메뉴 건너뛰기




Volumn 8, Issue 12, 2008, Pages 957-967

γH2AX and cancer

Author keywords

[No Author keywords available]

Indexed keywords

7 HYDROXYSTAUROSPORINE; AMINOFLAVONE; ANTINEOPLASTIC AGENT; AZACITIDINE; BATRACYLIN; BLEOMYCIN; CAMPTOTHECIN; CARBAZOLE DERIVATIVE; CISPLATIN; CYTARABINE; DNA DEPENDENT PROTEIN KINASE INHIBITOR; DOXORUBICIN; ETOPOSIDE; GEMCITABINE; HISTONE H2AX; HISTONE H2AX GAMMA; HYDROXYUREA; IMATINIB; INDENOISOQUINOLINE DERIVATIVE; INDOLOCARBAZOLE; ISOQUINOLINE DERIVATIVE; MELPHALAN; MITOXANTRONE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; REACTIVE OXYGEN METABOLITE; TEMOZOLOMIDE; TIRAPAZAMINE; TRABECTEDIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VORINOSTAT; H2AFX PROTEIN, HUMAN; HISTONE;

EID: 57149136324     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc2523     Document Type: Review
Times cited : (1377)

References (167)
  • 2
    • 36949030242 scopus 로고    scopus 로고
    • DNA double-strand breaks: Their cellular and clinical impact?
    • Jeggo, P. A. & Lobrich, M. DNA double-strand breaks: their cellular and clinical impact? Oncogene 26, 7717-7719 (2007).
    • (2007) Oncogene , vol.26 , pp. 7717-7719
    • Jeggo, P.A.1    Lobrich, M.2
  • 3
    • 39449085063 scopus 로고    scopus 로고
    • DNA-damage repair; the good, the bad, and the ugly
    • Hakem, R. DNA-damage repair; the good, the bad, and the ugly. EMBO J. 27, 589-605 (2008).
    • (2008) EMBO J , vol.27 , pp. 589-605
    • Hakem, R.1
  • 4
    • 3242881897 scopus 로고    scopus 로고
    • An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
    • O'Driscoll, M., Gennery, A. R., Seidel, J., Concannon, P. & Jeggo, P. A. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst.) 3, 1227-1235 (2004).
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 1227-1235
    • O'Driscoll, M.1    Gennery, A.R.2    Seidel, J.3    Concannon, P.4    Jeggo, P.A.5
  • 5
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou, E. P., Boon, C., Redon, C. & Bonner, W. M. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J. Cell Biol. 146, 905-916 (1999).
    • (1999) J. Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 7
    • 26444553297 scopus 로고    scopus 로고
    • Does γH2AX foci formation depend on the presence of DNA double strand breaks?
    • Takahashi, A. & Ohnishi, T. Does γH2AX foci formation depend on the presence of DNA double strand breaks? Cancer Lett. 229, 171-179 (2005).
    • (2005) Cancer Lett , vol.229 , pp. 171-179
    • Takahashi, A.1    Ohnishi, T.2
  • 9
    • 33845651212 scopus 로고    scopus 로고
    • γH2AX in cancer cells: A potential biomarker for cancer diagnostics, prediction and recurrence
    • Sedelnikova, O. A. & Bonner, W. M. γH2AX in cancer cells: a potential biomarker for cancer diagnostics, prediction and recurrence. Cell Cycle 5, 2909-2913 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 2909-2913
    • Sedelnikova, O.A.1    Bonner, W.M.2
  • 10
    • 55249116558 scopus 로고    scopus 로고
    • γH2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin
    • Kinner, A., Wu, W., Staudt, C. & Iliakis, G. γH2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin. Nucleic Acids Res. 36, 5678-5694 (2008).
    • (2008) Nucleic Acids Res , vol.36 , pp. 5678-5694
    • Kinner, A.1    Wu, W.2    Staudt, C.3    Iliakis, G.4
  • 11
    • 36749025467 scopus 로고    scopus 로고
    • Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
    • Wang, B. & Elledge, S. J. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc. Natl Acad. Sci. USA 104, 20759-20763 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 20759-20763
    • Wang, B.1    Elledge, S.J.2
  • 12
    • 36749084931 scopus 로고    scopus 로고
    • Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
    • Kolas, N. K. et al. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science 318, 1637-1640 (2007).
    • (2007) Science , vol.318 , pp. 1637-1640
    • Kolas, N.K.1
  • 14
    • 0032489520 scopus 로고    scopus 로고
    • DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
    • Rogakou, E. P., Pilch, D. R., Orr, A. H., Ivanova, V. S. & Bonner, W. M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273, 5858-5868 (1998).
    • (1998) J. Biol. Chem , vol.273 , pp. 5858-5868
    • Rogakou, E.P.1    Pilch, D.R.2    Orr, A.H.3    Ivanova, V.S.4    Bonner, W.M.5
  • 15
    • 0023408234 scopus 로고
    • Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3′ end of the mRNA
    • Levine, B. J., Chodchoy, N., Marzluff, W. F. & Skoultchi, A. I. Coupling of replication type histone mRNA levels to DNA synthesis requires the stem-loop sequence at the 3′ end of the mRNA. Proc. Natl Acad. Sci. USA 84, 6189-6193 (1987).
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 6189-6193
    • Levine, B.J.1    Chodchoy, N.2    Marzluff, W.F.3    Skoultchi, A.I.4
  • 16
    • 0019865207 scopus 로고
    • Separation of basal histone synthesis from S-phase histone synthesis in dividing cells
    • Wu, R. S. & Bonner, W. M. Separation of basal histone synthesis from S-phase histone synthesis in dividing cells. Cell 27, 321-330 (1981).
    • (1981) Cell , vol.27 , pp. 321-330
    • Wu, R.S.1    Bonner, W.M.2
  • 17
    • 0024395794 scopus 로고    scopus 로고
    • Mannironi, C., Bonner, W. M. & Hatch, C. L. H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals. Nucleic Acids Res. 17, 9113-9126 (1989).
    • Mannironi, C., Bonner, W. M. & Hatch, C. L. H2A.X. a histone isoprotein with a conserved C-terminal sequence, is encoded by a novel mRNA with both DNA replication type and polyA 3′ processing signals. Nucleic Acids Res. 17, 9113-9126 (1989).
  • 18
    • 36248966246 scopus 로고    scopus 로고
    • RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    • Mailand, N. et al. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell 131, 887-900 (2007).
    • (2007) Cell , vol.131 , pp. 887-900
    • Mailand, N.1
  • 19
    • 33644905252 scopus 로고    scopus 로고
    • Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks
    • Kruhlak, M. J. et al. Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J. Cell Biol. 172, 823-834 (2006).
    • (2006) J. Cell Biol , vol.172 , pp. 823-834
    • Kruhlak, M.J.1
  • 20
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • Paull, T. T. et al. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr. Biol. 10, 886-895 (2000).
    • (2000) Curr. Biol , vol.10 , pp. 886-895
    • Paull, T.T.1
  • 21
    • 4644257681 scopus 로고    scopus 로고
    • Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break
    • Shroff, R. et al. Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr. Biol. 14, 1703-1711 (2004).
    • (2004) Curr. Biol , vol.14 , pp. 1703-1711
    • Shroff, R.1
  • 22
    • 0043066728 scopus 로고    scopus 로고
    • Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage
    • 678-684
    • Redon, C. et al. Yeast histone 2A serine 129 is essential for the efficient repair of checkpoint-blind DNA damage. EMBO Rep. 4, 678-684 (2003).
    • (2003) EMBO Rep , vol.4
    • Redon, C.1
  • 23
    • 33751171564 scopus 로고    scopus 로고
    • Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM/p53 status: Implications for evaluation of clinical radiosensitivity
    • Mirzayans, R., Severin, D. & Murray, D. Relationship between DNA double-strand break rejoining and cell survival after exposure to ionizing radiation in human fibroblast strains with differing ATM/p53 status: implications for evaluation of clinical radiosensitivity. Int. J. Radiat. Oncol. Biol. Phys. 66, 1498-1505 (2006).
    • (2006) Int. J. Radiat. Oncol. Biol. Phys , vol.66 , pp. 1498-1505
    • Mirzayans, R.1    Severin, D.2    Murray, D.3
  • 24
    • 28444483130 scopus 로고    scopus 로고
    • γH2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
    • Chowdhury, D. et al. γH2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol. Cell 20, 801-809 (2005).
    • (2005) Mol. Cell , vol.20 , pp. 801-809
    • Chowdhury, D.1
  • 25
    • 31444445458 scopus 로고    scopus 로고
    • A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery
    • Keogh, M. C. et al. A phosphatase complex that dephosphorylates γH2AX regulates DNA damage checkpoint recovery. Nature 439, 497-501 (2006).
    • (2006) Nature , vol.439 , pp. 497-501
    • Keogh, M.C.1
  • 26
    • 46149117962 scopus 로고    scopus 로고
    • A PP4-phosphatase complex dephosphorylates γH2AX generated during DNA replication
    • Chowdhury, D. et al. A PP4-phosphatase complex dephosphorylates γH2AX generated during DNA replication. Mol. Cell 31, 33-46 (2008).
    • (2008) Mol. Cell , vol.31 , pp. 33-46
    • Chowdhury, D.1
  • 27
    • 53249100305 scopus 로고    scopus 로고
    • PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint, 1019-1026
    • Nakada, S., Chen, G. I., Gingras, A. C. & Durocher, D. PP4 is a γH2AX phosphatase required for recovery from the DNA damage checkpoint. EMBO Rep. 9, 1019-1026 (2008).
    • (2008) EMBO Rep , vol.9
    • Nakada, S.1    Chen, G.I.2    Gingras, A.C.3    Durocher, D.4
  • 28
    • 10944267160 scopus 로고    scopus 로고
    • Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites
    • Downs, J. A. et al. Binding of chromatin-modifying activities to phosphorylated histone H2A at DNA damage sites. Mol. Cell 16, 979-990 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 979-990
    • Downs, J.A.1
  • 29
    • 10944224673 scopus 로고    scopus 로고
    • INO80 and γH2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair
    • Morrison, A. J. et al. INO80 and γH2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Cell 119, 767-775 (2004).
    • (2004) Cell , vol.119 , pp. 767-775
    • Morrison, A.J.1
  • 30
    • 10844233155 scopus 로고    scopus 로고
    • Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions
    • Kusch, T. et al. Acetylation by Tip60 is required for selective histone variant exchange at DNA lesions. Science 306, 2084-2087 (2004).
    • (2004) Science , vol.306 , pp. 2084-2087
    • Kusch, T.1
  • 31
    • 10944233962 scopus 로고    scopus 로고
    • Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair
    • van Attikum, H., Fritsch, O., Hohn, B. & Gasser, S. M. Recruitment of the INO80 complex by H2A phosphorylation links ATP-dependent chromatin remodeling with DNA double-strand break repair. Cell 119, 777-788 (2004).
    • (2004) Cell , vol.119 , pp. 777-788
    • van Attikum, H.1    Fritsch, O.2    Hohn, B.3    Gasser, S.M.4
  • 32
    • 25444441167 scopus 로고    scopus 로고
    • ATP-dependent chromatin remodeling and DNA double-strand break repair
    • van Attikum, H. & Gasser, S. M. ATP-dependent chromatin remodeling and DNA double-strand break repair. Cell Cycle 4, 1011-1014 (2005).
    • (2005) Cell Cycle , vol.4 , pp. 1011-1014
    • van Attikum, H.1    Gasser, S.M.2
  • 33
    • 33845715977 scopus 로고    scopus 로고
    • ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling
    • Stiff, T. et al. ATR-dependent phosphorylation and activation of ATM in response to UV treatment or replication fork stalling. EMBO J. 25, 5775-5782 (2006).
    • (2006) EMBO J , vol.25 , pp. 5775-5782
    • Stiff, T.1
  • 34
    • 33745607326 scopus 로고    scopus 로고
    • Marti, T. M., Hefner, E., Feeney, L., Natale, V. & Cleaver, J. E. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc. Natl Acad. Sci. USA 103, 9891-9896 (2006).
    • Marti, T. M., Hefner, E., Feeney, L., Natale, V. & Cleaver, J. E. H2AX phosphorylation within the G1 phase after UV irradiation depends on nucleotide excision repair and not DNA double-strand breaks. Proc. Natl Acad. Sci. USA 103, 9891-9896 (2006).
  • 35
    • 36148951013 scopus 로고    scopus 로고
    • Hanasoge, S. & Ljungman, M. H2AX phosphorylation after UV-irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase. Carcinogenesis 28, 2298-2304 (2007).
    • Hanasoge, S. & Ljungman, M. H2AX phosphorylation after UV-irradiation is triggered by DNA repair intermediates and is mediated by the ATR kinase. Carcinogenesis 28, 2298-2304 (2007).
  • 36
    • 0037062492 scopus 로고    scopus 로고
    • Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX
    • Bassing, C. H. et al. Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX. Proc. Natl Acad. Sci. USA 99, 8173-8178 (2002).
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 8173-8178
    • Bassing, C.H.1
  • 37
    • 0042991379 scopus 로고    scopus 로고
    • Histone H2AX: A dosage-dependent suppressor of oncogenic translocations and tumors
    • Bassing, C. H. et al. Histone H2AX: a dosage-dependent suppressor of oncogenic translocations and tumors. Cell 114, 359-370 (2003).
    • (2003) Cell , vol.114 , pp. 359-370
    • Bassing, C.H.1
  • 38
    • 0027279628 scopus 로고
    • Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations
    • Thirman, M. J. et al. Rearrangement of the MLL gene in acute lymphoblastic and acute myeloid leukemias with 11q23 chromosomal translocations. N. Engl. J. Med. 329, 909-914 (1993).
    • (1993) N. Engl. J. Med , vol.329 , pp. 909-914
    • Thirman, M.J.1
  • 39
    • 34250358742 scopus 로고    scopus 로고
    • Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma
    • Parikh, R. A. et al. Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinoma. Genes Chromosomes Cancer 46, 761-775 (2007).
    • (2007) Genes Chromosomes Cancer , vol.46 , pp. 761-775
    • Parikh, R.A.1
  • 40
    • 38149028414 scopus 로고    scopus 로고
    • Copy number alterations of the H2AFX gene in sporadic breast cancer patients
    • Srivastava, N., Gochhait, S., Gupta, P. & Bamezai, R. N. Copy number alterations of the H2AFX gene in sporadic breast cancer patients. Cancer Genet. Cytogenet. 180, 121-128 (2008 ).
    • (2008) Cancer Genet. Cytogenet , vol.180 , pp. 121-128
    • Srivastava, N.1    Gochhait, S.2    Gupta, P.3    Bamezai, R.N.4
  • 41
    • 34250818190 scopus 로고    scopus 로고
    • Genetic variation in H2AFX contributes to risk of non-Hodgkin lymphoma
    • Novik, K. L. et al. Genetic variation in H2AFX contributes to risk of non-Hodgkin lymphoma. Cancer Epidemiol. Biomarkers Prev. 16, 1098-1106 (2007).
    • (2007) Cancer Epidemiol. Biomarkers Prev , vol.16 , pp. 1098-1106
    • Novik, K.L.1
  • 42
    • 34047270774 scopus 로고    scopus 로고
    • Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate
    • Liu, Y. et al. Histone H2AX is a mediator of gastrointestinal stromal tumor cell apoptosis following treatment with imatinib mesylate. Cancer Res. 67, 2685-2692 (2007).
    • (2007) Cancer Res , vol.67 , pp. 2685-2692
    • Liu, Y.1
  • 43
    • 0037012845 scopus 로고    scopus 로고
    • Genomic instability in mice lacking histone H2AX
    • Celeste, A. et al. Genomic instability in mice lacking histone H2AX. Science 296, 922-927 (2002).
    • (2002) Science , vol.296 , pp. 922-927
    • Celeste, A.1
  • 44
    • 0042991383 scopus 로고    scopus 로고
    • H2AX haploinsufficiency modifies genomic stability and tumor susceptibility
    • Celeste, A. et al. H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 114, 371-383 (2003).
    • (2003) Cell , vol.114 , pp. 371-383
    • Celeste, A.1
  • 45
    • 47349107760 scopus 로고    scopus 로고
    • ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin
    • Goodarzi, A. A. et al. ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin. Mol. Cell 31, 167-177 (2008).
    • (2008) Mol. Cell , vol.31 , pp. 167-177
    • Goodarzi, A.A.1
  • 47
    • 18844377923 scopus 로고    scopus 로고
    • High LET-induced H2AX phosphorylation around the Bragg curve
    • Desai, N., Durante, M., Lin, Z. W., Cucinotta, F. & Wu, H. High LET-induced H2AX phosphorylation around the Bragg curve. Adv. Space Res. 35, 236-242 (2005).
    • (2005) Adv. Space Res , vol.35 , pp. 236-242
    • Desai, N.1    Durante, M.2    Lin, Z.W.3    Cucinotta, F.4    Wu, H.5
  • 48
    • 0026647099 scopus 로고
    • Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks
    • Brenner, D. J. & Ward, J. F. Constraints on energy deposition and target size of multiply damaged sites associated with DNA double-strand breaks. Int. J. Radiat. Biol. 61, 737-748 (1992).
    • (1992) Int. J. Radiat. Biol , vol.61 , pp. 737-748
    • Brenner, D.J.1    Ward, J.F.2
  • 49
    • 0028223921 scopus 로고
    • Mechanisms of induction and repair of DNA double-strand breaks by ionizing radiation: Some contradictions
    • Hagen, U. Mechanisms of induction and repair of DNA double-strand breaks by ionizing radiation: some contradictions. Radiat. Environ. Biophys. 33, 45-61 (1994).
    • (1994) Radiat. Environ. Biophys , vol.33 , pp. 45-61
    • Hagen, U.1
  • 50
    • 7644225837 scopus 로고    scopus 로고
    • Phenomena leading to cell survival values which deviate from linear-quadratic models
    • Bonner, W. M. Phenomena leading to cell survival values which deviate from linear-quadratic models. Mutat. Res. 568, 33-39 (2004).
    • (2004) Mutat. Res , vol.568 , pp. 33-39
    • Bonner, W.M.1
  • 51
    • 0031426132 scopus 로고    scopus 로고
    • Wavelength dependence of oxidative DNA damage induced by UV and visible light
    • Kielbassa, C., Roza, L. & Epe, B. Wavelength dependence of oxidative DNA damage induced by UV and visible light. Carcinogenesis 18, 811-816 (1997).
    • (1997) Carcinogenesis , vol.18 , pp. 811-816
    • Kielbassa, C.1    Roza, L.2    Epe, B.3
  • 53
    • 33748927635 scopus 로고    scopus 로고
    • Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants
    • Tanaka, T., Halicka, H. D., Huang, X., Traganos, F. & Darzynkiewicz, Z. Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants. Cell Cycle 5, 1940-1945 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 1940-1945
    • Tanaka, T.1    Halicka, H.D.2    Huang, X.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 56
    • 38049090214 scopus 로고    scopus 로고
    • DNA replication stress, genome instability and aging
    • Burhans, W. C. & Weinberger, M. DNA replication stress, genome instability and aging. Nucleic Acids Res. 35, 7545-7556 (2007).
    • (2007) Nucleic Acids Res , vol.35 , pp. 7545-7556
    • Burhans, W.C.1    Weinberger, M.2
  • 57
    • 0141925645 scopus 로고    scopus 로고
    • Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses
    • Sobol, R. W. et al. Base excision repair intermediates induce p53-independent cytotoxic and genotoxic responses. J. Biol. Chem. 278, 39951-39959 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 39951-39959
    • Sobol, R.W.1
  • 58
    • 33749034730 scopus 로고    scopus 로고
    • Pommier, Y. Topoisomerase I inhibitors: camptothecins and beyond. Nature Rev. Cancer 6, 789-802 (2006).
    • Pommier, Y. Topoisomerase I inhibitors: camptothecins and beyond. Nature Rev. Cancer 6, 789-802 (2006).
  • 59
    • 0026678588 scopus 로고
    • Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives
    • Yamashita, Y. et al. Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives. Biochemistry 31, 12069-12075 (1992).
    • (1992) Biochemistry , vol.31 , pp. 12069-12075
    • Yamashita, Y.1
  • 60
    • 0033663604 scopus 로고    scopus 로고
    • Topoisomerase I-mediated DNA damage
    • Pourquier, P. & Pommier, Y. Topoisomerase I-mediated DNA damage. Adv. Cancer Res. 80, 189-216 (2001).
    • (2001) Adv. Cancer Res , vol.80 , pp. 189-216
    • Pourquier, P.1    Pommier, Y.2
  • 61
    • 34548391416 scopus 로고    scopus 로고
    • DNA topoisomerase II, genotoxicity, and cancer
    • McClendon, A. K. & Osheroff, N. DNA topoisomerase II, genotoxicity, and cancer. Mutat. Res. 623, 83-97 (2007).
    • (2007) Mutat. Res , vol.623 , pp. 83-97
    • McClendon, A.K.1    Osheroff, N.2
  • 62
    • 0033628701 scopus 로고    scopus 로고
    • Topoisomerase II as a target for anticancer drugs: When enzymes stop being nice
    • Fortune, J. M. & Osheroff, N. Topoisomerase II as a target for anticancer drugs: when enzymes stop being nice. Prog. Nucleic Acid Res. Mol. Biol. 64, 221-253 (2000).
    • (2000) Prog. Nucleic Acid Res. Mol. Biol , vol.64 , pp. 221-253
    • Fortune, J.M.1    Osheroff, N.2
  • 63
    • 55549128608 scopus 로고    scopus 로고
    • Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex
    • Guirouilh-Barbat, J., Redon, C. & Pommier, Y. Transcription-coupled DNA double-strand breaks are mediated via the nucleotide excision repair and the Mre11-Rad50-Nbs1 complex. Mol. Biol. Cell 19, 3969-3981 (2008).
    • (2008) Mol. Biol. Cell , vol.19 , pp. 3969-3981
    • Guirouilh-Barbat, J.1    Redon, C.2    Pommier, Y.3
  • 64
    • 33847007529 scopus 로고    scopus 로고
    • The mechanics of base excision repair, and its relationship to aging and disease
    • Wilson, D. M. 3rd & Bohr, V. A. The mechanics of base excision repair, and its relationship to aging and disease. DNA Repair (Amst.) 6, 544-559 (2007).
    • (2007) DNA Repair (Amst.) , vol.6 , pp. 544-559
    • Wilson 3rd, D.M.1    Bohr, V.A.2
  • 65
    • 36549076065 scopus 로고    scopus 로고
    • DNA mismatch repair-induced double-strand breaks
    • Nowosielska, A. & Marinus, M. G. DNA mismatch repair-induced double-strand breaks. DNA Repair (Amst.) 7, 48-56 (2008).
    • (2008) DNA Repair (Amst.) , vol.7 , pp. 48-56
    • Nowosielska, A.1    Marinus, M.G.2
  • 66
    • 38049125552 scopus 로고    scopus 로고
    • The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
    • McCulloch, S. D. & Kunkel, T. A. The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases. Cell Res. 18, 148-161 (2008).
    • (2008) Cell Res , vol.18 , pp. 148-161
    • McCulloch, S.D.1    Kunkel, T.A.2
  • 67
    • 34247169028 scopus 로고    scopus 로고
    • Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: A complex genotype-phenotype relationship
    • Kraemer, K. H. et al. Xeroderma pigmentosum, trichothiodystrophy and Cockayne syndrome: a complex genotype-phenotype relationship. Neuroscience 145, 1388-1396 (2007).
    • (2007) Neuroscience , vol.145 , pp. 1388-1396
    • Kraemer, K.H.1
  • 68
    • 33845683300 scopus 로고    scopus 로고
    • Nucleotide excision repair disorders and the balance between cancer and aging
    • Andressoo, J. O., Hoeijmakers, J. H. & Mitchell, J. R. Nucleotide excision repair disorders and the balance between cancer and aging. Cell Cycle 5, 2886-2888 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 2886-2888
    • Andressoo, J.O.1    Hoeijmakers, J.H.2    Mitchell, J.R.3
  • 69
    • 0141960200 scopus 로고    scopus 로고
    • Exposing the MYtH about base excision repair and human inherited disease
    • Cheadle, J. P. & Sampson, J. R. Exposing the MYtH about base excision repair and human inherited disease. Hum. Mol. Genet. 12, R159-R165 (2003).
    • (2003) Hum. Mol. Genet , vol.12
    • Cheadle, J.P.1    Sampson, J.R.2
  • 70
    • 35348992639 scopus 로고    scopus 로고
    • The genetics of hereditary colon cancer
    • Rustgi, A. K. The genetics of hereditary colon cancer. Genes Dev. 21, 2525-2538 (2007).
    • (2007) Genes Dev , vol.21 , pp. 2525-2538
    • Rustgi, A.K.1
  • 71
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi, J. & d'Adda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nature Rev. Mol. Cell Biol. 8, 729-740 (2007).
    • (2007) Nature Rev. Mol. Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 72
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: Cellular senescence as a DNA-damage response
    • d'Adda di Fagagna, F. Living on a break: cellular senescence as a DNA-damage response. Nature Rev. Cancer 8, 512-522 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 512-522
    • d'Adda di Fagagna, F.1
  • 73
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai, H., Smogorzewska, A. & de Lange, T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13, 1549-1556 (2003).
    • (2003) Curr. Biol , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 74
    • 69949125332 scopus 로고    scopus 로고
    • Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence
    • in the press
    • Nakamura, A. J. et al. Both telomeric and non-telomeric DNA damage are determinants of mammalian cellular senescence. Epigenet. Chromatin (in the press).
    • Epigenet. Chromatin
    • Nakamura, A.J.1
  • 75
    • 44349136891 scopus 로고    scopus 로고
    • Telomere dysfunction and tumour suppression: The senescence connection
    • Deng, Y., Chan, S. S. & Chang, S. Telomere dysfunction and tumour suppression: the senescence connection. Nature Rev. Cancer 8, 450-458 (2008).
    • (2008) Nature Rev. Cancer , vol.8 , pp. 450-458
    • Deng, Y.1    Chan, S.S.2    Chang, S.3
  • 76
    • 34249316487 scopus 로고    scopus 로고
    • Class switch recombination: A friend and a foe
    • Edry, E. & Melamed, D. Class switch recombination: a friend and a foe. Clin. Immunol. 123, 244-251 (2007).
    • (2007) Clin. Immunol , vol.123 , pp. 244-251
    • Edry, E.1    Melamed, D.2
  • 77
    • 36949037544 scopus 로고    scopus 로고
    • V(D)J and immunoglobulin class switch recombinations: A paradigm to study the regulation of DNA end-joining
    • Soulas-Sprauel, P. et al. V(D)J and immunoglobulin class switch recombinations: a paradigm to study the regulation of DNA end-joining. Oncogene 26, 7780-7791 (2007).
    • (2007) Oncogene , vol.26 , pp. 7780-7791
    • Soulas-Sprauel, P.1
  • 78
    • 0035097808 scopus 로고    scopus 로고
    • Recombinational DNA double-strand breaks in mice precede synapsis
    • Mahadevaiah, S. K. et al. Recombinational DNA double-strand breaks in mice precede synapsis. Nature Genet. 27, 271-276 (2001).
    • (2001) Nature Genet , vol.27 , pp. 271-276
    • Mahadevaiah, S.K.1
  • 79
    • 0346634937 scopus 로고    scopus 로고
    • H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis
    • Fernandez-Capetillo, O. et al. H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev. Cell 4, 497-508 (2003).
    • (2003) Dev. Cell , vol.4 , pp. 497-508
    • Fernandez-Capetillo, O.1
  • 80
    • 0034737439 scopus 로고    scopus 로고
    • Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
    • Rogakou, E. P., Nieves-Neira, W., Boon, C., Pommier, Y. & Bonner, W. M. Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139. J. Biol. Chem. 275, 9390-9395 (2000).
    • (2000) J. Biol. Chem , vol.275 , pp. 9390-9395
    • Rogakou, E.P.1    Nieves-Neira, W.2    Boon, C.3    Pommier, Y.4    Bonner, W.M.5
  • 81
    • 27744455447 scopus 로고    scopus 로고
    • Trashing the genome: The role of nucleases during apoptosis
    • Samejima, K. & Earnshaw, W. C. Trashing the genome: the role of nucleases during apoptosis. Nature Rev. Mol. Cell Biol. 6, 677-688 (2005).
    • (2005) Nature Rev. Mol. Cell Biol , vol.6 , pp. 677-688
    • Samejima, K.1    Earnshaw, W.C.2
  • 82
    • 34249910944 scopus 로고    scopus 로고
    • Gammaherpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication
    • Tarakanova, V. L. et al. Gammaherpesvirus kinase actively initiates a DNA damage response by inducing phosphorylation of H2AX to foster viral replication. Cell Host Microbe 1, 275-286 (2007).
    • (2007) Cell Host Microbe , vol.1 , pp. 275-286
    • Tarakanova, V.L.1
  • 83
    • 17244367849 scopus 로고    scopus 로고
    • DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis
    • Bartkova, J. et al. DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864-870 (2005).
    • (2005) Nature , vol.434 , pp. 864-870
    • Bartkova, J.1
  • 84
    • 17244366865 scopus 로고    scopus 로고
    • Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions
    • Gorgoulis, V. G. et al. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434, 907-913 (2005).
    • (2005) Nature , vol.434 , pp. 907-913
    • Gorgoulis, V.G.1
  • 86
    • 0037884963 scopus 로고    scopus 로고
    • Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses
    • Rothkamm, K. & Lobrich, M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc. Natl Acad. Sci. USA 100, 5057-5062 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , pp. 5057-5062
    • Rothkamm, K.1    Lobrich, M.2
  • 87
    • 1642602686 scopus 로고    scopus 로고
    • Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
    • Sedelnikova, O. A. et al. Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nature Cell Biol. 6, 168-170 (2004).
    • (2004) Nature Cell Biol , vol.6 , pp. 168-170
    • Sedelnikova, O.A.1
  • 88
    • 21144456719 scopus 로고    scopus 로고
    • In vivo formation and repair of DNA double-strand breaks after computed tomography examinations
    • Lobrich, M. et al. In vivo formation and repair of DNA double-strand breaks after computed tomography examinations. Proc. Natl Acad. Sci. USA 102, 8984-8989 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 8984-8989
    • Lobrich, M.1
  • 90
    • 57149126423 scopus 로고    scopus 로고
    • Huang, X., Halicka, H. D. & Darzynkiewicz, Z. Detection of histone H2AX phosphorylation on Ser-139 as an indicator of DNA damage (DNA double-strand breaks). Curr. Protoc. Cytom. Chapter 7 Unit 7.27 (2004).
    • Huang, X., Halicka, H. D. & Darzynkiewicz, Z. Detection of histone H2AX phosphorylation on Ser-139 as an indicator of DNA damage (DNA double-strand breaks). Curr. Protoc. Cytom. Chapter 7 Unit 7.27 (2004).
  • 91
    • 34548417690 scopus 로고    scopus 로고
    • Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents
    • Tanaka, T. et al. Cytometry of ATM activation and histone H2AX phosphorylation to estimate extent of DNA damage induced by exogenous agents. Cytometry A 71, 641-648 (2007).
    • (2007) Cytometry A , vol.71 , pp. 641-648
    • Tanaka, T.1
  • 92
    • 0942278942 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX as a measure of radiosensitivity
    • Olive, P. L. & Banath, J. P. Phosphorylation of histone H2AX as a measure of radiosensitivity. Int. J. Radiat. Oncol. Biol. Phys. 58, 331-335 (2004).
    • (2004) Int. J. Radiat. Oncol. Biol. Phys , vol.58 , pp. 331-335
    • Olive, P.L.1    Banath, J.P.2
  • 93
    • 33845606709 scopus 로고    scopus 로고
    • Leukocyte DNA damage after multi-detector row CT: A quantitative biomarker of low-level radiation exposure
    • Rothkamm, K., Balroop, S., Shekhdar, J., Fernie, P. & Goh, V. Leukocyte DNA damage after multi-detector row CT: a quantitative biomarker of low-level radiation exposure. Radiology 242, 244-251 (2007).
    • (2007) Radiology , vol.242 , pp. 244-251
    • Rothkamm, K.1    Balroop, S.2    Shekhdar, J.3    Fernie, P.4    Goh, V.5
  • 94
    • 34249315106 scopus 로고    scopus 로고
    • DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models
    • Sedelnikova, O. A. et al. DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res. 67, 4295-4302 (2007).
    • (2007) Cancer Res , vol.67 , pp. 4295-4302
    • Sedelnikova, O.A.1
  • 95
    • 38349134829 scopus 로고    scopus 로고
    • Delayed kinetics of DNA double-strand break processing in normal and pathological aging
    • Sedelnikova, O. A. et al. Delayed kinetics of DNA double-strand break processing in normal and pathological aging. Aging Cell 7, 89-100 (2008).
    • (2008) Aging Cell , vol.7 , pp. 89-100
    • Sedelnikova, O.A.1
  • 96
    • 37549071516 scopus 로고    scopus 로고
    • Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters
    • Takagi, K. et al. Novel E-ring camptothecin keto analogues (S38809 and S39625) are stable, potent, and selective topoisomerase I inhibitors without being substrates of drug efflux transporters. Mol. Cancer Ther. 6, 3229-3238 (2007).
    • (2007) Mol. Cancer Ther , vol.6 , pp. 3229-3238
    • Takagi, K.1
  • 97
    • 34249784216 scopus 로고    scopus 로고
    • Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models
    • Albert, J. M. et al. Inhibition of poly(ADP-ribose) polymerase enhances cell death and improves tumor growth delay in irradiated lung cancer models. Clin. Cancer Res. 13, 3033-3042 (2007).
    • (2007) Clin. Cancer Res , vol.13 , pp. 3033-3042
    • Albert, J.M.1
  • 98
    • 35448964674 scopus 로고    scopus 로고
    • Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone γ-H2AX as a biomarker of DNA damage
    • Rao, V. A., Agama, K., Holbeck, S. & Pommier, Y. Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone γ-H2AX as a biomarker of DNA damage. Cancer Res. 67, 9971-9979 (2007).
    • (2007) Cancer Res , vol.67 , pp. 9971-9979
    • Rao, V.A.1    Agama, K.2    Holbeck, S.3    Pommier, Y.4
  • 99
    • 37349039649 scopus 로고    scopus 로고
    • Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress
    • Shimura, T. et al. Bloom's syndrome helicase and Mus81 are required to induce transient double-strand DNA breaks in response to DNA replication stress. J. Mol. Biol. 375, 1152-1164 (2008).
    • (2008) J. Mol. Biol , vol.375 , pp. 1152-1164
    • Shimura, T.1
  • 100
    • 0037981413 scopus 로고    scopus 로고
    • Cell cycle-dependent expression of phosphorylated histone H2AX: Reduced expression in unirradiated but not X-irradiated G1-phase cells
    • MacPhail, S. H., Banath, J. P., Yu, Y., Chu, E. & Olive, P. L. Cell cycle-dependent expression of phosphorylated histone H2AX: reduced expression in unirradiated but not X-irradiated G1-phase cells. Radiat. Res. 159, 759-767 (2003).
    • (2003) Radiat. Res , vol.159 , pp. 759-767
    • MacPhail, S.H.1    Banath, J.P.2    Yu, Y.3    Chu, E.4    Olive, P.L.5
  • 101
    • 34247135323 scopus 로고    scopus 로고
    • An optimized method for detecting γ-H2AX in blood cells reveals a significant interindividual variation in the γ-H2AX response among humans
    • Ismail, I. H., Wadhra, T. I. & Hammarsten, O. An optimized method for detecting γ-H2AX in blood cells reveals a significant interindividual variation in the γ-H2AX response among humans. Nucleic Acids Res. 35, e36 (2007).
    • (2007) Nucleic Acids Res , vol.35
    • Ismail, I.H.1    Wadhra, T.I.2    Hammarsten, O.3
  • 102
    • 40249086612 scopus 로고    scopus 로고
    • Residual γH2AX after irradiation of human lymphocytes and monocytes in vitro and its relation to late effects after prostate brachytherapy
    • Olive, P. L., Banath, J. P. & Keyes, M. Residual γH2AX after irradiation of human lymphocytes and monocytes in vitro and its relation to late effects after prostate brachytherapy. Radiother Oncol. 86, 336-346 (2008).
    • (2008) Radiother Oncol , vol.86 , pp. 336-346
    • Olive, P.L.1    Banath, J.P.2    Keyes, M.3
  • 103
    • 8844259700 scopus 로고    scopus 로고
    • Generation of S. phase-dependent DNA double-strand breaks by Cr(VI) exposure: Involvement of ATM in Cr(VI) induction of γ-H2AX
    • Ha, L., Ceryak, S. & Patierno, S. R. Generation of S. phase-dependent DNA double-strand breaks by Cr(VI) exposure: involvement of ATM in Cr(VI) induction of γ-H2AX. Carcinogenesis 25, 2265-2274 (2004).
    • (2004) Carcinogenesis , vol.25 , pp. 2265-2274
    • Ha, L.1    Ceryak, S.2    Patierno, S.R.3
  • 104
    • 0038820065 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes
    • Furuta, T. et al. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem. 278, 20303-20312 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 20303-20312
    • Furuta, T.1
  • 105
    • 0037711771 scopus 로고    scopus 로고
    • Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks
    • Celeste, A. et al. Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nature Cell Biol. 5, 675-679 (2003).
    • (2003) Nature Cell Biol , vol.5 , pp. 675-679
    • Celeste, A.1
  • 106
    • 33748335527 scopus 로고    scopus 로고
    • Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo
    • Koturbash, I. et al. Epigenetic dysregulation underlies radiation-induced transgenerational genome instability in vivo. Int. J. Radiat. Oncol. Biol. Phys. 66, 327-330 (2006).
    • (2006) Int. J. Radiat. Oncol. Biol. Phys , vol.66 , pp. 327-330
    • Koturbash, I.1
  • 107
    • 37349096996 scopus 로고    scopus 로고
    • Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair
    • Xie, A. et al. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol. Cell 28, 1045-1057 (2007).
    • (2007) Mol. Cell , vol.28 , pp. 1045-1057
    • Xie, A.1
  • 108
    • 38849135851 scopus 로고    scopus 로고
    • DNA double-strand break repair defects in syndromes associated with acute radiation response: At least two different assays to predict intrinsic radiosensitivity?
    • Joubert, A. et al. DNA double-strand break repair defects in syndromes associated with acute radiation response: at least two different assays to predict intrinsic radiosensitivity? Int. J. Radiat. Biol. 84, 107-125 (2008).
    • (2008) Int. J. Radiat. Biol , vol.84 , pp. 107-125
    • Joubert, A.1
  • 109
    • 0141815630 scopus 로고    scopus 로고
    • Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA
    • Iwabuchi, K. et al. Potential role for 53BP1 in DNA end-joining repair through direct interaction with DNA. J. Biol. Chem. 278, 36487-36495 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 36487-36495
    • Iwabuchi, K.1
  • 110
    • 33846090789 scopus 로고    scopus 로고
    • Accumulation of senescent cells in mitotic tissue of aging primates
    • Jeyapalan, J. C., Ferreira, M., Sedivy, J. M. & Herbig, U. Accumulation of senescent cells in mitotic tissue of aging primates. Mech. Ageing Dev. 128, 36-44 (2007).
    • (2007) Mech. Ageing Dev , vol.128 , pp. 36-44
    • Jeyapalan, J.C.1    Ferreira, M.2    Sedivy, J.M.3    Herbig, U.4
  • 111
    • 33746503104 scopus 로고    scopus 로고
    • Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome
    • Porcedda, P. et al. Impaired elimination of DNA double-strand break-containing lymphocytes in ataxia telangiectasia and Nijmegen breakage syndrome. DNA Repair (Amst.) 5, 904-913 (2006).
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 904-913
    • Porcedda, P.1
  • 112
    • 33846227461 scopus 로고    scopus 로고
    • Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes
    • Tanaka, T., Kajstura, M., Halicka, H. D., Traganos, F. & Darzynkiewicz, Z. Constitutive histone H2AX phosphorylation and ATM activation are strongly amplified during mitogenic stimulation of lymphocytes. Cell Prolif. 40, 1-13 (2007).
    • (2007) Cell Prolif , vol.40 , pp. 1-13
    • Tanaka, T.1    Kajstura, M.2    Halicka, H.D.3    Traganos, F.4    Darzynkiewicz, Z.5
  • 113
    • 40449120350 scopus 로고    scopus 로고
    • An oncogene-induced DNA damage model for cancer development
    • Halazonetis, T. D., Gorgoulis, V. G. & Bartek, J. An oncogene-induced DNA damage model for cancer development. Science 319, 1352-1355 (2008).
    • (2008) Science , vol.319 , pp. 1352-1355
    • Halazonetis, T.D.1    Gorgoulis, V.G.2    Bartek, J.3
  • 114
    • 46249125252 scopus 로고    scopus 로고
    • NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer
    • Fagerholm, R. et al. NAD(P)H:quinone oxidoreductase 1 NQO1*2 genotype (P187S) is a strong prognostic and predictive factor in breast cancer. Nature Genet. 40, 844-853 (2008).
    • (2008) Nature Genet , vol.40 , pp. 844-853
    • Fagerholm, R.1
  • 115
    • 33746721468 scopus 로고    scopus 로고
    • Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability
    • Yu, T., MacPhail, S. H., Banath, J. P., Klokov, D. & Olive, P. L. Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability. DNA Repair (Amst.) 5, 935-946 (2006).
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 935-946
    • Yu, T.1    MacPhail, S.H.2    Banath, J.P.3    Klokov, D.4    Olive, P.L.5
  • 116
    • 48949083652 scopus 로고    scopus 로고
    • Utility of antiphosphorylated H2AX antibody (γ-H2AX) in diagnosing metastatic renal cell carcinoma
    • Wasco, M. J. & Pu, R. T. Utility of antiphosphorylated H2AX antibody (γ-H2AX) in diagnosing metastatic renal cell carcinoma. Appl. Immunohistochem. Mol. Morphol. 16, 349-356 (2008).
    • (2008) Appl. Immunohistochem. Mol. Morphol , vol.16 , pp. 349-356
    • Wasco, M.J.1    Pu, R.T.2
  • 117
    • 53449086211 scopus 로고    scopus 로고
    • Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies
    • Lakatos, P. L. & Lakatos, L. Risk for colorectal cancer in ulcerative colitis: Changes, causes and management strategies. World J. Gastroenterol. 14, 3937-3947 (2008).
    • (2008) World J. Gastroenterol , vol.14 , pp. 3937-3947
    • Lakatos, P.L.1    Lakatos, L.2
  • 118
    • 48549086606 scopus 로고    scopus 로고
    • Ulcerative colitis is a disease of accelerated colon aging: Evidence from telomere attrition and DNA damage
    • Risques, R. A. et al. Ulcerative colitis is a disease of accelerated colon aging: evidence from telomere attrition and DNA damage. Gastroenterology 135, 410-418 (2008).
    • (2008) Gastroenterology , vol.135 , pp. 410-418
    • Risques, R.A.1
  • 119
    • 44949093617 scopus 로고    scopus 로고
    • A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia
    • Porcedda, P. et al. A rapid flow cytometry test based on histone H2AX phosphorylation for the sensitive and specific diagnosis of ataxia telangiectasia. Cytometry A 73, 508-516 (2008).
    • (2008) Cytometry A , vol.73 , pp. 508-516
    • Porcedda, P.1
  • 120
    • 9744220428 scopus 로고    scopus 로고
    • Riballo, E. et al. A pathway of double-strand break rejoining dependent upon, A. T. M., Artemis, and proteins locating to γ-H2AX foci. Mol. Cell 16, 715-724 (2004).
    • Riballo, E. et al. A pathway of double-strand break rejoining dependent upon, A. T. M., Artemis, and proteins locating to γ-H2AX foci. Mol. Cell 16, 715-724 (2004).
  • 121
    • 51549098868 scopus 로고    scopus 로고
    • DNA double-strand breaks after percutaneous transluminal angioplasty
    • Geisel, D., Heverhagen, J. T., Kalinowski, M. & Wagner, H. J. DNA double-strand breaks after percutaneous transluminal angioplasty. Radiology 248, 852-859 (2008).
    • (2008) Radiology , vol.248 , pp. 852-859
    • Geisel, D.1    Heverhagen, J.T.2    Kalinowski, M.3    Wagner, H.J.4
  • 122
    • 34548359085 scopus 로고    scopus 로고
    • γ-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: Dependence on the dose-distribution, irradiated site and time from start of treatment
    • Sak, A. et al. γ-H2AX foci formation in peripheral blood lymphocytes of tumor patients after local radiotherapy to different sites of the body: dependence on the dose-distribution, irradiated site and time from start of treatment. Int. J. Radiat. Biol. 83, 639-652 (2007).
    • (2007) Int. J. Radiat. Biol , vol.83 , pp. 639-652
    • Sak, A.1
  • 123
    • 0028249115 scopus 로고
    • The MDR superfamily of genes and its biological implications
    • Childs, S. & Ling, V. The MDR superfamily of genes and its biological implications. Important Adv. Oncol. 21-36 (1994).
    • (1994) Important Adv. Oncol , vol.21-36
    • Childs, S.1    Ling, V.2
  • 124
    • 33846504444 scopus 로고    scopus 로고
    • Compressing drug development timelines in oncology using phase '0' trials
    • Kummar, S. et al. Compressing drug development timelines in oncology using phase '0' trials. Nature Rev. Cancer 7, 131-139 (2007).
    • (2007) Nature Rev. Cancer , vol.7 , pp. 131-139
    • Kummar, S.1
  • 125
    • 34548851697 scopus 로고    scopus 로고
    • A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias
    • Karp, J. E. et al. A phase 1 clinical-laboratory study of clofarabine followed by cyclophosphamide for adults with refractory acute leukemias. Blood 110, 1762-1769 (2007).
    • (2007) Blood , vol.110 , pp. 1762-1769
    • Karp, J.E.1
  • 126
    • 38649121719 scopus 로고    scopus 로고
    • Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location
    • Yauk, C. et al. Germ-line mutations, DNA damage, and global hypermethylation in mice exposed to particulate air pollution in an urban/industrial location. Proc. Natl Acad. Sci. USA 105, 605-610 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 605-610
    • Yauk, C.1
  • 127
    • 36049052510 scopus 로고    scopus 로고
    • Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs
    • Rekhadevi, P. V. et al. Genotoxicity assessment in oncology nurses handling anti-neoplastic drugs. Mutagenesis 22, 395-401 (2007).
    • (2007) Mutagenesis , vol.22 , pp. 395-401
    • Rekhadevi, P.V.1
  • 128
    • 25844432196 scopus 로고    scopus 로고
    • Microwaves from GSM mobile telephones affect 53BP1 and γ-H2AX foci in human lymphocytes from hypersensitive and healthy persons
    • Markova, E., Hillert, L., Malmgren, L., Persson, B. R. & Belyaev, I. Y. Microwaves from GSM mobile telephones affect 53BP1 and γ-H2AX foci in human lymphocytes from hypersensitive and healthy persons. Environ. Health Perspect. 113, 1172-1177 (2005).
    • (2005) Environ. Health Perspect , vol.113 , pp. 1172-1177
    • Markova, E.1    Hillert, L.2    Malmgren, L.3    Persson, B.R.4    Belyaev, I.Y.5
  • 129
    • 34948860488 scopus 로고    scopus 로고
    • Effect of consumption of organically and conventionally produced apples on antioxidant activity and DNA damage in humans
    • Briviba, K. et al. Effect of consumption of organically and conventionally produced apples on antioxidant activity and DNA damage in humans. J. Agric. Food Chem. 55, 7716-7721 (2007).
    • (2007) J. Agric. Food Chem , vol.55 , pp. 7716-7721
    • Briviba, K.1
  • 130
    • 34247634029 scopus 로고    scopus 로고
    • Kinetics and dose-response of residual 53BP1/ γ-H2AX foci: Co-localization, relationship with DSB repair and clonogenic survival
    • Markova, E., Schultz, N. & Belyaev, I. Y. Kinetics and dose-response of residual 53BP1/ γ-H2AX foci: co-localization, relationship with DSB repair and clonogenic survival. Int. J. Radiat. Biol. 83, 319-329 (2007).
    • (2007) Int. J. Radiat. Biol , vol.83 , pp. 319-329
    • Markova, E.1    Schultz, N.2    Belyaev, I.Y.3
  • 131
    • 26244439873 scopus 로고    scopus 로고
    • ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells
    • McManus, K. J. & Hendzel, M. J. ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol. Biol. Cell 16, 5013-5025 (2005).
    • (2005) Mol. Biol. Cell , vol.16 , pp. 5013-5025
    • McManus, K.J.1    Hendzel, M.J.2
  • 132
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward, I. M. & Chen, J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J. Biol. Chem. 276, 47759-47762 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 133
    • 25144461206 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX at M phase in human cells without DNA damage response
    • Ichijima, Y. et al. Phosphorylation of histone H2AX at M phase in human cells without DNA damage response. Biochem. Biophys. Res. Commun. 336, 807-812 (2005).
    • (2005) Biochem. Biophys. Res. Commun , vol.336 , pp. 807-812
    • Ichijima, Y.1
  • 134
    • 37848999008 scopus 로고    scopus 로고
    • Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization
    • Jeffers, L. J., Coull, B. J., Stack, S. J. & Morrison, C. G. Distinct BRCT domains in Mcph1/Brit1 mediate ionizing radiation-induced focus formation and centrosomal localization. Oncogene 27, 139-144 (2008).
    • (2008) Oncogene , vol.27 , pp. 139-144
    • Jeffers, L.J.1    Coull, B.J.2    Stack, S.J.3    Morrison, C.G.4
  • 135
    • 34250676017 scopus 로고    scopus 로고
    • Characterization of Spo11-dependent and independent phospho-H2AX foci during meiotic prophase I in the male mouse
    • Chicheportiche, A., Bernardino-Sgherri, J., de Massy, B. & Dutrillaux, B. Characterization of Spo11-dependent and independent phospho-H2AX foci during meiotic prophase I in the male mouse. J. Cell Sci. 120, 1733-1742 (2007).
    • (2007) J. Cell Sci , vol.120 , pp. 1733-1742
    • Chicheportiche, A.1    Bernardino-Sgherri, J.2    de Massy, B.3    Dutrillaux, B.4
  • 136
    • 8544226285 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair
    • Daniel, R. et al. Histone H2AX is phosphorylated at sites of retroviral DNA integration but is dispensable for postintegration repair. J. Biol. Chem. 279, 45810-45814 (2004).
    • (2004) J. Biol. Chem , vol.279 , pp. 45810-45814
    • Daniel, R.1
  • 137
    • 1942538492 scopus 로고    scopus 로고
    • ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation
    • Stiff, T. et al. ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation. Cancer Res. 64, 2390-2396 (2004).
    • (2004) Cancer Res , vol.64 , pp. 2390-2396
    • Stiff, T.1
  • 138
    • 33646106590 scopus 로고    scopus 로고
    • γH2AX and MDC1: Anchoring the DNA-damage-response machinery to broken chromosomes
    • Stucki, M. & Jackson, S. P. γH2AX and MDC1: anchoring the DNA-damage-response machinery to broken chromosomes. DNA Repair (Amst.) 5, 534-543 (2006).
    • (2006) DNA Repair (Amst.) , vol.5 , pp. 534-543
    • Stucki, M.1    Jackson, S.P.2
  • 139
    • 18644367144 scopus 로고    scopus 로고
    • NBS1 localizes to γ-H2AX foci through interaction with the FHA/BRCT domain
    • Kobayashi, J. et al. NBS1 localizes to γ-H2AX foci through interaction with the FHA/BRCT domain. Curr. Biol. 12, 1846-1851 (2002).
    • (2002) Curr. Biol , vol.12 , pp. 1846-1851
    • Kobayashi, J.1
  • 140
    • 41149127607 scopus 로고    scopus 로고
    • The R215W mutation in NBS1 impairs γ-H2AX binding and affects DNA repair: Molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients
    • di Masi, A. et al. The R215W mutation in NBS1 impairs γ-H2AX binding and affects DNA repair: molecular bases for the severe phenotype of 657del5/R215W Nijmegen breakage syndrome patients. Biochem. Biophys. Res. Commun. 369, 835-840 (2008).
    • (2008) Biochem. Biophys. Res. Commun , vol.369 , pp. 835-840
    • di Masi, A.1
  • 141
    • 30744465308 scopus 로고    scopus 로고
    • MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
    • Lou, Z. et al. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol. Cell 21, 187-200 (2006).
    • (2006) Mol. Cell , vol.21 , pp. 187-200
    • Lou, Z.1
  • 142
    • 36849000716 scopus 로고    scopus 로고
    • MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage
    • Wood, J. L., Singh, N., Mer, G. & Chen, J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J. Biol. Chem. 282, 35416-35423 (2007).
    • (2007) J. Biol. Chem , vol.282 , pp. 35416-35423
    • Wood, J.L.1    Singh, N.2    Mer, G.3    Chen, J.4
  • 143
    • 33745763425 scopus 로고    scopus 로고
    • Regulation of mitotic entry by microcephalin and its overlap with ATR signalling
    • Alderton, G. K. et al. Regulation of mitotic entry by microcephalin and its overlap with ATR signalling. Nature Cell Biol. 8, 725-733 (2006).
    • (2006) Nature Cell Biol , vol.8 , pp. 725-733
    • Alderton, G.K.1
  • 144
    • 33751218297 scopus 로고    scopus 로고
    • BRIT1/MCPH1: A guardian of genome and an enemy of tumors
    • Chaplet, M., Rai, R., Jackson-Bernitsas, D., Li, K. & Lin, S. Y. BRIT1/MCPH1: a guardian of genome and an enemy of tumors. Cell Cycle 5, 2579-2583 (2006).
    • (2006) Cell Cycle , vol.5 , pp. 2579-2583
    • Chaplet, M.1    Rai, R.2    Jackson-Bernitsas, D.3    Li, K.4    Lin, S.Y.5
  • 146
    • 35148894396 scopus 로고    scopus 로고
    • DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics
    • Ikura, T. et al. DNA damage-dependent acetylation and ubiquitination of H2AX enhances chromatin dynamics. Mol. Cell Biol. 27, 7028-7040 (2007).
    • (2007) Mol. Cell Biol , vol.27 , pp. 7028-7040
    • Ikura, T.1
  • 147
    • 34648834736 scopus 로고    scopus 로고
    • Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks
    • van Attikum, H., Fritsch, O. & Gasser, S. M. Distinct roles for SWR1 and INO80 chromatin remodeling complexes at chromosomal double-strand breaks. EMBO J. 26, 4113-4125 (2007).
    • (2007) EMBO J , vol.26 , pp. 4113-4125
    • van Attikum, H.1    Fritsch, O.2    Gasser, S.M.3
  • 148
    • 10944219768 scopus 로고    scopus 로고
    • Control of sister chromatid recombination by histone H2AX
    • Xie, A. et al. Control of sister chromatid recombination by histone H2AX. Mol. Cell 16, 1017-1025 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 1017-1025
    • Xie, A.1
  • 149
    • 10944262393 scopus 로고    scopus 로고
    • DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain
    • Unal, E. et al. DNA damage response pathway uses histone modification to assemble a double-strand break-specific cohesin domain. Mol. Cell 16, 991-1002 (2004).
    • (2004) Mol. Cell , vol.16 , pp. 991-1002
    • Unal, E.1
  • 150
    • 33745487368 scopus 로고    scopus 로고
    • Cell apoptosis: Requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3
    • Lu, C. et al. Cell apoptosis: requirement of H2AX in DNA ladder formation, but not for the activation of caspase-3. Mol. Cell 23, 121-132 (2006).
    • (2006) Mol. Cell , vol.23 , pp. 121-132
    • Lu, C.1
  • 151
    • 47849120976 scopus 로고    scopus 로고
    • Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway
    • Lu, C. et al. Serum starvation induces H2AX phosphorylation to regulate apoptosis via p38 MAPK pathway. FEBS Lett. 582, 2703-2708 (2008).
    • (2008) FEBS Lett , vol.582 , pp. 2703-2708
    • Lu, C.1
  • 152
    • 33750092260 scopus 로고    scopus 로고
    • Candidate protein biodosimeters of human exposure to ionizing radiation
    • Marchetti, F., Coleman, M. A., Jones, I. M. & Wyrobek, A. J. Candidate protein biodosimeters of human exposure to ionizing radiation. Int. J. Radiat. Biol. 82, 605-639 (2006).
    • (2006) Int. J. Radiat. Biol , vol.82 , pp. 605-639
    • Marchetti, F.1    Coleman, M.A.2    Jones, I.M.3    Wyrobek, A.J.4
  • 153
    • 0345835371 scopus 로고    scopus 로고
    • Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks
    • Banath, J. P. & Olive, P. L. Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks. Cancer Res. 63, 4347-4350 (2003).
    • (2003) Cancer Res , vol.63 , pp. 4347-4350
    • Banath, J.P.1    Olive, P.L.2
  • 154
    • 0034811207 scopus 로고    scopus 로고
    • Visualization of focal nuclear sites of DNA repair synthesis induced by bleomycin in human cells
    • Tomilin, N. V. et al. Visualization of focal nuclear sites of DNA repair synthesis induced by bleomycin in human cells. Radiat. Res. 156, 347-354 (2001).
    • (2001) Radiat. Res , vol.156 , pp. 347-354
    • Tomilin, N.V.1
  • 155
    • 35948968756 scopus 로고    scopus 로고
    • Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance
    • Antony, S. et al. Novel indenoisoquinolines NSC 725776 and NSC 724998 produce persistent topoisomerase I cleavage complexes and overcome multidrug resistance. Cancer Res. 67, 10397-10405 (2007).
    • (2007) Cancer Res , vol.67 , pp. 10397-10405
    • Antony, S.1
  • 156
    • 3442889371 scopus 로고    scopus 로고
    • Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide
    • Olive, P. L., Banath, J. P. & Sinnott, L. T. Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide. Cancer Res. 64, 5363-5369 (2004).
    • (2004) Cancer Res , vol.64 , pp. 5363-5369
    • Olive, P.L.1    Banath, J.P.2    Sinnott, L.T.3
  • 157
    • 2642528031 scopus 로고    scopus 로고
    • DNA damage-induced activation of ATM and ATM-dependent signaling pathways
    • Kurz, E. U. & Lees-Miller, S. P. DNA damage-induced activation of ATM and ATM-dependent signaling pathways. DNA Repair (Amst.) 3, 889-900 (2004).
    • (2004) DNA Repair (Amst.) , vol.3 , pp. 889-900
    • Kurz, E.U.1    Lees-Miller, S.P.2
  • 158
    • 37349106147 scopus 로고    scopus 로고
    • High mobility group protein B1 is an activator of apoptotic response to antimetabolite drugs
    • Krynetskaia, N., Xie, H., Vucetic, S., Obradovic, Z. & Krynetskiy, E. High mobility group protein B1 is an activator of apoptotic response to antimetabolite drugs. Mol. Pharmacol. 73, 260-269 (2008).
    • (2008) Mol. Pharmacol , vol.73 , pp. 260-269
    • Krynetskaia, N.1    Xie, H.2    Vucetic, S.3    Obradovic, Z.4    Krynetskiy, E.5
  • 159
    • 34248184571 scopus 로고    scopus 로고
    • Ewald, B., Sampath, D. & Plunkett, W. H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation. Mol. Cancer Ther. 6, 1239-1248 (2007).
    • Ewald, B., Sampath, D. & Plunkett, W. H2AX phosphorylation marks gemcitabine-induced stalled replication forks and their collapse upon S-phase checkpoint abrogation. Mol. Cancer Ther. 6, 1239-1248 (2007).
  • 160
    • 33645916409 scopus 로고    scopus 로고
    • Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis
    • Kurose, A. et al. Effects of hydroxyurea and aphidicolin on phosphorylation of ataxia telangiectasia mutated on Ser 1981 and histone H2AX on Ser 139 in relation to cell cycle phase and induction of apoptosis. Cytometry A 69, 212-221 (2006).
    • (2006) Cytometry A , vol.69 , pp. 212-221
    • Kurose, A.1
  • 161
    • 44249118962 scopus 로고    scopus 로고
    • ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis
    • Pabla, N., Huang, S., Mi, Q. S., Daniel, R. & Dong, Z. ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J. Biol. Chem. 283, 6572-6583 (2008).
    • (2008) J. Biol. Chem , vol.283 , pp. 6572-6583
    • Pabla, N.1    Huang, S.2    Mi, Q.S.3    Daniel, R.4    Dong, Z.5
  • 162
    • 33845214070 scopus 로고    scopus 로고
    • The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity
    • Mirzoeva, O. K., Kawaguchi, T. & Pieper, R. O. The Mre11/Rad50/Nbs1 complex interacts with the mismatch repair system and contributes to temozolomide-induced G2 arrest and cytotoxicity. Mol. Cancer Ther. 5, 2757-2766 (2006).
    • (2006) Mol. Cancer Ther , vol.5 , pp. 2757-2766
    • Mirzoeva, O.K.1    Kawaguchi, T.2    Pieper, R.O.3
  • 163
    • 20444442793 scopus 로고    scopus 로고
    • DNA-protein crosslinks and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against breast cancer cells
    • Meng, L., Kohlhagen, G., Sausville, E. A. & Pommier, Y. DNA-protein crosslinks and replication-dependent histone H2AX phosphorylation induced by aminoflavone (NSC 686288), a novel anticancer agent active against breast cancer cells. Cancer Res. 65, 5337-5343 (2005).
    • (2005) Cancer Res , vol.65 , pp. 5337-5343
    • Meng, L.1    Kohlhagen, G.2    Sausville, E.A.3    Pommier, Y.4
  • 164
    • 34250767283 scopus 로고    scopus 로고
    • 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells
    • Kiziltepe, T. et al. 5-Azacytidine, a DNA methyltransferase inhibitor, induces ATR-mediated DNA double-strand break responses, apoptosis, and synergistic cytotoxicity with doxorubicin and bortezomib against multiple myeloma cells. Mol. Cancer Ther. 6, 1718-1727 (2007).
    • (2007) Mol. Cancer Ther , vol.6 , pp. 1718-1727
    • Kiziltepe, T.1
  • 165
    • 33748360764 scopus 로고    scopus 로고
    • Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of γ-H2AX foci
    • Munshi, A. et al. Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of γ-H2AX foci. Mol. Cancer Ther. 5, 1967-1974 (2006).
    • (2006) Mol. Cancer Ther , vol.5 , pp. 1967-1974
    • Munshi, A.1
  • 166
    • 33744924482 scopus 로고    scopus 로고
    • Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441
    • Zhao, Y. et al. Preclinical evaluation of a potent novel DNA-dependent protein kinase inhibitor NU7441. Cancer Res. 66, 5354-5362 (2006).
    • (2006) Cancer Res , vol.66 , pp. 5354-5362
    • Zhao, Y.1
  • 167
    • 58149476936 scopus 로고    scopus 로고
    • Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways
    • in the press
    • Solier, S., Sordet, O., Kohn, K. W. & Pommier, Y. Death receptor-induced activation of the Chk2- and histone H2AX-associated DNA damage response pathways. Mol. Cell Biol. (in the press).
    • Mol. Cell Biol
    • Solier, S.1    Sordet, O.2    Kohn, K.W.3    Pommier, Y.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.