Bioactivities of alternative protein sources and their potential health benefits

Food and Function

Volumn 8, Issue 10, 2017, Pages 3443-3458

  Pihlanto, A ^a   Mattila, P ^a   Makinen S ^a   Pajari, A M ^b  

^a FINNISH FOREST RESEARCH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALS; HEALTH; NUTRITION;

ANIMAL HUSBANDRY; BIOACTIVE PEPTIDES; ESSENTIAL AMINO ACIDS; NUTRITIONAL PROPERTIES; NUTRITIONAL VALUE; POTENTIAL HEALTH; SOURCES OF ENERGY; STORAGE PROTEINS;

PROTEINS;

CANNABIS; PLANT PROTEIN;

ANIMAL; CHEMISTRY; CHENOPODIUM QUINOA; HEALTH; HUMAN; LUPIN; METABOLISM; NUTRITIONAL VALUE;

ANIMALS; CANNABIS; CHENOPODIUM QUINOA; HEALTH; HUMANS; LUPINUS; NUTRITIVE VALUE; PLANT PROTEINS;

EID: 85031809761     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c7fo00302a     Document Type: Article

References (123)

1. D. S. Dijkstra A. R. Linnemann T. A. J. S. van Boekel Towards sustainable production of protein-rich foods: Appraisal of eight crops for Western Europe. PART II: Analysis of the technological aspects of the production chain Crit. Rev. Food Sci. Nutr. 2003 43 481 506 10.1080/10408690390246332
2. C. Villarino V. Jayasena R. Coorey S. Chakrabarti-Bell R. Foley K. Fanning S. Johnson The effects of lupin (Lupinus angustifolius) addition to wheat bread on its nutritional, phytochemical and bioactive composition and protein quality Food Res. Int. 2015 76 58 65
3. A. M. Maradini Filho M. Pirozi S. B. Da H. M. Pinheiro Sant'Ana J. B. Paes Chaves R. C. Dos Quinoa: nutritional, functional and antinutritional aspects Crit. Rev. Food Sci. Nutr. 2015 57 1618 1630 10.1080/10408398.2014.1001811
4. S. Teh J. Birch Physicochemical and quality characteristics of cold-pressed hemp, flax and canola seed oils J. Food Compos. Anal. 2013 30 26 31
5. C. Villarino V. Jayasena R. Coorey S. Chakrabarti-Bell S. Johnson Nutritional, health, and technological functionality of lupin flour addition to bread and other baked products: Benefits and challenges Crit. Rev. Food Sci. Nutr. 2016 56 835 857
6. M. Saastamoinen M. Eurola V. Hietaniemi The chemical quality of some legumes, peas, fava beans, blue and white lupins and soybeans cultivated in Finland J. Agric. Sci. Technol. B 2013 3 92
7. A. Sujak A. Kotlarz W. Strobel Compositional and nutritional evaluation of several lupin seeds Food Chem. 2006 98 711 719 10.1016/j.foodchem.2005.06.036
8. C. I. Lizarazo A. Lampi J. Liu T. Sontag-Strohm V. Piironen F. L. Stoddard Nutritive quality and protein production from grain legumes in a boreal climate J. Sci. Food Agric. 2015 95 2053 2064
9. S. Multari M. Neacsu L. Scobbie L. Cantlay G. Duncan N. Vaughan D. Stewart W. R. Russell Nutritional and phytochemical content of high-protein crops J. Agric. Food Chem. 2016 64 7800 7811 10.1021/acs.jafc.6b00926
10. R. S. Hall S. J. Thomas S. K. Johnson Australian sweet lupin flour addition reduces the glycaemic index of a white bread breakfast without affecting palatability in healthy human volunteers Asia Pac. J. Clin. Nutr. 2005 14 91
11. M. Fogelholm New Nordic nutrition recommendations are here Food Nutr. Res. 2013 57 10.3402/fnr.v57i0.22903
12. A. Vega-Gálvez M. Miranda J. Vergara E. Uribe L. Puente E. A. Martínez Nutrition facts and functional potential of quinoa (Chenopodium quinoa willd.), an ancient Andean grain: a review J. Sci. Food Agric. 2010 90 2541 2547
13. V. Nowak J. Du U. R. Charrondière Assessment of the nutritional composition of quinoa (Chenopodium quinoa Willd) Food Chem. 2016 193 47 54
14. C. C. Mota M. Santos R. Mauro N. Samman A. S. Matos D. Torres I. Castanheira Protein content and amino acids profile of pseudocereals Food Chem. 2016 193 55 61
15. M. J. Kozioł Chemical composition and nutritional evaluation of quinoa (Chenopodium quinoa Willd.) J. Food Compos. Anal. 1992 5 38 68
16. J. Callaway Hempseed as a nutritional resource: an overview Euphytica 2004 140 65 72
17. J. D. House J. Neufeld G. Leson Evaluating the quality of protein from hemp seed (Cannabis sativa L.) products through the use of the protein digestibility-corrected amino acid score method J. Agric. Food Chem. 2010 58 11801 11807 10.1021/jf102636b
18. E. Vonapartis M. Aubin P. Seguin A. F. Mustafa J. Charron Seed composition of ten industrial hemp cultivars approved for production in Canada J. Food Compos. Anal. 2015 39 8 12
19. C. Tang Z. Ten X. Wang X. Yang Physicochemical and functional properties of hemp (Cannabis sativa L.) protein isolate J. Agric. Food Chem. 2006 54 8945 8950 10.1021/jf0619176
20. I. Galasso R. Russo S. Mapelli E. Ponzoni I. M. Brambilla G. Battelli R. Reggiani Variability in seed traits in a collection of Cannabis sativa, L. genotypes Front. Plant Sci. 2016 7 688 10.3389/fpls.2016.00688
21. C. Leizer D. Ribnicky A. Poulev S. Dushenkov I. Raskin The composition of hemp seed oil and its potential as an important source of nutrition J. Nutraceut. Funct. Med. Foods 2000 2 35 53
22. M. Pojic T. D. Hadnadev M. Hadnadev S. Rakita T. Brlek Bread supplementation with hemp seed cake: a by-product of hemp oil processing J. Food Qual. 2015 38 431 440 10.1111/jfq.12159
23. B. D. Oomah M. Busson D. V. Godfrey J. C. Drover Characteristics of hemp (Cannabis sativa L.) seed oil Food Chem. 2002 76 33 43
24. U. Kriese E. Schumann W. Weber M. Beyer L. Brühl Oil content, tocopherol composition and fatty acid patterns of the seeds of 51 Cannabis sativa L. genotypes Euphytica 2004 137 339 351
25. B. Matthäus L. Brühl Virgin hemp seed oil: an interesting niche product Eur. J. Lipid Sci. Technol. 2008 110 655 661
26. D. Boulter E. Derbyshire The general properties, classification and distribution of plant proteins Plant Proteins: Easter School in Agricultural Science 2013 1
27. M. Duranti A. Consonni C. Magni F. Sessa A. Scarafoni The major proteins of lupin seed: Characterisation and molecular properties for use as functional and nutraceutical ingredients Trends Food Sci. Technol. 2008 19 624 633 10.1016/j.tifs.2008.07.002
28. M. Duranti Grain legume proteins and nutraceutical properties Fitoterapia 2006 77 67 82
29. F. Cabello-Hurtado J. Keller J. Ley R. Sanchez-Lucas J. V. Jorrín-Novo A. Aïnouche Proteomics for exploiting diversity of lupin seed storage proteins and their use as nutraceuticals for health and welfare J. Proteomics 2016 143 57 68 10.1016/j.jprot.2016.03.026
30. I. S. Muranyi D. Volke R. Hoffmann P. Eisner T. Herfellner M. Brunnbauer P. Koehler U. Schweiggert-Weisz Protein distribution in lupin protein isolates from Lupinus angustifolius L. prepared by various isolation techniques Food Chem. 2016 207 6 15 10.1016/j.foodchem.2016.03.073
31. A. Arnoldi G. Boschin C. Zanoni C. Lammi The health benefits of sweet lupin seed flours and isolated proteins J. Funct. Foods 2015 18 Part A 550 563 10.1016/j.jff.2015.08.012
32. H. Lqari J. Pedroche J. Girón-Calle J. Vioque F. Millán Purification and partial characterization of storage proteins in Lupinus angustifolius seeds Grasas Aceites 2004 55 364 369
33. T. Ogura A. Hernandez T. Aizawa J. Ogihara M. Sunairi J. Alcaino Identification of a low digestibility delta-conglutin in yellow lupin (Lupinus luteus L.) seed meal for atlantic salmon (Salmo salar L.) by coupling 2D-PAGE and mass spectrometry PLoS One 2013 8 10.1371/journal.pone.0080369
34. R. S. Hall S. J. Thomas S. K. Johnson Australian sweet lupin flour addition reduces the glycaemic index of a white bread breakfast without affecting palatability in healthy human volunteers Asia Pac. J. Clin. Nutr. 2005 14 91
35. R. Hall S. Johnson A. Baxter M. Ball Lupin kernel fibre-enriched foods beneficially modify serum lipids in men Eur. J. Clin. Nutr. 2005 59 325 333
36. S. Patel R. Cudney A. McPherson Crystallographic characterization and molecular symmetry of edestin, a legumin from hemp J. Mol. Biol. 1994 235 361 363
37. X. Wang C. Tang X. Yang W. Gao Characterization, amino acid composition and in vitro digestibility of hemp (Cannabis sativa L.) proteins Food Chem. 2008 107 11 18 10.1016/j.foodchem.2007.06.064
38. S. Yin C. Tang J. Cao E. Hu Q. Wen X. Yang Effects of limited enzymatic hydrolysis with trypsin on the functional properties of hemp (Cannabis sativa L.) protein isolate Food Chem. 2008 106 1004 1013
39. C. Brinegar B. Sine L. Nwokocha High-cysteine 2S seed storage proteins from Quinoa (Chenopodium quinoa) J. Agric. Food Chem. 1996 44 1621 1623 10.1021/jf950830+
40. C. Brinegar S. Goundan Isolation and characterization of chenopodin, the 11S seed storage protein of quinoa (Chenopodium quinoa) J. Agric. Food Chem. 1993 41 182 185 10.1021/jf00026a006
41. H. Korhonen A. Pihlanto Bioactive peptides: production and functionality Int. Dairy J. 2006 16 945 960
42. A. Pihlanto and S. Mäkinen, Antihypertensive properties of plant protein derived peptides, in Bioactive Food Peptides in Health and Disease, ed., B. Hernandez-Ledesma, and, C.-C. Hsieh, INTECH Open Access Publisher, 2013, 10.5772/54565
43. C. Lammi G. Aiello G. Vistoli C. Zanoni A. Arnoldi Y. Sambuy S. Ferruzza G. Ranaldi A multidisciplinary investigation on the bioavailability and activity of peptides from lupin protein J. Funct. Foods 2016 24 297 306
44. C. Lammi C. Zanoni S. Ferruzza G. Ranaldi Y. Sambuy A. Arnoldi Hypocholesterolaemic activity of lupin peptides: Investigation on the crosstalk between human enterocytes and hepatocytes using a co-culture system including Caco-2 and HepG2 cells Nutrients 2016 8 437 10.3390/nu8070437
45. M. del Carmen Millán-Linares B. Bermúdez M. del Mar Yust F. Millán J. Pedroche Anti-inflammatory activity of lupine (Lupinus angustifolius L.) protein hydrolysates in THP-1-derived macrophages J. Funct. Foods 2014 8 224 233
46. C. G. Rizzello A. Lorusso V. Russo D. Pinto B. Marzani M. Gobbetti Improving the antioxidant properties of quinoa flour through fermentation with selected autochthonous lactic acid bacteria Int. J. Food Microbiol. 2017 241 252 261
47. A. B. Nongonierma R. J. FitzGerald The scientific evidence for the role of milk protein-derived bioactive peptides in humans. A review J. Funct. Foods 2015 17 640 656 10.1016/j.jff.2015.06.021
48. R. Aluko E. Monu Functional and bioactive properties of quinoa seed protein hydrolysates J. Food Sci. 2003 68 1254 1258
49. A. B. Nongonierma S. Le Maux C. Dubrulle C. Barre R. J. FitzGerald Quinoa (Chenopodium quinoa Willd.) protein hydrolysates with in vitro dipeptidyl peptidase IV (DPP-IV) inhibitory and antioxidant properties J. Cereal Sci. 2015 65 112 118
50. V. Aleksic P. Knezevic Antimicrobial and antioxidative activity of extracts and essential oils of Myrtus communis L Microbiol. Res. 2014 169 240 254
51. N. Rajapakse E. Mendis W. Jung J. Je S. Kim Purification of a radical scavenging peptide from fermented mussel sauce and its antioxidant properties Food Res. Int. 2005 38 175 182
52. A. P. Adebiyi A. O. Adebiyi J. Yamashita T. Ogawa K. Muramoto Purification and characterization of antioxidative peptides derived from rice bran protein hydrolysates Eur. Food Res. Technol. 2009 228 553 563
53. B. H. Sarmadi A. Ismail Antioxidative peptides from food proteins: a review Peptides 2010 31 1949 1956
54. Y. Chen S. W. Kwon S. C. Kim Y. Zhao Integrated approach for manual evaluation of peptides identified by searching protein sequence databases with tandem mass spectra J. Proteome Res. 2005 4 998 1005
55. T. Virtanen A. Pihlanto S. Akkanen H. Korhonen Development of antioxidant activity in milk whey during fermentation with lactic acid bacteria J. Appl. Microbiol. 2007 102 106 115
56. A. Pihlanto Antioxidative peptides derived from milk proteins Int. Dairy J. 2006 16 1306 1314
57. T. A. Girgih M. A. Alashi R. He A. S. Malomo P. Raj T. Netticadan E. R. Aluko A novel hemp seed meal protein hydrolysate reduces oxidative stress factors in spontaneously hypertensive rats Nutrients 2016 6 5652 5666 10.3390/nu6125652
58. S. Teh A. E. A. Bekhit A. Carne J. Birch Antioxidant and ACE-inhibitory activities of hemp (Cannabis sativa L.) protein hydrolysates produced by the proteases AFP, HT, Pro-G, actinidin and zingibain Food Chem. 2016 203 199 206 10.1016/j.foodchem.2016.02.057
59. A. T. Girgih C. C. Udenigwe H. Li A. P. Adebiyi R. E. Aluko Kinetics of enzyme inhibition and antihypertensive effects of hemp seed (Cannabis sativa L.) protein hydrolysates J. Am. Oil Chem. Soc. 2011 88 1767 1774
60. A. T. Girgih A. Alashi R. He S. Malomo R. E. Aluko Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats Eur. J. Nutr. 2014 53 1237 1246
61. D. C. Willcox G. Scapagnini B. J. Willcox Healthy aging diets other than the Mediterranean: a focus on the Okinawan diet Mech. Ageing Dev. 2014 136-137 148 162
62. S. A. Malomo R. E. Aluko In vitro acetylcholinesterase-inhibitory properties of enzymatic hemp seed protein hydrolysates J. Am. Oil Chem. Soc. 2016 93 411 420 10.1007/s11746-015-2779-0
63. R. J. Manders D. Hansen A. H. Zorenc P. Dendale J. Kloek W. H. Saris L. J. van Loon Protein co-ingestion strongly increases postprandial insulin secretion in type 2 diabetes patients J. Med. Food 2014 17 758 763
64. E. Méric S. Lemieux S. L. Turgeon L. Bazinet Insulin and glucose responses after ingestion of different loads and forms of vegetable or animal proteins in protein enriched fruit beverages J. Funct. Foods 2014 10 95 103
65. I. M. E. Lacroix E. Li-Chan Inhibition of dipeptidyl peptidase (DPP)-IV and glucosidase activities by pepsin-treated whey proteins J. Agric. Food Chem. 2013 61 7500 7506 10.1021/jf401000s
66. L. Mojica K. Chen E. G. Mejía Impact of commercial precooking of common bean (Phaseolus vulgaris) on the generation of peptides, after pepsin-pancreatin hydrolysis, capable to inhibit dipeptidyl peptidase-IV J. Food Sci. 2015 80 H188 H198
67. L. Juillerat-Jeanneret Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else? J. Med. Chem. 2013 57 2197 2212
68. A. B. Nongonierma R. J. FitzGerald An in silico model to predict the potential of dietary proteins as sources of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides Food Chem. 2014 165 489 498
69. B. D. Oomah N. Tiger M. Olson P. Balasubramanian Phenolics and antioxidative activities in narrow-leafed lupins (Lupinus angustifolius L.) Plant Foods Hum. Nutr. 2006 61 86 92
70. V. Jayasena A. P. James Total phenolic and phytosterol compounds and the radical scavenging activity of germinated Australian sweet lupin flour Plant Foods Hum. Nutr. 2013 68 352 357
71. M. K. Khan W. Karnpanit S. M. Nasar-Abbas Z. Huma V. Jayasena Phytochemical composition and bioactivities of lupin: a review Int. J. Food Sci. Technol. 2015 50 2004 2012
72. M. Duenas T. Hernandez I. Estrella D. Fernandez Germination as a process to increase the polyphenol content and antioxidant activity of lupin seeds (Lupinus angustifolius L.) Food Chem. 2009 117 599 607
73. N. Balasundram K. Sundram S. Samman Phenolic compounds in plants and agri-industrial by-products: Antioxidant activity, occurrence, and potential uses Food Chem. 2006 99 191 203
74. L. G. Ranilla M. I. Genovese F. M. Lajolo Isoflavones and antioxidant capacity of Peruvian and Brazilian lupin cultivars J. Food Compos. Anal. 2009 22 397 404
75. X. Han T. Shen H. Lou Dietary polyphenols and their biological significance Int. J. Mol. Sci. 2007 8 950 988
76. A. Scalbert C. Manach C. Morand C. Rémésy L. Jiménez Dietary polyphenols and the prevention of diseases Crit. Rev. Food Sci. Nutr. 2005 45 287 306
77. D. Del Rio A. Rodriguez-Mateos J. P. Spencer M. Tognolini G. Borges A. Crozier Dietary (poly) phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases Antioxid. Redox Signaling 2013 18 1818 1892
78. A. Siger J. Czubinski P. Kachlicki K. Dwiecki E. Lampart-Szczapa M. Nogala-Kalucka Antioxidant activity and phenolic content in three lupin species J. Food Compos. Anal. 2012 25 190 197
79. S. C. Magalhães M. Taveira A. R. Cabrita A. J. Fonseca P. Valentão P. B. Andrade European marketable grain legume seeds: Further insight into phenolic compounds profiles Food Chem. 2017 215 177 184
80. E. Szczapa J. Korczakb W. Nogala-Kaluckaa R. Zawirska-Wojtasiakc Antioxidant properties of lupin seed products Food Chem. 2003 83 279 285
81. L. Alemany R. Barbera A. Alegría J. Laparra Plant sterols from foods in inflammation and risk of cardiovascular disease: A real threat? Food Chem. Toxicol. 2014 69 140 149
82. R. Repo-Carrasco-Valencia J. K. Hellström J. Pihlava P. H. Mattila Flavonoids and other phenolic compounds in Andean indigenous grains: Quinoa (Chenopodium quinoa), kañiwa (Chenopodium pallidicaule) and kiwicha (Amaranthus caudatus) Food Chem. 2010 120 128 133
83. B. L. Graf L. E. Rojo J. Delatorre-Herrera A. Poulev C. Calfio I. Raskin Phytoecdysteroids and flavonoid glycosides among Chilean and commercial sources of Chenopodium quinoa: variation and correlation to physico-chemical characteristics J. Sci. Food Agric. 2016 96 633 643
84. M. Lutz A. Martínez E. A. Martínez Daidzein and genistein contents in seeds of quinoa (Chenopodium quinoa Willd.) from local ecotypes grown in arid Chile Ind. Crops Prod. 2013 49 117 121
85. E. Ryan K. Galvin T. O'Connor A. Maguire N. O'Brien Phytosterol, squalene, tocopherol content and fatty acid profile of selected seeds, grains, and legumes Plant Foods Hum. Nutr. 2007 62 85 91
86. E. Villacrés G. Pástor M. B. Quelal I. Zambrano S. Morales Effect of processing on the content of fatty acids, tocopherols and sterols in the oils of quinoa (Chenopodium quinoa Willd), lupine (Lupinus mutabilis Sweet), amaranth (Amaranthus caudatus L.) and sangorache (Amaranthus quitensis L.) GARJFST 2014 3 44 53
87. B. L. Graf P. Rojas-Silva L. E. Rojo J. Delatorre-Herrera M. E. Baldeón I. Raskin Innovations in health value and functional food development of quinoa (Chenopodium quinoa Willd) Compr. Rev. Food Sci. Food Saf. 2015 14 431 445
88. S. G. Sparg M. E. Light J. Van Staden Biological activities and distribution of plant saponins J. Ethnopharmacol. 2004 94 219 243
89. R. Brenneisen, Chemistry and analysis of phytocannabinoids and other Cannabis constituents, in Marijuana and the Cannabinoids, ed. Anonymous, Springer, 2007, pp. 17-49
90. I. J. Flores-Sanchez R. Verpoorte Secondary metabolism in cannabis Phytochem. Rev. 2008 7 615 639
91. A. I. Smeds P. C. Eklund S. M. Willför Content, composition, and stereochemical characterisation of lignans in berries and seeds Food Chem. 2012 134 1991 1998
92. X. Yan J. Tang C. dos Santos Passos A. Nurisso C. A. Simões-Pires M. Ji H. Lou P. Fan Characterization of lignanamides from hemp (Cannabis sativa L.) seed and their antioxidant and acetylcholinesterase inhibitory activities J. Agric. Food Chem. 2015 63 10611 10619
93. L. Sarmento, M. Carus, F. Grotenhermen, D. Kruse, R. Brenneisen, G. Grassi and C. Knapsack, Scientifically sound guidelines for THC in food in Europe, Report of nova-Institut GmbH, 2015
94. P. Bora Anti-nutritional factors in foods and their effects J. Acad. Ind. Res. 2014 3 285 290
95. S. Khokhar R. K. O. Apenten Antinutritional factors in food legumes and effects of processing The role of food, agriculture, forestry and fisheries in human nutrition 2003 4 82 116
96. S. A. Emire Y. K. Jha F. Mekam Role of anti-nutritional factors in food industry Beverage and Food World 2013 1 23 28
97. R. Y. Khattab S. D. Arntfield C. M. Nyachoti Nutritional quality of legume seeds as affected by some physical treatments, Part 1: Protein quality evaluation LWT-Food Sci. Technol. 2009 42 1107 1112 10.1016/j.lwt.2009.02.008
98. M. A. Ruiz A. Sotelo Chemical composition, nutritive value, and toxicology evalutaion of Mexican wild lupins J. Agric. Food Chem. 2001 49 5336 5339
99. A. Kouris-Blazos R. Belski Health benefits of legumes and pulses with a focus on Australian sweet lupins Asia Pac. J. Clin. Nutr. 2016 25 1 17
100. Z. Maknickienė A. Ražukas Narrow-leaved forage lupine (Lupinus angustifolius L.) breeding aspects Žemės ūkio mokslai 2007 14 27 31
101. N. Vertas M. Bilgicli Effect of different debittering processes in mineral and phytic acid content of lupin (Lupinus albus L.) seeds J. Food Sci. Technol. 2014 51 3348 3354
102. G. Chauhan N. Eskin R. Tkachuk Nurients and antinurients in quinoa seed Cereal Chem. 1992 69 85 88
103. J. Ruales B. M. Nair Saponins, phytic acid, tannins and protease inhibitors in quinoa (Chenopodium quinoa, Willd) seeds Food Chem. 1993 48 137 143
104. R. Russo R. Reggiani Variability in antinutritional compounds in hempseed meal of Italian and French varieties Plant 2013 1 25 29
105. M. Pojić A. Mišan M. Sakač T. Dapčević Hadnadev B. šarić I. Milovanović M. Hadnadev Characterization of byproducts originating from hemp oil processing J. Agric. Food Chem. 2014 62 12436 12442
106. K. Weiße C. Brandsch B. Zernsdorf G. S. N. Nembongwe K. Hofmann K. Eder G. I. Stangl Lupin protein compared to casein lowers the LDL cholesterol: HDL cholesterol-ratio of hypercholesterolemic adults Eur. J. Nutr. 2010 49 65 71
107. C. R. Sirtori M. Triolo R. Bosisio A. Bondioli L. Calabresi V. De Vergori M. Gomaraschi G. Mombelli F. Pazzucconi C. Zacherl Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals Br. J. Nutr. 2012 107 1176 1183
108. M. Bähr A. Fechner M. Kiehntopf G. Jahreis Consuming a mixed diet enriched with lupin protein beneficially affects plasma lipids in hypercholesterolemic subjects: A randomized controlled trial Clin. Nutr. 2015 34 7 14
109. C. R. Sirtori M. R. Lovati C. Manzoni S. Castiglioni M. Duranti C. Magni S. Morandi A. D'Agostina A. Arnoldi Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells J. Nutr. 2004 134 18 23
110. A. Fechner M. Kiehntopf G. Jahreis The formation of short-chain fatty acids is positively associated with the blood lipid-lowering effect of lupin kernel fiber in moderately hypercholesterolemic adults J. Nutr. 2014 144 599 607 10.3945/jn.113.186858
111. C. Cornfine K. Hasenkopf P. Eisner U. Schweiggert Influence of chemical and physical modification on the bile acid binding capacity of dietary fibre from lupins (Lupinus angustifolius L.) Food Chem. 2010 122 638 644
112. E. R. Dove T. A. Mori G. T. Chew A. E. Barden R. J. Woodman I. B. Puddey S. Sipsas J. M. Hodgson Lupin and soya reduce glycaemia acutely in type 2 diabetes Br. J. Nutr. 2011 106 1045 1051
113. S. K. Johnson V. Chua R. S. Hall A. L. Baxter Lupin kernel fibre foods improve bowel function and beneficially modify some putative faecal risk factors for colon cancer in men Br. J. Nutr. 2006 95 372 378
114. S. C. Smith R. Choy S. K. Johnson R. S. Hall A. C. Wildeboer-Veloo G. W. Welling Lupin kernel fiber consumption modifies fecal microbiota in healthy men as determined by rRNA gene fluorescent in situ hybridization Eur. J. Nutr. 2006 45 335 341
115. A. Fechner K. Fenske G. Jahreis Effects of legume kernel fibres and citrus fibre on putative risk factors for colorectal cancer: a randomised, double-blind, crossover human intervention trial Nutr. J. 2013 12 101
116. F. G. De Carvalho P. P. Ovídio G. J. Padovan A. A. Jordao Junior J. S. Marchini A. M. Navarro Metabolic parameters of postmenopausal women after quinoa or corn flakes intake-A prospective and double-blind study Int. J. Food Sci. Nutr. 2014 65 380 385
117. T. G. Simnadis L. C. Tapsell E. J. Beck Physiological effects associated with Quinoa consumption and implications for research involving humans: a review Plant Foods Hum. Nutr. 2015 70 238 249
118. Y. Tang B. Zhang X. Li P. X. Chen H. Zhang R. Liu R. Tsao Bound phenolics of quinoa seeds released by acid, alkaline, and enzymatic treatments and their antioxidant and α-glucosidase and pancreatic lipase inhibitory effects J. Agric. Food Chem. 2016 64 1712 1719
119. B. Gullón P. Gullón F. K. Tavaria R. Yáñez Assessment of the prebiotic effect of quinoa and amaranth in the human intestinal ecosystem Food Funct. 2016 7 3782 3788
120. V. F. Zevallos L. I. Herencia F. Chang S. Donnelly H. J. Ellis P. J. Ciclitira Gastrointestinal effects of eating quinoa (Chenopodium quinoa Willd.) in celiac patients Am. J. Gastroenterol. 2014 109 270 278
121. U. S. Schwab J. C. Callaway A. T. Erkkilä J. Gynther M. I. Uusitupa T. Järvinen Effects of hempseed and flaxseed oils on the profile of serum lipids, serum total and lipoprotein lipid concentrations and haemostatic factors Eur. J. Nutr. 2006 45 470 477
122. N. Kaul R. Kreml J. A. Austria M. N. Richard A. L. Edel E. Dibrov S. Hirono M. E. Zettler G. N. Pierce A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers J. Am. Coll. Nutr. 2008 27 51 58
123. J. Callaway U. Schwab I. Harvima P. Halonen O. Mykkänen P. Hyvönen T. Järvinen Efficacy of dietary hempseed oil in patients with atopic dermatitis J. Dermatol. Treat. 2005 16 87 94