Genetic Loss of Murine Pyrin, the Familial Mediterranean Fever Protein, Increases Interleukin-1β Levels

PLoS ONE

Volumn 7, Issue 11, 2012, Pages

  Hesker, Pamela R ^a,c,d   Nguyen, MyTrang ^b   Kovarova, Martina ^b   Ting, Jenny P Y ^a,b   Koller, Beverly H ^a,b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CRYOPYRIN; CYTOPLASM PROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PROTEIN NLRC4; PROTEIN NLRP1B; PYRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; ENZYME ACTIVITY; FAMILIAL MEDITERRANEAN FEVER; GENE; GENE LOCUS; GENE LOSS; GENOME SIZE; IMMUNOCOMPETENT CELL; INFLAMMATION; MACROPHAGE; MEFV GENE; MOUSE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PROCESSING; STIMULUS RESPONSE;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CALCIUM-BINDING PROTEINS; CARRIER PROTEINS; CASPASE 1; CYTOSKELETAL PROTEINS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LYMPHOCYTES; MACROPHAGES; MICE;

ANIMALIA; MURINAE;

EID: 84870595842     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051105     Document Type: Article

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