Human cell line-dependent WC-Co nanoparticle cytotoxicity and genotoxicity: A key role of ROS production

Toxicological Sciences

Volumn 143, Issue 2, 2015, Pages 385-397

  Paget, V ^a   Moche, H ^b,c,d   Kortulewski, T ^a   Grall, R ^a   Irbah, L ^a   Nesslany, F ^b,d   Chevillard, S ^a  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b INSTITUT PASTEUR DE LILLE   (France)

^c INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

^d UFR3S Pharmacie   (France)

Author keywords

Cytotoxicity; Genotoxicity; Impedance (xCELLigence); ROS; WC Co nanoparticles

Indexed keywords

COBALT; HISTONE H2AX; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; TUNGSTEN CARBIDE; TUNGSTEN DERIVATIVE; UNCLASSIFIED DRUG;

A549 CELL LINE; ARTICLE; CAKI 1 CELL LINE; CELL CYCLE ARREST; CELL CYCLE CHECKPOINT; CELL SURVIVAL; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DOUBLE STRANDED DNA BREAK; FLOW CYTOMETRY; GENOTOXICITY; HEP3B CELL LINE; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; ANTIBODY SPECIFICITY; CELL LINE; DNA DAMAGE; DRUG EFFECTS; KIDNEY; LIVER; METABOLISM; PATHOLOGY;

CELL CYCLE CHECKPOINTS; CELL LINE; CELL SURVIVAL; COBALT; DNA DAMAGE; FLOW CYTOMETRY; HUMANS; KIDNEY; LIVER; MICROSCOPY, CONFOCAL; NANOPARTICLES; ORGAN SPECIFICITY; REACTIVE OXYGEN SPECIES; TUNGSTEN COMPOUNDS;

EID: 84924680107     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfu238     Document Type: Article

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