Cytotoxicity assessment based on the AUC50 using multi-concentration time-dependent cellular response curves

Analytica Chimica Acta

Volumn 764, Issue , 2013, Pages 44-52

  Pan, Tianhong ^a,b   Huang, Biao ^b   Zhang, Weiping ^c   Gabos, Stephan ^c   Huang, Dorothy Yu ^d   Devendran, Vignesh ^b  

^a JIANGSU UNIVERSITY   (China)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Alberta Health   (Canada)

^d UNIVERSITY OF CALGARY   (Canada)

Author keywords

Area under the control line; High throughput screening; In vitro cytotoxicity assay; Repeatability; Time dependent cellular response curve

Indexed keywords

CELLULAR RESPONSE; CONTROL LINES; HIGH-THROUGHPUT SCREENING; IN-VITRO; REPEATABILITY;

CELL CULTURE; CHEMICAL COMPOUNDS; CYTOTOXICITY; TOXICITY;

CELLS;

CHEMICAL COMPOUND;

ANALYTICAL PARAMETERS; ARTICLE; AUC50; BIOLOGICAL MONITORING; CELL ASSAY; CELL COUNT; CELL GROWTH; CELL STRAIN HEPG2; CELLULAR PARAMETERS; CHEMICAL ANALYSIS; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DYNAMICS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; NORMALIZED CELL INDEX; PRIORITY JOURNAL; REAL TIME CELL ANALYSIS HIGH THROUGHPUT SYSTEM; TIME DEPENDENT CELLULAR RESPONSE CURVE; TOXICITY TESTING; TOXICOLOGICAL PARAMETERS; VALIDATION PROCESS;

AREA UNDER CURVE; CELL SURVIVAL; COLCHICINE; HEP G2 CELLS; HUMANS; MODELS, THEORETICAL; TIME FACTORS; TOXICITY TESTS;

EID: 84873076653     PISSN: 00032670     EISSN: 18734324     Source Type: Journal    
DOI: 10.1016/j.aca.2012.12.047     Document Type: Article

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