Disruption of glycolytic flux is a signal for inflammasome signaling and pyroptotic cell death

eLife

Volumn 5, Issue MARCH2016, 2016, Pages

  Sanman, Laura E ^a   Qian, Yu ^b   Eisele, Nicholas A ^a   Ng, Tessie M ^a   van der Linden, Wouter A ^a   Monack, Denise M ^a   Weerapana, Eranthie ^b   Bogyo, Matthew ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CHEMICAL COMPOUND; CHLOROMETHYLKETONE; CRYOPYRIN; ENOLASE; INFLAMMASOME; INTERLEUKIN 1BETA; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PHOSPHOENOLPYRUVATE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG; IL1B PROTEIN, MOUSE; NLRP3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BONE MARROW; CHEMICAL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GLUCOSE TRANSPORT; GLYCOLYTIC FLUX; IMMUNOCOMPETENT CELL; INFLAMMATION; INTRACELLULAR SIGNALING; LIQUID CHROMATOGRAPHY; MACROPHAGE; MASS SPECTROMETRY; METABOLISM; MITOCHONDRION; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; POTASSIUM TRANSPORT; PYROPTOSIS; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM; WESTERN BLOTTING; ANIMAL; CELL CULTURE; GLYCOLYSIS; IMMUNOLOGY; MOUSE; SIGNAL TRANSDUCTION;

ANIMALS; CELLS, CULTURED; GLYCOLYSIS; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROPHAGES; MICE; NAD; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PYROPTOSIS; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION;

EID: 84969142199     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.13663     Document Type: Article

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