's disease