-
1
-
-
77950343791
-
Pattern recognition receptors and inflammation
-
Takeuchi, O. and Akira, S. 2010. Pattern recognition receptors and inflammation. Cell 140:805.
-
(2010)
Cell
, vol.140
, pp. 805
-
-
Takeuchi, O.1
Akira, S.2
-
2
-
-
77950362382
-
The inflammasomes
-
Schroder, K. and Tschopp, J. 2010. The inflammasomes. Cell 140:821.
-
(2010)
Cell
, vol.140
, pp. 821
-
-
Schroder, K.1
Tschopp, J.2
-
3
-
-
84927639135
-
Innate immune pattern recognition: a cell biological perspective
-
Brubaker, S. W., Bonham, K. S., Zanoni, I. et al. 2015. Innate immune pattern recognition: a cell biological perspective. Annu. Rev. Immunol. 33:257.
-
(2015)
Annu. Rev. Immunol.
, vol.33
, pp. 257
-
-
Brubaker, S.W.1
Bonham, K.S.2
Zanoni, I.3
-
4
-
-
84927732725
-
Regulation of inflammasome activation
-
Man, S. M. and Kanneganti, T. D. 2015. Regulation of inflammasome activation. Immunol. Rev. 265:6.
-
(2015)
Immunol. Rev.
, vol.265
, pp. 6
-
-
Man, S.M.1
Kanneganti, T.D.2
-
5
-
-
84864755627
-
The mammalian PYHIN gene family: phylogeny, evolution and expression
-
Cridland, J. A., Curley, E. Z., Wykes, M. N. et al. 2012. The mammalian PYHIN gene family: phylogeny, evolution and expression. BMC Evol. Biol. 12:140.
-
(2012)
BMC Evol. Biol.
, vol.12
, pp. 140
-
-
Cridland, J.A.1
Curley, E.Z.2
Wykes, M.N.3
-
6
-
-
0037108346
-
Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains
-
Harton, J. A., Linhoff, M. W., Zhang, J. et al. 2002. Cutting edge: CATERPILLER: a large family of mammalian genes containing CARD, pyrin, nucleotide-binding, and leucine-rich repeat domains. J. Immunol. 169:4088.
-
(2002)
J. Immunol.
, vol.169
, pp. 4088
-
-
Harton, J.A.1
Linhoff, M.W.2
Zhang, J.3
-
7
-
-
0036671894
-
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
-
Martinon, F., Burns, K. and Tschopp, J. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10:417.
-
(2002)
Mol. Cell
, vol.10
, pp. 417
-
-
Martinon, F.1
Burns, K.2
Tschopp, J.3
-
8
-
-
35348932070
-
Intracellular NOD-like receptors in host defense and disease
-
Kanneganti, T. D., Lamkanfi, M. and Núñez, G. 2007. Intracellular NOD-like receptors in host defense and disease. Immunity 27:549.
-
(2007)
Immunity
, vol.27
, pp. 549
-
-
Kanneganti, T.D.1
Lamkanfi, M.2
Núñez, G.3
-
9
-
-
84952630550
-
Converging roles of caspases in inflammasome activation, cell death and innate immunity
-
Man, S. M. and Kanneganti, T. D. 2016. Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat. Rev. Immunol. 16:7.
-
(2016)
Nat. Rev. Immunol.
, vol.16
, pp. 7
-
-
Man, S.M.1
Kanneganti, T.D.2
-
10
-
-
0033532091
-
Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB
-
Bertin, J., Nir, W. J., Fischer, C. M. et al. 1999. Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kappaB. J. Biol. Chem. 274:12955.
-
(1999)
J. Biol. Chem.
, vol.274
-
-
Bertin, J.1
Nir, W.J.2
Fischer, C.M.3
-
11
-
-
0033591330
-
Nod1, an Apaf- 1-like activator of caspase-9 and nuclear factor-kappaB
-
Inohara, N., Koseki, T., del Peso, L. et al. 1999. Nod1, an Apaf- 1-like activator of caspase-9 and nuclear factor-kappaB. J. Biol. Chem. 274:14560.
-
(1999)
J. Biol. Chem.
, vol.274
-
-
Inohara, N.1
Koseki, T.2
del Peso, L.3
-
12
-
-
84975453384
-
The cell biology of inflammasomes: mechanisms of inflammasome activation and regulation
-
Sharma, D. and Kanneganti, T. D. 2016. The cell biology of inflammasomes: mechanisms of inflammasome activation and regulation. J. Cell Biol. 213:617.
-
(2016)
J. Cell Biol.
, vol.213
, pp. 617
-
-
Sharma, D.1
Kanneganti, T.D.2
-
13
-
-
80455176839
-
Noncanonical inflammasome activation targets caspase-11
-
Kayagaki, N., Warming, S., Lamkanfi, M. et al. 2011. Noncanonical inflammasome activation targets caspase-11. Nature 479:117.
-
(2011)
Nature
, vol.479
, pp. 117
-
-
Kayagaki, N.1
Warming, S.2
Lamkanfi, M.3
-
14
-
-
0032548919
-
Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
-
Wang, S., Miura, M., Jung, Y. K. et al. 1998. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell 92:501.
-
(1998)
Cell
, vol.92
, pp. 501
-
-
Wang, S.1
Miura, M.2
Jung, Y.K.3
-
15
-
-
79957576718
-
NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis
-
Elinav, E., Strowig, T., Kau, A. L. et al. 2011. NLRP6 inflammasome regulates colonic microbial ecology and risk for colitis. Cell 145:745.
-
(2011)
Cell
, vol.145
, pp. 745
-
-
Elinav, E.1
Strowig, T.2
Kau, A.L.3
-
16
-
-
79956061094
-
IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
-
Kerur, N., Veettil, M. V., Sharma-Walia, N. et al. 2011. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe 9:363.
-
(2011)
Cell Host Microbe
, vol.9
, pp. 363
-
-
Kerur, N.1
Veettil, M.V.2
Sharma-Walia, N.3
-
17
-
-
84858796861
-
An NLRP7- containing inflammasome mediates recognition of microbial lipopeptides in human macrophages
-
Khare, S., Dorfleutner, A., Bryan, N. B. et al. 2012. An NLRP7- containing inflammasome mediates recognition of microbial lipopeptides in human macrophages. Immunity 36:464.
-
(2012)
Immunity
, vol.36
, pp. 464
-
-
Khare, S.1
Dorfleutner, A.2
Bryan, N.B.3
-
18
-
-
84879577117
-
Human astrocytes express a novel NLRP2 inflammasome
-
Minkiewicz, J., de Rivero Vaccari, J. P. and Keane, R. W. 2013. Human astrocytes express a novel NLRP2 inflammasome. Glia 61:1113.
-
(2013)
Glia
, vol.61
, pp. 1113
-
-
Minkiewicz, J.1
de Rivero Vaccari, J.P.2
Keane, R.W.3
-
19
-
-
74049126045
-
Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production
-
Poeck, H., Bscheider, M., Gross, O. et al. 2010. Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production. Nat. Immunol. 11:63.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 63
-
-
Poeck, H.1
Bscheider, M.2
Gross, O.3
-
20
-
-
84864317101
-
The NLRP12 inflammasome recognizes Yersinia pestis
-
Vladimer, G. I., Weng, D., Paquette, S. W. et al. 2012. The NLRP12 inflammasome recognizes Yersinia pestis. Immunity 37:96.
-
(2012)
Immunity
, vol.37
, pp. 96
-
-
Vladimer, G.I.1
Weng, D.2
Paquette, S.W.3
-
21
-
-
31744441475
-
Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin
-
Boyden, E. D. and Dietrich, W. F. 2006. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat. Genet. 38:240.
-
(2006)
Nat. Genet.
, vol.38
, pp. 240
-
-
Boyden, E.D.1
Dietrich, W.F.2
-
22
-
-
85007583900
-
Functional and evolutionary analyses identify proteolysis as a general mechanism for NLRP1 inflammasome activation
-
Chavarría-Smith, J., Mitchell, P. S., Ho, A. M. et al. 2016. Functional and evolutionary analyses identify proteolysis as a general mechanism for NLRP1 inflammasome activation. PLoS Pathog. 12:e1006052.
-
(2016)
PLoS Pathog.
, vol.12
-
-
Chavarría-Smith, J.1
Mitchell, P.S.2
Ho, A.M.3
-
23
-
-
84879508269
-
Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor
-
Chavarría-Smith, J. and Vance, R. E. 2013. Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor. PLoS Pathog. 9:e1003452.
-
(2013)
PLoS Pathog.
, vol.9
-
-
Chavarría-Smith, J.1
Vance, R.E.2
-
24
-
-
84869073837
-
Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages
-
Hellmich, K. A., Levinsohn, J. L., Fattah, R. et al. 2012. Anthrax lethal factor cleaves mouse nlrp1b in both toxin-sensitive and toxin-resistant macrophages. PLoS One 7:e49741.
-
(2012)
PLoS One
, vol.7
-
-
Hellmich, K.A.1
Levinsohn, J.L.2
Fattah, R.3
-
25
-
-
84861215715
-
Proteolytic processing of Nlrp1b is required for inflammasome activity
-
Frew, B. C., Joag, V. R. and Mogridge, J. 2012. Proteolytic processing of Nlrp1b is required for inflammasome activity. PLoS Pathog. 8:e1002659.
-
(2012)
PLoS Pathog.
, vol.8
-
-
Frew, B.C.1
Joag, V.R.2
Mogridge, J.3
-
26
-
-
84988622178
-
Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation
-
Zhong, F. L., Mamaï, O., Sborgi, L. et al. 2016. Germline NLRP1 mutations cause skin inflammatory and cancer susceptibility syndromes via inflammasome activation. Cell 167:187.
-
(2016)
Cell
, vol.167
, pp. 187
-
-
Zhong, F.L.1
Mamaï, O.2
Sborgi, L.3
-
27
-
-
7944232105
-
Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
-
Martinon, F., Agostini, L., Meylan, E. et al. 2004. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr. Biol. 14:1929.
-
(2004)
Curr. Biol.
, vol.14
, pp. 1929
-
-
Martinon, F.1
Agostini, L.2
Meylan, E.3
-
28
-
-
32944462834
-
Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3
-
Kanneganti, T. D., Ozören, N., Body-Malapel, M. et al. 2006. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440:233.
-
(2006)
Nature
, vol.440
, pp. 233
-
-
Kanneganti, T.D.1
Ozören, N.2
Body-Malapel, M.3
-
29
-
-
32944470765
-
Cryopyrin activates the inflammasome in response to toxins and ATP
-
Mariathasan, S., Weiss, D. S., Newton, K. et al. 2006. Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228.
-
(2006)
Nature
, vol.440
, pp. 228
-
-
Mariathasan, S.1
Weiss, D.S.2
Newton, K.3
-
30
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 inflammasome
-
Martinon, F., Pétrilli, V., Mayor, A. et al. 2006. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237.
-
(2006)
Nature
, vol.440
, pp. 237
-
-
Martinon, F.1
Pétrilli, V.2
Mayor, A.3
-
31
-
-
64049111768
-
The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
-
Allen, I. C., Scull, M. A., Moore, C. B. et al. 2009. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 30:556.
-
(2009)
Immunity
, vol.30
, pp. 556
-
-
Allen, I.C.1
Scull, M.A.2
Moore, C.B.3
-
32
-
-
64049096334
-
The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
-
Thomas, P. G., Dash, P., Aldridge, J. R., Jr et al. 2009. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 30:566.
-
(2009)
Immunity
, vol.30
, pp. 566
-
-
Thomas, P.G.1
Dash, P.2
Aldridge, J.R.3
-
33
-
-
67349271142
-
Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
-
Gross, O., Poeck, H., Bscheider, M. et al. 2009. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 459:433.
-
(2009)
Nature
, vol.459
, pp. 433
-
-
Gross, O.1
Poeck, H.2
Bscheider, M.3
-
34
-
-
33846014297
-
Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
-
Kanneganti, T. D., Body-Malapel, M., Amer, A. et al. 2006. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J. Biol. Chem. 281:36560.
-
(2006)
J. Biol. Chem.
, vol.281
-
-
Kanneganti, T.D.1
Body-Malapel, M.2
Amer, A.3
-
35
-
-
68949092245
-
Fungal zymosan and mannan activate the cryopyrin inflammasome
-
Lamkanfi, M., Malireddi, R. K. and Kanneganti, T. D. 2009. Fungal zymosan and mannan activate the cryopyrin inflammasome. J. Biol. Chem. 284:20574.
-
(2009)
J. Biol. Chem.
, vol.284
-
-
Lamkanfi, M.1
Malireddi, R.K.2
Kanneganti, T.D.3
-
36
-
-
77953464026
-
Nlrp3: an immune sensor of cellular stress and infection
-
Lamkanfi, M. and Kanneganti, T. D. 2010. Nlrp3: an immune sensor of cellular stress and infection. Int. J. Biochem. Cell Biol. 42:792.
-
(2010)
Int. J. Biochem. Cell Biol.
, vol.42
, pp. 792
-
-
Lamkanfi, M.1
Kanneganti, T.D.2
-
37
-
-
70249138036
-
Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression
-
Bauernfeind, F. G., Horvath, G., Stutz, A. et al. 2009. Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 183:787.
-
(2009)
J. Immunol.
, vol.183
, pp. 787
-
-
Bauernfeind, F.G.1
Horvath, G.2
Stutz, A.3
-
38
-
-
64049084303
-
Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages
-
Netea, M. G., Nold-Petry, C. A., Nold, M. F. et al. 2009. Differential requirement for the activation of the inflammasome for processing and release of IL-1beta in monocytes and macrophages. Blood 113:2324.
-
(2009)
Blood
, vol.113
, pp. 2324
-
-
Netea, M.G.1
Nold-Petry, C.A.2
Nold, M.F.3
-
39
-
-
84976516826
-
Inflammasomes: mechanism of assembly, regulation and signalling
-
Broz, P. and Dixit, V. M. 2016. Inflammasomes: mechanism of assembly, regulation and signalling. Nat. Rev. Immunol. 16:407.
-
(2016)
Nat. Rev. Immunol.
, vol.16
, pp. 407
-
-
Broz, P.1
Dixit, V.M.2
-
40
-
-
84879596906
-
K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
-
Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G et al. 2013. K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity 38:1142.
-
(2013)
Immunity
, vol.38
, pp. 1142
-
-
Muñoz-Planillo, R.1
Kuffa, P.2
Martínez-Colón, G.3
-
41
-
-
84994910645
-
K(+) effluxindependent NLRP3 inflammasome activation by small molecules targeting mitochondria
-
Groß, C. J., Mishra, R., Schneider, K. S. et al. 2016. K(+) effluxindependent NLRP3 inflammasome activation by small molecules targeting mitochondria. Immunity 45:761.
-
(2016)
Immunity
, vol.45
, pp. 761
-
-
Groß, C.J.1
Mishra, R.2
Schneider, K.S.3
-
42
-
-
84969142199
-
Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death
-
Sanman, L. E., Qian, Y., Eisele, N. A. et al. 2016. Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death. Elife 5:e13663.
-
(2016)
Elife
, vol.5
, pp. e13663
-
-
Sanman, L.E.1
Qian, Y.2
Eisele, N.A.3
-
43
-
-
84894271641
-
FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes
-
Gurung, P., Anand, P. K., Malireddi, R. K. et al. 2014. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J. Immunol. 192:1835.
-
(2014)
J. Immunol.
, vol.192
, pp. 1835
-
-
Gurung, P.1
Anand, P.K.2
Malireddi, R.K.3
-
44
-
-
84964402403
-
NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1beta-mediated osteomyelitis
-
Gurung, P., Burton, A., and Kanneganti, T. D. 2016. NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1beta-mediated osteomyelitis. Proc. Natl Acad. Sci. USA 113:4452.
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 4452
-
-
Gurung, P.1
Burton, A.2
Kanneganti, T.D.3
-
45
-
-
84867241369
-
Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-ß (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome- mediated host defense against enteropathogens
-
Gurung, P., Malireddi, R. K., Anand, P. K. et al. 2012. Toll or interleukin-1 receptor (TIR) domain-containing adaptor inducing interferon-ß (TRIF)-mediated caspase-11 protease production integrates Toll-like receptor 4 (TLR4) protein- and Nlrp3 inflammasome- mediated host defense against enteropathogens. J. Biol. Chem. 287:34474.
-
(2012)
J. Biol. Chem.
, vol.287
-
-
Gurung, P.1
Malireddi, R.K.2
Anand, P.K.3
-
46
-
-
85022040336
-
ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways
-
Kuriakose, T., Man, S. M., Malireddi, R. K. et al. 2016. ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways. Sci. Immunol. 1:aag2045.
-
(2016)
Sci. Immunol.
, vol.1
-
-
Kuriakose, T.1
Man, S.M.2
Malireddi, R.K.3
-
47
-
-
84958971929
-
NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
-
He, Y., Zeng, M. Y., Yang, D. et al. 2016. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature 530:354.
-
(2016)
Nature
, vol.530
, pp. 354
-
-
He, Y.1
Zeng, M.Y.2
Yang, D.3
-
48
-
-
84952931119
-
A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation
-
Schmid-Burgk, J. L., Chauhan, D., Schmidt, T. et al. 2016. A genome-wide CRISPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation. J. Biol. Chem. 291:103.
-
(2016)
J. Biol. Chem.
, vol.291
, pp. 103
-
-
Schmid-Burgk, J.L.1
Chauhan, D.2
Schmidt, T.3
-
49
-
-
84949595485
-
NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
-
Shi, H., Wang, Y., Li, X. et al. 2016. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat. Immunol. 17:250.
-
(2016)
Nat. Immunol.
, vol.17
, pp. 250
-
-
Shi, H.1
Wang, Y.2
Li, X.3
-
50
-
-
84872782298
-
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
-
Py, B. F., Kim, M. S., Vakifahmetoglu-Norberg, H. et al. 2013. Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity. Mol. Cell 49:331.
-
(2013)
Mol. Cell
, vol.49
, pp. 331
-
-
Py, B.F.1
Kim, M.S.2
Vakifahmetoglu-Norberg, H.3
-
51
-
-
84988458393
-
NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
-
Spalinger, M. R., Kasper, S., Gottier, C. et al. 2016. NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. J. Clin. Invest. 126:1783.
-
(2016)
J. Clin. Invest.
, vol.126
, pp. 1783
-
-
Spalinger, M.R.1
Kasper, S.2
Gottier, C.3
-
52
-
-
0035958867
-
Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1
-
Poyet, J. L., Srinivasula, S. M., Tnani, M. et al. 2001. Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276:28309.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 28309
-
-
Poyet, J.L.1
Srinivasula, S.M.2
Tnani, M.3
-
53
-
-
33744464740
-
Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages
-
Franchi, L., Amer, A., Body-Malapel, M. et al. 2006. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Nat. Immunol. 7:576.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 576
-
-
Franchi, L.1
Amer, A.2
Body-Malapel, M.3
-
54
-
-
33744493091
-
Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
-
Miao, E. A., Alpuche-Aranda, C. M., Dors, M. et al. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7:569.
-
(2006)
Nat. Immunol.
, vol.7
, pp. 569
-
-
Miao, E.A.1
Alpuche-Aranda, C.M.2
Dors, M.3
-
55
-
-
77649241461
-
Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome
-
Miao, E. A., Mao, D. P., Yudkovsky, N. et al. 2010. Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc. Natl Acad. Sci. USA 107:3076.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 3076
-
-
Miao, E.A.1
Mao, D.P.2
Yudkovsky, N.3
-
56
-
-
80053349020
-
The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
-
Zhao, Y., Yang, J., Shi, J. et al. 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature 477:596.
-
(2011)
Nature
, vol.477
, pp. 596
-
-
Zhao, Y.1
Yang, J.2
Shi, J.3
-
57
-
-
80053379974
-
Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
-
Kofoed, E. M. and Vance, R. E. 2011. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature 477:592.
-
(2011)
Nature
, vol.477
, pp. 592
-
-
Kofoed, E.M.1
Vance, R.E.2
-
58
-
-
84898031590
-
Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes
-
Tenthorey, J. L., Kofoed, E. M., Daugherty, M. D. et al. 2014. Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Mol. Cell 54:17.
-
(2014)
Mol. Cell
, vol.54
, pp. 17
-
-
Tenthorey, J.L.1
Kofoed, E.M.2
Daugherty, M.D.3
-
59
-
-
84883329029
-
Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation
-
Yang, J., Zhao, Y., Shi, J. et al. 2013. Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc. Natl Acad. Sci. USA 110:14408.
-
(2013)
Proc. Natl Acad. Sci. USA
, vol.110
, pp. 14408
-
-
Yang, J.1
Zhao, Y.2
Shi, J.3
-
60
-
-
84937706079
-
Cutting edge: inflammasome activation in primary human macrophages is dependent on flagellin
-
Kortmann, J., Brubaker, S. W. and Monack, D. M. 2015. Cutting edge: inflammasome activation in primary human macrophages is dependent on flagellin. J. Immunol. 195:815.
-
(2015)
J. Immunol.
, vol.195
, pp. 815
-
-
Kortmann, J.1
Brubaker, S.W.2
Monack, D.M.3
-
61
-
-
3142654767
-
Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
-
Mariathasan, S., Newton, K., Monack, D. M. et al. 2004. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213.
-
(2004)
Nature
, vol.430
, pp. 213
-
-
Mariathasan, S.1
Newton, K.2
Monack, D.M.3
-
62
-
-
84887439544
-
Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1ß production
-
Man, S. M., Tourlomousis, P., Hopkins, L. et al. 2013. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1ß production. J. Immunol. 191:5239.
-
(2013)
J. Immunol.
, vol.191
, pp. 5239
-
-
Man, S.M.1
Tourlomousis, P.2
Hopkins, L.3
-
63
-
-
84927126118
-
An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
-
Canna, S. W., de Jesus, A. A., Gouni, S. et al. 2014. An activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome. Nat. Genet. 46:1140.
-
(2014)
Nat. Genet.
, vol.46
, pp. 1140
-
-
Canna, S.W.1
de Jesus, A.A.2
Gouni, S.3
-
64
-
-
84867861468
-
Phosphorylation of NLRC4 is critical for inflammasome activation
-
Qu, Y., Misaghi, S., Izrael-Tomasevic, A. et al. 2012. Phosphorylation of NLRC4 is critical for inflammasome activation. Nature 490:539.
-
(2012)
Nature
, vol.490
, pp. 539
-
-
Qu, Y.1
Misaghi, S.2
Izrael-Tomasevic, A.3
-
65
-
-
84895771345
-
Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcd
-
Suzuki, S., Franchi, L., He, Y. et al. 2014. Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcd. PLoS Pathog. 10:e1003926.
-
(2014)
PLoS Pathog.
, vol.10
, pp. e1003926
-
-
Suzuki, S.1
Franchi, L.2
He, Y.3
-
66
-
-
84922311780
-
Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5
-
Matusiak, M., Van Opdenbosch, N., Vande Walle, L. et al. 2015. Flagellin-induced NLRC4 phosphorylation primes the inflammasome for activation by NAIP5. Proc. Natl Acad. Sci. USA 112:1541.
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 1541
-
-
Matusiak, M.1
Van Opdenbosch, N.2
Vande Walle, L.3
-
67
-
-
63649145255
-
AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
-
Fernandes-Alnemri, T., Yu, J. W., Datta, P. et al. 2009. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458:509.
-
(2009)
Nature
, vol.458
, pp. 509
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Datta, P.3
-
68
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC
-
Hornung, V., Ablasser, A., Charrel-Dennis, M. et al. 2009. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458:514.
-
(2009)
Nature
, vol.458
, pp. 514
-
-
Hornung, V.1
Ablasser, A.2
Charrel-Dennis, M.3
-
69
-
-
60749136484
-
An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome
-
Bürckstümmer, T., Baumann, C., Blüml, S. et al. 2009. An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat. Immunol. 10:266.
-
(2009)
Nat. Immunol.
, vol.10
, pp. 266
-
-
Bürckstümmer, T.1
Baumann, C.2
Blüml, S.3
-
70
-
-
60749104535
-
HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA
-
Roberts, T. L., Idris, A., Dunn, J. A. et al. 2009. HIN-200 proteins regulate caspase activation in response to foreign cytoplasmic DNA. Science 323:1057.
-
(2009)
Science
, vol.323
, pp. 1057
-
-
Roberts, T.L.1
Idris, A.2
Dunn, J.A.3
-
71
-
-
40449097257
-
The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
-
Muruve, D. A., Pétrilli, V., Zaiss, A. K. et al. 2008. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 452:103.
-
(2008)
Nature
, vol.452
, pp. 103
-
-
Muruve, D.A.1
Pétrilli, V.2
Zaiss, A.K.3
-
72
-
-
77951263260
-
The AIM2 inflammasome is critical for innate immunity to Francisella tularensis
-
Fernandes-Alnemri, T., Yu, J. W., Juliana, C. et al. 2010. The AIM2 inflammasome is critical for innate immunity to Francisella tularensis. Nat. Immunol. 11:385.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 385
-
-
Fernandes-Alnemri, T.1
Yu, J.W.2
Juliana, C.3
-
73
-
-
77951269392
-
The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses
-
Rathinam, V. A., Jiang, Z., Waggoner, S. N. et al. 2010. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat. Immunol. 11:395.
-
(2010)
Nat. Immunol.
, vol.11
, pp. 395
-
-
Rathinam, V.A.1
Jiang, Z.2
Waggoner, S.N.3
-
74
-
-
77953116282
-
Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis
-
Jones, J. W., Kayagaki, N., Broz, P. et al. 2010. Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis. Proc. Natl Acad. Sci. USA 107:9771.
-
(2010)
Proc. Natl Acad. Sci. USA
, vol.107
, pp. 9771
-
-
Jones, J.W.1
Kayagaki, N.2
Broz, P.3
-
75
-
-
77955294800
-
Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol
-
Sauer, J. D., Witte, C. E., Zemansky, J. et al. 2010. Listeria monocytogenes triggers AIM2-mediated pyroptosis upon infrequent bacteriolysis in the macrophage cytosol. Cell Host Microbe 7:412.
-
(2010)
Cell Host Microbe
, vol.7
, pp. 412
-
-
Sauer, J.D.1
Witte, C.E.2
Zemansky, J.3
-
76
-
-
34249044447
-
Type I interferon signaling is required for activation of the inflammasome during Francisella infection
-
Henry, T., Brotcke, A., Weiss, D. S. et al. 2007. Type I interferon signaling is required for activation of the inflammasome during Francisella infection. J. Exp. Med. 204:987.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 987
-
-
Henry, T.1
Brotcke, A.2
Weiss, D.S.3
-
77
-
-
84928545520
-
The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
-
Man, S. M., Karki, R., Malireddi, R. K. et al. 2015. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nat. Immunol. 16:467.
-
(2015)
Nat. Immunol.
, vol.16
, pp. 467
-
-
Man, S.M.1
Karki, R.2
Malireddi, R.K.3
-
78
-
-
84990856288
-
IRGB10 liberates bacterial ligands for sensing by the AIM2 and Caspase-11-NLRP3 inflammasomes
-
Man, S. M., Karki, R., Sasai, M. et al. 2016. IRGB10 liberates bacterial ligands for sensing by the AIM2 and Caspase-11-NLRP3 inflammasomes. Cell 167:382.
-
(2016)
Cell
, vol.167
, pp. 382
-
-
Man, S.M.1
Karki, R.2
Sasai, M.3
-
79
-
-
84928538482
-
Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida
-
Meunier, E., Wallet, P., Dreier, R. F. et al. 2015. Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida. Nat. Immunol. 16:476.
-
(2015)
Nat. Immunol.
, vol.16
, pp. 476
-
-
Meunier, E.1
Wallet, P.2
Dreier, R.F.3
-
80
-
-
84902655075
-
Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms
-
Dihlmann, S., Erhart, P., Mehrabi, A. et al. 2014. Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms. Mol. Med. 20:230.
-
(2014)
Mol. Med.
, vol.20
, pp. 230
-
-
Dihlmann, S.1
Erhart, P.2
Mehrabi, A.3
-
81
-
-
79955897768
-
Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions
-
Dombrowski, Y., Peric, M., Koglin, S. et al. 2011. Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions. Sci. Transl. Med. 3:82ra38.
-
(2011)
Sci. Transl. Med.
, vol.3
-
-
Dombrowski, Y.1
Peric, M.2
Koglin, S.3
-
82
-
-
75649151209
-
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus
-
Javierre, B. M., Fernandez, A. F., Richter, J. et al. 2010. Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res. 20:170.
-
(2010)
Genome Res.
, vol.20
, pp. 170
-
-
Javierre, B.M.1
Fernandez, A.F.2
Richter, J.3
-
83
-
-
84934346989
-
Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer
-
Man, S. M., Zhu, Q., Zhu, L. et al. 2015. Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer. Cell 162:45.
-
(2015)
Cell
, vol.162
, pp. 45
-
-
Man, S.M.1
Zhu, Q.2
Zhu, L.3
-
84
-
-
84938996802
-
Inflammasomeindependent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt
-
Wilson, J. E., Petrucelli, A. S., Chen, L. et al. 2015. Inflammasomeindependent role of AIM2 in suppressing colon tumorigenesis via DNA-PK and Akt. Nat. Med. 21:906.
-
(2015)
Nat. Med.
, vol.21
, pp. 906
-
-
Wilson, J.E.1
Petrucelli, A.S.2
Chen, L.3
-
85
-
-
84992597199
-
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
-
Xie, M., Yu, Y., Kang, R. et al. 2016. PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation. Nat. Commun. 7:13280.
-
(2016)
Nat. Commun.
, vol.7
, pp. 13280
-
-
Xie, M.1
Yu, Y.2
Kang, R.3
-
86
-
-
84994507182
-
The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury
-
Hu, B., Jin, C., Li, H. B. et al. 2016. The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury. Science 354:765.
-
(2016)
Science
, vol.354
, pp. 765
-
-
Hu, B.1
Jin, C.2
Li, H.B.3
-
87
-
-
84982972146
-
AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity
-
Di Micco, A., Frera, G., Lugrin, J. et al. 2016. AIM2 inflammasome is activated by pharmacological disruption of nuclear envelope integrity. Proc. Natl Acad. Sci. USA 113:E4671.
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. E4671
-
-
Di Micco, A.1
Frera, G.2
Lugrin, J.3
-
88
-
-
79956299492
-
Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin- 1ß activation and severe autoinflammation in mice
-
Chae, J. J., Cho, Y. H., Lee, G. S. et al. 2011. Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin- 1ß activation and severe autoinflammation in mice. Immunity 34:755.
-
(2011)
Immunity
, vol.34
, pp. 755
-
-
Chae, J.J.1
Cho, Y.H.2
Lee, G.S.3
-
89
-
-
16944365196
-
A candidate gene for familial Mediterranean fever
-
French FMF Consortium. 1997. A candidate gene for familial Mediterranean fever. Nat. Genet. 17:25.
-
(1997)
Nat. Genet.
, vol.17
, pp. 25
-
-
-
90
-
-
33745631232
-
The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production
-
Chae, J. J., Wood, G., Masters, S. L. et al. 2006. The B30.2 domain of pyrin, the familial Mediterranean fever protein, interacts directly with caspase-1 to modulate IL-1beta production. Proc. Natl Acad. Sci. USA 103:9982.
-
(2006)
Proc. Natl Acad. Sci. USA
, vol.103
, pp. 9982
-
-
Chae, J.J.1
Wood, G.2
Masters, S.L.3
-
91
-
-
84870595842
-
Genetic loss of murine pyrin, the Familial Mediterranean fever protein, increases interleukin-1ß levels
-
Hesker, P. R., Nguyen, M., Kovarova, M. et al. 2012. Genetic loss of murine pyrin, the Familial Mediterranean fever protein, increases interleukin-1ß levels. PLoS One 7:e51105.
-
(2012)
PLoS One
, vol.7
, pp. e51105
-
-
Hesker, P.R.1
Nguyen, M.2
Kovarova, M.3
-
92
-
-
84859403876
-
Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia
-
Gavrilin, M. A., Abdelaziz, D. H., Mostafa, M. et al. 2012. Activation of the pyrin inflammasome by intracellular Burkholderia cenocepacia. J. Immunol. 188:3469.
-
(2012)
J. Immunol.
, vol.188
, pp. 3469
-
-
Gavrilin, M.A.1
Abdelaziz, D.H.2
Mostafa, M.3
-
93
-
-
84964664672
-
A Burkholderia type vi effector deamidates Rho GTPases to activate the Pyrin inflammasome and trigger inflammation
-
Aubert, D. F., Xu, H., Yang, J. et al. 2016. A Burkholderia type vi effector deamidates Rho GTPases to activate the Pyrin inflammasome and trigger inflammation. Cell Host Microbe 19:664.
-
(2016)
Cell Host Microbe
, vol.19
, pp. 664
-
-
Aubert, D.F.1
Xu, H.2
Yang, J.3
-
94
-
-
84907270863
-
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
-
Xu, H., Yang, J., Gao, W. et al. 2014. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature 513:237.
-
(2014)
Nature
, vol.513
, pp. 237
-
-
Xu, H.1
Yang, J.2
Gao, W.3
-
95
-
-
84962744592
-
Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation
-
Masters, S. L., Lagou, V., Jéru, I. et al. 2016. Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation. Sci. Transl. Med. 8:332ra45.
-
(2016)
Sci. Transl. Med.
, vol.8
-
-
Masters, S.L.1
Lagou, V.2
Jéru, I.3
-
96
-
-
84976329660
-
Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS
-
Park, Y. H., Wood, G., Kastner, D. L. et al. 2016. Pyrin inflammasome activation and RhoA signaling in the autoinflammatory diseases FMF and HIDS. Nat. Immunol. 17:914.
-
(2016)
Nat. Immunol.
, vol.17
, pp. 914
-
-
Park, Y.H.1
Wood, G.2
Kastner, D.L.3
-
97
-
-
60549111042
-
Pyrin and ASC colocalize to cellular sites that are rich in polymerizing actin
-
Waite, A. L., Schaner, P., Hu, C. et al. 2009. Pyrin and ASC colocalize to cellular sites that are rich in polymerizing actin. Exp. Biol. Med. 234:40.
-
(2009)
Exp. Biol. Med.
, vol.234
, pp. 40
-
-
Waite, A.L.1
Schaner, P.2
Hu, C.3
-
98
-
-
84940453310
-
Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1ß
-
Kim, M. L., Chae, J. J., Park, Y. H. et al. 2015. Aberrant actin depolymerization triggers the pyrin inflammasome and autoinflammatory disease that is dependent on IL-18, not IL-1ß. J. Exp. Med. 212:927.
-
(2015)
J. Exp. Med.
, vol.212
, pp. 927
-
-
Kim, M.L.1
Chae, J.J.2
Park, Y.H.3
-
99
-
-
84976313489
-
Control of the innate immune response by the mevalonate pathway
-
Akula, M. K., Shi, M., Jiang, Z. et al. 2016. Control of the innate immune response by the mevalonate pathway. Nat. Immunol. 17:922.
-
(2016)
Nat. Immunol.
, vol.17
, pp. 922
-
-
Akula, M.K.1
Shi, M.2
Jiang, Z.3
-
100
-
-
84960432718
-
TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity
-
Kimura, T., Jain, A., Choi, S. W. et al. 2015. TRIM-mediated precision autophagy targets cytoplasmic regulators of innate immunity. J. Cell Biol. 210:973.
-
(2015)
J. Cell Biol.
, vol.210
, pp. 973
-
-
Kimura, T.1
Jain, A.2
Choi, S.W.3
-
101
-
-
84949201317
-
Cryoelectron tomography of the NAIP5/NLRC4 inflammasome: implications for NLR activation
-
Diebolder, C. A., Halff, E. F., Koster, A. J. et al. 2015. Cryoelectron tomography of the NAIP5/NLRC4 inflammasome: implications for NLR activation. Structure 23:2349.
-
(2015)
Structure
, vol.23
, pp. 2349
-
-
Diebolder, C.A.1
Halff, E.F.2
Koster, A.J.3
-
102
-
-
84869044838
-
Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin
-
Halff, E. F., Diebolder, C. A., Versteeg, M. et al. 2012. Formation and structure of a NAIP5-NLRC4 inflammasome induced by direct interactions with conserved N- and C-terminal regions of flagellin. J. Biol. Chem. 287:38460.
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 38460
-
-
Halff, E.F.1
Diebolder, C.A.2
Versteeg, M.3
-
103
-
-
84944748927
-
Structural and biochemical basis for induced self-propagation of NLRC4
-
Hu, Z., Zhou, Q., Zhang, C. et al. 2015. Structural and biochemical basis for induced self-propagation of NLRC4. Science 350:399.
-
(2015)
Science
, vol.350
, pp. 399
-
-
Hu, Z.1
Zhou, Q.2
Zhang, C.3
-
104
-
-
84944747007
-
Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
-
Zhang, L., Chen, S., Ruan, J. et al. 2015. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science 350:404.
-
(2015)
Science
, vol.350
, pp. 404
-
-
Zhang, L.1
Chen, S.2
Ruan, J.3
-
105
-
-
84901008921
-
Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex
-
Man, S. M., Hopkins, L. J., Nugent, E. et al. 2014. Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex. Proc. Natl Acad. Sci. USA 111:7403.
-
(2014)
Proc. Natl Acad. Sci. USA
, vol.111
, pp. 7403
-
-
Man, S.M.1
Hopkins, L.J.2
Nugent, E.3
-
106
-
-
84971577029
-
NLRP3 recruitment by NLRC4 during Salmonella infection
-
Qu, Y., Misaghi, S., Newton, K. et al. 2016. NLRP3 recruitment by NLRC4 during Salmonella infection. J. Exp. Med. 213:877.
-
(2016)
J. Exp. Med.
, vol.213
, pp. 877
-
-
Qu, Y.1
Misaghi, S.2
Newton, K.3
-
107
-
-
84926164932
-
Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection
-
Karki, R., Man, S. M., Malireddi, R. K. et al. 2015. Concerted activation of the AIM2 and NLRP3 inflammasomes orchestrates host protection against Aspergillus infection. Cell Host Microbe 17:357.
-
(2015)
Cell Host Microbe
, vol.17
, pp. 357
-
-
Karki, R.1
Man, S.M.2
Malireddi, R.K.3
-
108
-
-
84859986329
-
Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
-
Jin, T., Perry, A., Jiang, J. et al. 2012. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity 36:561.
-
(2012)
Immunity
, vol.36
, pp. 561
-
-
Jin, T.1
Perry, A.2
Jiang, J.3
-
109
-
-
84951838786
-
Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2
-
Lu, A., Li, Y., Yin, Q. et al. 2015. Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2. Cell Discov. 1:15013.
-
(2015)
Cell Discov.
, vol.1
, pp. 15013
-
-
Lu, A.1
Li, Y.2
Yin, Q.3
-
110
-
-
84904646033
-
The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response
-
Baroja-Mazo, A., Martín-Sánchez, F., Gomez, A. I. et al. 2014. The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response. Nat. Immunol. 15:738.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 738
-
-
Baroja-Mazo, A.1
Martín-Sánchez, F.2
Gomez, A.I.3
-
111
-
-
84904692363
-
The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation
-
Franklin, B. S., Bossaller, L., De Nardo, D. et al. 2014. The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation. Nat. Immunol. 15:727.
-
(2014)
Nat. Immunol.
, vol.15
, pp. 727
-
-
Franklin, B.S.1
Bossaller, L.2
De Nardo, D.3
-
112
-
-
84896332642
-
Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes
-
Lu, A., Magupalli, V. G., Ruan, J. et al. 2014. Unified polymerization mechanism for the assembly of ASC-dependent inflammasomes. Cell 156:1193.
-
(2014)
Cell
, vol.156
, pp. 1193
-
-
Lu, A.1
Magupalli, V.G.2
Ruan, J.3
-
113
-
-
84976315206
-
ASC filament formation serves as a signal amplification mechanism for inflammasomes
-
Dick, M. S., Sborgi, L., Rühl, S. et al. 2016. ASC filament formation serves as a signal amplification mechanism for inflammasomes. Nat. Commun. 7:11929.
-
(2016)
Nat. Commun.
, vol.7
, pp. 11929
-
-
Dick, M.S.1
Sborgi, L.2
Rühl, S.3
-
114
-
-
16244362671
-
Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells
-
Fink, S. L. and Cookson, B. T. 2005. Apoptosis, pyroptosis, and necrosis: mechanistic description of dead and dying eukaryotic cells. Infect. Immun. 73:1907.
-
(2005)
Infect. Immun.
, vol.73
, pp. 1907
-
-
Fink, S.L.1
Cookson, B.T.2
-
115
-
-
84942892037
-
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
-
Shi, J., Zhao, Y., Wang, K. et al. 2015. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 526:660.
-
(2015)
Nature
, vol.526
, pp. 660
-
-
Shi, J.1
Zhao, Y.2
Wang, K.3
-
116
-
-
84885813096
-
Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome
-
Tanaka, S., Mizushina, Y., Kato, Y. et al. 2013. Functional conservation of Gsdma cluster genes specifically duplicated in the mouse genome. G3 (Bethesda) 3:1843.
-
(2013)
G3 (Bethesda)
, vol.3
, pp. 1843
-
-
Tanaka, S.1
Mizushina, Y.2
Kato, Y.3
-
117
-
-
84942856523
-
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
-
Kayagaki, N., Stowe, I. B., Lee, B. L. et al. 2015. Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling. Nature 526:666.
-
(2015)
Nature
, vol.526
, pp. 666
-
-
Kayagaki, N.1
Stowe, I.B.2
Lee, B.L.3
-
118
-
-
84978128481
-
GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes
-
Aglietti, R. A., Estevez, A., Gupta, A. et al. 2016. GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes. Proc. Natl Acad. Sci. USA 113:7858.
-
(2016)
Proc. Natl Acad. Sci. USA
, vol.113
, pp. 7858
-
-
Aglietti, R.A.1
Estevez, A.2
Gupta, A.3
-
119
-
-
84978419608
-
Pore-forming activity and structural autoinhibition of the gasdermin family
-
Ding, J., Wang, K., Liu, W. et al. 2016. Pore-forming activity and structural autoinhibition of the gasdermin family. Nature 535:111.
-
(2016)
Nature
, vol.535
, pp. 111
-
-
Ding, J.1
Wang, K.2
Liu, W.3
-
120
-
-
84982102736
-
GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death
-
Sborgi, L., Rühl, S., Mulvihill, E. et al. 2016. GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death. EMBO J. 35:1766.
-
(2016)
EMBO J.
, vol.35
, pp. 1766
-
-
Sborgi, L.1
Rühl, S.2
Mulvihill, E.3
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