Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence

Nature

Volumn 459, Issue 7245, 2009, Pages 433-436

  Gross, Olaf ^a,b   Poeck, Hendrik ^a   Bscheider, Michael ^c   Dostert, Catherine ^b   Hannesschläger, Nicole ^a   Endres, Stefan ^c   Hartmann, Gunther ^d   Tardivel, Aubry ^b   Schweighoffer, Edina ^e   Tybulewicz, Victor ^e   Mocsai, Attila ^f   Tschopp, Jürg ^b   Ruland, Jürgen ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF MUNICH   (Germany)

^d UNIVERSITY HOSPITAL BONN   (Germany)

^e NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^f SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL TOXIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CRYOPYRIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MULTIPROTEIN COMPLEX; NIGERICIN; POTASSIUM; PROTEIN KINASE SYK; REACTIVE OXYGEN METABOLITE;

ENZYME; FUNGAL DISEASE; GENETIC ANALYSIS; IMMUNE SYSTEM; IMMUNITY; INFECTIOUS DISEASE; MOLECULAR ANALYSIS; OXYGEN;

ANIMAL TISSUE; ANTIFUNGAL ACTIVITY; ARTICLE; CANDIDA ALBICANS; CANDIDIASIS; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE DELETION; HOST RESISTANCE; HUMAN; HUMAN CELL; INFECTION SENSITIVITY; INFLAMMATION; MOLECULAR RECOGNITION; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CANDIDA ALBICANS; CARRIER PROTEINS; CASPASE 1; ENZYME ACTIVATION; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MACROPHAGES; MICE; MONOCYTES; NIGERICIN; POTASSIUM; PROTEIN-TYROSINE KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); CANDIDA ALBICANS; FUNGI; MAMMALIA; MUS; SALMONELLA TYPHIMURIUM;

EID: 67349271142     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature07965     Document Type: Article

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