The Intracellular Sensor NLRP3 Mediates Key Innate and Healing Responses to Influenza A Virus via the Regulation of Caspase-1

Immunity

Volumn 30, Issue 4, 2009, Pages 566-575

  Thomas, Paul G ^a   Dash, Pradyot ^a   Aldridge Jr , Jerry R ^a   Ellebedy, Ali H ^a   Reynolds, Cory ^a   Funk, Amy J ^a   Martin, William J ^a   Lamkanfi, Mohamed ^b   Webby, Richard J ^a   Boyd, Kelli L ^a   Doherty, Peter C ^a,c   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b GENENTECH INC   (United States)

^c UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

MOLIMMUNO

Indexed keywords

COLLAGEN; CRYOPYRIN; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; VIRUS RNA;

ADAPTIVE IMMUNITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE PREDISPOSITION; ENZYME REGULATION; IMMUNE RESPONSE; INFLUENZA; INFLUENZA VIRUS A; INNATE IMMUNITY; LEUKOCYTE ROLLING; LUNG FUNCTION; MOUSE; NEUTROPHIL CHEMOTAXIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION;

ANIMALS; ANTIGEN-PRESENTING CELLS; CARRIER PROTEINS; CASPASE 1; CELLS, CULTURED; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; IMMUNITY, INNATE; INFLUENZA A VIRUS; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT;

EID: 64049096334     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2009.02.006     Document Type: Article

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