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Volumn 9, Issue 1, 2017, Pages

High throughput toxicity screening and intracellular detection of nanomaterials

(33)  Collins, Andrew R a   Annangi, Balasubramanyam c   Rubio, Laura b   Marcos, Ricard b,c   Dorn, Marco d   Merker, Carolin d   Estrela Lopis, Irina d   Cimpan, Mihaela Roxana e   Ibrahim, Mohamed e   Cimpan, Emil f   Ostermann, Melanie e   Sauter, Alexander e   Yamani, Naouale El a,g   Shaposhnikov, Sergey a   Chevillard, Sylvie h   Paget, Vincent h   Grall, Romain h   Delic, Jozo h   de Cerio, Felipe Goñi i   Suarez Merino, Blanca i   more..

h DIF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

MATERIALS TESTING; NANOSTRUCTURED MATERIALS; RISK ASSESSMENT; SAFETY TESTING; TOXICITY;

EID: 85006488641     PISSN: 19395116     EISSN: 19390041     Source Type: Journal    
DOI: 10.1002/wnan.1413     Document Type: Review
Times cited : (133)

References (192)
  • 1
    • 31944451232 scopus 로고    scopus 로고
    • Toxic potential of materials at the nanolevel
    • Nel A, Xia T, Madler L, Li N. Toxic potential of materials at the nanolevel. Science 2006, 311:622–627.
    • (2006) Science , vol.311 , pp. 622-627
    • Nel, A.1    Xia, T.2    Madler, L.3    Li, N.4
  • 2
    • 84880958977 scopus 로고    scopus 로고
    • Nanotoxicity: challenging the myth of nano-specific toxicity
    • Donaldson K, Poland CA. Nanotoxicity: challenging the myth of nano-specific toxicity. Curr Opin Biotechnol 2013, 24:724–734.
    • (2013) Curr Opin Biotechnol , vol.24 , pp. 724-734
    • Donaldson, K.1    Poland, C.A.2
  • 3
    • 84875346892 scopus 로고    scopus 로고
    • In silico analysis of nanomaterials hazard and risk
    • Cohen Y, Rallo R, Liu R, Liu HH. In silico analysis of nanomaterials hazard and risk. Acc Chem Res 2013, 46:802–812.
    • (2013) Acc Chem Res , vol.46 , pp. 802-812
    • Cohen, Y.1    Rallo, R.2    Liu, R.3    Liu, H.H.4
  • 4
    • 84875357552 scopus 로고    scopus 로고
    • Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening
    • Nel A, Xia T, Meng H, Wang X, Lin S, Ji Z, Zhang H. Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening. Acc Chem Res 2013, 46:607–621.
    • (2013) Acc Chem Res , vol.46 , pp. 607-621
    • Nel, A.1    Xia, T.2    Meng, H.3    Wang, X.4    Lin, S.5    Ji, Z.6    Zhang, H.7
  • 5
    • 84855785145 scopus 로고    scopus 로고
    • Nanotoxicology and in vitro studies: the need of the hour
    • Arora S, Rajwade JM, Paknikar KM. Nanotoxicology and in vitro studies: the need of the hour. Toxicol Appl Pharmacol 2012, 258:151–165.
    • (2012) Toxicol Appl Pharmacol , vol.258 , pp. 151-165
    • Arora, S.1    Rajwade, J.M.2    Paknikar, K.M.3
  • 7
    • 84930010071 scopus 로고    scopus 로고
    • Safety of nanomaterial in nanomedicine
    • In, Hunter RJ, Preedy VR, eds., Jersey, British Isles Enfield, New Hampshire, CRC Press
    • Dusinska M, Fjellsbø LM, Magdolenova Z, Ravnum S, Rinna A. Safety of nanomaterial in nanomedicine. In: Hunter RJ, Preedy VR, eds. Nanomedicine in Health and Disease. Jersey, British Isles Enfield, New Hampshire: CRC Press; 2011, 203–226.
    • (2011) Nanomedicine in Health and Disease , pp. 203-226
    • Dusinska, M.1    Fjellsbø, L.M.2    Magdolenova, Z.3    Ravnum, S.4    Rinna, A.5
  • 9
    • 38849111818 scopus 로고    scopus 로고
    • Cytotoxicity of nanoparticles
    • Lewinski N, Colvin V, Drezek R. Cytotoxicity of nanoparticles. Small 2008, 4:26–49.
    • (2008) Small , vol.4 , pp. 26-49
    • Lewinski, N.1    Colvin, V.2    Drezek, R.3
  • 10
    • 79952952840 scopus 로고    scopus 로고
    • Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials
    • George S, Xia T, Rallo R, Zhao Y, Ji Z, Lin S, Wang X, Zhang H, France B, Schoenfeld D, et al. Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials. ACS Nano 2011, 5:1805–1817.
    • (2011) ACS Nano , vol.5 , pp. 1805-1817
    • George, S.1    Xia, T.2    Rallo, R.3    Zhao, Y.4    Ji, Z.5    Lin, S.6    Wang, X.7    Zhang, H.8    France, B.9    Schoenfeld, D.10
  • 11
    • 84963803427 scopus 로고    scopus 로고
    • Advanced methodologies and techniques for assessing nanomaterials toxicity from manufacturing to nanomedecine screening
    • In, Boca Raton, Florida, CRC Press, Taylor Francis Group
    • Prina-Mello A, Bashir M, Verma N, Namrata J, Volkov Y. Advanced methodologies and techniques for assessing nanomaterials toxicity from manufacturing to nanomedecine screening. In: Nanotoxicology: Progress toward Nanomedicine. Boca Raton, Florida: CRC Press, Taylor Francis Group; 2014, 155–176.
    • (2014) Nanotoxicology: Progress toward Nanomedicine , pp. 155-176
    • Prina-Mello, A.1    Bashir, M.2    Verma, N.3    Namrata, J.4    Volkov, Y.5
  • 12
    • 84871839877 scopus 로고    scopus 로고
    • Multiparametric toxicity evaluation of SPIONs by high content screening technique: identification of biocompatible multifunctional nanoparticles for nanomedicine
    • Prina-Mello A, Crosbie-Staunton K, Salas G, del Puerto MM, Volkov Y. Multiparametric toxicity evaluation of SPIONs by high content screening technique: identification of biocompatible multifunctional nanoparticles for nanomedicine. IEEE Trans Magn 2013, 49:377–382.
    • (2013) IEEE Trans Magn , vol.49 , pp. 377-382
    • Prina-Mello, A.1    Crosbie-Staunton, K.2    Salas, G.3    del Puerto, M.M.4    Volkov, Y.5
  • 14
    • 36249024777 scopus 로고    scopus 로고
    • Quantitative detection of engineered nanoparticles in tissues and organs: an investigation of efficacy and linear dynamic ranges using ICP-AES
    • Fischer HC, Fournier-Bidoz S, Chan WCW, Pang KS. Quantitative detection of engineered nanoparticles in tissues and organs: an investigation of efficacy and linear dynamic ranges using ICP-AES. Nanobiotechnology 2007, 3:46–54.
    • (2007) Nanobiotechnology , vol.3 , pp. 46-54
    • Fischer, H.C.1    Fournier-Bidoz, S.2    Chan, W.C.W.3    Pang, K.S.4
  • 15
    • 84878300080 scopus 로고    scopus 로고
    • Simultaneous quantification of cells and nanomaterials by inductive-coupled plasma techniques
    • Albanese A, Tsoi KM, Chan WC. Simultaneous quantification of cells and nanomaterials by inductive-coupled plasma techniques. J Lab Autom 2013, 18:99–104.
    • (2013) J Lab Autom , vol.18 , pp. 99-104
    • Albanese, A.1    Tsoi, K.M.2    Chan, W.C.3
  • 16
    • 77951525639 scopus 로고    scopus 로고
    • Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres
    • Malugin A, Ghandehari H. Cellular uptake and toxicity of gold nanoparticles in prostate cancer cells: a comparative study of rods and spheres. J Appl Toxicol 2010, 30:212–217.
    • (2010) J Appl Toxicol , vol.30 , pp. 212-217
    • Malugin, A.1    Ghandehari, H.2
  • 17
    • 84904316824 scopus 로고    scopus 로고
    • A quantitative study of the intracellular concentration of graphene/noble metal nanoparticle composites and their cytotoxicity
    • Zhou X, Dorn M, Vogt J, Spemann D, Yu W, Mao Z, Estrela-Lopis I, Donath E, Gao C. A quantitative study of the intracellular concentration of graphene/noble metal nanoparticle composites and their cytotoxicity. Nanoscale 2014, 6:8535–8542.
    • (2014) Nanoscale , vol.6 , pp. 8535-8542
    • Zhou, X.1    Dorn, M.2    Vogt, J.3    Spemann, D.4    Yu, W.5    Mao, Z.6    Estrela-Lopis, I.7    Donath, E.8    Gao, C.9
  • 18
    • 84900214162 scopus 로고    scopus 로고
    • Single particle inductively coupled plasma mass spectrometry: a powerful tool for nanoanalysis
    • Laborda F, Bolea E, Jimenez-Lamana J. Single particle inductively coupled plasma mass spectrometry: a powerful tool for nanoanalysis. Anal Chem 2014, 86:2270–2278.
    • (2014) Anal Chem , vol.86 , pp. 2270-2278
    • Laborda, F.1    Bolea, E.2    Jimenez-Lamana, J.3
  • 21
  • 23
    • 0142227102 scopus 로고    scopus 로고
    • Biocompatibility of micro- and nano-particles in the colon. Part II
    • Gatti AM. Biocompatibility of micro- and nano-particles in the colon. Part II. Biomaterials 2004, 25:385–392.
    • (2004) Biomaterials , vol.25 , pp. 385-392
    • Gatti, A.M.1
  • 25
    • 77950366807 scopus 로고    scopus 로고
    • PET/MRI: paving the way for the next generation of clinical multimodality imaging applications
    • Pichler BJ, Kolb A, Nagele T, Schlemmer HP. PET/MRI: paving the way for the next generation of clinical multimodality imaging applications. J Nucl Med 2010, 51:333–336.
    • (2010) J Nucl Med , vol.51 , pp. 333-336
    • Pichler, B.J.1    Kolb, A.2    Nagele, T.3    Schlemmer, H.P.4
  • 26
    • 84876521475 scopus 로고    scopus 로고
    • Biodistribution of different sized nanoparticles assessed by positron emission tomography: a general strategy for direct activation of metal oxide particles
    • Perez-Campana C, Gomez-Vallejo V, Puigivila M, Martin A, Calvo-Fernandez T, Moya SE, Ziolo RF, Reese T, Llop J. Biodistribution of different sized nanoparticles assessed by positron emission tomography: a general strategy for direct activation of metal oxide particles. ACS Nano 2013, 7:3498–3505.
    • (2013) ACS Nano , vol.7 , pp. 3498-3505
    • Perez-Campana, C.1    Gomez-Vallejo, V.2    Puigivila, M.3    Martin, A.4    Calvo-Fernandez, T.5    Moya, S.E.6    Ziolo, R.F.7    Reese, T.8    Llop, J.9
  • 27
    • 84903550341 scopus 로고    scopus 로고
    • Assessing the efficacy of nano- and micro-sized magnetic particles as contrast agents for MRI cell tracking
    • Taylor A, Herrmann A, Moss D, See V, Davies K, Williams SR, Murray P. Assessing the efficacy of nano- and micro-sized magnetic particles as contrast agents for MRI cell tracking. PLoS One 2014, 9:e100259.
    • (2014) PLoS One , vol.9
    • Taylor, A.1    Herrmann, A.2    Moss, D.3    See, V.4    Davies, K.5    Williams, S.R.6    Murray, P.7
  • 28
    • 80052505577 scopus 로고    scopus 로고
    • Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study
    • Monteiro-Riviere NA, Wiench K, Landsiedel R, Schulte S, Inman AO, Riviere JE. Safety evaluation of sunscreen formulations containing titanium dioxide and zinc oxide nanoparticles in UVB sunburned skin: an in vitro and in vivo study. Toxicol Sci 2011, 123:264–280.
    • (2011) Toxicol Sci , vol.123 , pp. 264-280
    • Monteiro-Riviere, N.A.1    Wiench, K.2    Landsiedel, R.3    Schulte, S.4    Inman, A.O.5    Riviere, J.E.6
  • 29
    • 33847720649 scopus 로고    scopus 로고
    • Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats
    • Nemmar A, Al-Maskari S, Ali BH, Al-Amri IS. Cardiovascular and lung inflammatory effects induced by systemically administered diesel exhaust particles in rats. Am J Physiol Lung Cell Mol Physiol 2007, 292:L664–L670.
    • (2007) Am J Physiol Lung Cell Mol Physiol , vol.292 , pp. L664-L670
    • Nemmar, A.1    Al-Maskari, S.2    Ali, B.H.3    Al-Amri, I.S.4
  • 32
    • 79955448933 scopus 로고    scopus 로고
    • Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: visualization of nanosilver in human macrophages and cellular responses
    • Haase A, Arlinghaus HF, Tentschert J, Jungnickel H, Graf P, Mantion A, Draude F, Galla S, Plendl J, Goetz ME, et al. Application of laser postionization secondary neutral mass spectrometry/time-of-flight secondary ion mass spectrometry in nanotoxicology: visualization of nanosilver in human macrophages and cellular responses. ACS Nano 2011, 5:3059–3068.
    • (2011) ACS Nano , vol.5 , pp. 3059-3068
    • Haase, A.1    Arlinghaus, H.F.2    Tentschert, J.3    Jungnickel, H.4    Graf, P.5    Mantion, A.6    Draude, F.7    Galla, S.8    Plendl, J.9    Goetz, M.E.10
  • 35
    • 79959387920 scopus 로고    scopus 로고
    • Raman spectroscopy and support vector machines for quick toxicological evaluation of titania nanoparticles
    • Pyrgiotakis G, Kundakcioglu OE, Pardalos PM, Moudgil BM. Raman spectroscopy and support vector machines for quick toxicological evaluation of titania nanoparticles. J Raman Spectrosc 2011, 42:1222–1231.
    • (2011) J Raman Spectrosc , vol.42 , pp. 1222-1231
    • Pyrgiotakis, G.1    Kundakcioglu, O.E.2    Pardalos, P.M.3    Moudgil, B.M.4
  • 36
    • 79952926843 scopus 로고    scopus 로고
    • Non-invasive time-course imaging of apoptotic cells by confocal Raman micro-spectroscopy
    • Zoladek A, Pascut FC, Patel P, Notingher I. Non-invasive time-course imaging of apoptotic cells by confocal Raman micro-spectroscopy. J Raman Spectrosc 2011, 42:251–258.
    • (2011) J Raman Spectrosc , vol.42 , pp. 251-258
    • Zoladek, A.1    Pascut, F.C.2    Patel, P.3    Notingher, I.4
  • 38
    • 33745686170 scopus 로고    scopus 로고
    • Studies on stress-induced changes at the subcellular level by Raman microspectroscopic mapping
    • Krafft C, Knetschke T, Funk RH, Salzer R. Studies on stress-induced changes at the subcellular level by Raman microspectroscopic mapping. Anal Chem 2006, 78:4424–4429.
    • (2006) Anal Chem , vol.78 , pp. 4424-4429
    • Krafft, C.1    Knetschke, T.2    Funk, R.H.3    Salzer, R.4
  • 40
    • 84862231815 scopus 로고    scopus 로고
    • A micro-Raman spectroscopic investigation of leukemic U-937 cells treated with Crotalaria agatiflora Schweinf and the isolated compound madurensine
    • le Roux K, Prinsloo LC, Hussein AA, Lall N. A micro-Raman spectroscopic investigation of leukemic U-937 cells treated with Crotalaria agatiflora Schweinf and the isolated compound madurensine. Spectrochim Acta A Mol Biomol Spectrosc 2012, 95:547–554.
    • (2012) Spectrochim Acta A Mol Biomol Spectrosc , vol.95 , pp. 547-554
    • le Roux, K.1    Prinsloo, L.C.2    Hussein, A.A.3    Lall, N.4
  • 42
    • 34447319681 scopus 로고    scopus 로고
    • Label-free detection of mitochondrial distribution in cells by nonresonant Raman microspectroscopy
    • Matthaus C, Chernenko T, Newmark JA, Warner CM, Diem M. Label-free detection of mitochondrial distribution in cells by nonresonant Raman microspectroscopy. Biophys J 2007, 93:668–673.
    • (2007) Biophys J , vol.93 , pp. 668-673
    • Matthaus, C.1    Chernenko, T.2    Newmark, J.A.3    Warner, C.M.4    Diem, M.5
  • 44
    • 42549143246 scopus 로고    scopus 로고
    • New ways of imaging uptake and intracellular fate of liposomal drug carrier systems inside individual cells, based on Raman microscopy
    • Matthaus C, Kale A, Chernenko T, Torchilin V, Diem M. New ways of imaging uptake and intracellular fate of liposomal drug carrier systems inside individual cells, based on Raman microscopy. Mol Pharm 2008, 5:287–293.
    • (2008) Mol Pharm , vol.5 , pp. 287-293
    • Matthaus, C.1    Kale, A.2    Chernenko, T.3    Torchilin, V.4    Diem, M.5
  • 46
    • 84880703574 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) nanoparticles, layer by layer engineered for the sustainable delivery of antiTNF-α
    • Romero G, Ochoteco O, Sanz DJ, Estrela-Lopis I, Donath E, Moya SE. Poly(lactide-co-glycolide) nanoparticles, layer by layer engineered for the sustainable delivery of antiTNF-α. Macromol Biosci 2013, 13:903–912.
    • (2013) Macromol Biosci , vol.13 , pp. 903-912
    • Romero, G.1    Ochoteco, O.2    Sanz, D.J.3    Estrela-Lopis, I.4    Donath, E.5    Moya, S.E.6
  • 47
    • 79960774946 scopus 로고    scopus 로고
    • Stepwise surface tailoring of carbon nanotubes with polyelectrolyte brushes and lipid layers to control their intracellular distribution and “in vitro” toxicity
    • Romero G, Estrela-Lopis I, Castro-Hartmann P, Rojas E, Llarena I, Sanz D, Donath E, Moya SE. Stepwise surface tailoring of carbon nanotubes with polyelectrolyte brushes and lipid layers to control their intracellular distribution and “in vitro” toxicity. Soft Matter 2011, 7:6883–6890.
    • (2011) Soft Matter , vol.7 , pp. 6883-6890
    • Romero, G.1    Estrela-Lopis, I.2    Castro-Hartmann, P.3    Rojas, E.4    Llarena, I.5    Sanz, D.6    Donath, E.7    Moya, S.E.8
  • 48
    • 80052067397 scopus 로고    scopus 로고
    • Nanoparticle uptake and their co-localization with cell compartments – a confocal Raman microscopy study at single cell level
    • Estrela-Lopis I, Romero G, Rojas E, Moya SE, Donath E. Nanoparticle uptake and their co-localization with cell compartments – a confocal Raman microscopy study at single cell level. J Phys Conf Ser 2011, 304:012017.
    • (2011) J Phys Conf Ser , vol.304 , pp. 012017
    • Estrela-Lopis, I.1    Romero, G.2    Rojas, E.3    Moya, S.E.4    Donath, E.5
  • 49
    • 33745741441 scopus 로고    scopus 로고
    • Oops they did it again! Carbon nanotubes hoax scientists in viability assays
    • Worle-Knirsch JM, Pulskamp K, Krug HF. Oops they did it again! Carbon nanotubes hoax scientists in viability assays. Nano Lett 2006, 6:1261–1268.
    • (2006) Nano Lett , vol.6 , pp. 1261-1268
    • Worle-Knirsch, J.M.1    Pulskamp, K.2    Krug, H.F.3
  • 50
    • 84885860345 scopus 로고    scopus 로고
    • Analytical and bioanalytical approaches to unravel the selenium-mercury antagonism: a review
    • Luque-Garcia JL, Cabezas-Sanchez P, Anunciacao DS, Camara C. Analytical and bioanalytical approaches to unravel the selenium-mercury antagonism: a review. Anal Chim Acta 2013, 801:1–13.
    • (2013) Anal Chim Acta , vol.801 , pp. 1-13
    • Luque-Garcia, J.L.1    Cabezas-Sanchez, P.2    Anunciacao, D.S.3    Camara, C.4
  • 52
    • 57649243749 scopus 로고    scopus 로고
    • Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro
    • Park EJ, Park K. Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro. Toxicol Lett 2009, 184:18–25.
    • (2009) Toxicol Lett , vol.184 , pp. 18-25
    • Park, E.J.1    Park, K.2
  • 53
    • 19444368620 scopus 로고    scopus 로고
    • Cytotoxicity test based on electrochemical impedance measurement of HepG2 cultured in microfabricated cell chip
    • Yeon JH, Park JK. Cytotoxicity test based on electrochemical impedance measurement of HepG2 cultured in microfabricated cell chip. Anal Biochem 2005, 341:308–315.
    • (2005) Anal Biochem , vol.341 , pp. 308-315
    • Yeon, J.H.1    Park, J.K.2
  • 55
    • 77957594401 scopus 로고    scopus 로고
    • Whole cell based electrical impedance sensing approach for a rapid nanotoxicity assay
    • Hondroulis E, Liu C, Li CZ. Whole cell based electrical impedance sensing approach for a rapid nanotoxicity assay. Nanotechnology 2010, 21:315103.
    • (2010) Nanotechnology , vol.21 , pp. 315103
    • Hondroulis, E.1    Liu, C.2    Li, C.Z.3
  • 56
    • 58149267870 scopus 로고    scopus 로고
    • Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line
    • Monteiro-Riviere NA, Inman AO, Zhang LW. Limitations and relative utility of screening assays to assess engineered nanoparticle toxicity in a human cell line. Toxicol Appl Pharmacol 2009, 234:222–235.
    • (2009) Toxicol Appl Pharmacol , vol.234 , pp. 222-235
    • Monteiro-Riviere, N.A.1    Inman, A.O.2    Zhang, L.W.3
  • 57
    • 32044468707 scopus 로고    scopus 로고
    • Challenges for assessing carbon nanomaterial toxicity to the skin
    • Monteiro-Riviere NA, Inman AO. Challenges for assessing carbon nanomaterial toxicity to the skin. Carbon 2006, 44:1070–1078.
    • (2006) Carbon , vol.44 , pp. 1070-1078
    • Monteiro-Riviere, N.A.1    Inman, A.O.2
  • 58
    • 84876867467 scopus 로고    scopus 로고
    • An impedance-based high-throughput method for evaluating the cytotoxicity of nanoparticles
    • Cimpan M, Mordal T, Allouni Z, Pliquett U, Cimpan E. An impedance-based high-throughput method for evaluating the cytotoxicity of nanoparticles. J Phys Conf Ser 2013, 429:012026. doi:10.1088/1742-6596/429/1/012026.
    • (2013) J Phys Conf Ser , vol.429 , pp. 012026
    • Cimpan, M.1    Mordal, T.2    Allouni, Z.3    Pliquett, U.4    Cimpan, E.5
  • 59
    • 67650718169 scopus 로고    scopus 로고
    • A 21st century paradigm for evaluating the health hazards of nanoscale materials?
    • Walker NJ, Bucher JR. A 21st century paradigm for evaluating the health hazards of nanoscale materials? Toxicol Sci 2009, 110:251–254.
    • (2009) Toxicol Sci , vol.110 , pp. 251-254
    • Walker, N.J.1    Bucher, J.R.2
  • 60
    • 78649886516 scopus 로고    scopus 로고
    • Nanotoxicology: no small matter
    • Feliu N, Fadeel B. Nanotoxicology: no small matter. Nanoscale 2010, 2:2514–2520.
    • (2010) Nanoscale , vol.2 , pp. 2514-2520
    • Feliu, N.1    Fadeel, B.2
  • 61
    • 84930003770 scopus 로고    scopus 로고
    • Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells
    • Guadagnini R, Moreau K, Hussain S, Marano F, Boland S. Toxicity evaluation of engineered nanoparticles for medical applications using pulmonary epithelial cells. Nanotoxicology 2015, 9:25–32.
    • (2015) Nanotoxicology , vol.9 , pp. 25-32
    • Guadagnini, R.1    Moreau, K.2    Hussain, S.3    Marano, F.4    Boland, S.5
  • 63
    • 71349085412 scopus 로고    scopus 로고
    • Real-time xCELLigence impedance analysis of the cytotoxicity of dental composite components on human gingival fibroblasts
    • Urcan E, Haertel U, Styllou M, Hickel R, Scherthan H, Reichl FX. Real-time xCELLigence impedance analysis of the cytotoxicity of dental composite components on human gingival fibroblasts. Dent Mater 2010, 26:51–58.
    • (2010) Dent Mater , vol.26 , pp. 51-58
    • Urcan, E.1    Haertel, U.2    Styllou, M.3    Hickel, R.4    Scherthan, H.5    Reichl, F.X.6
  • 64
    • 0034714440 scopus 로고    scopus 로고
    • Electric Cell–Substrate Impedance Sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces
    • Wegener J, Keese CR, Giaever I. Electric Cell–Substrate Impedance Sensing (ECIS) as a noninvasive means to monitor the kinetics of cell spreading to artificial surfaces. Exp Cell Res 2000, 259:158–166.
    • (2000) Exp Cell Res , vol.259 , pp. 158-166
    • Wegener, J.1    Keese, C.R.2    Giaever, I.3
  • 65
    • 77949408218 scopus 로고    scopus 로고
    • High-content screening: a decade of evolution
    • Thomas N. High-content screening: a decade of evolution. J Biomol Screen 2010, 15:1–9.
    • (2010) J Biomol Screen , vol.15 , pp. 1-9
    • Thomas, N.1
  • 66
    • 34447562370 scopus 로고    scopus 로고
    • A pharmaceutical company user's perspective on the potential of high content screening in drug discovery
    • Hoffman AF, Garippa RJ. A pharmaceutical company user's perspective on the potential of high content screening in drug discovery. Methods Mol Biol 2007, 356:19–31.
    • (2007) Methods Mol Biol , vol.356 , pp. 19-31
    • Hoffman, A.F.1    Garippa, R.J.2
  • 67
    • 33750815755 scopus 로고    scopus 로고
    • Assay development and case history of a 32 K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform
    • Trask OJ Jr, Baker A, Williams RG, Nickischer D, Kandasamy R, Laethem C, Johnston PA, Johnston PA. Assay development and case history of a 32 K-biased library high-content MK2-EGFP translocation screen to identify p38 mitogen-activated protein kinase inhibitors on the ArrayScan 3.1 imaging platform. Methods Enzymol 2006, 414:419–439.
    • (2006) Methods Enzymol , vol.414 , pp. 419-439
    • Trask, O.J.1    Baker, A.2    Williams, R.G.3    Nickischer, D.4    Kandasamy, R.5    Laethem, C.6    Johnston, P.A.7    Johnston, P.A.8
  • 69
    • 84907216713 scopus 로고    scopus 로고
    • High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles
    • Anguissola S, Garry D, Salvati A, O'Brien PJ, Dawson KA. High content analysis provides mechanistic insights on the pathways of toxicity induced by amine-modified polystyrene nanoparticles. PLoS One 2014, 9:e108025.
    • (2014) PLoS One , vol.9
    • Anguissola, S.1    Garry, D.2    Salvati, A.3    O'Brien, P.J.4    Dawson, K.A.5
  • 70
    • 45749083389 scopus 로고    scopus 로고
    • High-content screening as a universal tool for fingerprinting of cytotoxicity of nanoparticles
    • Jan E, Byrne SJ, Cuddihy M, Davies AM, Volkov Y, Gun'ko YK, Kotov NA. High-content screening as a universal tool for fingerprinting of cytotoxicity of nanoparticles. ACS Nano 2008, 2:928–938.
    • (2008) ACS Nano , vol.2 , pp. 928-938
    • Jan, E.1    Byrne, S.J.2    Cuddihy, M.3    Davies, A.M.4    Volkov, Y.5    Gun'ko, Y.K.6    Kotov, N.A.7
  • 72
    • 80053332510 scopus 로고    scopus 로고
    • High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles
    • Lin S, Zhao Y, Xia T, Meng H, Ji Z, Liu R, George S, Xiong S, Wang X, Zhang H, et al. High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles. ACS Nano 2011, 5:7284–7295.
    • (2011) ACS Nano , vol.5 , pp. 7284-7295
    • Lin, S.1    Zhao, Y.2    Xia, T.3    Meng, H.4    Ji, Z.5    Liu, R.6    George, S.7    Xiong, S.8    Wang, X.9    Zhang, H.10
  • 78
    • 84864833730 scopus 로고    scopus 로고
    • Detection of TiO2 nanoparticles in cells by flow cytometry
    • Zucker RM, Daniel KM. Detection of TiO2 nanoparticles in cells by flow cytometry. Methods Mol Biol 2012, 906:497–509.
    • (2012) Methods Mol Biol , vol.906 , pp. 497-509
    • Zucker, R.M.1    Daniel, K.M.2
  • 81
    • 84884976387 scopus 로고    scopus 로고
    • Detection of silver nanoparticles in cells by flow cytometry using light scatter and far-red fluorescence
    • Zucker RM, Daniel KM, Massaro EJ, Karafas SJ, Degn LL, Boyes WK. Detection of silver nanoparticles in cells by flow cytometry using light scatter and far-red fluorescence. Cytometry A 2013, 83:962–972.
    • (2013) Cytometry A , vol.83 , pp. 962-972
    • Zucker, R.M.1    Daniel, K.M.2    Massaro, E.J.3    Karafas, S.J.4    Degn, L.L.5    Boyes, W.K.6
  • 82
    • 84924680107 scopus 로고    scopus 로고
    • Human cell line-dependent WC-Co nanoparticle cytotoxicity and genotoxicity: a key role of ROS production
    • Paget V, Moche H, Kortulewski T, Grall R, Irbah L, Nesslany F, Chevillard S. Human cell line-dependent WC-Co nanoparticle cytotoxicity and genotoxicity: a key role of ROS production. Toxicol Sci 2015, 143:385–397.
    • (2015) Toxicol Sci , vol.143 , pp. 385-397
    • Paget, V.1    Moche, H.2    Kortulewski, T.3    Grall, R.4    Irbah, L.5    Nesslany, F.6    Chevillard, S.7
  • 84
  • 85
    • 0027754169 scopus 로고
    • A morphological biosensor for mammalian cells
    • Giaever I, Keese CR. A morphological biosensor for mammalian cells. Nature 1993, 366:591–592.
    • (1993) Nature , vol.366 , pp. 591-592
    • Giaever, I.1    Keese, C.R.2
  • 86
    • 84897358626 scopus 로고    scopus 로고
    • Impedance measurements in the biomedical sciences
    • Coffman FD, Cohen S. Impedance measurements in the biomedical sciences. Stud Health Technol Inform 2013, 185:185–205.
    • (2013) Stud Health Technol Inform , vol.185 , pp. 185-205
    • Coffman, F.D.1    Cohen, S.2
  • 87
    • 84872160978 scopus 로고    scopus 로고
    • Bioelectrical impedance analysis for assessment of fluid status and body composition in neonates—the good, the bad and the unknown
    • Lingwood BE. Bioelectrical impedance analysis for assessment of fluid status and body composition in neonates—the good, the bad and the unknown. Eur J Clin Nutr 2013, 67(Suppl 1):S28–S33.
    • (2013) Eur J Clin Nutr , vol.67 , pp. S28-S33
    • Lingwood, B.E.1
  • 89
    • 77953024342 scopus 로고    scopus 로고
    • Bioimpedance: a review for food processing
    • Pliquett U. Bioimpedance: a review for food processing. Food Eng Rev 2010, 2:74–94.
    • (2010) Food Eng Rev , vol.2 , pp. 74-94
    • Pliquett, U.1
  • 90
    • 84872156713 scopus 로고    scopus 로고
    • Evolution of bioimpedance: a circuitous journey from estimation of physiological function to assessment of body composition and a return to clinical research
    • Lukaski HC. Evolution of bioimpedance: a circuitous journey from estimation of physiological function to assessment of body composition and a return to clinical research. Eur J Clin Nutr 2013, 67(Suppl 1):S2–S9.
    • (2013) Eur J Clin Nutr , vol.67 , pp. S2-S9
    • Lukaski, H.C.1
  • 91
    • 0037112536 scopus 로고    scopus 로고
    • Assessment of cytotoxicity using electric cell-substrate impedance sensing: concentration and time response function approach
    • Xiao C, Lachance B, Sunahara G, Luong JH. Assessment of cytotoxicity using electric cell-substrate impedance sensing: concentration and time response function approach. Anal Chem 2002, 74:5748–5753.
    • (2002) Anal Chem , vol.74 , pp. 5748-5753
    • Xiao, C.1    Lachance, B.2    Sunahara, G.3    Luong, J.H.4
  • 92
    • 79954623274 scopus 로고    scopus 로고
    • Rapid and quantitative assessment of cell quality, identity, and functionality for cell-based assays using real-time cellular analysis
    • Irelan JT, Wu MJ, Morgan J, Ke N, Xi B, Wang X, Xu X, Abassi YA. Rapid and quantitative assessment of cell quality, identity, and functionality for cell-based assays using real-time cellular analysis. J Biomol Screen 2011, 16:313–322.
    • (2011) J Biomol Screen , vol.16 , pp. 313-322
    • Irelan, J.T.1    Wu, M.J.2    Morgan, J.3    Ke, N.4    Xi, B.5    Wang, X.6    Xu, X.7    Abassi, Y.A.8
  • 93
    • 84873076653 scopus 로고    scopus 로고
    • Cytotoxicity assessment based on the AUC50 using multi-concentration time-dependent cellular response curves
    • Pan T, Huang B, Zhang W, Gabos S, Huang DY, Devendran V. Cytotoxicity assessment based on the AUC50 using multi-concentration time-dependent cellular response curves. Anal Chim Acta 2013, 764:44–52.
    • (2013) Anal Chim Acta , vol.764 , pp. 44-52
    • Pan, T.1    Huang, B.2    Zhang, W.3    Gabos, S.4    Huang, D.Y.5    Devendran, V.6
  • 94
  • 97
    • 79960133978 scopus 로고    scopus 로고
    • The xCELLigence system for real-time and label-free monitoring of cell viability
    • Ke N, Wang X, Xu X, Abassi YA. The xCELLigence system for real-time and label-free monitoring of cell viability. Methods Mol Biol 2011, 740:33–43.
    • (2011) Methods Mol Biol , vol.740 , pp. 33-43
    • Ke, N.1    Wang, X.2    Xu, X.3    Abassi, Y.A.4
  • 98
    • 84866427377 scopus 로고    scopus 로고
    • Application and validation of an impedance-based real time cell analyzer to measure the toxicity of nanoparticles impacting human bronchial epithelial cells
    • Otero-Gonzalez L, Sierra-Alvarez R, Boitano S, Field JA. Application and validation of an impedance-based real time cell analyzer to measure the toxicity of nanoparticles impacting human bronchial epithelial cells. Environ Sci Technol 2012, 46:10271–10278.
    • (2012) Environ Sci Technol , vol.46 , pp. 10271-10278
    • Otero-Gonzalez, L.1    Sierra-Alvarez, R.2    Boitano, S.3    Field, J.A.4
  • 100
    • 84929501365 scopus 로고    scopus 로고
    • Specific uptake and genotoxicity induced by polystyrene nanobeads with distinct surface chemistry on human lung epithelial cells and macrophages
    • Paget V, Dekali S, Kortulewski T, Grall R, Gamez C, Blazy K, Aguerre-Chariol O, Chevillard S, Braun A, Rat P, et al. Specific uptake and genotoxicity induced by polystyrene nanobeads with distinct surface chemistry on human lung epithelial cells and macrophages. PLoS One 2015, 10:e0123297.
    • (2015) PLoS One , vol.10
    • Paget, V.1    Dekali, S.2    Kortulewski, T.3    Grall, R.4    Gamez, C.5    Blazy, K.6    Aguerre-Chariol, O.7    Chevillard, S.8    Braun, A.9    Rat, P.10
  • 101
    • 84934437678 scopus 로고    scopus 로고
    • Use of the xCELLigence system for real-time analysis of changes in cellular motility and adhesion in physiological conditions
    • Scrace S, O'Neill E, Hammond EM, Pires IM. Use of the xCELLigence system for real-time analysis of changes in cellular motility and adhesion in physiological conditions. Methods Mol Biol 2013, 1046:295–306.
    • (2013) Methods Mol Biol , vol.1046 , pp. 295-306
    • Scrace, S.1    O'Neill, E.2    Hammond, E.M.3    Pires, I.M.4
  • 103
    • 84880312450 scopus 로고    scopus 로고
    • Real-time cell-microelectronic sensing of nanoparticle-induced cytotoxic effects
    • Moe B, Gabos S, Li XF. Real-time cell-microelectronic sensing of nanoparticle-induced cytotoxic effects. Anal Chim Acta 2013, 789:83–90.
    • (2013) Anal Chim Acta , vol.789 , pp. 83-90
    • Moe, B.1    Gabos, S.2    Li, X.F.3
  • 104
    • 84879530107 scopus 로고    scopus 로고
    • Dielectric spectroscopy as a viable biosensing tool for cell and tissue characterization and analysis
    • Heileman K, Daoud J, Tabrizian M. Dielectric spectroscopy as a viable biosensing tool for cell and tissue characterization and analysis. Biosens Bioelectron 2013, 49:348–359.
    • (2013) Biosens Bioelectron , vol.49 , pp. 348-359
    • Heileman, K.1    Daoud, J.2    Tabrizian, M.3
  • 105
    • 33751519745 scopus 로고    scopus 로고
    • Comparison of impedance-based sensors for cell adhesion monitoring and in vitro methods for detecting cytotoxicity induced by chemicals
    • Ponti J, Ceriotti L, Munaro B, Farina M, Munari A, Whelan M, Colpo P, Sabbioni E, Rossi F. Comparison of impedance-based sensors for cell adhesion monitoring and in vitro methods for detecting cytotoxicity induced by chemicals. Altern Lab Anim 2006, 34:515–525.
    • (2006) Altern Lab Anim , vol.34 , pp. 515-525
    • Ponti, J.1    Ceriotti, L.2    Munaro, B.3    Farina, M.4    Munari, A.5    Whelan, M.6    Colpo, P.7    Sabbioni, E.8    Rossi, F.9
  • 106
    • 84877662963 scopus 로고    scopus 로고
    • A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects
    • Kustermann S, Boess F, Buness A, Schmitz M, Watzele M, Weiser T, Singer T, Suter L, Roth A. A label-free, impedance-based real time assay to identify drug-induced toxicities and differentiate cytostatic from cytotoxic effects. Toxicol In Vitro 2013, 27:1589–1595.
    • (2013) Toxicol In Vitro , vol.27 , pp. 1589-1595
    • Kustermann, S.1    Boess, F.2    Buness, A.3    Schmitz, M.4    Watzele, M.5    Weiser, T.6    Singer, T.7    Suter, L.8    Roth, A.9
  • 107
    • 80051593626 scopus 로고    scopus 로고
    • Real-time profiling of NK cell killing of human astrocytes using xCELLigence technology
    • Moodley K, Angel CE, Glass M, Graham ES. Real-time profiling of NK cell killing of human astrocytes using xCELLigence technology. J Neurosci Methods 2011, 200:173–180.
    • (2011) J Neurosci Methods , vol.200 , pp. 173-180
    • Moodley, K.1    Angel, C.E.2    Glass, M.3    Graham, E.S.4
  • 108
    • 84938224329 scopus 로고    scopus 로고
    • Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts
    • Fang R, Qiao S, Liu Y, Meng Q, Chen X, Song B, Hou X, Tian W. Sustained co-delivery of BIO and IGF-1 by a novel hybrid hydrogel system to stimulate endogenous cardiac repair in myocardial infarcted rat hearts. Int J Nanomedicine 2015, 10:4691–4703.
    • (2015) Int J Nanomedicine , vol.10 , pp. 4691-4703
    • Fang, R.1    Qiao, S.2    Liu, Y.3    Meng, Q.4    Chen, X.5    Song, B.6    Hou, X.7    Tian, W.8
  • 109
    • 84943391063 scopus 로고    scopus 로고
    • Acid-responsive PEGylated doxorubicin prodrug nanoparticles for neuropilin-1 receptor-mediated targeted drug delivery
    • Song H, Zhang J, Wang W, Huang P, Zhang Y, Liu J, Li C, Kong D. Acid-responsive PEGylated doxorubicin prodrug nanoparticles for neuropilin-1 receptor-mediated targeted drug delivery. Colloids Surf B Biointerfaces 2015, 136:365–374.
    • (2015) Colloids Surf B Biointerfaces , vol.136 , pp. 365-374
    • Song, H.1    Zhang, J.2    Wang, W.3    Huang, P.4    Zhang, Y.5    Liu, J.6    Li, C.7    Kong, D.8
  • 110
    • 84878376886 scopus 로고    scopus 로고
    • A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating
    • Wang T, Hu N, Cao J, Wu J, Su K, Wang P. A cardiomyocyte-based biosensor for antiarrhythmic drug evaluation by simultaneously monitoring cell growth and beating. Biosens Bioelectron 2013, 49:9–13.
    • (2013) Biosens Bioelectron , vol.49 , pp. 9-13
    • Wang, T.1    Hu, N.2    Cao, J.3    Wu, J.4    Su, K.5    Wang, P.6
  • 111
    • 80051827676 scopus 로고    scopus 로고
    • Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging
    • Li JM, Zhao MX, Su H, Wang YY, Tan CP, Ji LN, Mao ZW. Multifunctional quantum-dot-based siRNA delivery for HPV18 E6 gene silence and intracellular imaging. Biomaterials 2011, 32:7978–7987.
    • (2011) Biomaterials , vol.32 , pp. 7978-7987
    • Li, J.M.1    Zhao, M.X.2    Su, H.3    Wang, Y.Y.4    Tan, C.P.5    Ji, L.N.6    Mao, Z.W.7
  • 112
    • 84862815497 scopus 로고    scopus 로고
    • Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking
    • Li JM, Wang YY, Zhao MX, Tan CP, Li YQ, Le XY, Ji LN, Mao ZW. Multifunctional QD-based co-delivery of siRNA and doxorubicin to HeLa cells for reversal of multidrug resistance and real-time tracking. Biomaterials 2012, 33:2780–2790.
    • (2012) Biomaterials , vol.33 , pp. 2780-2790
    • Li, J.M.1    Wang, Y.Y.2    Zhao, M.X.3    Tan, C.P.4    Li, Y.Q.5    Le, X.Y.6    Ji, L.N.7    Mao, Z.W.8
  • 113
  • 115
    • 70350666201 scopus 로고    scopus 로고
    • Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: need for multiparametric evaluation due to adsorption artifacts
    • Val S, Hussain S, Boland S, Hamel R, Baeza-Squiban A, Marano F. Carbon black and titanium dioxide nanoparticles induce pro-inflammatory responses in bronchial epithelial cells: need for multiparametric evaluation due to adsorption artifacts. Inhal Toxicol 2009, 21(Suppl 1):115–122.
    • (2009) Inhal Toxicol , vol.21 , pp. 115-122
    • Val, S.1    Hussain, S.2    Boland, S.3    Hamel, R.4    Baeza-Squiban, A.5    Marano, F.6
  • 116
    • 77954551782 scopus 로고    scopus 로고
    • An integrated approach to the study of the interaction between proteins and nanoparticles
    • Turci F, Ghibaudi E, Colonna M, Boscolo B, Fenoglio I, Fubini B. An integrated approach to the study of the interaction between proteins and nanoparticles. Langmuir 2010, 26:8336–8346.
    • (2010) Langmuir , vol.26 , pp. 8336-8346
    • Turci, F.1    Ghibaudi, E.2    Colonna, M.3    Boscolo, B.4    Fenoglio, I.5    Fubini, B.6
  • 118
    • 84926630289 scopus 로고    scopus 로고
    • Luminex and other multiplex high throughput technologies for the identification of, and host response to, environmental triggers of type 1 diabetes
    • Purohit S, Sharma A, She JX. Luminex and other multiplex high throughput technologies for the identification of, and host response to, environmental triggers of type 1 diabetes. Biomed Res Int 2015, 2015:326918.
    • (2015) Biomed Res Int , vol.2015 , pp. 326918
    • Purohit, S.1    Sharma, A.2    She, J.X.3
  • 119
    • 84868453850 scopus 로고    scopus 로고
    • A gold nanoparticle platform for the delivery of functional microRNAs into cancer cells
    • Ghosh R, Singh LC, Shohet JM, Gunaratne PH. A gold nanoparticle platform for the delivery of functional microRNAs into cancer cells. Biomaterials 2013, 34:807–816.
    • (2013) Biomaterials , vol.34 , pp. 807-816
    • Ghosh, R.1    Singh, L.C.2    Shohet, J.M.3    Gunaratne, P.H.4
  • 120
    • 84874623578 scopus 로고    scopus 로고
    • Multifunctional gold nanoparticles for diagnosis and therapy of disease
    • Mieszawska AJ, Mulder WJ, Fayad ZA, Cormode DP. Multifunctional gold nanoparticles for diagnosis and therapy of disease. Mol Pharm 2013, 10:831–847.
    • (2013) Mol Pharm , vol.10 , pp. 831-847
    • Mieszawska, A.J.1    Mulder, W.J.2    Fayad, Z.A.3    Cormode, D.P.4
  • 121
    • 25444448098 scopus 로고    scopus 로고
    • Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity
    • Connor EE, Mwamuka J, Gole A, Murphy CJ, Wyatt MD. Gold nanoparticles are taken up by human cells but do not cause acute cytotoxicity. Small 2005, 1:325–327.
    • (2005) Small , vol.1 , pp. 325-327
    • Connor, E.E.1    Mwamuka, J.2    Gole, A.3    Murphy, C.J.4    Wyatt, M.D.5
  • 132
    • 84896911744 scopus 로고    scopus 로고
    • High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology
    • Watson C, Ge J, Cohen J, Pyrgiotakis G, Engelward BP, Demokritou P. High-throughput screening platform for engineered nanoparticle-mediated genotoxicity using CometChip technology. ACS Nano 2014, 8:2118–2133.
    • (2014) ACS Nano , vol.8 , pp. 2118-2133
    • Watson, C.1    Ge, J.2    Cohen, J.3    Pyrgiotakis, G.4    Engelward, B.P.5    Demokritou, P.6
  • 136
    • 84940477791 scopus 로고    scopus 로고
    • Automation of the in vitro micronucleus and chromosome aberration assay for the assessment of the genotoxicity of the particulate and gas–vapor phase of cigarette smoke
    • Roemer E, Zenzen V, Conroy LL, Luedemann K, Dempsey R, Schunck C, Sticken ET. Automation of the in vitro micronucleus and chromosome aberration assay for the assessment of the genotoxicity of the particulate and gas–vapor phase of cigarette smoke. Toxicol Mech Methods 2015, 25:320–333.
    • (2015) Toxicol Mech Methods , vol.25 , pp. 320-333
    • Roemer, E.1    Zenzen, V.2    Conroy, L.L.3    Luedemann, K.4    Dempsey, R.5    Schunck, C.6    Sticken, E.T.7
  • 137
    • 0021339858 scopus 로고
    • Flow cytometric analysis of micronuclei found in cells after irradiation
    • Nusse M, Kramer J. Flow cytometric analysis of micronuclei found in cells after irradiation. Cytometry 1984, 5:20–25.
    • (1984) Cytometry , vol.5 , pp. 20-25
    • Nusse, M.1    Kramer, J.2
  • 138
    • 34248525923 scopus 로고    scopus 로고
    • In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity
    • Bryce SM, Bemis JC, Avlasevich SL, Dertinger SD. In vitro micronucleus assay scored by flow cytometry provides a comprehensive evaluation of cytogenetic damage and cytotoxicity. Mutat Res 2007, 630:78–91.
    • (2007) Mutat Res , vol.630 , pp. 78-91
    • Bryce, S.M.1    Bemis, J.C.2    Avlasevich, S.L.3    Dertinger, S.D.4
  • 139
    • 78549250674 scopus 로고    scopus 로고
    • Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships
    • Bryce SM, Avlasevich SL, Bemis JC, Phonethepswath S, Dertinger SD. Miniaturized flow cytometric in vitro micronucleus assay represents an efficient tool for comprehensively characterizing genotoxicity dose–response relationships. Mutat Res 2010, 703:191–199.
    • (2010) Mutat Res , vol.703 , pp. 191-199
    • Bryce, S.M.1    Avlasevich, S.L.2    Bemis, J.C.3    Phonethepswath, S.4    Dertinger, S.D.5
  • 142
    • 34248523857 scopus 로고    scopus 로고
    • Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells
    • Diaz D, Scott A, Carmichael P, Shi W, Costales C. Evaluation of an automated in vitro micronucleus assay in CHO-K1 cells. Mutat Res 2007, 630:1–13.
    • (2007) Mutat Res , vol.630 , pp. 1-13
    • Diaz, D.1    Scott, A.2    Carmichael, P.3    Shi, W.4    Costales, C.5
  • 143
    • 84969403013 scopus 로고    scopus 로고
    • An assessment of the performance of an automated scoring system (Cellomics) for the in vitro micronucleus assay in CHO-K1 cells
    • Scott A, Malcomber S, Maskell S, Moore C, Windebank S, Diaz D, Carmichael P. An assessment of the performance of an automated scoring system (Cellomics) for the in vitro micronucleus assay in CHO-K1 cells. Toxicology 2007, 231:111–112.
    • (2007) Toxicology , vol.231 , pp. 111-112
    • Scott, A.1    Malcomber, S.2    Maskell, S.3    Moore, C.4    Windebank, S.5    Diaz, D.6    Carmichael, P.7
  • 144
    • 77958514290 scopus 로고    scopus 로고
    • High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery
    • Mondal MS, Gabriels J, McGinnis C, Magnifico M, Marsilje TH, Urban L, Collis A, Bojanic D, Biller SA, Frieauff W, et al. High-content micronucleus assay in genotoxicity profiling: initial-stage development and some applications in the investigative/lead-finding studies in drug discovery. Toxicol Sci 2010, 118:71–85.
    • (2010) Toxicol Sci , vol.118 , pp. 71-85
    • Mondal, M.S.1    Gabriels, J.2    McGinnis, C.3    Magnifico, M.4    Marsilje, T.H.5    Urban, L.6    Collis, A.7    Bojanic, D.8    Biller, S.A.9    Frieauff, W.10
  • 145
    • 79960990848 scopus 로고    scopus 로고
    • Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells
    • Westerink WM, Schirris TJ, Horbach GJ, Schoonen WG. Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells. Mutat Res 2011, 724:7–21.
    • (2011) Mutat Res , vol.724 , pp. 7-21
    • Westerink, W.M.1    Schirris, T.J.2    Horbach, G.J.3    Schoonen, W.G.4
  • 148
    • 77950961695 scopus 로고    scopus 로고
    • γH2AX: a sensitive molecular marker of DNA damage and repair
    • Mah LJ, El-Osta A, Karagiannis TC. γH2AX: a sensitive molecular marker of DNA damage and repair. Leukemia 2010, 24:679–686.
    • (2010) Leukemia , vol.24 , pp. 679-686
    • Mah, L.J.1    El-Osta, A.2    Karagiannis, T.C.3
  • 150
    • 80755153618 scopus 로고    scopus 로고
    • Use of the γH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines
    • Audebert M, Dolo L, Perdu E, Cravedi JP, Zalko D. Use of the γH2AX assay for assessing the genotoxicity of bisphenol A and bisphenol F in human cell lines. Arch Toxicol 2011, 85:1463–1473.
    • (2011) Arch Toxicol , vol.85 , pp. 1463-1473
    • Audebert, M.1    Dolo, L.2    Perdu, E.3    Cravedi, J.P.4    Zalko, D.5
  • 151
    • 29244437908 scopus 로고    scopus 로고
    • The role of double-strand break repair – insights from human genetics
    • O'Driscoll M, Jeggo PA. The role of double-strand break repair – insights from human genetics. Nat Rev Genet 2006, 7:45–54.
    • (2006) Nat Rev Genet , vol.7 , pp. 45-54
    • O'Driscoll, M.1    Jeggo, P.A.2
  • 154
    • 45049085581 scopus 로고    scopus 로고
    • Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy
    • Clingen PH, Wu JY, Miller J, Mistry N, Chin F, Wynne P, Prise KM, Hartley JA. Histone H2AX phosphorylation as a molecular pharmacological marker for DNA interstrand crosslink cancer chemotherapy. Biochem Pharmacol 2008, 76:19–27.
    • (2008) Biochem Pharmacol , vol.76 , pp. 19-27
    • Clingen, P.H.1    Wu, J.Y.2    Miller, J.3    Mistry, N.4    Chin, F.5    Wynne, P.6    Prise, K.M.7    Hartley, J.A.8
  • 156
    • 38049163924 scopus 로고    scopus 로고
    • DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells
    • Zhu L, Chang DW, Dai L, Hong Y. DNA damage induced by multiwalled carbon nanotubes in mouse embryonic stem cells. Nano Lett 2007, 7:3592–3597.
    • (2007) Nano Lett , vol.7 , pp. 3592-3597
    • Zhu, L.1    Chang, D.W.2    Dai, L.3    Hong, Y.4
  • 157
    • 71549153541 scopus 로고    scopus 로고
    • Using carbon nanotubes to induce micronuclei and double strand breaks of the DNA in human cells
    • Cveticanin J, Joksic G, Leskovac A, Petrovic S, Sobot AV, Neskovic O. Using carbon nanotubes to induce micronuclei and double strand breaks of the DNA in human cells. Nanotechnology 2010, 21:015102.
    • (2010) Nanotechnology , vol.21 , pp. 015102
    • Cveticanin, J.1    Joksic, G.2    Leskovac, A.3    Petrovic, S.4    Sobot, A.V.5    Neskovic, O.6
  • 158
    • 84871791641 scopus 로고    scopus 로고
    • Molecularly targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor xenografts to X-radiation
    • Chattopadhyay N, Cai Z, Kwon YL, Lechtman E, Pignol JP, Reilly RM. Molecularly targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor xenografts to X-radiation. Breast Cancer Res Treat 2013, 137:81–91.
    • (2013) Breast Cancer Res Treat , vol.137 , pp. 81-91
    • Chattopadhyay, N.1    Cai, Z.2    Kwon, Y.L.3    Lechtman, E.4    Pignol, J.P.5    Reilly, R.M.6
  • 159
    • 77955495793 scopus 로고    scopus 로고
    • DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential?
    • Msiska Z, Pacurari M, Mishra A, Leonard SS, Castranova V, Vallyathan V. DNA double-strand breaks by asbestos, silica, and titanium dioxide: possible biomarker of carcinogenic potential? Am J Respir Cell Mol Biol 2010, 43:210–219.
    • (2010) Am J Respir Cell Mol Biol , vol.43 , pp. 210-219
    • Msiska, Z.1    Pacurari, M.2    Mishra, A.3    Leonard, S.S.4    Castranova, V.5    Vallyathan, V.6
  • 160
    • 72249115549 scopus 로고    scopus 로고
    • Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice
    • Trouiller B, Reliene R, Westbrook A, Solaimani P, Schiestl RH. Titanium dioxide nanoparticles induce DNA damage and genetic instability in vivo in mice. Cancer Res 2009, 69:8784–8789.
    • (2009) Cancer Res , vol.69 , pp. 8784-8789
    • Trouiller, B.1    Reliene, R.2    Westbrook, A.3    Solaimani, P.4    Schiestl, R.H.5
  • 161
    • 84856079653 scopus 로고    scopus 로고
    • Titanium dioxide particles phosphorylate histone H2AX independent of ROS production
    • Toyooka T, Amano T, Ibuki Y. Titanium dioxide particles phosphorylate histone H2AX independent of ROS production. Mutat Res 2012, 742:84–91.
    • (2012) Mutat Res , vol.742 , pp. 84-91
    • Toyooka, T.1    Amano, T.2    Ibuki, Y.3
  • 162
    • 70249114048 scopus 로고    scopus 로고
    • Microscopic imaging of DNA repair foci in irradiated normal tissues
    • Bhogal N, Jalali F, Bristow RG. Microscopic imaging of DNA repair foci in irradiated normal tissues. Int J Radiat Biol 2009, 85:732–746.
    • (2009) Int J Radiat Biol , vol.85 , pp. 732-746
    • Bhogal, N.1    Jalali, F.2    Bristow, R.G.3
  • 164
    • 67449088381 scopus 로고    scopus 로고
    • Computational analysis of the number, area and density of γ-H2AX foci in breast cancer cells exposed to (111)In-DTPA-hEGF or γ-rays using Image-J software
    • Cai Z, Vallis KA, Reilly RM. Computational analysis of the number, area and density of γ-H2AX foci in breast cancer cells exposed to (111)In-DTPA-hEGF or γ-rays using Image-J software. Int J Radiat Biol 2009, 85:262–271.
    • (2009) Int J Radiat Biol , vol.85 , pp. 262-271
    • Cai, Z.1    Vallis, K.A.2    Reilly, R.M.3
  • 167
    • 74649084970 scopus 로고    scopus 로고
    • FociCounter: a freely available PC programme for quantitative and qualitative analysis of γ-H2AX foci
    • Jucha A, Wegierek-Ciuk A, Koza Z, Lisowska H, Wojcik A, Wojewodzka M, Lankoff A. FociCounter: a freely available PC programme for quantitative and qualitative analysis of γ-H2AX foci. Mutat Res 2010, 696:16–20.
    • (2010) Mutat Res , vol.696 , pp. 16-20
    • Jucha, A.1    Wegierek-Ciuk, A.2    Koza, Z.3    Lisowska, H.4    Wojcik, A.5    Wojewodzka, M.6    Lankoff, A.7
  • 168
    • 79951968948 scopus 로고    scopus 로고
    • A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs)
    • Yip KW, Cuddy M, Pinilla C, Giulanotti M, Heynen-Genel S, Matsuzawa S, Reed JC. A high-content screening (HCS) assay for the identification of chemical inducers of PML oncogenic domains (PODs). J Biomol Screen 2011, 16:251–258.
    • (2011) J Biomol Screen , vol.16 , pp. 251-258
    • Yip, K.W.1    Cuddy, M.2    Pinilla, C.3    Giulanotti, M.4    Heynen-Genel, S.5    Matsuzawa, S.6    Reed, J.C.7
  • 172
    • 84937759207 scopus 로고    scopus 로고
    • Developing tools for defining and establishing pathways of toxicity
    • Andersen ME, McMullen PD, Krewski D. Developing tools for defining and establishing pathways of toxicity. Arch Toxicol 2015, 89:809–812.
    • (2015) Arch Toxicol , vol.89 , pp. 809-812
    • Andersen, M.E.1    McMullen, P.D.2    Krewski, D.3
  • 176
    • 84921768315 scopus 로고    scopus 로고
    • Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells
    • Feliu N, Kohonen P, Ji J, Zhang Y, Karlsson HL, Palmberg L, Nystrom A, Fadeel B. Next-generation sequencing reveals low-dose effects of cationic dendrimers in primary human bronchial epithelial cells. ACS Nano 2015, 9:146–163.
    • (2015) ACS Nano , vol.9 , pp. 146-163
    • Feliu, N.1    Kohonen, P.2    Ji, J.3    Zhang, Y.4    Karlsson, H.L.5    Palmberg, L.6    Nystrom, A.7    Fadeel, B.8
  • 177
    • 79952096381 scopus 로고    scopus 로고
    • The evolution of bioinformatics in toxicology: advancing toxicogenomics
    • Afshari CA, Hamadeh HK, Bushel PR. The evolution of bioinformatics in toxicology: advancing toxicogenomics. Toxicol Sci 2011, 120(Suppl 1):S225–S237.
    • (2011) Toxicol Sci , vol.120 , pp. S225-S237
    • Afshari, C.A.1    Hamadeh, H.K.2    Bushel, P.R.3
  • 178
    • 76749123852 scopus 로고    scopus 로고
    • Application of connectivity mapping in predictive toxicology based on gene-expression similarity
    • Smalley JL, Gant TW, Zhang SD. Application of connectivity mapping in predictive toxicology based on gene-expression similarity. Toxicology 2010, 268:143–146.
    • (2010) Toxicology , vol.268 , pp. 143-146
    • Smalley, J.L.1    Gant, T.W.2    Zhang, S.D.3
  • 179
    • 84904812772 scopus 로고    scopus 로고
    • Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action
    • Gusenleitner D, Auerbach SS, Melia T, Gomez HF, Sherr DH, Monti S. Genomic models of short-term exposure accurately predict long-term chemical carcinogenicity and identify putative mechanisms of action. PLoS One 2014, 9:e102579.
    • (2014) PLoS One , vol.9
    • Gusenleitner, D.1    Auerbach, S.S.2    Melia, T.3    Gomez, H.F.4    Sherr, D.H.5    Monti, S.6
  • 180
    • 33845876254 scopus 로고    scopus 로고
    • The Connectivity Map: a new tool for biomedical research
    • Lamb J. The Connectivity Map: a new tool for biomedical research. Nat Rev Cancer 2007, 7:54–60.
    • (2007) Nat Rev Cancer , vol.7 , pp. 54-60
    • Lamb, J.1
  • 181
    • 66449107552 scopus 로고    scopus 로고
    • The impact of toxicity testing costs on nanomaterial regulation
    • Choi JY, Ramachandran G, Kandlikar M. The impact of toxicity testing costs on nanomaterial regulation. Environ Sci Technol 2009, 43:3030–3034.
    • (2009) Environ Sci Technol , vol.43 , pp. 3030-3034
    • Choi, J.Y.1    Ramachandran, G.2    Kandlikar, M.3
  • 182
    • 84856250240 scopus 로고    scopus 로고
    • Adaptation of high-throughput screening in drug discovery-toxicological screening tests
    • Szymanski P, Markowicz M, Mikiciuk-Olasik E. Adaptation of high-throughput screening in drug discovery-toxicological screening tests. Int J Mol Sci 2012, 13:427–452.
    • (2012) Int J Mol Sci , vol.13 , pp. 427-452
    • Szymanski, P.1    Markowicz, M.2    Mikiciuk-Olasik, E.3
  • 183
    • 78650640476 scopus 로고    scopus 로고
    • Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure
    • Rossnerova A, Spatova M, Schunck C, Sram RJ. Automated scoring of lymphocyte micronuclei by the MetaSystems Metafer image cytometry system and its application in studies of human mutagen sensitivity and biodosimetry of genotoxin exposure. Mutagenesis 2011, 26:169–175.
    • (2011) Mutagenesis , vol.26 , pp. 169-175
    • Rossnerova, A.1    Spatova, M.2    Schunck, C.3    Sram, R.J.4
  • 184
    • 84885385963 scopus 로고    scopus 로고
    • Assay development guidelines for image-based high content screening, high content analysis and high content imaging
    • In, Sittampalam GS, Coussens NP, Nelson H, Arkin M, Auld D, Austin C, Bejcek B, Glicksman M, Inglese J, Iversen PW, eds., Bethesda, MD, Eli Lilly & Company and the National Center for Advancing Translational Sciences
    • Buchser W, Collins M, Garyantes T, Guha R, Haney S, Lemmon V, Li Z, Trask OJ. Assay development guidelines for image-based high content screening, high content analysis and high content imaging. In: Sittampalam GS, Coussens NP, Nelson H, Arkin M, Auld D, Austin C, Bejcek B, Glicksman M, Inglese J, Iversen PW, et al., eds. Assay Guidance Manual. Bethesda, MD: Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004.
    • (2004) Assay Guidance Manual
    • Buchser, W.1    Collins, M.2    Garyantes, T.3    Guha, R.4    Haney, S.5    Lemmon, V.6    Li, Z.7    Trask, O.J.8
  • 186
    • 84866019700 scopus 로고    scopus 로고
    • Interference of engineered nanoparticles with in vitro toxicity assays
    • Kroll A, Pillukat MH, Hahn D, Schnekenburger J. Interference of engineered nanoparticles with in vitro toxicity assays. Arch Toxicol 2012, 86:1123–1136.
    • (2012) Arch Toxicol , vol.86 , pp. 1123-1136
    • Kroll, A.1    Pillukat, M.H.2    Hahn, D.3    Schnekenburger, J.4
  • 189
    • 84940730176 scopus 로고    scopus 로고
    • It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system
    • Farrera C, Fadeel B. It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system. Eur J Pharm Biopharm 2015, 95:3–12.
    • (2015) Eur J Pharm Biopharm , vol.95 , pp. 3-12
    • Farrera, C.1    Fadeel, B.2
  • 190
    • 29344440042 scopus 로고    scopus 로고
    • Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity
    • Yu SJ, Kang MW, Chang HC, Chen KM, Yu YC. Bright fluorescent nanodiamonds: no photobleaching and low cytotoxicity. J Am Chem Soc 2005, 127:17604–17605.
    • (2005) J Am Chem Soc , vol.127 , pp. 17604-17605
    • Yu, S.J.1    Kang, M.W.2    Chang, H.C.3    Chen, K.M.4    Yu, Y.C.5
  • 192
    • 84890322405 scopus 로고    scopus 로고
    • Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles
    • Wang XZ, Yang Y, Li R, McGuinnes C, Adamson J, Megson IL, Donaldson K. Principal component and causal analysis of structural and acute in vitro toxicity data for nanoparticles. Nanotoxicology 2014, 8:465–476.
    • (2014) Nanotoxicology , vol.8 , pp. 465-476
    • Wang, X.Z.1    Yang, Y.2    Li, R.3    McGuinnes, C.4    Adamson, J.5    Megson, I.L.6    Donaldson, K.7


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