γh2AX: A sensitive molecular marker of DNA damage and repair

Leukemia

Volumn 24, Issue 4, 2010, Pages 679-686

  Mah, L J ^a,b   El Osta, A ^a,b   Karagiannis, T C ^a,b  

^a BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Chromatin modification; DNA damage; Double strand break; Repair; radiation; H2AX

Indexed keywords

3 [3' (1 ADAMANTYL) 4' HYDROXYBIPHENYL 4 YL]ACRYLIC ACID; ANTHRACYCLINE; AZACITIDINE; BLEOMYCIN; CISPLATIN; COMPLEMENTARY DNA; DNA METHYLTRANSFERASE INHIBITOR; DNA TOPOISOMERASE INHIBITOR; DOXORUBICIN; ENTINOSTAT; ETOPOSIDE; GAMMA HISTONE H2AX; HISTONE DEACETYLASE INHIBITOR; HISTONE H2AX; HYDROXAMIC ACID; HYDROXYUREA; IDARUBICIN; MITOXANTRONE; N (2 AMINOPHENYL) 4 (3 PYRIDINYLMETHOXYCARBONYLAMINOMETHYL)BENZAMIDE; RC 307; SERINE; TRICHOSTATIN A; UNCLASSIFIED DRUG; VALPROIC ACID; VORINOSTAT; H2AFX PROTEIN, HUMAN; HISTONE; TUMOR MARKER;

ACUTE GRANULOCYTIC LEUKEMIA; ADVANCED CANCER; BYSTANDER EFFECT; CANCER INHIBITION; CHROMOSOME ABERRATION; CLINICAL TRIAL; CUTANEOUS T CELL LYMPHOMA; DNA DAMAGE; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; DRUG MECHANISM; DRUG POTENTIATION; EPIGENETICS; GAMMA RADIATION; GENOMIC INSTABILITY; GENOTOXICITY; HEMATOLOGIC MALIGNANCY; HUMAN; IONIZING RADIATION; METABOLIC STRESS; MYELODYSPLASTIC SYNDROME; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN DNA INTERACTION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RADIATION EXPOSURE; RADIOSENSITIVITY; REVIEW; SIGNAL TRANSDUCTION; PHOSPHORYLATION;

DNA DAMAGE; DNA REPAIR; HISTONES; HUMANS; PHOSPHORYLATION; TUMOR MARKERS, BIOLOGICAL;

EID: 77950961695     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.6     Document Type: Review

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