Development and validation of a high-content screening in vitro micronucleus assay in CHO-k1 and HepG2 cells

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 724, Issue 1-2, 2011, Pages 7-21

  Westerink, Walter M A ^a   Schirris, Tom J J ^a   Horbach, G Jean ^a   Schoonen, Willem G E J ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Automated in vitro micronucleus assay; CHO k1; Genotoxicity; HepG2; High throughput screening

Indexed keywords

ANEUGEN; CLASTOGEN; DNA; PROTEIN P53; TRANSCRIPTION FACTOR NRF2;

ANIMAL CELL; ARTICLE; AUTOMATION; CELL STRAIN HEPG2; CHO CELL; CONTROLLED STUDY; DNA REPAIR; ENZYME METABOLISM; GENOTOXICITY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; MICRONUCLEUS TEST; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY;

ANEUGENS; ANIMALS; BIOTRANSFORMATION; CHO CELLS; CRICETINAE; CRICETULUS; HEP G2 CELLS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MICRONUCLEUS TESTS; SENSITIVITY AND SPECIFICITY;

RODENTIA;

EID: 79960990848     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2011.05.007     Document Type: Article

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