Lupin protein compared to casein lowers the LDL cholesterol:HDL cholesterol-ratio of hypercholesterolemic adults

European Journal of Nutrition

Volumn 49, Issue 2, 2010, Pages 65-71

  Weie, Kristin ^a   Brandsch, Corinna ^a   Zernsdorf, Bianca ^a   Nkengfack Nembongwe, Germaine S ^a   Hofmann, Kathleen ^a   Eder, Klaus ^a   Stangl, Gabriele I ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

Hypercholesterolemic subjects; Lupin protein; Plasma lipids

Indexed keywords

ANTILIPEMIC AGENT; CASEIN; GLUCOSE; HIGH DENSITY LIPOPROTEIN; HOMOCYSTEINE; LOW DENSITY LIPOPROTEIN; TAURINE; TRIACYLGLYCEROL; VEGETABLE PROTEIN;

ADULT; AGED; AMINO ACID BLOOD LEVEL; AMINO ACID COMPOSITION; ARTICLE; CHOLESTEROL BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERCHOLESTEROLEMIA; LIPID ANALYSIS; LUPIN; MALE; RANDOMIZED CONTROLLED TRIAL; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; AMINO ACIDS; BLOOD GLUCOSE; CASEINS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; DIETARY PROTEINS; DOUBLE-BLIND METHOD; FEMALE; FOOD, FORMULATED; GENE EXPRESSION REGULATION; HUMANS; HYPERCHOLESTEROLEMIA; LUPINUS; MALE; MIDDLE AGED; PHYTOTHERAPY; PLANT PROTEINS; SEEDS; TRIGLYCERIDES; YOUNG ADULT;

ANIMALIA;

EID: 77950857432     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-009-0049-3     Document Type: Article

References (23)

1. JW Anderson BM Johnstone ME Cook-Newell 1995 Meta-analysis of the effects of soybean protein intake on serum lipids N Engl J Med 333 276 282 10.1056/NEJM199508033330502 1:CAS:528:DyaK2MXntlKht74%3D
2. A Bettzieche C Brandsch K Weisse F Hirche K Eder GI Stangl 2008 Lupin protein influences the expression of hepatic genes involved in fatty acid synthesis and triacylglycerol hydrolysis of adult rats Br J Nutr 99 952 962 10.1017/S0007114507857266 1:CAS:528:DC%2BD1cXls1agur8%3D
3. SJ Cho MA Juillerat CH Lee 2008 Identification of LDL-receptor transcription stimulating peptides from soybean hydrolysate in human hepatocytes J Agric Food Chem 56 4372 4376 10.1021/jf800676a 1:CAS:528:DC%2BD1cXmt1yns7s%3D (Pubitemid 351999358)
4. Food and Drug Administration 1999 Food labeling, health claims, soy protein, and coronary heart disease Fed Regist 57 699 733
5. JD Horton JL Goldstein MS Brown 2002 SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver J Clin Invest 109 1125 1131 1:CAS:528:DC%2BD38XjsFals7c%3D
6. Y Katagiri RK Ibrahim S Tahara 2000 HPLC analysis of white lupin isoflavonoids Biosci Biotechnol Biochem 64 1118 1125 10.1271/bbb.64.1118 1:CAS:528:DC%2BD3cXks1Kqsbg%3D
7. K Koba JW Liu E Bobik Jr DE Mills M Sugano YS Huang 2003 Effect of phytate in soy protein on the serum and liver cholesterol levels and liver fatty acid profile in rats Biosci Biotechnol Biochem 67 15 22 10.1271/bbb.67.15 1:CAS:528:DC%2BD3sXhtVWqtrg%3D (Pubitemid 39260139)
8. AH Lichtenstein SM Jalbert H Adlercreutz BR Goldin H Rasmussen EJ Schaefer LM Ausman 2002 Lipoprotein response to diets high in soy or animal protein with and without isoflavones in moderately hypercholesterolemic subjects Arterioscler Thromb Vasc Biol 22 1852 1858 10.1161/01.ATV.0000033513.18431.A1 1:CAS:528:DC%2BD38Xot1Oit7c%3D (Pubitemid 35315772)
9. JM Martins M Riottot MC de Abreu AM Viegas-Crespo MJ Lança JA Almeida JB Freire OP Bento 2005 Cholesterol-lowering effects of dietary blue lupin (Lupinus angustifolius L.) in intact and ileorectal anastomosed pigs J Lipid Res 46 1539 1547 10.1194/jlr.M500129-JLR200 1:CAS:528:DC%2BD2MXmtFKktr8%3D (Pubitemid 43109819)
10. C Nagata H Shimizu R Takami M Hayashi N Takeda K Yasuda 2003 Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women J Nutr 133 797 800 1:CAS:528:DC%2BD3sXhvFylurs%3D (Pubitemid 36268357)
11. Petterson DS (1998) Composition and food uses of lupins. In: Gladstones JS, Atkins CA, Hamblin J (eds) Lupins as crop plants: biology, production and utilization. CAB International, Wallingford, UK, pp 353-384
12. MW Pfaffl 2001 A new mathematical model for relative quantification in real-time RT-PCR Nucleic Acids Res 29 e45 10.1093/nar/29.9.e45 1:STN:280:DC%2BD38nis12jtw%3D%3D
13. D Schuster MW Modi D Lalka FM Gengo 1988 Reversed-phase high-performance liquid chromatographic assay to quantitate diastereomeric derivatives of metoprolol enantiomers in plasma J Chromatogr 433 318 325 10.1016/S0378-4347(00) 80615-5 1:CAS:528:DyaL1MXmvVyqtg%3D%3D (Pubitemid 19005173)
14. CR Sirtori MR Lovati C Manzoni S Castiglioni M Duranti C Magni S Morandi A D'Agostina A Arnoldi 2004 Proteins of white lupin seed, a naturally isoflavone-poor legume, reduce cholesterolemia in rats and increase LDL receptor activity in HepG2 cells J Nutr 134 18 23 1:CAS:528:DC%2BD2cXitlCnuw%3D%3D (Pubitemid 38057417)
15. CR Sirtori MR Lovati C Manzoni E Gianazza A Bondioli B Staels J Auwerx 1998 Reduction of serum cholesterol by soybean proteins: clinical experience and potential molecular mechanisms Nutr Metab Cardiovasc Dis 8 334 340 1:CAS:528:DyaK1MXhtVyqu70%3D (Pubitemid 128554004)
16. J Spielmann A Shukla C Brandsch F Hirche GI Stangl K Eder 2007 Dietary lupin protein lowers triglyceride concentrations in liver and plasma in rats by reducing hepatic gene expression of sterol regulatory element-binding protein-1c Ann Nutr Metab 51 387 392 10.1159/000107720 1:CAS:528:DC%2BD2sXhtVGrsrbL (Pubitemid 47442982)
17. HJ Teede FS Dalais D Kotsopoulos YL Liang S Davis BP McGrath 2001 Dietary soy has both beneficial and potentially adverse cardiovascular effects: a placebo-controlled study in men and postmenopausal women J Clin Endocrinol Metab 86 3053 3060 10.1210/jc.86.7.3053 1:CAS:528:DC%2BD3MXlt1Gjsbo%3D (Pubitemid 32673465)
18. S Tonstad K Smerud L Høie 2002 A comparison of the effects of 2 doses of soy protein or casein on serum lipids, serum lipoproteins, and plasma total homocysteine in hypercholesterolemic subjects Am J Clin Nutr 76 78 84 1:CAS:528:DC%2BD38XltVyhurw%3D (Pubitemid 34686552)
19. AR Tovar F Murguía C Cruz R Hernández-Pando CA Aguilar-Salinas J Pedraza-Chaverri R Correa-Rotter N Torres 2002 A soy protein diet alters hepatic lipid metabolism gene expression and reduces serum lipids and renal fibrogenic cytokines in rats with chronic nephrotic syndrome J Nutr 132 2562 2569 1:CAS:528:DC%2BD38XntFOgsro%3D (Pubitemid 35013234)
20. D Vanuzzo L Pilotto R Mirolo S Pirelli 2008 Cardiovascular risk and cardiometabolic risk: and epidemiological evaluation G Ital Cardiol 9 6S 17S
21. B Vester K Rasmussen 1991 High performance liquid chromatography method for rapid and accurate determination of homocysteine in plasma and serum Eur J Clin Chem Clin Biochem 29 549 554 1:CAS:528:DyaK38XhslyktQ%3D%3D
22. GN Welch J Loscalzo 1998 Homocysteine and atherothrombosis N Engl J Med 338 1042 1050 10.1056/NEJM199804093381507 1:CAS:528:DyaK1cXislaqtr4%3D (Pubitemid 28180407)
23. G Yuan KZ Al-Shali RA Hegele 2007 Hypertriglyceridemia: its etiology, effects and treatment CMAJ 176 1113 1120 (Pubitemid 46649735)