메뉴 건너뛰기




Volumn 42, Issue 6, 2010, Pages 792-795

Nlrp3: An immune sensor of cellular stress and infection

Author keywords

Caspase 1; Inflammasome; Interleukin 1; NLR; Nlrp3

Indexed keywords

CANAKINUMAB; CRYOPYRIN; CYTOKINE; ENZYME PRECURSOR; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 1BETA CONVERTING ENZYME INHIBITOR; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; NUCLEOTIDE BINDING PROTEIN; PATTERN RECOGNITION RECEPTOR; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; RILONACEPT; UNCLASSIFIED DRUG; VX 765;

EID: 77953464026     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.01.008     Document Type: Short Survey
Times cited : (116)

References (33)
  • 1
    • 1642285783 scopus 로고    scopus 로고
    • NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder
    • Agostini L., Martinon F., Burns K., McDermott M.F., Hawkins P.N., Tschopp J. NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder. Immunity 2004, 20:319-325.
    • (2004) Immunity , vol.20 , pp. 319-325
    • Agostini, L.1    Martinon, F.2    Burns, K.3    McDermott, M.F.4    Hawkins, P.N.5    Tschopp, J.6
  • 2
    • 64049111768 scopus 로고    scopus 로고
    • The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA
    • Allen I.C., Scull M.A., Moore C.B., Holl E.K., McElvania-TeKippe E., Taxman D.J., et al. The NLRP3 inflammasome mediates in vivo innate immunity to influenza A virus through recognition of viral RNA. Immunity 2009, 30:556-565.
    • (2009) Immunity , vol.30 , pp. 556-565
    • Allen, I.C.1    Scull, M.A.2    Moore, C.B.3    Holl, E.K.4    McElvania-TeKippe, E.5    Taxman, D.J.6
  • 3
    • 66949115474 scopus 로고    scopus 로고
    • Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity
    • Brydges S.D., Mueller J.L., McGeough M.D., Pena C.A., Misaghi A., Gandhi C., et al. Inflammasome-mediated disease animal models reveal roles for innate but not adaptive immunity. Immunity 2009, 30:875-887.
    • (2009) Immunity , vol.30 , pp. 875-887
    • Brydges, S.D.1    Mueller, J.L.2    McGeough, M.D.3    Pena, C.A.4    Misaghi, A.5    Gandhi, C.6
  • 4
    • 2542452727 scopus 로고    scopus 로고
    • Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC
    • Dowds T.A., Masumoto J., Zhu L., Inohara N., Nunez G. Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC. J Biol Chem 2004, 279:21924-21928.
    • (2004) J Biol Chem , vol.279 , pp. 21924-21928
    • Dowds, T.A.1    Masumoto, J.2    Zhu, L.3    Inohara, N.4    Nunez, G.5
  • 5
    • 0036302235 scopus 로고    scopus 로고
    • Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes
    • Feldmann J., Prieur A.M., Quartier P., Berquin P., Certain S., Cortis E., et al. Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. Am J Hum Genet 2002, 71:198-203.
    • (2002) Am J Hum Genet , vol.71 , pp. 198-203
    • Feldmann, J.1    Prieur, A.M.2    Quartier, P.3    Berquin, P.4    Certain, S.5    Cortis, E.6
  • 6
    • 34250835251 scopus 로고    scopus 로고
    • The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes
    • Feldmeyer L., Keller M., Niklaus G., Hohl D., Werner S., Beer H.D. The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 2007, 17:1140-1145.
    • (2007) Curr Biol , vol.17 , pp. 1140-1145
    • Feldmeyer, L.1    Keller, M.2    Niklaus, G.3    Hohl, D.4    Werner, S.5    Beer, H.D.6
  • 7
    • 67349271142 scopus 로고    scopus 로고
    • Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence
    • Gross O., Poeck H., Bscheider M., Dostert C., Hannesschlager N., Endres S., et al. Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence. Nature 2009, 459:433-436.
    • (2009) Nature , vol.459 , pp. 433-436
    • Gross, O.1    Poeck, H.2    Bscheider, M.3    Dostert, C.4    Hannesschlager, N.5    Endres, S.6
  • 8
    • 0037792866 scopus 로고    scopus 로고
    • Interleukin-1-receptor antagonist in the Muckle-Wells syndrome
    • Hawkins P.N., Lachmann H.J., McDermott M.F. Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N Engl J Med 2003, 348:2583-2584.
    • (2003) N Engl J Med , vol.348 , pp. 2583-2584
    • Hawkins, P.N.1    Lachmann, H.J.2    McDermott, M.F.3
  • 9
    • 65549154784 scopus 로고    scopus 로고
    • An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans
    • Hise A.G., Tomalka J., Ganesan S., Patel K., Hall B.A., Brown G.D., et al. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 2009, 5:487-497.
    • (2009) Cell Host Microbe , vol.5 , pp. 487-497
    • Hise, A.G.1    Tomalka, J.2    Ganesan, S.3    Patel, K.4    Hall, B.A.5    Brown, G.D.6
  • 10
    • 0035179970 scopus 로고    scopus 로고
    • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
    • Hoffman H.M., Mueller J.L., Broide D.H., Wanderer A.A., Kolodner R.D. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat Genet 2001, 29:301-305.
    • (2001) Nat Genet , vol.29 , pp. 301-305
    • Hoffman, H.M.1    Mueller, J.L.2    Broide, D.H.3    Wanderer, A.A.4    Kolodner, R.D.5
  • 11
    • 8444225132 scopus 로고    scopus 로고
    • Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
    • Hoffman H.M., Rosengren S., Boyle D.L., Cho J.Y., Nayar J., Mueller J.L., et al. Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist. Lancet 2004, 364:1779-1785.
    • (2004) Lancet , vol.364 , pp. 1779-1785
    • Hoffman, H.M.1    Rosengren, S.2    Boyle, D.L.3    Cho, J.Y.4    Nayar, J.5    Mueller, J.L.6
  • 12
    • 49449094179 scopus 로고    scopus 로고
    • Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies
    • Hoffman H.M., Throne M.L., Amar N.J., Sebai M., Kivitz A.J., Kavanaugh A., et al. Efficacy and safety of rilonacept (interleukin-1 Trap) in patients with cryopyrin-associated periodic syndromes: results from two sequential placebo-controlled studies. Arthritis Rheum 2008, 58:2443-2452.
    • (2008) Arthritis Rheum , vol.58 , pp. 2443-2452
    • Hoffman, H.M.1    Throne, M.L.2    Amar, N.J.3    Sebai, M.4    Kivitz, A.J.5    Kavanaugh, A.6
  • 13
    • 60549112774 scopus 로고    scopus 로고
    • Inflammasome recognition of influenza virus is essential for adaptive immune responses
    • Ichinohe T., Lee H.K., Ogura Y., Flavell R., Iwasaki A. Inflammasome recognition of influenza virus is essential for adaptive immune responses. J Exp Med 2009, 206:79-87.
    • (2009) J Exp Med , vol.206 , pp. 79-87
    • Ichinohe, T.1    Lee, H.K.2    Ogura, Y.3    Flavell, R.4    Iwasaki, A.5
  • 14
    • 70349317039 scopus 로고    scopus 로고
    • Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome
    • Joly S., Ma N., Sadler J.J., Soll D.R., Cassel S.L., Sutterwala F.S. Cutting edge: Candida albicans hyphae formation triggers activation of the Nlrp3 inflammasome. J Immunol 2009, 183:3578-3581.
    • (2009) J Immunol , vol.183 , pp. 3578-3581
    • Joly, S.1    Ma, N.2    Sadler, J.J.3    Soll, D.R.4    Cassel, S.L.5    Sutterwala, F.S.6
  • 15
    • 33846014297 scopus 로고    scopus 로고
    • Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA
    • Kanneganti T.D., Body-Malapel M., Amer A., Park J.H., Whitfield J., Franchi L., et al. Critical role for Cryopyrin/Nalp3 in activation of caspase-1 in response to viral infection and double-stranded RNA. J Biol Chem 2006, 281:36560-36568.
    • (2006) J Biol Chem , vol.281 , pp. 36560-36568
    • Kanneganti, T.D.1    Body-Malapel, M.2    Amer, A.3    Park, J.H.4    Whitfield, J.5    Franchi, L.6
  • 16
    • 34247118826 scopus 로고    scopus 로고
    • Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling
    • Kanneganti T.D., Lamkanfi M., Kim Y.G., Chen G., Park J.H., Franchi L., et al. Pannexin-1-mediated recognition of bacterial molecules activates the cryopyrin inflammasome independent of Toll-like receptor signaling. Immunity 2007, 26:433-443.
    • (2007) Immunity , vol.26 , pp. 433-443
    • Kanneganti, T.D.1    Lamkanfi, M.2    Kim, Y.G.3    Chen, G.4    Park, J.H.5    Franchi, L.6
  • 17
    • 35348932070 scopus 로고    scopus 로고
    • Intracellular NOD-like receptors in host defense and disease
    • Kanneganti T.D., Lamkanfi M., Nunez G. Intracellular NOD-like receptors in host defense and disease. Immunity 2007, 27:549-559.
    • (2007) Immunity , vol.27 , pp. 549-559
    • Kanneganti, T.D.1    Lamkanfi, M.2    Nunez, G.3
  • 19
    • 65649141586 scopus 로고    scopus 로고
    • Pathogen recognition in the innate immune response
    • Kumar H., Kawai T., Akira S. Pathogen recognition in the innate immune response. Biochem J 2009, 420:1-16.
    • (2009) Biochem J , vol.420 , pp. 1-16
    • Kumar, H.1    Kawai, T.2    Akira, S.3
  • 20
    • 34247574122 scopus 로고    scopus 로고
    • Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response
    • Kummer J.A., Broekhuizen R., Everett H., Agostini L., Kuijk L., Martinon F., et al. Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response. J Histochem Cytochem 2007, 55:443-452.
    • (2007) J Histochem Cytochem , vol.55 , pp. 443-452
    • Kummer, J.A.1    Broekhuizen, R.2    Everett, H.3    Agostini, L.4    Kuijk, L.5    Martinon, F.6
  • 22
    • 58049202273 scopus 로고    scopus 로고
    • Inflammasomes: guardians of cytosolic sanctity
    • Lamkanfi M., Dixit V.M. Inflammasomes: guardians of cytosolic sanctity. Immunol Rev 2009, 227:95-105.
    • (2009) Immunol Rev , vol.227 , pp. 95-105
    • Lamkanfi, M.1    Dixit, V.M.2
  • 23
    • 68949092245 scopus 로고    scopus 로고
    • Fungal zymosan and mannan activate the cryopyrin inflammasome
    • Lamkanfi M., Malireddi R.K., Kanneganti T.D. Fungal zymosan and mannan activate the cryopyrin inflammasome. J Biol Chem 2009, 284:20574-20581.
    • (2009) J Biol Chem , vol.284 , pp. 20574-20581
    • Lamkanfi, M.1    Malireddi, R.K.2    Kanneganti, T.D.3
  • 24
    • 3142654767 scopus 로고    scopus 로고
    • Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf
    • Mariathasan S., Newton K., Monack D.M., Vucic D., French D.M., Lee W.P., et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 2004, 430:213-218.
    • (2004) Nature , vol.430 , pp. 213-218
    • Mariathasan, S.1    Newton, K.2    Monack, D.M.3    Vucic, D.4    French, D.M.5    Lee, W.P.6
  • 26
    • 7944232105 scopus 로고    scopus 로고
    • Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome
    • Martinon F., Agostini L., Meylan E., Tschopp J. Identification of bacterial muramyl dipeptide as activator of the NALP3/cryopyrin inflammasome. Curr Biol 2004, 14:1929-1934.
    • (2004) Curr Biol , vol.14 , pp. 1929-1934
    • Martinon, F.1    Agostini, L.2    Meylan, E.3    Tschopp, J.4
  • 27
    • 37549066934 scopus 로고    scopus 로고
    • Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death
    • McCall S.H., Sahraei M., Young A.B., Worley C.S., Duncan J.A., Ting J.P., et al. Osteoblasts express NLRP3, a nucleotide-binding domain and leucine-rich repeat region containing receptor implicated in bacterially induced cell death. J Bone Miner Res 2008, 23:30-40.
    • (2008) J Bone Miner Res , vol.23 , pp. 30-40
    • McCall, S.H.1    Sahraei, M.2    Young, A.B.3    Worley, C.S.4    Duncan, J.A.5    Ting, J.P.6
  • 28
    • 66949175347 scopus 로고    scopus 로고
    • A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses
    • Meng G., Zhang F., Fuss I., Kitani A., Strober W. A mutation in the Nlrp3 gene causing inflammasome hyperactivation potentiates Th17 cell-dominant immune responses. Immunity 2009, 30:860-874.
    • (2009) Immunity , vol.30 , pp. 860-874
    • Meng, G.1    Zhang, F.2    Fuss, I.3    Kitani, A.4    Strober, W.5
  • 29
    • 40449097257 scopus 로고    scopus 로고
    • The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response
    • Muruve D.A., Petrilli V., Zaiss A.K., White L.R., Clark S.A., Ross P.J., et al. The inflammasome recognizes cytosolic microbial and host DNA and triggers an innate immune response. Nature 2008, 452:103-107.
    • (2008) Nature , vol.452 , pp. 103-107
    • Muruve, D.A.1    Petrilli, V.2    Zaiss, A.K.3    White, L.R.4    Clark, S.A.5    Ross, P.J.6
  • 30
    • 23444439667 scopus 로고    scopus 로고
    • IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients
    • Stack J.H., Beaumont K., Larsen P.D., Straley K.S., Henkel G.W., Randle J.C., et al. IL-converting enzyme/caspase-1 inhibitor VX-765 blocks the hypersensitive response to an inflammatory stimulus in monocytes from familial cold autoinflammatory syndrome patients. J Immunol 2005, 175:2630-2634.
    • (2005) J Immunol , vol.175 , pp. 2630-2634
    • Stack, J.H.1    Beaumont, K.2    Larsen, P.D.3    Straley, K.S.4    Henkel, G.W.5    Randle, J.C.6
  • 31
    • 33644985564 scopus 로고    scopus 로고
    • Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1
    • Sutterwala F.S., Ogura Y., Szczepanik M., Lara-Tejero M., Lichtenberger G.S., Grant E.P., et al. Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 2006, 24:317-327.
    • (2006) Immunity , vol.24 , pp. 317-327
    • Sutterwala, F.S.1    Ogura, Y.2    Szczepanik, M.3    Lara-Tejero, M.4    Lichtenberger, G.S.5    Grant, E.P.6
  • 32
    • 64049096334 scopus 로고    scopus 로고
    • The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1
    • Thomas P.G., Dash P., Aldridge J.R., Ellebedy A.H., Reynolds C., Funk A.J., et al. The intracellular sensor NLRP3 mediates key innate and healing responses to influenza A virus via the regulation of caspase-1. Immunity 2009, 30:566-575.
    • (2009) Immunity , vol.30 , pp. 566-575
    • Thomas, P.G.1    Dash, P.2    Aldridge, J.R.3    Ellebedy, A.H.4    Reynolds, C.5    Funk, A.J.6
  • 33
    • 58149159542 scopus 로고    scopus 로고
    • Common variants in the NLRP3 region contribute to Crohn's disease susceptibility
    • Villani A.C., Lemire M., Fortin G., Louis E., Silverberg M.S., Collette C., et al. Common variants in the NLRP3 region contribute to Crohn's disease susceptibility. Nat Genet 2009, 41:71-76.
    • (2009) Nat Genet , vol.41 , pp. 71-76
    • Villani, A.C.1    Lemire, M.2    Fortin, G.3    Louis, E.4    Silverberg, M.S.5    Collette, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.