K+ Efflux-Independent NLRP3 Inflammasome Activation by Small Molecules Targeting Mitochondria

Immunity

Volumn 45, Issue 4, 2016, Pages 761-773

  Groß, Christina J ^a   Mishra, Ritu ^a   Schneider, Katharina S ^a   Médard, Guillaume ^b   Wettmarshausen, Jennifer ^d   Dittlein, Daniela C ^c   Shi, Hexin ^f   Gorka, Oliver ^a   Koenig, Paul Albert ^a   Fromm, Stephan ^b   Magnani, Giovanni ^a   Ćiković, Tamara ^a   Hartjes, Lara ^a   Smollich, Joachim ^a   Robertson, Avril A B ^g   Cooper, Matthew A ^g   Schmidt Supprian, Marc ^a,b   Schuster, Michael ^b   Schroder, Kate ^g   Broz, Petr ^h   Traidl Hoffmann, Claudia ^c   Beutler, Bruce ^f   Kuster, Bernhard ^b,e   Ruland, Jürgen ^a,b   Schneider, Sabine ^b,e   Perocchi, Fabiana ^d   Groß, Olaf ^a,b   more..

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

^e Munich Center for Integrated Protein Science   (Germany)

^f UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^g UNIVERSITY OF QUEENSLAND   (Australia)

^h UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CL 097; CRYOPYRIN; CYSTEINE; IMIDAZOQUINOLINE DERIVATIVE; IMIQUIMOD; INTERLEUKIN 1; OXIDOREDUCTASE; POTASSIUM ION; PROTEIN; PROTEIN NEK7; PROTEIN NQO2; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE); THIOL; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG; INFLAMMASOME; NIMA RELATED KINASE; NLRP3 PROTEIN, MOUSE; NRH - QUINONE OXIDOREDUCTASE2; POTASSIUM; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SMALL NUCLEAR RNA; TOLL LIKE RECEPTOR 7;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL DISRUPTION; CONTROLLED STUDY; DRUG MECHANISM; DRUG TARGETING; ELECTRON TRANSPORT; ENZYME INHIBITION; LYSOSOME; MITOCHONDRION; MOUSE; NONHUMAN; OLIGOMERIZATION; OXIDATION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN SECRETION; PYROPTOSIS; ANIMAL; DRUG EFFECTS; METABOLISM;

ANIMALS; ELECTRON TRANSPORT COMPLEX I; INFLAMMASOMES; MICE; MITOCHONDRIA; NIMA-RELATED KINASES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; POTASSIUM; QUINONE REDUCTASES; REACTIVE OXYGEN SPECIES; RNA, SMALL NUCLEAR; TOLL-LIKE RECEPTOR 7;

EID: 84994910645     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.08.010     Document Type: Article

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