Molecularly targeted gold nanoparticles enhance the radiation response of breast cancer cells and tumor xenografts to X-radiation

Breast Cancer Research and Treatment

Volumn 137, Issue 1, 2013, Pages 81-91

  Chattopadhyay, Niladri ^a   Cai, Zhongli ^a   Kwon, Yongkyu Luke ^a   Lechtman, Eli ^b   Pignol, Jean Philippe ^b,c   Reilly, Raymond M ^a,b,d  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c SUNNYBROOK RESEARCH INSTITUTE   (Canada)

^d UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Antibody; Breast cancer; Dose enhancement; HER 2; Intratumoral; Nanoparticles; Radiation therapy; Radiosensitizer

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR 2; GOLD NANOPARTICLE; TRASTUZUMAB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER CELL; CANCER RADIOTHERAPY; CELL SURVIVAL; CLONOGENIC ASSAY; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; IN VITRO STUDY; IN VIVO STUDY; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIATION EXPOSURE; RADIATION RESPONSE; RADIOSENSITIZATION; TUMOR VOLUME; TUMOR XENOGRAFT;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DNA BREAKS, DOUBLE-STRANDED; FEMALE; GOLD; HISTONES; HUMANS; INJECTIONS, INTRALESIONAL; METAL NANOPARTICLES; MICE; MICE, NUDE; MOLECULAR TARGETED THERAPY; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; RADIOTHERAPY DOSAGE; RECEPTOR, ERBB-2; TUMOR BURDEN; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84871791641     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2338-4     Document Type: Article

References (34)

1. Abed R, Younge D (2008) Surgical management of very large musculoskeletal sarcomas. Ann N Y Acad Sci 1138:77-83
2. Calitchi E, Kirova YM, Otmezguine Y et al (2001) Long-term results of neoadjuvant radiation therapy for breast cancer. Int J Cancer 96:253-259
3. Darai E, Mosseri V, Hamelin JP et al (1991) Conservative surgery after radiotherapy with preoperative doses in the treatment of breast cancer. Presse Med 20:2144-2148
4. Chattopadhyay N, Cai Z, Pignol JP et al (2010) Design and characterization of HER-2-targeted gold nanoparticles for enhanced X-radiation treatment of locally advanced breast cancer. Mol Pharm 7:2194-2206
5. Farokhzad OC, Langer R (2006) Nanomedicine: developing smarter therapeutic and diagnostic modalities. Adv Drug Deliv Rev 58:1456-1459
6. Huang X, El-Sayed IH, Qian W et al (2006) Cancer cell imaging and photothermal therapy in the near-infrared region by using gold nanorods. J Am Chem Soc 128:2115-2120
7. I- Kim, Y- Kang, Lee DS et al (2009) Antitumor activity of EGFR targeted pH-sensitive immunoliposomes encapsulating gemcitabine in A549 xenograft nude mice. J Controlled Release 140:55-60
8. Libutti SK, Paciotti GF, Byrnes AA et al (2010) Phase I and pharmacokinetic studies of CYT-6091, a novel PEGylated colloidal gold-rhTNF nanomedicine. Clin Cancer Res 16:6139-6149
9. Larson D, Bodell WJ, Ling C et al (1989) Auger electron contribution to bromodeoxyuridine cellular radiosensitization. Int J Radiat Oncol Biol Phys 16:171-176
10. Hainfeld JF, Dilmanian FA, Slatkin DN et al (2008) Radiotherapy enhancement with gold nanoparticles. J Pharm Pharmacol 60:977-985
11. Leung MK, Chow JC, Chithrani BD et al (2011) Irradiation of gold nanoparticles by x-rays: Monte Carlo simulation of dose enhancements and the spatial properties of the secondary electrons production. Med Phys 38:624-631
12. Lechtman E, Chattopadhyay N, Cai Z et al (2011) Implications on clinical scenario of gold nanoparticle radiosensitization in regards to photon energy, nanoparticle size, concentration and location. Phys Med Biol 56:4631-4647
13. Kassis AI (2008) Therapeutic radionuclides: biophysical and radiobiologic principles. Semin Nucl Med 38:358-366
14. Hainfeld JF, Slatkin DN, Smilowitz HM (2004) The use of gold nanoparticles to enhance radiotherapy in mice. Phys Med Biol 49:N309-N315
15. Herold DM, Das IJ, Stobbe CC et al (2000) Gold microspheres: a selective technique for producing biologically effective dose enhancement. Int J Radiat Biol 76:1357-1364
16. Chattopadhyay N, Fonge H, Cai Z, Scollard D, Lechtman E, Done SJ, Pignol JP, Reilly RM (2012) Role of antibody-mediated tumor targeting and route of administration in nanoparticle tumor accumulation in vivo. Mol Pharm 9:2168-2179
17. 111In-DTPA-trastuzumab, HER2 density and response to trastuzumab (Herceptin) in athymic mice bearing subcutaneous human tumour xenografts. Eur J Nucl Med Mol Imaging 36:81-93
18. Clarkson R, Lindsay PE, Ansell S et al (2011) Characterization of image quality and image-guidance performance of a preclinical microirradiator. Med Phys 38:845-856
19. Ma CM, Coffey CW, DeWerd LA et al (2001) AAPM protocol for 40-300 kV X-ray beam dosimetry in radiotherapy and radiobiology. Med Phys 28:868-893
20. Butson MJ, Cheung T, Yu PK et al (2009) Dose and absorption spectra response of EBT2 Gafchromic film to high energy X-rays. Australas Phys Eng Sci Med 32:196-202
21. Cai Z, Pan X, Hunting D et al (2003) Dosimetry of ultrasoft X-rays (1.5 keV AlKα) using radiochromatic films and colour scanner. Phys Med Biol 48:4111-4124
22. Gribel BF, Gribel MN, Frazao DC et al (2011) Accuracy and reliability of craniometric measurements on lateral cephalometry and 3D measurements on CBCT scans. Angle Orthod 81:26-35
23. Cai Z, Chattopadhyay N, Liu WJ et al (2011) Optimized digital counting colonies of clonogenic assays using ImageJ software and customized macros: comparison with manual counting. Int J Radiat Biol 87:1135-1146
24. 111In-DTPA-hEGF or γ-rays using Image-J software. Int J Radiat Biol 85:262-271
25. Chow JC, Leung MK, Lindsay PE et al (2010) Dosimetric variation due to the photon beam energy in the small-animal irradiation: a Monte Carlo study. Med Phys 37:5322-5329
26. Meesungnoen J, J- Jay-Gerin, Filali-Mouhim A et al (2002) Low-energy electron penetration range in liquid water. Radiat Res 158:657-660
27. 111In using monte carlo N-particle computer code: comparison with analytic methods and correlation with in vitro cytotoxicity. J Nucl Med 51:462-470
28. Kong T, Zeng J, Wang X et al (2008) Enhancement of radiation cytotoxicity in breast-cancer cells by localized attachment of gold nanoparticles. Small 4:1537-1543
29. Chithrani DB, Jelveh S, Jalali F et al (2010) Gold nanoparticles as radiation sensitizers in cancer therapy. Radiat Res 173:719-728
30. Kassis AI, Adelstein SJ (2005) Radiobiologic principles in radionuclide therapy. J Nucl Med 46(Suppl 1):4S-12S
31. Hainfeld JF, Dilmanian FA, Zhong Z et al (2010) Gold nanoparticles enhance the radiation therapy of a murine squamous cell carcinoma. Phys Med Biol 55:3045-3059
32. Hebert EM, Debouttiere PJ, Lepage M et al (2010) Preferential tumour accumulation of gold nanoparticles, visualised by Magnetic Resonance Imaging: radiosensitization studies in vivo and in vitro. Int J Radiat Biol 86:692-700
33. Huang X, Peng X, Wang Y et al (2010) A reexamination of active and passive tumor targeting by using rod-shaped gold nanocrystals and covalently conjugated peptide ligands. ACS Nano 4:5887-5896
34. Glazer ES, Zhu C, Hamir AN et al (2011) Biodistribution and acute toxicity of naked gold nanoparticles in a rabbit hepatic tumor model. Nanotoxicology 5:459-468