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Volumn 95, Issue , 2015, Pages 3-12

It takes two to tango: Understanding the interactions between engineered nanomaterials and the immune system

Author keywords

Bio corona; Danger signals; Inflammasome; Macrophages; Nanomaterials; Nanotoxicology

Indexed keywords

INFLAMMASOME; NANOMATERIAL; NANOPARTICLE;

EID: 84940730176     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2015.03.007     Document Type: Article
Times cited : (87)

References (105)
  • 1
    • 79551672488 scopus 로고    scopus 로고
    • Nanotoxicology: An interdisciplinary challenge
    • H.F. Krug, and P. Wick Nanotoxicology: an interdisciplinary challenge Angew. Chem. Int. Ed. Engl. 50 2011 1260 1278
    • (2011) Angew. Chem. Int. Ed. Engl. , vol.50 , pp. 1260-1278
    • Krug, H.F.1    Wick, P.2
  • 3
    • 84875357552 scopus 로고    scopus 로고
    • Nanomaterial toxicity testing in the 21st century: Use of a predictive toxicological approach and high-throughput screening
    • A. Nel, T. Xia, H. Meng, X. Wang, S. Lin, Z. Ji, and H. Zhang Nanomaterial toxicity testing in the 21st century: use of a predictive toxicological approach and high-throughput screening Acc. Chem. Res. 46 2013 607 621
    • (2013) Acc. Chem. Res. , vol.46 , pp. 607-621
    • Nel, A.1    Xia, T.2    Meng, H.3    Wang, X.4    Lin, S.5    Ji, Z.6    Zhang, H.7
  • 5
    • 71949102618 scopus 로고    scopus 로고
    • Close encounters of the small kind: Adverse effects of man-made materials interfacing with the nano-cosmos of biological systems
    • A.A. Shvedova, V.E. Kagan, and B. Fadeel Close encounters of the small kind: adverse effects of man-made materials interfacing with the nano-cosmos of biological systems Annu. Rev. Pharmacol. Toxicol. 50 2010 63 88
    • (2010) Annu. Rev. Pharmacol. Toxicol. , vol.50 , pp. 63-88
    • Shvedova, A.A.1    Kagan, V.E.2    Fadeel, B.3
  • 6
    • 84905050462 scopus 로고    scopus 로고
    • Assembly and localization of Toll-like receptor signalling complexes
    • N.J. Gay, M.F. Symmons, M. Gangloff, and C.E. Bryant Assembly and localization of Toll-like receptor signalling complexes Nat. Rev. Immunol. 14 2014 546 558
    • (2014) Nat. Rev. Immunol. , vol.14 , pp. 546-558
    • Gay, N.J.1    Symmons, M.F.2    Gangloff, M.3    Bryant, C.E.4
  • 7
    • 70849093813 scopus 로고    scopus 로고
    • Materials engineering for immunomodulation
    • J.A. Hubbell, S.N. Thomas, and M.A. Swartz Materials engineering for immunomodulation Nature 462 2009 449 460
    • (2009) Nature , vol.462 , pp. 449-460
    • Hubbell, J.A.1    Thomas, S.N.2    Swartz, M.A.3
  • 8
    • 79952097548 scopus 로고    scopus 로고
    • The new toxicology of sophisticated materials: Nanotoxicology and beyond
    • A.D. Maynard, D.B. Warheit, and M.A. Philbert The new toxicology of sophisticated materials: nanotoxicology and beyond Toxicol. Sci. 120 Suppl. 1 2011 S109 S129
    • (2011) Toxicol. Sci. , vol.120 , pp. S109-S129
    • Maynard, A.D.1    Warheit, D.B.2    Philbert, M.A.3
  • 9
    • 71949117632 scopus 로고    scopus 로고
    • Safety assessment for nanotechnology and nanomedicine: Concepts of nanotoxicology
    • G. Oberdörster Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology J. Intern. Med. 267 2010 89 105
    • (2010) J. Intern. Med. , vol.267 , pp. 89-105
    • Oberdörster, G.1
  • 10
    • 84915748313 scopus 로고    scopus 로고
    • Nanosafety research-are we on the right track?
    • H.F. Krug Nanosafety research-are we on the right track? Angew. Chem. Int. Ed. Engl. 53 2014 12304 12319
    • (2014) Angew. Chem. Int. Ed. Engl. , vol.53 , pp. 12304-12319
    • Krug, H.F.1
  • 11
    • 84880958977 scopus 로고    scopus 로고
    • Nanotoxicity: Challenging the myth of nano-specific toxicity
    • K. Donaldson, and C.A. Poland Nanotoxicity: challenging the myth of nano-specific toxicity Curr. Opin. Biotechnol. 24 2013 724 734
    • (2013) Curr. Opin. Biotechnol. , vol.24 , pp. 724-734
    • Donaldson, K.1    Poland, C.A.2
  • 13
    • 84873853768 scopus 로고    scopus 로고
    • Biomolecular coronas provide the biological identity of nanosized materials
    • M.P. Monopoli, C. Åberg, A. Salvati, and K.A. Dawson Biomolecular coronas provide the biological identity of nanosized materials Nat. Nanotechnol. 7 2012 779 786
    • (2012) Nat. Nanotechnol. , vol.7 , pp. 779-786
    • Monopoli, M.P.1    Åberg, C.2    Salvati, A.3    Dawson, K.A.4
  • 16
    • 77957323640 scopus 로고    scopus 로고
    • Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality
    • W.K. Oh, S. Kim, M. Choi, C. Kim, Y.S. Jeong, B.R. Cho, J.S. Hahn, and J. Jang Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality ACS Nano 4 2010 5301 5313
    • (2010) ACS Nano , vol.4 , pp. 5301-5313
    • Oh, W.K.1    Kim, S.2    Choi, M.3    Kim, C.4    Jeong, Y.S.5    Cho, B.R.6    Hahn, J.S.7    Jang, J.8
  • 17
    • 84856423834 scopus 로고    scopus 로고
    • Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment
    • C.D. Walkey, and W.C. Chan Understanding and controlling the interaction of nanomaterials with proteins in a physiological environment Chem. Soc. Rev. 41 2012 2780 2799
    • (2012) Chem. Soc. Rev. , vol.41 , pp. 2780-2799
    • Walkey, C.D.1    Chan, W.C.2
  • 18
    • 84886447813 scopus 로고    scopus 로고
    • The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes
    • F. Wang, L. Yu, M.P. Monopoli, P. Sandin, E. Mahon, A. Salvati, and K.A. Dawson The biomolecular corona is retained during nanoparticle uptake and protects the cells from the damage induced by cationic nanoparticles until degraded in the lysosomes Nanomedicine 9 2013 1159 1168
    • (2013) Nanomedicine , vol.9 , pp. 1159-1168
    • Wang, F.1    Yu, L.2    Monopoli, M.P.3    Sandin, P.4    Mahon, E.5    Salvati, A.6    Dawson, K.A.7
  • 19
    • 84910665847 scopus 로고    scopus 로고
    • Shifting identities of metal oxide nanoparticles: Focus on inflammation
    • K. Bhattacharya, L. Farcal, and B. Fadeel Shifting identities of metal oxide nanoparticles: focus on inflammation MRS Bull. 39 2014 970 975
    • (2014) MRS Bull. , vol.39 , pp. 970-975
    • Bhattacharya, K.1    Farcal, L.2    Fadeel, B.3
  • 22
    • 79959772416 scopus 로고    scopus 로고
    • Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity
    • N. Gao, Q. Zhang, Q. Mu, Y. Bai, L. Li, H. Zhou, E.R. Butch, T.B. Powell, S.E. Snyder, G. Jiang, and B. Yan Steering carbon nanotubes to scavenger receptor recognition by nanotube surface chemistry modification partially alleviates NFκB activation and reduces its immunotoxicity ACS Nano 5 2011 4581 4591
    • (2011) ACS Nano , vol.5 , pp. 4581-4591
    • Gao, N.1    Zhang, Q.2    Mu, Q.3    Bai, Y.4    Li, L.5    Zhou, H.6    Butch, E.R.7    Powell, T.B.8    Snyder, S.E.9    Jiang, G.10    Yan, B.11
  • 23
    • 78650606928 scopus 로고    scopus 로고
    • Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation
    • Z.J. Deng, M. Liang, M. Monteiro, I. Toth, and R.F. Minchin Nanoparticle-induced unfolding of fibrinogen promotes Mac-1 receptor activation and inflammation Nat. Nanotechnol. 6 2011 39 44
    • (2011) Nat. Nanotechnol. , vol.6 , pp. 39-44
    • Deng, Z.J.1    Liang, M.2    Monteiro, M.3    Toth, I.4    Minchin, R.F.5
  • 24
    • 84891370315 scopus 로고    scopus 로고
    • Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines
    • Y. Yan, K.T. Gause, M.M. Kamphuis, C.S. Ang, N.M. O'Brien-Simpson, J.C. Lenzo, E.C. Reynolds, E.C. Nice, and F. Caruso Differential roles of the protein corona in the cellular uptake of nanoporous polymer particles by monocyte and macrophage cell lines ACS Nano 7 2013 10960 10970
    • (2013) ACS Nano , vol.7 , pp. 10960-10970
    • Yan, Y.1    Gause, K.T.2    Kamphuis, M.M.3    Ang, C.S.4    O'Brien-Simpson, N.M.5    Lenzo, J.C.6    Reynolds, E.C.7    Nice, E.C.8    Caruso, F.9
  • 26
    • 84906101721 scopus 로고    scopus 로고
    • Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles
    • M.A. Dobrovolskaia, B.W. Neun, S. Man, X. Ye, M. Hansen, A.K. Patri, R.M. Crist, and S.E. McNeil Protein corona composition does not accurately predict hematocompatibility of colloidal gold nanoparticles Nanomedicine 10 2014 1453 1463
    • (2014) Nanomedicine , vol.10 , pp. 1453-1463
    • Dobrovolskaia, M.A.1    Neun, B.W.2    Man, S.3    Ye, X.4    Hansen, M.5    Patri, A.K.6    Crist, R.M.7    McNeil, S.E.8
  • 30
    • 84864241697 scopus 로고    scopus 로고
    • Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells
    • A. Lesniak, F. Fenaroli, M.P. Monopoli, C. Åberg, K.A. Dawson, and A. Salvati Effects of the presence or absence of a protein corona on silica nanoparticle uptake and impact on cells ACS Nano 6 2012 5845 5857
    • (2012) ACS Nano , vol.6 , pp. 5845-5857
    • Lesniak, A.1    Fenaroli, F.2    Monopoli, M.P.3    Åberg, C.4    Dawson, K.A.5    Salvati, A.6
  • 31
    • 84948680390 scopus 로고    scopus 로고
    • Proteomics analysis reveals distinct corona compositions on magnetic nanoparticles with different surface coating: Implications for interactions with primary human macrophages
    • (Submitted for publication)
    • C. Vogt, M. Pernemalm, P. Kohonen, S. Laurent, K. Hultenby, M. Vahter, J. Lehtiö, M. Toprak, B. Fadeel, Proteomics analysis reveals distinct corona compositions on magnetic nanoparticles with different surface coating: implications for interactions with primary human macrophages, PLoS One (2015) (Submitted for publication).
    • (2015) PLoS One
    • Vogt, C.1
  • 33
    • 84857868987 scopus 로고    scopus 로고
    • A chemical approach for cell-specific targeting of nanomaterials: Small-molecule-initiated misfolding of nanoparticle corona proteins
    • K. Prapainop, D.P. Witter, and P. Wentworth A chemical approach for cell-specific targeting of nanomaterials: small-molecule-initiated misfolding of nanoparticle corona proteins J. Am. Chem. Soc. 134 2012 4100 4103
    • (2012) J. Am. Chem. Soc. , vol.134 , pp. 4100-4103
    • Prapainop, K.1    Witter, D.P.2    Wentworth, P.3
  • 34
    • 79956079190 scopus 로고    scopus 로고
    • Immunological mechanisms of vaccination
    • B. Pulendran, and R. Ahmed Immunological mechanisms of vaccination Nat. Immunol. 12 2011 509 517
    • (2011) Nat. Immunol. , vol.12 , pp. 509-517
    • Pulendran, B.1    Ahmed, R.2
  • 35
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities
    • C. Nathan Neutrophils and immunity: challenges and opportunities Nat. Rev. Immunol. 6 2006 173 182
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 173-182
    • Nathan, C.1
  • 36
    • 84555197147 scopus 로고    scopus 로고
    • Interaction of nanoparticles with immunocompetent cells: Nanosafety considerations
    • D. Boraschi, L. Costantino, and P. Italiani Interaction of nanoparticles with immunocompetent cells: nanosafety considerations Nanomedicine (Lond.) 7 2012 121 131
    • (2012) Nanomedicine (Lond.) , vol.7 , pp. 121-131
    • Boraschi, D.1    Costantino, L.2    Italiani, P.3
  • 38
    • 84862883553 scopus 로고    scopus 로고
    • Information processing during phagocytosis
    • D.M. Underhill, and H.S. Goodridge Information processing during phagocytosis Nat. Rev. Immunol. 12 2012 492 502
    • (2012) Nat. Rev. Immunol. , vol.12 , pp. 492-502
    • Underhill, D.M.1    Goodridge, H.S.2
  • 40
    • 84857883847 scopus 로고    scopus 로고
    • Macrophage plasticity and polarization: In vivo veritas
    • A. Sica, and A. Mantovani Macrophage plasticity and polarization: in vivo veritas J. Clin. Invest. 122 2012 787 795
    • (2012) J. Clin. Invest. , vol.122 , pp. 787-795
    • Sica, A.1    Mantovani, A.2
  • 42
    • 70350690489 scopus 로고    scopus 로고
    • Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses
    • E. Witasp, A.A. Shvedova, V.E. Kagan, and B. Fadeel Single-walled carbon nanotubes impair human macrophage engulfment of apoptotic cell corpses Inhal. Toxicol. 21 Suppl. 1 2009 131 136
    • (2009) Inhal. Toxicol. , vol.21 , pp. 131-136
    • Witasp, E.1    Shvedova, A.A.2    Kagan, V.E.3    Fadeel, B.4
  • 43
    • 31544476250 scopus 로고    scopus 로고
    • Aggregates of ultrafine particles impair phagocytosis of microorganisms by human alveolar macrophages
    • M. Lundborg, S.E. Dahlén, U. Johard, P. Gerde, C. Jarstrand, P. Camner, and L. Låstbom Aggregates of ultrafine particles impair phagocytosis of microorganisms by human alveolar macrophages Environ. Res. 100 2006 197 204
    • (2006) Environ. Res. , vol.100 , pp. 197-204
    • Lundborg, M.1    Dahlén, S.E.2    Johard, U.3    Gerde, P.4    Jarstrand, C.5    Camner, P.6    Låstbom, L.7
  • 46
    • 84888870978 scopus 로고    scopus 로고
    • Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo
    • G.P. Kotchey, Y. Zhao, V.E. Kagan, and A. Star Peroxidase-mediated biodegradation of carbon nanotubes in vitro and in vivo Adv. Drug Deliv. Rev. 65 2013 1921 1932
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1921-1932
    • Kotchey, G.P.1    Zhao, Y.2    Kagan, V.E.3    Star, A.4
  • 51
    • 84887181870 scopus 로고    scopus 로고
    • Confocal Raman imaging study showing macrophage mediated biodegradation of graphene in vivo
    • C.M. Girish, A. Sasidharan, G.S. Gowd, S. Nair, and M. Koyakutty Confocal Raman imaging study showing macrophage mediated biodegradation of graphene in vivo Adv. Healthc. Mater. 2 2013 1489 1500
    • (2013) Adv. Healthc. Mater. , vol.2 , pp. 1489-1500
    • Girish, C.M.1    Sasidharan, A.2    Gowd, G.S.3    Nair, S.4    Koyakutty, M.5
  • 52
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • M.E. Bianchi DAMPs, PAMPs and alarmins: all we need to know about danger J. Leukoc. Biol. 81 2007 1 5
    • (2007) J. Leukoc. Biol. , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 55
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • C. Dostert, V. Pétrilli, R. Van Bruggen, C. Steele, B.T. Mossman, and J. Tschopp Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica Science 320 2008 674 677
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Pétrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 56
    • 78650610580 scopus 로고    scopus 로고
    • Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    • A.S. Yazdi, G. Guarda, N. Riteau, S.K. Drexler, A. Tardivel, I. Couillin, and J. Tschopp Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β Proc. Natl. Acad. Sci. U.S.A. 107 2010 19449 19454
    • (2010) Proc. Natl. Acad. Sci. U.S.A. , vol.107 , pp. 19449-19454
    • Yazdi, A.S.1    Guarda, G.2    Riteau, N.3    Drexler, S.K.4    Tardivel, A.5    Couillin, I.6    Tschopp, J.7
  • 59
    • 84925047701 scopus 로고    scopus 로고
    • NLRP3 inflammasome: From a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases
    • A. Abderrazak, T. Syrovets, D. Couchie, K. El Hadri, B. Friguet, T. Simmet, and M. Rouis NLRP3 inflammasome: from a danger signal sensor to a regulatory node of oxidative stress and inflammatory diseases Redox Biol. 4C 2015 296 307
    • (2015) Redox Biol. , vol.4 C , pp. 296-307
    • Abderrazak, A.1    Syrovets, T.2    Couchie, D.3    El Hadri, K.4    Friguet, B.5    Simmet, T.6    Rouis, M.7
  • 60
    • 45749111446 scopus 로고    scopus 로고
    • Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants
    • S.C. Eisenbarth, O.R. Colegio, W. O'Connor, F.S. Sutterwala, and R.A. Flavell Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants Nature 453 2008 1122 1126
    • (2008) Nature , vol.453 , pp. 1122-1126
    • Eisenbarth, S.C.1    Colegio, O.R.2    O'Connor, W.3    Sutterwala, F.S.4    Flavell, R.A.5
  • 62
    • 84870597632 scopus 로고    scopus 로고
    • Programmed cell death: Molecular mechanisms and implications for safety assessment of nanomaterials
    • F.T. Andón, and B. Fadeel Programmed cell death: molecular mechanisms and implications for safety assessment of nanomaterials Acc. Chem. Res. 46 2013 733 742
    • (2013) Acc. Chem. Res. , vol.46 , pp. 733-742
    • Andón, F.T.1    Fadeel, B.2
  • 63
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    • C.S. Shi, K. Shenderov, N.N. Huang, J. Kabat, M. Abu-Asab, K.A. Fitzgerald, A. Sher, and J.H. Kehrl Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction Nat. Immunol. 13 2012 255 263
    • (2012) Nat. Immunol. , vol.13 , pp. 255-263
    • Shi, C.S.1    Shenderov, K.2    Huang, N.N.3    Kabat, J.4    Abu-Asab, M.5    Fitzgerald, K.A.6    Sher, A.7    Kehrl, J.H.8
  • 64
    • 84908425670 scopus 로고    scopus 로고
    • Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagic flux and regulation of an interleukin-1β producing inflammasome
    • R. Li, Z. Ji, H. Qin, X. Kang, B. Sun, M. Wang, C.H. Chang, X. Wang, H. Zhang, H. Zou, A.E. Nel, and T. Xia Interference in autophagosome fusion by rare earth nanoparticles disrupts autophagic flux and regulation of an interleukin-1β producing inflammasome ACS Nano 8 2014 10280 10292
    • (2014) ACS Nano , vol.8 , pp. 10280-10292
    • Li, R.1    Ji, Z.2    Qin, H.3    Kang, X.4    Sun, B.5    Wang, M.6    Chang, C.H.7    Wang, X.8    Zhang, H.9    Zou, H.10    Nel, A.E.11    Xia, T.12
  • 65
    • 84928954789 scopus 로고    scopus 로고
    • NADPH oxidase-dependent NLRP3 inflammasome activation and its important role in lung fibrosis by multiwalled carbon nanotubes
    • (Epub ahead of print)
    • B. Sun, X. Wang, Z. Ji, M. Wang, Y.P. Liao, C.H. Chang, R. Li, H. Zhang, A.E. Nel, and T. Xia NADPH oxidase-dependent NLRP3 inflammasome activation and its important role in lung fibrosis by multiwalled carbon nanotubes Small 2015 (Epub ahead of print)
    • (2015) Small
    • Sun, B.1    Wang, X.2    Ji, Z.3    Wang, M.4    Liao, Y.P.5    Chang, C.H.6    Li, R.7    Zhang, H.8    Nel, A.E.9    Xia, T.10
  • 66
    • 84878098268 scopus 로고    scopus 로고
    • NLRP3 inflammasome activation induced by engineered nanomaterials
    • B. Sun, X. Wang, Z. Ji, R. Li, and T. Xia NLRP3 inflammasome activation induced by engineered nanomaterials Small 9 2013 1595 1607
    • (2013) Small , vol.9 , pp. 1595-1607
    • Sun, B.1    Wang, X.2    Ji, Z.3    Li, R.4    Xia, T.5
  • 67
    • 84924240183 scopus 로고    scopus 로고
    • Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammation in vivo
    • (Epub ahead of print)
    • F. Jessop, and A. Holian Extracellular HMGB1 regulates multi-walled carbon nanotube-induced inflammation in vivo Nanotoxicology July 1 2014 1 8 (Epub ahead of print)
    • (2014) Nanotoxicology , Issue.JULY 1 , pp. 1-8
    • Jessop, F.1    Holian, A.2
  • 68
    • 84863737713 scopus 로고    scopus 로고
    • Clear and present danger? Engineered nanoparticles and the immune system
    • B. Fadeel Clear and present danger? Engineered nanoparticles and the immune system Swiss Med. Wkly. 142 2012 w13609
    • (2012) Swiss Med. Wkly. , vol.142 , pp. w13609
    • Fadeel, B.1
  • 70
    • 84855394395 scopus 로고    scopus 로고
    • Size-dependent attenuation of TLR9 signaling by gold nanoparticles in macrophages
    • C.Y. Tsai, S.L. Lu, C.W. Hu, C.S. Yeh, G.B. Lee, and H.Y. Lei Size-dependent attenuation of TLR9 signaling by gold nanoparticles in macrophages J. Immunol. 188 2012 68 76
    • (2012) J. Immunol. , vol.188 , pp. 68-76
    • Tsai, C.Y.1    Lu, S.L.2    Hu, C.W.3    Yeh, C.S.4    Lee, G.B.5    Lei, H.Y.6
  • 73
    • 84896348692 scopus 로고    scopus 로고
    • Immunotoxicity of nanoparticles: A computational study suggests that CNTs and C60 fullerenes might be recognized as pathogens by Toll-like receptors
    • M. Turabekova, B. Rasulev, M. Theodore, J. Jackman, D. Leszczynska, and J. Leszczynski Immunotoxicity of nanoparticles: a computational study suggests that CNTs and C60 fullerenes might be recognized as pathogens by Toll-like receptors Nanoscale 6 2014 3488 3495
    • (2014) Nanoscale , vol.6 , pp. 3488-3495
    • Turabekova, M.1    Rasulev, B.2    Theodore, M.3    Jackman, J.4    Leszczynska, D.5    Leszczynski, J.6
  • 76
    • 0032546352 scopus 로고    scopus 로고
    • Dendritic cells and the control of immunity
    • J. Banchereau, and R.M. Steinman Dendritic cells and the control of immunity Nature 392 1998 245 252
    • (1998) Nature , vol.392 , pp. 245-252
    • Banchereau, J.1    Steinman, R.M.2
  • 77
    • 84872527864 scopus 로고    scopus 로고
    • Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients
    • G. Laverny, A. Casset, A. Purohit, E. Schaeffer, C. Spiegelhalter, F. de Blay, and F. Pons Immunomodulatory properties of multi-walled carbon nanotubes in peripheral blood mononuclear cells from healthy subjects and allergic patients Toxicol. Lett. 217 2013 91 101
    • (2013) Toxicol. Lett. , vol.217 , pp. 91-101
    • Laverny, G.1    Casset, A.2    Purohit, A.3    Schaeffer, E.4    Spiegelhalter, C.5    De Blay, F.6    Pons, F.7
  • 81
  • 82
    • 34547690726 scopus 로고    scopus 로고
    • Immunological properties of engineered nanomaterials
    • M.A. Dobrovolskaia, and S.E. McNeil Immunological properties of engineered nanomaterials Nat. Nanotechnol. 2 2007 469 478
    • (2007) Nat. Nanotechnol. , vol.2 , pp. 469-478
    • Dobrovolskaia, M.A.1    McNeil, S.E.2
  • 83
    • 67651227154 scopus 로고    scopus 로고
    • Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice
    • L.A. Mitchell, F.T. Lauer, S.W. Burchiel, and J.D. McDonald Mechanisms for how inhaled multiwalled carbon nanotubes suppress systemic immune function in mice Nat. Nanotechnol. 4 2009 451 456
    • (2009) Nat. Nanotechnol. , vol.4 , pp. 451-456
    • Mitchell, L.A.1    Lauer, F.T.2    Burchiel, S.W.3    McDonald, J.D.4
  • 84
    • 56749179475 scopus 로고    scopus 로고
    • Efficient modulation of T-cell response by dual-mode, single-carrier delivery of cytokine-targeted siRNA and DNA vaccine to antigen-presenting cells
    • A. Singh, H. Nie, B. Ghosn, H. Qin, L.W. Kwak, and K. Roy Efficient modulation of T-cell response by dual-mode, single-carrier delivery of cytokine-targeted siRNA and DNA vaccine to antigen-presenting cells Mol. Ther. 16 2008 2011 2021
    • (2008) Mol. Ther. , vol.16 , pp. 2011-2021
    • Singh, A.1    Nie, H.2    Ghosn, B.3    Qin, H.4    Kwak, L.W.5    Roy, K.6
  • 85
    • 84872411858 scopus 로고    scopus 로고
    • Functionalized polystyrene nanoparticles trigger human dendritic cell maturation resulting in enhanced CD4+ T cell activation
    • S.U. Frick, N. Bacher, G. Baier, V. Mailänder, K. Landfester, and K. Steinbrink Functionalized polystyrene nanoparticles trigger human dendritic cell maturation resulting in enhanced CD4+ T cell activation Macromol. Biosci. 12 2012 1637 1647
    • (2012) Macromol. Biosci. , vol.12 , pp. 1637-1647
    • Frick, S.U.1    Bacher, N.2    Baier, G.3    Mailänder, V.4    Landfester, K.5    Steinbrink, K.6
  • 87
    • 70349547212 scopus 로고    scopus 로고
    • Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct
    • B.C. Schanen, A.S. Karakoti, S. Seal, D.R. Drake, W.L. Warren, and W.T. Self Exposure to titanium dioxide nanomaterials provokes inflammation of an in vitro human immune construct ACS Nano 3 2009 2523 2532
    • (2009) ACS Nano , vol.3 , pp. 2523-2532
    • Schanen, B.C.1    Karakoti, A.S.2    Seal, S.3    Drake, D.R.4    Warren, W.L.5    Self, W.T.6
  • 88
    • 84891486024 scopus 로고    scopus 로고
    • Myeloid derived suppressor cells in physiological and pathological conditions: The good, the bad, and the ugly
    • P. Serafini Myeloid derived suppressor cells in physiological and pathological conditions: the good, the bad, and the ugly Immunol. Res. 57 2013 172 184
    • (2013) Immunol. Res. , vol.57 , pp. 172-184
    • Serafini, P.1
  • 90
    • 84862898405 scopus 로고    scopus 로고
    • Nanoparticle-induced exosomes target antigen-presenting cells to initiate Th1-type immune activation
    • M. Zhu, X. Tian, X. Song, Y. Li, Y. Tian, Y. Zhao, and G. Nie Nanoparticle-induced exosomes target antigen-presenting cells to initiate Th1-type immune activation Small 8 2012 2841 2848
    • (2012) Small , vol.8 , pp. 2841-2848
    • Zhu, M.1    Tian, X.2    Song, X.3    Li, Y.4    Tian, Y.5    Zhao, Y.6    Nie, G.7
  • 91
    • 84864140479 scopus 로고    scopus 로고
    • Engineering nano- and microparticles to tune immunity
    • J.J. Moon, B. Huang, and D.J. Irvine Engineering nano- and microparticles to tune immunity Adv. Mater. 24 2012 3724 3746
    • (2012) Adv. Mater. , vol.24 , pp. 3724-3746
    • Moon, J.J.1    Huang, B.2    Irvine, D.J.3
  • 93
    • 51149090409 scopus 로고    scopus 로고
    • Alum adjuvanticity: Unraveling a century old mystery
    • E. De Gregorio, E. Tritto, and R. Rappuoli Alum adjuvanticity: unraveling a century old mystery Eur. J. Immunol. 38 2008 2068 2071
    • (2008) Eur. J. Immunol. , vol.38 , pp. 2068-2071
    • De Gregorio, E.1    Tritto, E.2    Rappuoli, R.3
  • 96
    • 84890564255 scopus 로고    scopus 로고
    • Nanoparticle-detained toxins for safe and effective vaccination
    • C.M. Hu, R.H. Fang, B.T. Luk, and L. Zhang Nanoparticle-detained toxins for safe and effective vaccination Nat. Nanotechnol. 8 2013 933 938
    • (2013) Nat. Nanotechnol. , vol.8 , pp. 933-938
    • Hu, C.M.1    Fang, R.H.2    Luk, B.T.3    Zhang, L.4
  • 97
    • 84888873074 scopus 로고    scopus 로고
    • When carbon nanotubes encounter the immune system: Desirable and undesirable effects
    • H. Dumortier When carbon nanotubes encounter the immune system: desirable and undesirable effects Adv. Drug Deliv. Rev. 65 2013 2120 2126
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 2120-2126
    • Dumortier, H.1
  • 101
    • 84889260511 scopus 로고    scopus 로고
    • Mechanisms of carbon nanotube-induced toxicity: Focus on pulmonary inflammation
    • K. Bhattacharya, F.T. Andón, R. El-Sayed, and B. Fadeel Mechanisms of carbon nanotube-induced toxicity: focus on pulmonary inflammation Adv. Drug Deliv. Rev. 65 2013 2087 2097
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 2087-2097
    • Bhattacharya, K.1    Andón, F.T.2    El-Sayed, R.3    Fadeel, B.4
  • 103
    • 43149095577 scopus 로고    scopus 로고
    • A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response
    • H. Zhou, Q. Mu, N. Gao, A. Liu, Y. Xing, S. Gao, Q. Zhang, G. Qu, Y. Chen, G. Liu, B. Zhang, and B. Yan A nano-combinatorial library strategy for the discovery of nanotubes with reduced protein-binding, cytotoxicity, and immune response Nano Lett. 8 2008 859 865
    • (2008) Nano Lett. , vol.8 , pp. 859-865
    • Zhou, H.1    Mu, Q.2    Gao, N.3    Liu, A.4    Xing, Y.5    Gao, S.6    Zhang, Q.7    Qu, G.8    Chen, Y.9    Liu, G.10    Zhang, B.11    Yan, B.12
  • 104
    • 84887413652 scopus 로고    scopus 로고
    • Differential uptake of nanoparticles and microparticles by pulmonary APC subsets induces discrete immunological imprints
    • C.L. Hardy, J.S. Lemasurier, R. Mohamud, J. Yao, S.D. Xiang, J.M. Rolland, R.E. O'Hehir, and M. Plebanski Differential uptake of nanoparticles and microparticles by pulmonary APC subsets induces discrete immunological imprints J. Immunol. 191 2013 5278 5290
    • (2013) J. Immunol. , vol.191 , pp. 5278-5290
    • Hardy, C.L.1    Lemasurier, J.S.2    Mohamud, R.3    Yao, J.4    Xiang, S.D.5    Rolland, J.M.6    O'Hehir, R.E.7    Plebanski, M.8
  • 105
    • 84891363798 scopus 로고    scopus 로고
    • Engineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticles
    • B. Sun, Z. Ji, Y.P. Liao, M. Wang, X. Wang, J. Dong, C.H. Chang, R. Li, H. Zhang, A.E. Nel, and T. Xia Engineering an effective immune adjuvant by designed control of shape and crystallinity of aluminum oxyhydroxide nanoparticles ACS Nano 7 2013 10834 10849
    • (2013) ACS Nano , vol.7 , pp. 10834-10849
    • Sun, B.1    Ji, Z.2    Liao, Y.P.3    Wang, M.4    Wang, X.5    Dong, J.6    Chang, C.H.7    Li, R.8    Zhang, H.9    Nel, A.E.10    Xia, T.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.