Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials

ACS Nano

Volumn 5, Issue 3, 2011, Pages 1805-1817

  George, Saji ^a   Xia, Tian ^a   Rallo, Robert ^a,c   Zhao, Yan ^b   Ji, Zhaoxia ^a   Lin, Sijie ^a   Wang, Xiang ^a   Zhang, Haiyuan ^a   France, Bryan ^b   Schoenfeld, David ^a,b   Damoiseaux, Robert ^a,b   Liu, Rong ^a,c   Lin, Shuo ^b   Bradley, Kenneth A ^a,b   Cohen, Yoram ^a,c   Nel, André E ^a  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c University of California   (United States)

Author keywords

hazard ranking; high throughput screening; nanotoxicology; self organizing map; zebrafish

Indexed keywords

AUTOMATED SCREENING; CELLULAR INJURY; DATA TRANSFORMATION; ENGINEERED NANOMATERIALS; EPIFLUORESCENCE MICROSCOPY; HAZARD RANKING; HIGH-THROUGHPUT ANALYSIS; HIGH-THROUGHPUT SCREENING; IN-SILICO; IN-VITRO; IN-VIVO; INHIBITORY EFFECT; INTRACELLULAR CALCIUM; MORPHOLOGICAL DEFECTS; MORTALITY RATE; NANO-ZNO; NANOTOXICOLOGY; OXIDE NANOPARTICLES; PLASMA MEMBRANE PERMEABILITY; QUANTUM DOT; RESPONSE PARAMETERS; SIMILARITY PATTERNS; SPEED-UPS; SUBLETHAL EFFECTS; VOLUME DATA SETS; Z-SCORES; ZEBRAFISH; ZEBRAFISH EMBRYOS; ZNO;

AUTOMATION; CELL MEMBRANES; CHALCOGENIDES; CONFORMAL MAPPING; DATA HANDLING; HAZARDS; METADATA; NANOSTRUCTURED MATERIALS; ORGANIC SOLVENTS; PLATINUM; SEMICONDUCTOR QUANTUM DOTS; SILICON COMPOUNDS; SILVER; THROUGHPUT; TOLUENE; TOXICITY; ZINC OXIDE;

SELF ORGANIZING MAPS;

NANOMATERIAL; QUANTUM DOT;

ANIMAL; ANIMAL EMBRYO; ARTICLE; BIOASSAY; DRUG EFFECT; DRUG SCREENING; FLUORESCENCE MICROSCOPY; METHODOLOGY; PATHOLOGY; TOXICITY TESTING; ZEBRA FISH;

ANIMALS; BIOLOGICAL ASSAY; DRUG EVALUATION, PRECLINICAL; EMBRYO, NONMAMMALIAN; MICROSCOPY, FLUORESCENCE; NANOSTRUCTURES; QUANTUM DOTS; TOXICITY TESTS; ZEBRAFISH;

EID: 79952952840     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn102734s     Document Type: Article

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